Works Published in 2012
Displaying all 15 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Potential of healing a transected anterior cruciate ligament with genetically modified extracellular matrix bioscaffolds in a goat model
Knee Surgery, Sports Traumatology, Arthroscopy, 20(7), 1357–1365.
MeSH headings : Animals; Anterior Cruciate Ligament / surgery; Anterior Cruciate Ligament Injuries; Anterior Cruciate Ligament Reconstruction / methods; Biomechanical Phenomena; Extracellular Matrix; Galactosyltransferases / deficiency; Goats; Guided Tissue Regeneration; Hydrogel, Polyethylene Glycol Dimethacrylate; Materials Testing; Models, Animal; Prostheses and Implants; Swine; Tissue Engineering; Tissue Scaffolds
TL;DR:
The application of an ECM bioscaffold and hydrogel was found to accelerate the healing of a transected ACL following suture repair in the goat model with limited tissue hypertrophy and improvement in some of its biomechanical properties.
(via Semantic Scholar)
Source: Crossref
Added: February 7, 2021
2012 journal article
GENERATION AND CHARACTERISATION OF INDUCED PLURIPOTENT STEM CELLS (iPSCs) FROM ADULT CANINE FIBROBLASTS
Reproduction, Fertility and Development, 24(1), 285.
TL;DR:
The isolated canine iPSCs have similar characteristics to ESCs from other species, but the exact cellular mechanisms behind their unique co-dependency on both FGF and LIF is still unknown.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Safety and Efficacy of Allogeneic Cell Therapy in Infarcted Rats Transplanted With Mismatched Cardiosphere-Derived Cells
Circulation, 125(1), 100–112.
author keywords: allogeneic transplantation; paracrine communication; regeneration; stem cells
MeSH headings : Animals; Cell Survival / physiology; Cells, Cultured; Female; Graft Survival / genetics; Graft Survival / physiology; Humans; Male; Myocardial Infarction / pathology; Myocardial Infarction / surgery; Myocytes, Cardiac / pathology; Myocytes, Cardiac / physiology; Myocytes, Cardiac / transplantation; Rats; Rats, Inbred BN; Rats, Inbred WKY; Spheroids, Cellular / pathology; Spheroids, Cellular / physiology; Spheroids, Cellular / transplantation; Transplantation, Homologous; Treatment Outcome
TL;DR:
Allogeneic CDC transplantation without immunosuppression is safe, promotes cardiac regeneration, and improves heart function in a rat myocardial infarction model, mainly through stimulation of endogenous repair mechanisms.
(via Semantic Scholar)
www.ahajournals.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2012 journal article
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
The Lancet, 379(9819), 895–904.
MeSH headings : Cicatrix / etiology; Cicatrix / pathology; Coronary Vessels; Female; Heart / physiopathology; Humans; Infusions, Intra-Arterial; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / cytology; Myocardium / pathology; Regeneration; Stem Cell Transplantation; Stroke Volume; Transplantation, Autologous; Ventricular Dysfunction, Left / etiology; Ventricular Dysfunction, Left / therapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2012 journal article
Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel
Biomaterials, 33(21), 5317–5324.
author keywords: Acute myocardial infarction; Biodegradable polymers; Hyaluronan; Cardiac stem cells
MeSH headings : Animals; Apoptosis / drug effects; Cell Differentiation / drug effects; Cell Movement / drug effects; Cell Survival / drug effects; Gelatin / pharmacology; Humans; Hyaluronic Acid / pharmacology; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacology; Male; Mice; Microscopy, Fluorescence; Myocardium / cytology; Neovascularization, Physiologic / drug effects; Polymerization / drug effects; Spheroids, Cellular / cytology; Spheroids, Cellular / drug effects; Spheroids, Cellular / transplantation; Tissue Preservation
TL;DR:
A CDC/hydrogel formulation suitable for catheter-based intramyocardial injection exhibits superior engraftment and functional benefits relative to naked CDCs.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2012 journal article
Intramyocardial Injection of Platelet Gel Promotes Endogenous Repair and Augments Cardiac Function in Rats With Myocardial Infarction
Journal of the American College of Cardiology, 59(3), 256–264.
