Works Published in 2006
Displaying works 1 - 20 of 96 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2006 journal article
Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair.
The Journal of Biological Chemistry.
MeSH headings : Adenosine Triphosphate / metabolism; Calcium / metabolism; Cell Death / drug effects; Chelating Agents / pharmacology; DNA / genetics; DNA Damage / genetics; DNA Repair / genetics; Egtazic Acid / analogs & derivatives; Egtazic Acid / pharmacology; Enzyme Activation / drug effects; Humans; Hydrogen Peroxide / pharmacology; NAD / metabolism; Naphthoquinones / pharmacology; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases / genetics; Poly(ADP-ribose) Polymerases / metabolism; Time Factors
TL;DR:
β-lapachone is the first chemotherapeutic agent to elicit a Ca2+-mediated cell death by PARP-1 hyperactivation at clinically relevent doses in cancer cells expressing elevated NAD(P)H:quinone oxidoreductase 1 (NQO1) levels.
(via Semantic Scholar)
www.jbc.org (publisher PDF)
Source: ORCID
Added: June 25, 2021
2006 journal article
New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors.
Journal of Molecular Histology.
author keywords: DNA repair inhibitors; carcinogenesis; beta-lapachone; DNA repair; NQ01; poly(ADP-ribose) polymerase-1; DNA damage; cancer therapy; cancer prevention
MeSH headings : Anticarcinogenic Agents / pharmacology; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Repair; Humans; Models, Biological; Naphthoquinones / pharmacology; Naphthoquinones / toxicity; Neoplasms / drug therapy; Neoplasms / enzymology; Neoplasms / genetics; Neoplasms / prevention & control; Poly(ADP-ribose) Polymerases / genetics
TL;DR:
A novel anti-tumor agent, β-lapachone, is focused on and its potential to block transformation by modulating poly(ADP-ribose) polymerase-1 is explored, which could decrease carcinogenicity and prevent tumorigenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 25, 2021
2006 journal article
Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses.
Journal of Cellular Physiology.
MeSH headings : Apoptosis / drug effects; Cell Cycle / drug effects; Cell Cycle / physiology; Cell Death / drug effects; Cell Physiological Phenomena; Clusterin / genetics; Clusterin / metabolism; DNA Mismatch Repair; Feedback, Physiological / physiology; Humans; Naphthoquinones / pharmacology; Naphthoquinones / therapeutic use; Neoplasms / drug therapy; Radiation-Sensitizing Agents / pharmacology; Radiation-Sensitizing Agents / therapeutic use
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 25, 2021
2006 chapter
Chapter 7: Bivalves
In G. Lewbart (Ed.), Invertebrate Medicine (pp. 91–115). Ames, Iowa: Blackwell Publishing.
Ed(s): G. Lewbart
Source: NC State University Libraries
Added: April 24, 2021
2006 journal article
Transglutaminase-dependent RhoA Activation and Depletion by Serotonin in Vascular Smooth Muscle Cells
Journal of Biological Chemistry, 282(5), 2918–2928.
MeSH headings : Animals; Aorta; Cell Hypoxia; DNA Primers; Enzyme Activation; Hypertension / physiopathology; Hypoxia / physiopathology; Kinetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle, Smooth, Vascular / drug effects; Muscle, Smooth, Vascular / enzymology; Muscle, Smooth, Vascular / physiology; Pulmonary Artery / drug effects; Pulmonary Artery / enzymology; Pulmonary Artery / physiology; RNA, Small Interfering / genetics; Rats; Serotonin / pharmacology; Transglutaminases / deficiency; Transglutaminases / genetics; Transglutaminases / metabolism; rhoA GTP-Binding Protein / metabolism
TL;DR:
Evidence is provided that 5-HT, internalized through the 5- HT transporter, is transamidated to RhoA by transglutaminase, which in turn is responsible for Akt activation and contraction inhibition in arterial smooth muscle.
