Works Published in 2018
Displaying all 20 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic
ACS Nano, 12(8), 7826–7837.
author keywords: microgels; myocardial infarction; fibrin; fibrinolytic; fibrosis; ischemia reperfusion; drug delivery
MeSH headings : Acrylic Resins / chemical synthesis; Acrylic Resins / chemistry; Acrylic Resins / therapeutic use; Animals; Fibrosis / complications; Fibrosis / drug therapy; Fibrosis / metabolism; Ischemia / complications; Ischemia / drug therapy; Ischemia / metabolism; Myocardial Infarction / drug therapy; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Nanogels; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polyethylene Glycols / therapeutic use; Polyethyleneimine / chemical synthesis; Polyethyleneimine / chemistry; Polyethyleneimine / therapeutic use; Rats
TL;DR:
In vivo and in vitro, FSNs localize to fibrin in injured heart tissue and, when loaded with tPA and Y-27632, showed significant improvement in left ventricular ejection fraction 2 and 4 weeks post-I/R as well as significantly decreased infarct size, α-smooth muscle actin expression, and connective tissue growth factor expression 4 weeks after the I/R.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: February 21, 2020
2018 journal article
Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure
ACS Nano, 12(7), 6536–6544.
author keywords: mesenchymal stem cells; red blood cells; biomimetic; nanoparticles; membrane cloaking; liver failure
MeSH headings : Animals; Apoptosis; Biomimetic Materials / chemistry; Biomimetic Materials / therapeutic use; Carbon Tetrachloride; Cell Line; Cell Proliferation; Disease Models, Animal; Erythrocyte Membrane / chemistry; Humans; Liver Failure, Acute / chemically induced; Liver Failure, Acute / pathology; Liver Failure, Acute / physiopathology; Liver Failure, Acute / therapy; Liver Regeneration; Male; Mesenchymal Stem Cells / chemistry; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / therapeutic use
TL;DR:
This work fabricated a nanoparticle that carries the beneficial regenerative factors from mesenchymal stem cells and further coated it with the membranes of red blood cells to increase blood stability and promote liver cell proliferation in vitro and have lower internalization by macrophage cells.
(via Semantic Scholar)
www.ncbi.nlm.nih.gov (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: February 21, 2020
2018 journal article
A Case Study for Blockchain in Manufacturing: “FabRec”: A Prototype for Peer-to-Peer Network of Manufacturing Nodes
Procedia Manufacturing, 26, 1180–1192.
author keywords: blockchain; cyber-physical systems; smart contracts; ethereum; decentralized networks; shareable databases
TL;DR:
The proposed FabRec system decentralizes critical information about the manufacturer and makes it available on a peer-to-peer network composed of fiduciary nodes to ensure transparency and data provenance through a verifiable audit trail.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 25, 2020
2018 review
Xenotransplantation: Progress Along Paths Uncertain from Models to Application
[Review of ]. ILAR JOURNAL, 59(3), 286–308.
author keywords: adaptive immunity; clinical xenotransplantation; gene editing; innate immunity; molecular incompatibility; nonhuman primate; reverse xenograft; transgenic pig; xenotransplantation; zoonosis
MeSH headings : Adaptive Immunity; Animals; Gene Editing / methods; Genetic Engineering; Heterografts; Humans; Immunity, Innate / physiology; Primates; Stem Cells / metabolism; Swine
TL;DR:
The last 2 decades have brought progressive advances in approaches that can be applied to genetic modification of large animals, which make it appropriate to consider the potential limitation of genetic engineering and of current models for advancing the clinical applications of xenotransplantation and reverse xenotranplantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 2, 2019
2018 article
INTRODUCTION: Immune Relevant Animal Models: Opportunities and Challenges
ILAR JOURNAL, Vol. 59, pp. 209–210.
author keywords: animal models; immunology; preclinical validity
MeSH headings : Allergy and Immunology; Animals; Disease Models, Animal; Inflammation
TL;DR:
Assessment of immune-relevant animal models used in oncology, hematopoietic-, CAR-T cell- and xenotransplantation, adjuvants and infectious diseases, and immune privileged inflammation that are providing key insights into unmet human clinical needs are provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 2, 2019
2018 article
Metastatic melanoma and cervical tumor cell clusters can exit blood vessels through angiopellosis augmenting tumor formation ability
Allen, T., Amu, E., Asad, D., & Cheng, K. (2018, July). CANCER RESEARCH, Vol. 78.
