Works Published in 2015

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Displaying all 17 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2015 journal article

Characterization of putative haematopoietic cells from bovine yolk sac

Journal of Tissue Engineering and Regenerative Medicine, 11(4), 1132–1140.

By: V. Oliveira*, C. Mançanares*, L. Oliveira*, N. Gonçalves*, M. Miglino*, F. Perecin*, F. Meirelles*, J. Piedrahita n, C. Ambrósio*

author keywords: yolk sac; bovine; embryos; haematopoietic cell
MeSH headings : Animals; Cattle; Cell Adhesion / drug effects; Cell Survival / drug effects; Cells, Cultured; Colony-Forming Units Assay; Embryo, Mammalian / cytology; Female; Flow Cytometry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / drug effects; Hematopoietic Stem Cells / ultrastructure; Methylcellulose / pharmacology; Polymerase Chain Reaction; Pregnancy; Yolk Sac / cytology
TL;DR: Cells were found to be capable of survival post‐cryopreservation and exhibited varying abilities to form colonies in a methylcellulose matrix, depending on gestational age. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: January 21, 2021

2015 journal article

Repair of dense connective tissues via biomaterial-mediated matrix reprogramming of the wound interface

Biomaterials, 39, 85–94.

By: F. Qu*, M. Pintauro*, J. Haughan*, E. Henning*, J. Esterhai*, T. Schaer*, R. Mauck*, M. Fisher*

author keywords: Connective tissue; Drug delivery; ECM (extracellular matrix); In vivo test; Scaffold; Wound healing
MeSH headings : Animals; Biocompatible Materials / chemistry; Connective Tissue / physiology; Microscopy, Atomic Force; Polyethylene Glycols / chemistry; Rats; Sheep; Tissue Scaffolds / chemistry; Wound Healing / physiology
TL;DR: Findings show that partial digestion of the wound interface improves repair by creating a more compliant and porous microenvironment that expedites cell migration to and/or proliferation at the wound margin. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2015 journal article

Alginate Microspheroid Encapsulation and Delivery of MG-63 Cells Into Polycaprolactone Scaffolds: A New Biofabrication Approach for Tissue Engineering Constructs

Journal of Nanotechnology in Engineering and Medicine, 6(2).

By: L. Narayanan n, A. Kumar n, Z. Tan n, S. Bernacki n, B. Starly n & R. Shirwaiker n

TL;DR: A new cell delivery approach utilizing deposition of hydrogel-cell encapsulated microspheroids into polycaprolactone (PCL) scaffolds to improve the seeding efficiency is investigated and the role and critical challenges to be addressed are highlighted to successfully utilize 3D-bioprinting for microencapsulated cell delivery. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 15, 2019

2015 journal article

Biofabrication of Multimaterial Three-Dimensional Constructs Embedded With Patterned Alginate Strands Encapsulating PC12 Neural Cell Lines

Journal of Nanotechnology in Engineering and Medicine, 6(2).

TL;DR: The bioprinting of a three-dimensional (3D) heterogeneous conduit structure encapsulating PC12 neural cells, which was shown to be printed with high cell viability and to proliferate within the rolled construct at a rate consistent with traditional two-dimensional culture. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 15, 2019

2015 chapter

Generation of Induced Pluripotent Stem Cells (iPSCs) from Adult Canine Fibroblasts

In Methods in Molecular Biology (pp. 69–78).

By: S. Koh* & J. Piedrahita n

MeSH headings : Animals; Cell Culture Techniques; Cell Differentiation; Cellular Reprogramming; Dogs; Feeder Cells; Fibroblasts / cytology; Fibroblasts / metabolism; Genetic Vectors / genetics; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; Kruppel-Like Factor 4; Mice; Retroviridae / genetics; Transcription Factors / genetics; Transduction, Genetic; Transgenes
TL;DR: Detailed protocols for generation of iPSCs from adult canine fibroblasts are described, which will provide powerful tools not only to study human diseases, but also for the development of therapeutic approaches. (via Semantic Scholar)
Source: Crossref
Added: July 28, 2019

2015 journal article

Impact of guidance documents on translational large animal studies of cartilage repair

SCIENCE TRANSLATIONAL MEDICINE, 7(310).