(via Semantic Scholar)
Source: Crossref
Added: December 29, 2020
2006 journal article
The Speciation of Metals in Mammals Influences Their Toxicokinetics and Toxicodynamics and Therefore Human Health Risk Assessment
Journal of Toxicology and Environmental Health, Part B, 9(1), 63–85.
author keywords: metal speciation; risk assessment; toxicodynamics; toxicokinetics
MeSH headings : Biotransformation; Databases as Topic; Humans; Metals / chemistry; Metals / pharmacokinetics; Metals / toxicity; Particle Size; Risk Assessment
TL;DR:
The influence of speciation on metal toxicokinetics and toxicodynamics in mammals, and therefore the adverse effects of metals, is reviewed to illustrate how the physicochemical characteristics of metals and their handling in the body (toxicokinetics) can influence toxicity (t toxicodynamics).
(via Semantic Scholar)
Source: Crossref
Added: December 29, 2020
2006 chapter
The role of intra-luteal factors in the control of the porcine corpus luteum
In E. C. J. Ashworth & R. R. Kraeling (Eds.), Control of Pig Reproduction VII, Reproduction Supplement 62 (pp. 69–83). Nottingham, U.K: Nottingham University Press.
Ed(s): E. Ashworth & R. Kraeling
Source: NC State University Libraries
Added: October 23, 2020
2006 chapter
Trichomoniasis
In C. E. Green (Ed.), Infectious Diseases of the Dog and Cat (3rd ed., pp. 740–744). St. Louis, MO: Saunder/Elsevier.
Ed(s): C. Green
Source: NC State University Libraries
Added: October 21, 2020
2006 journal article
Regulation of Rho Proteins by Phosphorylation in the Cardiovascular System
Trends in Cardiovascular Medicine, 16(6), 199–204.
MeSH headings : Animals; Cardiovascular Diseases / metabolism; Cardiovascular Diseases / pathology; Cardiovascular Diseases / physiopathology; Cardiovascular System / metabolism; Cardiovascular System / pathology; Cardiovascular System / physiopathology; Humans; Phosphorylation; Signal Transduction; rho GTP-Binding Proteins / classification; rho GTP-Binding Proteins / metabolism; rho GTP-Binding Proteins / physiology
TL;DR:
The small G protein Rho signaling pathways are recognized as major regulators of cardiovascular functions, and activation of Rho proteins appears to be a common component for the pathogenesis of hypertension and vascular proliferative disorders.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2006 journal article
Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation
Cardiovascular Research, 72(2), 339–348.
author keywords: smooth muscle; extracellular matrix; signal transduction; receptors; G-proteins
MeSH headings : Actins / metabolism; Amides / pharmacology; Animals; Antibodies, Monoclonal / pharmacology; Aorta; Bacterial Toxins / pharmacology; Cell Movement / drug effects; Cells, Cultured; Chromones / pharmacology; Complement C3 / genetics; Cytoskeleton / metabolism; Dose-Response Relationship, Drug; Enterotoxins / pharmacology; Escherichia coli Proteins / pharmacology; Extracellular Matrix Proteins / metabolism; Genes, tat; Hyaluronan Receptors / immunology; Hyaluronan Receptors / metabolism; Hyaluronic Acid / pharmacology; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Morpholines / pharmacology; Muscle, Smooth, Vascular / cytology; Muscle, Smooth, Vascular / drug effects; Muscle, Smooth, Vascular / metabolism; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases / antagonists & inhibitors; Pyridines / pharmacology; RNA Interference; RNA, Small Interfering / pharmacology; Rats; Recombinant Fusion Proteins / pharmacology; Signal Transduction; Simvastatin / pharmacology; Stimulation, Chemical; rac GTP-Binding Proteins / antagonists & inhibitors; rac GTP-Binding Proteins / genetics; rac GTP-Binding Proteins / metabolism; rho-Associated Kinases; rhoA GTP-Binding Protein / antagonists & inhibitors; rhoA GTP-Binding Protein / metabolism
TL;DR:
High-molecular weight HA independently activates RhoA and Rac through CD44 and RHAMM, respectively, and depends exclusively on RHAMm-mediated PI3K-dependent Rac activation.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2006 journal article
Reply
Gastroenterology, 130(3), 1013–1014.
