Works Published in 2007
Displaying works 1 - 20 of 113 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2007 journal article
Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar.
International Journal of Cancer.
author keywords: cytochrome P450; polycyclic aromatic hydrocarbons; coal tar; DNA adducts; chemical inhibition
MeSH headings : Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / drug effects; Benzo(a)pyrene / antagonists & inhibitors; Benzo(a)pyrene / toxicity; Benzopyrenes / toxicity; Carcinogens / antagonists & inhibitors; Carcinogens / toxicity; Coal Tar / chemistry; Complex Mixtures / isolation & purification; Complex Mixtures / pharmacology; Complex Mixtures / standards; Cytochrome P-450 CYP1A1 / antagonists & inhibitors; Cytochrome P-450 CYP1A1 / drug effects; Cytochrome P-450 CYP1B1; DNA / drug effects; DNA / metabolism; DNA Adducts / analysis; Humans; Polycyclic Aromatic Hydrocarbons / isolation & purification; Polycyclic Aromatic Hydrocarbons / pharmacology; Polycyclic Aromatic Hydrocarbons / standards; Tumor Cells, Cultured
TL;DR:
The decreases in PAH‐DNA adduct formation on co‐treatment with SRM 1597 revealed inhibitory effects on the CYP enzymes that convert carcinogenic PAH into DNA‐binding metabolites.
(via Semantic Scholar)
Source: ORCID
Added: March 23, 2022
2007 journal article
Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma
Leukemia, 21(1), 184–187.
MeSH headings : Age of Onset; Animals; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Gene Silencing; Genes, Retinoblastoma; Genes, p16; Genetic Predisposition to Disease; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / physiopathology; Lymphoma, Non-Hodgkin / veterinary; Predictive Value of Tests; Species Specificity
TL;DR:
Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma is predicted to be low.
(via Semantic Scholar)
www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: September 18, 2021
2007 journal article
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
Cancer Research.
MeSH headings : Antineoplastic Agents / pharmacology; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Breaks; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Humans; Models, Biological; Naphthoquinones / pharmacology; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases / metabolism; Reverse Transcriptase Inhibitors / pharmacology; Time Factors
TL;DR:
Insight is given into the mechanism by whichbeta-lap radiosensitizes cancer cells and NHEJ is a potent target for enhancing the therapeutic efficacy of beta-lap alone or in combination with other agents in cancer cells that express elevated NQO1 levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 25, 2021
2007 journal article
An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.
Proceedings of the National Academy of Sciences of the United States of America.
author keywords: DNA repair inhibitor; non-small-cell lung cancer; NQO1; apoptosis; mu-calpain cell death
MeSH headings : Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Apoptosis / physiology; Carcinoma, Non-Small-Cell Lung / drug therapy; Carcinoma, Non-Small-Cell Lung / enzymology; Carcinoma, Non-Small-Cell Lung / metabolism; Cell Line; Cell Line, Tumor; Humans; Lung Neoplasms / drug therapy; Lung Neoplasms / enzymology; Lung Neoplasms / metabolism; NAD(P)H Dehydrogenase (Quinone) / biosynthesis; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / physiology; Naphthoquinones / pharmacology; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Tumor Cells, Cultured
TL;DR:
The data indicate that the most efficacious strategy using β-lapachone in chemotherapy was to deliver the drug in short pulses, greatly reducing cytotoxicity to NQO1− “normal” cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 25, 2021
2007 journal article
Effect of seaweed extract supplementation in goats exposed to simulated preslaughter stress
Small Ruminant Research, 73(1-3), 221–227.
author keywords: goats; stress; anti-oxidant activity; brown seaweed extract
TL;DR:
A feed supplement containing brown seaweed extract may increase anti-oxidant activity in other domestic animals, but its effect on goats has not been studied.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2007 journal article
Rho GTPase signaling directs the late stage morphogenesis of the Xenopus digestive system
Developmental Biology, 306(1), 441.
Source: Crossref
Added: August 28, 2020
2007 journal article
Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala
NeuroImage, 34(3), 905–923.
MeSH headings : Amygdala / cytology; Amygdala / physiology; Animals; Emotions / physiology; Female; Information Storage and Retrieval / methods; Macaca mulatta; Male; Microscopy, Fluorescence / methods; Models, Anatomic; Models, Neurological; Nerve Net / cytology; Nerve Net / physiology; Neural Pathways / cytology; Neural Pathways / physiology; Neurons / cytology; Neurons / physiology; Prefrontal Cortex / cytology; Prefrontal Cortex / physiology
TL;DR:
Investigation of the largely unknown extent and laminar relationship of prefrontal input-output zones linked with the amygdala using neural tracers injected in the amygdala in rhesus monkeys indicates that the connections between prefrontal cortices and the amygdala follow similar patterns as corticocortical connections.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Pharmacokinetic Modeling of Manganese. II. Hepatic Processing After Ingestion and Inhalation
Journal of Toxicology and Environmental Health, Part A, 70(18), 1505–1514.