Source: Web Of Science
Added: June 17, 2019
2018 journal article
Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair
ACS NANO, 12(12), 12193–12200.
author keywords: pretargeting; bioorthogonal click chemistry; heart repair; endogenous stem cells; engineered antibodies
MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / metabolism; Blood Vessels / metabolism; Blood Vessels / pathology; Cells, Cultured; Click Chemistry; Collagen / chemistry; Collagen / metabolism; Disease Models, Animal; Endothelial Progenitor Cells / cytology; Endothelial Progenitor Cells / metabolism; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Mice; Mice, Inbred C57BL; Molecular Structure; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
TL;DR:
In a mouse model of acute myocardial infarction, the in vivo results of cardiac function, heart morphometry, and immunohistochemistry assessment all confirmed effective heart repair by the PTBC system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 14, 2019
2018 journal article
Cardiac cell-integrated microneedle patch for treating myocardial infarction
SCIENCE ADVANCES, 4(11).
MeSH headings : Animals; Cells, Cultured; Microtechnology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Needles; Rats; Rats, Inbred WKY; Regeneration; Stromal Cells / cytology; Stromal Cells / transplantation; Swine; Tissue Engineering / instrumentation
TL;DR:
The microneedle patch integrated with cardiac stromal cells (MN-CSCs) represents an innovative approach delivering therapeutic cells for heart regeneration and polymeric MNs are used to create “channels” between host myocardium and therapeutic CSCs to promote heart repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 31, 2018
2018 review
Platelets and their biomimetics for regenerative medicine and cancer therapies
[Review of ]. JOURNAL OF MATERIALS CHEMISTRY B, 6(45), 7354–7365.
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Blood Platelets / chemistry; Blood Platelets / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Drug Carriers / chemistry; Humans; Nanoparticles / chemistry; Regenerative Medicine / methods
TL;DR:
This review will highlight the recent progress made in the development of disease-targeting platelets- and platelet-mimicking-vehicles as therapeutic platforms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 10, 2018
2018 journal article
NIPAM-based Microgel Microenvironment Regulates the Therapeutic Function of Cardiac Stromal Cells
ACS APPLIED MATERIALS & INTERFACES, 10(44), 37783–37796.
author keywords: injectable hydrogels; NIPAM microgel; thermo-responsive microgel; cardiac stromal cells; multicellular spheroids; heart repair
MeSH headings : Acrylamides / administration & dosage; Acrylamides / chemistry; Animals; Cellular Microenvironment / drug effects; Chemokine CXCL12 / genetics; Gene Expression Regulation / drug effects; Humans; Hydrogels / administration & dosage; Hydrogels / chemistry; Hydrophobic and Hydrophilic Interactions / drug effects; Insulin-Like Growth Factor I / genetics; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Polymers / administration & dosage; Polymers / chemistry; Rats; Stromal Cells / drug effects; Stromal Cells / pathology; Succinates / chemistry; T-Lymphocytes / drug effects; Vascular Endothelial Growth Factor A / genetics
TL;DR:
The result revealed the treatment-promoted MI heart repair through angiogenesis and inhibition of apoptosis with an improved cell retention rate, which will open a door for tailoring poly( N-isopropylacrylamide)-based microgel as a delivery vehicle for CSC therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 3, 2018
2018 journal article
Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy
NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.
MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
TL;DR:
It is shown that systemically delivered blood platelets decorated with anti-PD-1 antibodies and conjugated to haematopoietic stem cells reduce the growth and recurrence of leukaemia in mice and significantly augment the therapeutic efficacy of checkpoint blockade.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 26, 2018
2018 review
Body builder: from synthetic cells to engineered tissues
[Review of ]. CURRENT OPINION IN CELL BIOLOGY, 54, 37–42.