author keywords: biomaterials; endogenous recruitment; myocardial infarction
MeSH headings : Animals; Blood Platelets; Female; Gels; Heart Function Tests / methods; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Random Allocation; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Regeneration / physiology
TL;DR:
Intramyocardial injection of autologous platelet gel ameliorated cardiac dysfunction after myocardial infarction and provided striking functional benefits, the simplicity of manufacturing, and the potentially autologueous nature of this biomaterial provide impetus for further translation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2012 journal article
Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction
Biomaterials, 33(10), 2872–2879.
author keywords: Cardiac stem cells; Platelet gel; Myocardial infarction; Cardiac regeneration
MeSH headings : Animals; Blood Platelets / cytology; Blood Platelets / ultrastructure; Cell Shape; Cells, Cultured; Endothelial Cells / cytology; Gels / pharmacology; Heart Function Tests; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Regeneration; Stem Cell Transplantation
TL;DR:
Histological analysis revealed that, though some transplanted CDCs differentiated into cardiomyocytes and endothelial cells in the recipients' hearts, most of the incremental benefit arose from CDC-mediated endogenous repair, and hypothesize that pre-seeding platelet gel with CDCs can enhance therapeutic efficacy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2012 journal article
Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction
Journal of Cellular and Molecular Medicine, 16(9), 2112–2116.
author keywords: cell transplantation; stem cells; cardiospheres; myocardial infarction; dose effects
MeSH headings : Acute Disease; Animals; Humans; Male; Mice; Mice, SCID; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / pathology; Myocytes, Cardiac / transplantation; Neovascularization, Physiologic; Spheroids, Cellular; Stem Cell Transplantation / methods; Stem Cells / cytology; Stem Cells / metabolism; Ventricular Remodeling
TL;DR:
Functional assessment and quantitative heart morphometry indicated benefit from higher cell doses in terms of ejection fraction, infarct size and capillary density, and Histological analysis indicated that the dose‐dependent benefit was primarily because of indirect effects of transplanted cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2012 journal article
Three Dimensional Neuronal Cell Cultures More Accurately Model Voltage Gated Calcium Channel Functionality in Freshly Dissected Nerve Tissue
PLoS ONE, 7(9), e45074.
Ed(s): G. Cymbalyuk
MeSH headings : Animals; Calcium / metabolism; Calcium Channels / metabolism; Caveolae / physiology; Caveolin 1 / genetics; Caveolin 1 / metabolism; Cell Culture Techniques; Coated Materials, Biocompatible / chemistry; DNA-Directed RNA Polymerases / genetics; DNA-Directed RNA Polymerases / metabolism; Gene Expression; Ion Channel Gating / physiology; Lactic Acid / chemistry; Mice; Molecular Imaging; Polyesters; Polymers / chemistry; Polystyrenes / chemistry; Superior Cervical Ganglion / cytology; Superior Cervical Ganglion / metabolism; Tissue Scaffolds
TL;DR:
The results support the view that exaggerated VGCC functionality from 2D cultured SCG cells is possibly due to differences in membrane architecture, characterized by uniquely organized caveolar lipid rafts, and the practical implication of use of 3D-cultured cells in preclinical drug discovery studies would be more effective in eliminating false positive hits and as such improve the overall yield from screening campaigns.
(via Semantic Scholar)
Source: Crossref
Added: July 21, 2019
2012 journal article
Direct Comparison of Different Stem Cell Types and Subpopulations Reveals Superior Paracrine Potency and Myocardial Repair Efficacy With Cardiosphere-Derived Cells
Journal of the American College of Cardiology, 59(10), 942–953.
author keywords: cardiac stem cells; mesenchymal stem cells; myocardial regeneration; paracrine effects
MeSH headings : Albumins / pharmacology; Animals; Apoptosis; Bone Marrow Cells / cytology; Cell Differentiation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; In Situ Nick-End Labeling; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Mice; Mice, SCID; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Paracrine Communication / physiology; Polyesters / pharmacology; Rats; Rats, Inbred WKY; Stem Cell Transplantation; Wound Healing
TL;DR:
CDCs exhibited a balanced profile of paracrine factor production and, among various comparator cell types/subpopulations, provided the greatest functional benefit in experimental myocardial infarction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2012 journal article
Brief Report: Mechanism of Extravasation of Infused Stem Cells
STEM CELLS, 30(12), 2835–2842.