MeSH headings : Animals; Cartilage / physiopathology; Models, Animal; Translational Research, Biomedical; United States; United States Food and Drug Administration
TL;DR: A systematic review of large animal cartilage repair studies demonstrates that few investigators attend to guidance documents published by regulatory agencies, and the availability of the documents appears to have little effect on adherence by researchers to the recommendations therein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Large scale industrialized cell expansion: producing the critical raw material for biofabrication processes

BIOFABRICATION, 7(4).

By: A. Kumar n & B. Starly n

author keywords: cell expansion; bioreactors; cellular biomanufacturing; 3D culture
MeSH headings : Bioreactors; Cell Culture Techniques / methods; Cell Proliferation; Tissue Engineering / methods
TL;DR: Some of the challenges in the field of cellular biomanufacturing that must be addressed are highlighted to achieve desired cellular yields while adhering to the key pillars of good manufacturing practices—safety, purity, stability, potency and identity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips

PLOS ONE, 10(11).

By: J. Andrade n, J. Tang n, M. Hensley n, A. Vandergriff n, J. Cores n, E. Henry n, T. Allen n, T. Caranasos* ...

MeSH headings : Animals; Coronary Vessels / surgery; Disease Models, Animal; Ligation; Mice; Myocardial Infarction / etiology; Myocardial Infarction / mortality; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Surgical Instruments; Suture Techniques; Vascular Surgical Procedures
TL;DR: This new method, taking only less than 3 minutes to complete, represents an efficient myocardial infarction model in rodents and improved post-MI survival rate. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Isolation and Cryopreservation of Neonatal Rat Cardiomyocytes

Journal of Visualized Experiments, (98).

author keywords: Developmental Biology; Issue 98; Cryopreservation; Cardiomyocytes; Cell-based Assay; Cell Culture; Cardiac Research; In Vitro Assay
MeSH headings : Actinin / analysis; Actinin / metabolism; Animals; Animals, Newborn; Cell Culture Techniques; Cell Separation / methods; Cell Survival / physiology; Cryopreservation / methods; Cryoprotective Agents / chemistry; Dimethyl Sulfoxide / chemistry; Freezing; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats; Sarcomeres / chemistry; Sarcomeres / metabolism
TL;DR: Cryopreservation methods allow one to easily cryopreserve and thaw neonatal rat cardiomyocytes, which gives researchers a greater amount of flexibility in planning experiments as well as reducing the use of animals. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 chapter

Cryopreservation of Neonatal Cardiomyocytes

In Methods in Molecular Biology (Vol. 1299, pp. 153–160).

By: A. Vandergriff n, M. Hensley n & K. Cheng n

author keywords: Cardiomyocytes; Cryopreservation; Cardiac research
MeSH headings : Animals; Animals, Newborn; Cell Culture Techniques; Cells, Cultured; Cryopreservation / methods; Myocytes, Cardiac / cytology; Rats
TL;DR: A method for cryopreserving neonatal rat cardiomyocytes (NRCMs), and subsequently thawing them for use in assays and to reduce the time requirements and the impact on research animals is described. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis

STEM CELLS TRANSLATIONAL MEDICINE, 4(11), 1265–1274.

By: E. Henry n, J. Cores n, M. Hensley n, S. Anthony n, A. Vandergriff n, J. Andrade n, T. Allen n, T. Caranasos*, L. Lobo*, K. Cheng n

author keywords: Adult lung stem cells; Mesenchymal stem cells; Pulmonary fibrosis; Spheroid cell culture
MeSH headings : Adult; Animals; Antibiotics, Antineoplastic / adverse effects; Antibiotics, Antineoplastic / pharmacology; Bleomycin / adverse effects; Bleomycin / pharmacology; Female; Heterografts; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / pathology; Mice; Mice, SCID; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / metabolism; Pulmonary Fibrosis / pathology; Pulmonary Fibrosis / therapy; Regeneration; Spheroids, Cellular / metabolism; Spheroids, Cellular / transplantation
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy

Stem Cells International, 2015, 1–8.