MeSH headings : Artificial Cells / metabolism; Humans; Models, Biological; Regenerative Medicine; Tissue Engineering / methods
TL;DR:
This review summarized recent advances in fabricating synthetic cells, with a specific focus on their application to cardiac regenerative medicine and tissue engineering, and pointed to challenges and future directions for the field.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 12, 2018
2018 journal article
Reverse auction mechanism design for the acquisition of prototyping services in a manufacturing-as-a-service marketplace
JOURNAL OF MANUFACTURING SYSTEMS, 48, 134–143.
author keywords: Distributed manufacturing; Reverse auction; Mechanism design; Name Your Own Price (TM)
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 5, 2018
2018 journal article
Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction
ACS APPLIED MATERIALS & INTERFACES, 10(39), 33088–33096.
author keywords: microvessels; hydrodynamic focusing; cardiac stem cells; cardiomyocyte proliferation; angiogenesis; myocardial infarction
MeSH headings : Animals; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Microfluidic Analytical Techniques; Myocardial Infarction / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Rats; Rats, Nude; Stem Cells / cytology; Stem Cells / physiology
TL;DR:
It is shown that the endothelialized BMVs mimicked the natural architecture and function of capillaries and that the resultant vascularized cardiac patch (BMV-CSC patch) exhibited equivalent release of paracrine factors compared to those of coculture of genuine human CSCs and HUVECs after 7 days of in vitro culture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 29, 2018
2018 journal article
High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism
Proceedings of the National Academy of Sciences, 115(21), 5420–5425.
author keywords: HMGA2; dwarfism; swine; gene editing; organ size
MeSH headings : Animals; Cryptorchidism / etiology; Cryptorchidism / pathology; Dwarfism / etiology; Dwarfism / pathology; Female; Fetal Diseases / etiology; Fetal Diseases / pathology; Genotype; HMGA2 Protein / deficiency; HMGA2 Protein / genetics; Litter Size; Male; Nuclear Transfer Techniques / veterinary; Pregnancy; Reproduction; Swine; Swine Diseases / etiology; Swine Diseases / pathology
TL;DR:
The results show that the effect of HMGA2 with respect to growth regulation is highly conserved among mammals and opens up the possibility of regulating body and organ size in a variety of mammalian species including food and companion animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2018 journal article
Label free process monitoring of 3D bioprinted engineered constructs via dielectric impedance spectroscopy
BIOFABRICATION, 10(3).
author keywords: FDA PAT; Process Analytical Technology; bioprinting process parameters; biofabrication process monitoring; quality assessment
MeSH headings : Bioprinting / standards; Cell Line; Cell Survival / physiology; Cells, Cultured; Dielectric Spectroscopy / methods; Humans; Materials Testing / methods; Printing, Three-Dimensional; Stem Cells / cytology; Tissue Engineering / standards
TL;DR:
The findings of this study support the use of dielectric impedance spectroscopy as a label-free and non-destructive method to characterize the critical quality attributes of bioprinted constructs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
Targeted repair of heart injury by stem cells fused with platelet nanovesicles
NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26.
TL;DR:
The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Large-scale digitization of herbarium specimens: Development and usage of an automated, high-throughput conveyor system
TAXON, 67(1), 165–178.
author keywords: automation; biodiversity informatics; digitization; herbarium specimens; imaging; New England; transcription; workflows
TL;DR:
To create a dataset for the study of global change in New England, an industrial-scale, conveyor-based digitization workflow for herbarium specimen sheets is designed and implemented and demonstrated that it is possible to capture both an image of a specimen and a core database record in 35 seconds per her barium sheet.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide
THERANOSTICS, 8(7), 1869–1878.
author keywords: Targeting; exosomes; cardiac regeneration; heart disease; myocardial infarction
MeSH headings : Administration, Intravenous; Animals; Biological Products / administration & dosage; Biological Products / pharmacokinetics; Biological Therapy / methods; Cell Survival; Disease Models, Animal; Echocardiography; Exosomes; Molecular Targeted Therapy / methods; Myocardial Infarction / therapy; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Peptides / administration & dosage; Peptides / pharmacokinetics; Rats; Treatment Outcome
TL;DR:
By targeting exosomes to the infarcted heart, there was a significant improvement in outcomes with reduced fibrosis and scar size, and increased cellular proliferation and angiogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 review
Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future
[Review of ]. STEM CELLS TRANSLATIONAL MEDICINE, 7(4), 354–359.
author keywords: Myocardial injury; Stem cell therapy; Synthetic stem cells; Biomaterials
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart / physiology; Heart Diseases / therapy; Humans; Regeneration / physiology; Stem Cell Transplantation / methods; Stem Cells / cytology
TL;DR:
This concise review provides a brief introduction into stem cell therapies for ischemic heart disease, and summarizes cell‐based and cell‐free paradigms, their limitations, and the benefits of using them to target disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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