Works Published in 2022
Displaying works 1 - 20 of 26 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2022 journal article
Differences in Gait Biomechanics Between Adolescents and Young Adults With Anterior Cruciate Ligament Reconstruction
JOURNAL OF ATHLETIC TRAINING, 57(9-10), 921–928.
author keywords: knee; age; pediatric; youth
MeSH headings : Humans; Female; Young Adult; Adolescent; Adult; Biomechanical Phenomena; Case-Control Studies; Cross-Sectional Studies; Anterior Cruciate Ligament Injuries / surgery; Gait; Knee Joint / surgery; Anterior Cruciate Ligament Reconstruction / methods
TL;DR:
Adolescents and adults demonstrated different gait patterns post-ACLR, suggesting that age may play a role in altered gait biomechanics.
(via Semantic Scholar)
meridian.allenpress.com (publisher PDF)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: March 6, 2023
2022 journal article
Age- and Sex-Specific Joint Biomechanics in Response to Partial and Complete Anterior Cruciate Ligament Injury in the Porcine Model
JOURNAL OF ATHLETIC TRAINING, 57(9-10), 978–989.
author keywords: knee; transection studies; sex factors
MeSH headings : Male; Female; Humans; Animals; Swine; Anterior Cruciate Ligament Injuries / surgery; Anterior Cruciate Ligament / surgery; Anterior Cruciate Ligament / physiology; Biomechanical Phenomena; Joint Instability; Knee Joint; Cadaver
TL;DR:
Increased forces in the MCL and medial meniscus after ACL transection suggest that rehabilitation protocols may need to focus on protecting these tissues, and operative treatment should be considered in active, late adolescent patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: March 6, 2023
2022 article
Sealing the heart from the inside out
Huang, K., & Cheng, K. (2022, December 29). NATURE BIOMEDICAL ENGINEERING.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 6, 2023
2022 article
Towards a standardized multi-tissue decellularization protocol for the derivation of extracellular matrix materials
Biehl, A., Martins, A. M. G. M., Davis, Z. G. G., Sze, D., Collins, L., Mora-Navarro, C., … Freytes, D. O. O. (2022, December 12). BIOMATERIALS SCIENCE.
MeSH headings : Tissue Engineering / methods; Proteomics; Extracellular Matrix / chemistry; Hydrogels / chemistry; Biocompatible Materials / analysis; Tissue Scaffolds
TL;DR:
The present study is the first proof-of-concept towards the development of a standardized protocol that can be used to derive multiple ECM biomaterials via a previously established automated system and showed gelation and rheological properties consistent with previous ECM hydrogels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 3, 2023
2022 journal article
Ontogeny of cellular organization and LGR5 expression in porcine cochlea revealed using tissue clearing and 3D imaging
ISCIENCE, 25(8).
TL;DR:
Data reveal that hair cell organization, inner ear morphology, cellular cartography in the organ of Corti, and spatiotemporal expression of LGR5 are dynamic over developmental stages in a pattern not previously documented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 19, 2022
2022 journal article
Allogeneic and xenogeneic lymphoid reconstitution in a RAG2(-/-)IL2RG(y/-) severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation
FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: severe combined immunodeficiency; pig; xenotransplantation; allotransplantation; hematopoietic; RAG2; IL2RG; transgenic
TL;DR:
The data shows that the pig thymus provides a microenvironment conducive to engraftment, survival and development of human T-cells and provides evidence that the developing T-cell compartment can be populated to a significant extent by human cells in large animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 14, 2022
2022 journal article
Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3
CIRCULATION RESEARCH, 131(10), E135–E150.
author keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell
MeSH headings : Humans; Exosomes / metabolism; Forkhead Box Protein O3 / genetics; Forkhead Box Protein O3 / metabolism; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / pathology; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Heart Injuries / metabolism
TL;DR:
A novel mechanism underlying the immunomodulation effects of MSC exosomes is revealed and provides a promising candidate (PP2A/p-Akt/Foxo3 signaling pathway) with a favorable delivery route (intrapericardial injection) for cardiac repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 14, 2022
2022 journal article
Inhalable dry powder mRNA vaccines based on extracellular vesicles
MATTER, 5(9), 2960–2974.