Source: Crossref
Added: August 28, 2020
2006 journal article
Massive small bowel resection results in sustained increases in intestinal stem cell number
Journal of Surgical Research, 130(2), 253.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2006 journal article
32 CRYOPRESERVATION OF DONOR CELLS FOR NUCLEAR TRANSFER: EFFECT OF CELL FREEZING METHOD ON THE EFFICIENCY OF SOMATIC CELL NUCLEAR TRANSFER IN PIGS
Reproduction, Fertility and Development, 18(2), 125.
TL;DR:
Evaluated the effect of the cell freezing method on development of pig SCNT embryos in vitro and indicates that blastocyst development after SCNT does not differ when fetal fibroblasts are frozen by the two methods tested.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2006 journal article
263 USE OF PORCINE PARTHENOTES AND GENE EXPRESSION PROFILING USING MICROARRAYS FOR IDENTIFICATION OF IMPRINTED GENES
Reproduction, Fertility and Development, 18(2), 239.
TL;DR:
Overall, utilizing the PRT models and gene expression profiles, thirteen genes where imprinting is conserved between swine and humans/mice, and several candidate genes that represent potentially imprinted genes are identified.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2006 chapter
Reactors and Reactions: In Situ Reaction Imaging in Fixed-bed Reactors Using MRI
In NMR Imaging in Chemical Engineering (pp. 590–608).
Contributors: L. Gladden *, B. Akpa* , M. Mantle* & A. Sederman *
Source: ORCID
Added: April 7, 2020
2006 journal article
Respiration in Sprague-Dawley Rats During Pregnancy
Inhalation Toxicology, 18(4), 305–312.
MeSH headings : Animals; Female; Plethysmography, Whole Body; Pregnancy / physiology; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Reference Values; Respiration; Tidal Volume
TL;DR:
Important reference values that can be used in pharmacokinetic models during pregnancy are provided, including minute ventilation and tidal volume, which were significantly increased in pregnant rats compared to nonpregnant rats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2006 journal article
Changes in Intracellular pH Play a Secondary Role in Hydrogen Sulfide-Induced Nasal Cytotoxicity
Inhalation Toxicology, 18(3), 159–167.
MeSH headings : Animals; Benzopyrans / metabolism; Cell Survival / drug effects; Cyanates / toxicity; Dose-Response Relationship, Drug; Hydrogen Sulfide / toxicity; Hydrogen-Ion Concentration; Male; Naphthols / metabolism; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Rats; Rhodamines / metabolism
TL;DR:
The intracellular acidification of nasal epithelial cells by high-dose H2S exposure and the inhibition of cytochrome oxidase at much lower H1N1 concentrations suggest that changes in intrACEllular pH play a secondary role in H 2S-induced nasal injury.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2006 journal article
Lethargy and hind limb paralysis in a day-23 timed pregnant rat
Lab Animal, 35(2), 19–19.
MeSH headings : Animals; Dystocia / etiology; Dystocia / pathology; Dystocia / veterinary; Fatal Outcome; Female; Paralysis / etiology; Paralysis / veterinary; Pregnancy; Rats; Rats, Sprague-Dawley; Rodent Diseases / diagnosis; Rodent Diseases / pathology; Urinary Bladder Calculi / complications; Urinary Bladder Calculi / pathology; Urinary Bladder Calculi / veterinary
TL;DR:
Based on the clinical and necropsy findings what is the cause of the rat’s morbidity and paralysis?
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2006 journal article
Life beyond the air phase: adding tissue disposition to models of nasal airway transport
Journal of Biomechanics, 39, S270–S271.
Source: Crossref
Added: February 24, 2020
2006 journal article
Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain
NeuroToxicology, 27(5), 788–797.
author keywords: manganese; neurotoxicity; manganism; oxidative stress; reactive oxygen species
MeSH headings : Age Factors; Animals; Animals, Newborn; Biomarkers; Brain / metabolism; Brain / pathology; Brain Chemistry / drug effects; Female; Inhalation Exposure; Male; Manganese / toxicity; Oxidative Stress / drug effects; Oxidative Stress / physiology; Rats; Sex Factors; Time Factors
TL;DR:
The collective results of these studies argue against extensive involvement of ROS in Mn neurotoxicity in rats of differing genders and ages, but there are, however, instances of changes in individual endpoints consistent with oxidative stress in certain brain tissues.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
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