Works Published in 2023
Displaying all 16 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2023 article
Adrenomedullin Stimulates Proliferation, Migration and Adhesion of Porcine Trophectoderm Cells Via CALCRL-AKT-TSC2-MTORC1 Cell Signaling Pathway
Liu, B., Paudel, S., Flowers, W. L., Piedrahita, J. A., & Wang, X. (2023, May). JOURNAL OF ANIMAL SCIENCE, Vol. 101.
author keywords: adrenomedullin; peri-implantation; pig conceptus
TL;DR:
Results suggest that porcine ADM in histotroph act on its receptor component CALCRL to activate AKT-TSC2-MTOR, particularly MTORC1 signaling cascade, leading to elongation, migration and attachment of conceptuses.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
Source: Web Of Science
Added: March 4, 2024
2023 article
Systems and Methods for Authenticating Manufacturing Machines Through an Unobservable Fingerprinting System
Koprov, P., Gadhwala, S., Walimbe, A., Fang, X., & Starly, B. (2023, August). MANUFACTURING LETTERS, Vol. 35, pp. 1009–1018.
author keywords: Cybersecurity; Connected Manufacturing; Authentication; Physical Unclonable Function; Digital Twin; Vibration
Sources: Web Of Science, ORCID
Added: February 12, 2024
2023 article
Wound-triggered shape change microgels for the development of enhanced biomimetic function platelet-like particles
Chee, E., Mihalko, E., Nellenbach, K., Sollinger, J., Huang, K., Hon, M., … Brown, A. (2023, October 17). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.
author keywords: fibrin; hemostasis; synthetic platelet; trauma; wound healing
TL;DR:
Thrombin-sensitive PLPs are created that exhibit a wound-triggered shape change, induce significant clot retraction following exposure to thrombin and promote hemostasis and healing in vivo after trauma.
(via Semantic Scholar)
Source: Web Of Science
Added: November 6, 2023
2023 article
Pericardial Delivery of SDF-1 α Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling
Luo, L., Li, Y., Bao, Z., Zhu, D., Chen, G., Li, W., … Li, Z. (2023, September 15). ADVANCED MATERIALS.
author keywords: cardiac arrhythmias; electrical coupling; endogenous repair; inflammation regulation; myocardial infarction; SDF-1
TL;DR:
SDF‐1α‐encapsulated Puerarin (PUE) hydrogel (SDF‐1α@PUE) is capable of enhancing endogenous stem cell homing and simultaneously polarizing the recruited monocyte/macrophages into a repairing phenotype, demonstrating a promising therapeutic platform for MI that not only facilitates heart regeneration but also reduces the risk of cardiac arrhythmias.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: October 23, 2023
2023 article
Structure-guided AAV capsid evolution strategies for enhanced CNS gene delivery
Gonzalez, T. J., Mitchell-Dick, A., Blondel, L. O., Fanous, M. M., Hull, J. A., Oh, D. K., … Asokan, A. (2023, September 21). NATURE PROTOCOLS.
TL;DR:
A detailed protocol describing two distinct evolution strategies using structurally divergent AAV serotypes as templates, exemplified by improving CNS gene transfer efficiency in vivo, can be adapted to expand the AAV vector toolkit for genetic manipulation of animal models and development of human gene therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 16, 2023
2023 journal article
Tendon Extracellular Matrix Promotes Myotendinous Junction Protein Expression in Engineered Muscle Tissue under Both Static and Mechanically Stimulated Culture Conditions
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2023.
TL;DR:
This research combined a relevant microenvironment to study muscle and tendon interactions with a novel bioreactor to apply mechanical strain, an important regulator of the formation and maintenance of the native MTJ.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 18, 2023
2023 journal article
“Unreal” factories: Next generation of digital twins of machines and factories in the Industrial Metaverse
Manufacturing Letters, 37, 50–52.
author keywords: Digital twins; Digital fabrication; Computational fabrication; Smart manufacturing; Industry 4; 0
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: September 5, 2023
2023 journal article
Tissue clearing and three-dimensional imaging of the whole cochlea and vestibular system from multiple large-animal models
STAR PROTOCOLS, 4(2).
author keywords: imaged cochleae using open -source software.; several mm; larger animal inner; open -source software
TL;DR:
A protocol that enables three-dimensional (3D) characterization of intact inner ears from large-animal models is presented and a pipeline to count hair cells in antibody-stained and 3D imaged cochleae using open-source software is detailed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 5, 2023
2023 journal article
Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials
NANO RESEARCH, 16(5), 7248–7259.
author keywords: nanovesicles (NVs); exosomes; cardiac repair; mesenchymal stem cells (MSCs); extracellular vesicles (EVs); myocardial infarction (Ml)
TL;DR:
Proteomics and RNA sequencing data revealed that NVs resemble MSCs more closely than EVs, and microRNAs in NVs are related to cardiac repair, fibrosis repression, and angiogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 28, 2023
2023 journal article
A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans
NPJ REGENERATIVE MEDICINE, 8(1).