TL;DR:
The results suggest that extracellular vesicles can serve as an inhaled mRNA drug-delivery system that is superior to synthetic liposomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 17, 2022
2022 journal article
Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing
NATURE COMMUNICATIONS, 13(1).
MeSH headings : Animals; Dependovirus / metabolism; Gene Editing; Genetic Therapy; Genetic Vectors / genetics; Humans; Macaca / genetics; Mice; Swine; Transduction, Genetic
TL;DR:
A highly potent new variant of AAV, AAV.cc47, is described with enhanced transduction efficiency over AAV serotype 9 and its efficacy is shown in different mouse models, pigs and non-human primates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 17, 2022
2022 article
Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair
Hu, S., Zhu, D., Li, Z., & Cheng, K. (2022, September 23). ACS NANO.
author keywords: mesenchymal stromal cell; secreted factors; microneedle patch; elastin-like peptide gel; hyaluronic acid gel; myocardial infarction; cardiac repair
MeSH headings : Animals; Rats; Elastin; Polylactic Acid-Polyglycolic Acid Copolymer; Hyaluronic Acid; Mesenchymal Stem Cells; Myocytes, Cardiac; Myocardium; Nanoparticles; Peptides
TL;DR:
A detachable therapeutic microneedle patch, which is comprised of mesenchymal stromal cell-secreted factors (MSCF)-loaded poly(lactic-co-glycolic acid) nanoparticles (NP) in MN tips made of elastin-like polypeptide gel, provides a promising treatment approach for cardiac diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 11, 2022
2022 article
Decoy Exosomes Offer Protection Against Chemotherapy-Induced Toxicity
Fan, M., Li, H., Shen, D., Wang, Z., Liu, H., Zhu, D., … Li, Z. (2022, September 4). ADVANCED SCIENCE.
author keywords: cardio-oncology; cardiotoxicity; chemotherapy; exosome; tetrahedral DNA nanostructure
MeSH headings : Humans; Exosomes / genetics; Exosomes / metabolism; Cardiotoxicity / etiology; Cardiotoxicity / prevention & control; Cardiotoxicity / metabolism; Quality of Life; Neoplasms; Antineoplastic Agents / toxicity; Antineoplastic Agents / metabolism; Chemical and Drug Induced Liver Injury / metabolism
TL;DR:
This decoy exosome strategy serves as a promising therapy to reduce chemo‐induced toxicity and can also promote macrophage polarization into the M2 type for tissue repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 12, 2022
2022 article
The use of autologous skeletal muscle progenitor cells for adjunctive treatment of presumptive urethral sphincter mechanism incompetence in female dogs
Vaden, S. L., Mathews, K. G., Yoo, J., Williams, J. K., Harris, T., Secoura, P., … Piedrahita, J. (2022, August 5). JOURNAL OF VETERINARY INTERNAL MEDICINE.
author keywords: canine; regenerative medicine; stem cell; urinary incontinence
MeSH headings : Animals; Dog Diseases / surgery; Dogs; Female; Muscle, Skeletal; Stem Cells; Urethra / surgery; Urinary Incontinence / therapy; Urinary Incontinence / veterinary
TL;DR:
Urethral submucosal injection of autologous skeletal muscle progenitor cells (skMPC) can be used adjunctively to improve continence in dogs with difficult to manage USMI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 29, 2022
2022 article
Donor Age and Time in Culture Affect Dermal Fibroblast Contraction in an In Vitro Hydrogel Model
Detwiler, A., Polkoff, K., Gaffney, L., Freytes, D. O., & Piedrahita, J. A. (2022, August 4). TISSUE ENGINEERING PART A.