By: A. Vandergriff n, J. de Andrade n, J. Tang n, M. Hensley n, J. Piedrahita n, T. Caranasos*, K. Cheng n

TL;DR: Mice receiving CSC-XOs showed improved heart function via echocardiography, as well as decreased apoptosis and fibrosis, and mice showed no adverse immune reaction, showing promise for overcoming the limitations of stem cells and improving cardiac therapies. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Cellular Postconditioning Allogeneic Cardiosphere-Derived Cells Reduce Infarct Size and Attenuate Microvascular Obstruction When Administered After Reperfusion in Pigs With Acute Myocardial Infarction

CIRCULATION-HEART FAILURE, 8(2), 322–332.

By: H. Kanazawa, E. Tseliou, K. Malliaras, K. Yee, J. Dawkins, G. De Couto, R. Smith, M. Kreke ...

author keywords: acute myocardial infarction; animal models; coronary interventions; ischemic postconditioning
MeSH headings : Animals; Coronary Vessels; Disease Models, Animal; Heart Failure / surgery; Injections, Intra-Arterial; Ischemic Postconditioning / methods; Myocardial Infarction / complications; Myocardial Infarction / therapy; Myocardial Reperfusion; Stem Cell Transplantation / methods; Swine; Swine, Miniature; Transplantation, Homologous; Ventricular Remodeling / physiology
TL;DR: A novel cardioprotective effect, which the authors call cellular postconditioning, differs from previous strategies to reduce IS in that it works even when initiated with significant delay after reflow. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts

Journal of Cellular and Molecular Medicine, 19(8), 1805–1813.

author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy
MeSH headings : Aging; Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Dogs; Female; Fibrosis; Heart / physiology; Heart Function Tests; Mice, SCID; Myocardium / pathology; Myocytes, Cardiac / cytology; Neovascularization, Physiologic; Paracrine Communication; Regeneration; Spheroids, Cellular / cytology
TL;DR: It is shown that canine CDCs can be produced from adult dog hearts and display similar phenotypes in comparison to previously studied CDCs derived from rodents and human beings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 article

Meniscus mechanics and mechanobiology

Donahue, T. L. H., Fisher, M. B., & Maher, S. A. (2015, June 1). JOURNAL OF BIOMECHANICS, Vol. 48, pp. 1341–1342.

By: T. Donahue*, M. Fisher n & S. Maher*

UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Engineering meniscus structure and function via multi-layered mesenchymal stem cell-seeded nanofibrous scaffolds

JOURNAL OF BIOMECHANICS, 48(8), 1412–1419.

By: M. Fisher n, E. Henning*, N. Soeegaard, M. Bostrom*, J. Esterhai* & R. Mauck*

author keywords: Tissue engineering; Meniscus; Nanofibrous scaffold; Electrospinning; Mechanical properties
MeSH headings : Animals; Cattle; Cells, Cultured; Collagen / metabolism; Elastic Modulus; Materials Testing; Menisci, Tibial / pathology; Mesenchymal Stem Cells / physiology; Nanofibers / chemistry; Polyesters / chemistry; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR: This study developed multi-lamellar mesenchymal stem cell-seeded nanofibrous constructs that may serve as functional substitutes for the meniscus as well as test beds to understand the complex mechanical principles that enable meniscUS function. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Manufacturing Road Map for Tissue Engineering and Regenerative Medicine Technologies

STEM CELLS TRANSLATIONAL MEDICINE, 4(2), 130–135.

By: J. Hunsberger*, O. Harrysson n, R. Shirwaiker n, B. Starly n, R. Wysk n, P. Cohen n, J. Allickson*, J. Yoo*, A. Atala*

MeSH headings : Biological Specimen Banks; Drug Industry / methods; Drug Industry / organization & administration; Humans; Regenerative Medicine / methods; Regenerative Medicine / organization & administration; Tissue Engineering / methods; Translational Research, Biomedical / methods; Translational Research, Biomedical / organization & administration
TL;DR: A road map for developing the manufacturing infrastructure, resources, standards, capabilities, education, training, and workforce development to realize the promise of TERM is outlined. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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