TL;DR:
Hepato/pancreatic multipotentiality was demonstrated by the stem/progenitors’ responses under distinct ex vivo conditions or in vivo when patch grafted as organoids onto the liver versus the pancreas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 21, 2023
2023 journal article
A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus
SCIENCE ADVANCES, 9(25).
MeSH headings : Cricetinae; Animals; Humans; Mice; Influenza Vaccines; SARS-CoV-2; Influenza, Human; Influenza A Virus, H1N1 Subtype; Pandemics; COVID-19 / prevention & control; COVID-19 Vaccines; Influenza A virus
TL;DR:
The Flu-RBD VLP vaccine is a promising candidate for combating COVID-19, influenza A, and coinfection and elicited a strong neutralization activity against both SARS-CoV-2 Delta pseudovirus and wild-type influenza A H1N1 inactivated virus in mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 21, 2023
2023 article
Microneedle Patch Delivery of PROTACs for Anti-Cancer Therapy
Cheng, X., Hu, S., & Cheng, K. (2023, June 9). ACS NANO.
author keywords: PROTAC; estrogen receptor; microneedle patch; hyaluronic acid gel; ER-positive breast cancer
MeSH headings : Humans; Female; Estrogen Receptor alpha / metabolism; Proteolysis Targeting Chimera; Breast Neoplasms / pathology; Drug Delivery Systems / methods; Proteolysis
TL;DR:
The work demonstrates the feasibility and proof-of-concept therapeutic potential of using microneedle patches to directly deliver PROTACs into tumors and can sufficiently degrade ERα in MCF7 cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 26, 2023
2023 journal article
A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease
FASEB JOURNAL, 37(6).
author keywords: APC mutation; colorectal cancer; intestine; Lgr5; porcine; stem cell; transgenic large animal
MeSH headings : Humans; Swine; Animals; Mice; In Situ Hybridization, Fluorescence; Intestines; Stem Cells; Ileum; Colon; Coleoptera; Green Fluorescent Proteins / genetics; Receptors, G-Protein-Coupled / genetics
TL;DR:
This study validates ISC isolation in a new porcine Leucine Rich Repeat Containing G Protein‐Coupled Receptor 5 (LGR5) reporter line and demonstrates the use of these pigs as a novel colorectal cancer model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 12, 2023
2023 article
Uterine histotroph and conceptus development: III. Adrenomedullin stimulates proliferation, migration and adhesion of porcine trophectoderm cells via AKT-TSC2-MTOR cell signaling pathway
Liu, B., Paudel, S., Flowers, W. L., Piedrahita, J. A., & Wang, X. (2023, April 10). AMINO ACIDS.
author keywords: Adrenomedullin; Trophectoderm cells; MTOR; Pigs; Implantation
MeSH headings : Pregnancy; Female; Swine; Animals; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Adrenomedullin / pharmacology; Signal Transduction; TOR Serine-Threonine Kinases / genetics; TOR Serine-Threonine Kinases / metabolism; Cell Proliferation; Sirolimus / pharmacology
TL;DR:
Results suggest that porcine ADM in histotroph acts on its receptor component CALCRL to activate AKT-TSC2-MTOR, particularly MTORC1 signaling cascade, leading to elongation, migration and attachment of conceptuses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 24, 2023
2023 article
Intrapericardial long non-coding RNA-Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair
Zhu, D., Liu, S., Huang, K., Li, J., Mei, X., Li, Z., & Cheng, K. (2023, March 14). EUROPEAN HEART JOURNAL.
author keywords: Myocardial infarction; Adverse remodelling; Mesenchymal stem cell; EVs; lncRNA; Tcf21
MeSH headings : Mice; Animals; Swine; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; RNA, Antisense / genetics; RNA, Antisense / metabolism; Ventricular Remodeling; Myocardial Infarction / genetics; Myocardial Infarction / therapy; Myocardial Infarction / metabolism; Fibrosis; Demethylation
TL;DR:
Novel mechanisms underlying EV therapy for improving adverse remodelling are established and a lncRNA therapy for cardiac fibrosis is proposed, which could be a promising way to treat myocardial fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 4, 2023
2023 article
An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection
Mei, X., Li, J., Wang, Z., Zhu, D., Huang, K., Hu, S., … Cheng, K. (2023, February 9). NATURE MATERIALS.
TL;DR:
A physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel, named spherical hydrogels inhalation for enhanced lung defence (SHIELD), which is conveniently delivered via a dry powder inhaler and made with food-grade materials and does not affect normal respiratory functions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 6, 2023
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