author keywords: cell proliferation; collagen; dermis; extracellular matrix; fibroblasts; hydrogels; skin; wound healing
MeSH headings : Adult; Infant, Newborn; Humans; Swine; Animals; Hydrogels / pharmacology; Reproducibility of Results; Wound Healing; Collagen / chemistry; Fibroblasts
TL;DR:
Results show how cellular responses in a hydrogel scaffold differ based on donor age and time in culture in vitro, and suggest that consistency in the cellular component of bioengineered skin products could be beneficial in the biomanufacturing of consistent, reliable skin grafts and graft in vivo models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 29, 2022
2022 journal article
Engineering stem cell therapeutics for cardiac repair
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 171, 56–68.
author keywords: Stem cell engineering; Genetic engineering; Micro; nanotechnology; Cardiovascular bioengineering
MeSH headings : Biocompatible Materials; Heart; Humans; Hydrogels; Stem Cells; Tissue Engineering / methods
TL;DR:
This review summarizes the state-of-art stem cell-based therapeutics for cardiac regeneration and discusses the emerged bioengineering approaches toward the enhancement of therapeutic efficacy of stem cell therapies in cardiac repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 22, 2022
2022 journal article
Gecko-Inspired Adhesives with Asymmetrically Tilting-Oriented Micropillars
LANGMUIR, 38(29).
MeSH headings : Adhesiveness; Adhesives; Animals; Finite Element Analysis; Lizards; Locomotion
Source: Web Of Science
Added: August 1, 2022
2022 journal article
Knowledge graph construction for product designs from large CAD model repositories
ADVANCED ENGINEERING INFORMATICS, 53.
author keywords: Digital manufacturing; 3D shape search; 3D recommendation; Deep learning
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2022
2022 article
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine
Wang, Z., Popowski, K. D., Zhu, D., Abad, B. L. de J., Wang, X., Liu, M., … Cheng, K. (2022, July 4). NATURE BIOMEDICAL ENGINEERING.
MeSH headings : Animals; Antibodies, Neutralizing; CD8-Positive T-Lymphocytes; COVID-19 / prevention & control; COVID-19 Vaccines; Exosomes; Humans; Mice; Mice, Inbred BALB C; SARS-CoV-2; Viral Vaccines
TL;DR:
The design and preclinical testing of an inhalable virus-like-particle as a COVID-19 vaccine that, after lyophilisation, is stable at room temperature for over three months and elicits systemic and mucosal immune responses in small animals is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 11, 2022
2022 article
Skin-Interfaced Deep-Tissue Sensing Patch via Microneedle Waveguides
Liu, Y., Menon, R., Putcha, A., Huang, K., Bonilla, L., Vora, R., … Bai, W. (2022, June 29). ADVANCED MATERIALS TECHNOLOGIES.
author keywords: biosensors; microneedles; optoelectronics; waveguides; wearable devices
TL;DR:
A wireless, wearable deep‐tissue sensing patch is put forward by incorporating biocompatible microneedle waveguides at the sensing interface, to bypass the light extinction in epidermic and dermic tissue and enable the tracking of oximetry at muscular tissue.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 5, 2022
2022 journal article
Effect of epitendinous suture augmentation to a double Krackow suture pattern for canine gastrocnemius tendon repair
AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(7).
MeSH headings : Animals; Biomechanical Phenomena; Cadaver; Dog Diseases / surgery; Dogs; Suture Techniques / veterinary; Sutures / veterinary; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / surgery; Tensile Strength
TL;DR:
Augmentation of a primary DK repair with an ES significantly improved construct strength in canine GT constructs while increasing loads required to cause 1- and 3-mm gap formation, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 27, 2022
2022 journal article
LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis
SCIENTIFIC REPORTS, 12(1).
MeSH headings : Animals; Animals, Genetically Modified; Biomarkers / metabolism; Hair Follicle / metabolism; Humans; Morphogenesis; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Skin; Stem Cells / metabolism; Swine
TL;DR:
It is demonstrated that LGR5 is a marker of hair follicle stem cells across species in homeostasis and development and the strong similarities and important differences in expression patterns, gene expression profiles, and developmental processes between species are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 20, 2022
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