author keywords: Cell migration; Extravasation; Vasculature; Cell adhesion molecules; Metalloproteinases
MeSH headings : Animals; Cell Movement / physiology; Endothelium, Vascular / cytology; Endothelium, Vascular / metabolism; Female; Humans; Integrins / metabolism; MCF-7 Cells; Matrix Metalloproteinases / metabolism; Myocardium / cytology; Myocardium / metabolism; Peripheral Blood Stem Cell Transplantation / methods; Rats; Rats, Inbred WKY; Spheroids, Cellular; Stem Cells / cytology; Stem Cells / metabolism; Transplantation, Autologous
TL;DR:
In vitro models revealed that active vascular expulsion is generalizable to other stem cell types and to breast cancer cells, and Integrins and matrix metalloproteinases play critical roles in active vascular expelled.
(via Semantic Scholar)
Source: Crossref
Added: July 21, 2019
2012 conference paper
Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts
Reproduction in Domestic Animals, 47, 418–419.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Isolation and characterization of neural progenitor cells from adult canine brains
American Journal of Veterinary Research, 73(12), 1963–1968.
MeSH headings : Animals; Cell Culture Techniques / veterinary; Cell Differentiation; Cell Lineage; Dogs; Female; Hippocampus / cytology; Hippocampus / metabolism; Immunohistochemistry / veterinary; Lateral Ventricles / cytology; Lateral Ventricles / metabolism; Male; Neural Stem Cells / cytology; Neural Stem Cells / physiology; RNA / analysis; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
Results suggested the persistence of SOX2- Positive, nestin-positive, GFAP- positive,GFAP-Positive, OCT4-negative, and NANOG-negative neural progenitor cells in the SVZ and SGZ regions of mature canine brains, which are capable of producing multiple cell lineages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2012 journal article
Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells
EPIGENETICS, 7(5), 429–431.
author keywords: genomic imprinting; PRIM2; pseudogene; placenta; WBC; SNP; sequencing
MeSH headings : Alleles; DNA Primase / genetics; DNA Primase / metabolism; DNA Replication; Databases, Nucleic Acid; Female; Gene Frequency; Genetic Loci; Genome, Human; Genomic Imprinting; Heterozygote; Humans; Leukocytes / cytology; Leukocytes / enzymology; Molecular Sequence Annotation; Placenta / cytology; Placenta / enzymology; Polymorphism, Single Nucleotide; Pregnancy; Pseudogenes; RNA, Messenger / genetics; RNA, Messenger / metabolism; Transcription, Genetic
TL;DR:
It is reported here their failure to confirm imprinting of the PRIM2 locus in human placenta or WBC, and the discordance between results and those of others is likely due to an incorrectly annotatedPRIM2 pseudogene found in the human genome database.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Transgenic Stra8-EYFP pigs: a model for developing male germ cell technologies
TRANSGENIC RESEARCH, 21(2), 383–392.
author keywords: Pig; Transgenic; Stra8; Spermatogonia; Marker gene
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Blotting, Western; Cells, Cultured; Cloning, Molecular; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Regulation, Developmental; Genes, Reporter; Germ Cells / cytology; Germ Cells / metabolism; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Immunohistochemistry; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Mice; Microscopy, Fluorescence / methods; Mitochondria / genetics; Mitochondria / metabolism; Nuclear Transfer Techniques; Plasmids / genetics; Plasmids / metabolism; Promoter Regions, Genetic; Proteins / genetics; Proteins / metabolism; Swine; Testis / cytology; Testis / metabolism; Transfection; Transgenes; Tretinoin / pharmacology
TL;DR:
Transgenic pigs expressing mitochondrial localized enhanced yellow fluorescent protein (EYFP-mito) under control of the germ cell specific Stimulated by Retinoic Acid 8 (Stra8) promoter indicates that these pigs will be useful by providing labelled cells for use in such technologies such as germ cell transplantation and in vitro spermatogenic studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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