MeSH headings : Administration, Inhalation; Administration, Oral; Animals; Intestinal Absorption; Intestinal Mucosa / metabolism; Liver / metabolism; Male; Manganese / pharmacokinetics; Models, Biological; Rats; Rats, Inbred Strains
TL;DR:
Differences in hepatic processing of blood Mn derived from different dose routes need to be accounted for in more complete PK models for Mn that are intended to support human health risk assessments.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Pharmacokinetic Modeling of Manganese. I. Dose Dependencies of Uptake and Elimination
Journal of Toxicology and Environmental Health, Part A, 70(18), 1493–1504.
MeSH headings : Animals; Bile / chemistry; Dose-Response Relationship, Drug; Intestinal Mucosa / metabolism; Liver / metabolism; Male; Manganese / pharmacokinetics; Mice; Models, Biological; Rats; Rats, Inbred Strains
TL;DR:
D dose dependencies in uptake and elimination are necessary inputs for comprehensive PK models guiding human health risk assessments with Mn, and differential control of absorption in single gavage oral dose studies versus continuous high oral doses in the feed is indicated.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Basal Gene Expression in Male and Female Sprague-Dawley Rat Nasal Respiratory and Olfactory Epithelium
Inhalation Toxicology, 19(11), 941–949.
MeSH headings : Animals; Female; Gene Expression Profiling / methods; Gene Expression Regulation / physiology; Male; Nasal Mucosa / metabolism; Nasal Mucosa / physiology; Nasal Mucosa / ultrastructure; Olfactory Mucosa / metabolism; Olfactory Mucosa / physiology; Olfactory Mucosa / ultrastructure; Rats; Rats, Sprague-Dawley; Xenobiotics / metabolism
TL;DR:
To better understand and predict gender differences in response of the nasal epithelium to inhaled xenobiotics, gene expression profiles from naive male and female Sprague-Dawley rats were constructed and surprisingly, there were few gender Differences in gene expression.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Inhibition and recovery of maternal and foetal cholinesterase enzymes following fenitrothion administration in CD rats
Xenobiotica, 37(1), 19–29.
author keywords: toxicology; pharmacokinetics; fenitrothion; neurotoxicity; esterases; rodent
MeSH headings : Animals; Brain / drug effects; Brain / enzymology; Cholinesterase Inhibitors / administration & dosage; Cholinesterase Inhibitors / blood; Cholinesterase Inhibitors / pharmacokinetics; Cholinesterase Inhibitors / pharmacology; Cholinesterases / metabolism; Female; Fenitrothion / administration & dosage; Fenitrothion / blood; Fenitrothion / pharmacokinetics; Fenitrothion / pharmacology; Fetus / drug effects; Fetus / enzymology; Liver / drug effects; Liver / enzymology; Pregnancy; Rats
TL;DR:
Esterase inhibition occurred at a fenitrothion dose that has not been previously associated with reproductive toxicity, suggesting that esterase inhibition should be considered as the critical effect in risk assessments for this pesticide.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Preliminary investigation of changes in the sexually dimorphic nucleus of the rat medial preoptic area following prenatal exposure to fenitrothion
Journal of Applied Toxicology, 27(6), 631–636.
author keywords: anti-androgen; SDN-POA; fenitrothion; developmental neurotoxicity
MeSH headings : Administration, Oral; Androgen Antagonists / administration & dosage; Androgen Antagonists / toxicity; Animals; Body Weight / drug effects; Cholinesterase Inhibitors / administration & dosage; Cholinesterase Inhibitors / toxicity; Dose-Response Relationship, Drug; Female; Fenitrothion / administration & dosage; Fenitrothion / toxicity; Gait / drug effects; Insecticides / administration & dosage; Insecticides / toxicity; Lacrimal Apparatus / drug effects; Lacrimal Apparatus / metabolism; Litter Size / drug effects; Male; Pilot Projects; Pregnancy; Prenatal Exposure Delayed Effects; Preoptic Area / drug effects; Preoptic Area / growth & development; Preoptic Area / pathology; Rats; Sexual Maturation; Tears / metabolism; Tremor / chemically induced
TL;DR:
There was a dose‐related increase in the SDN‐POA volume in males and a dose-related decrease in SDN-POAVolume in females exposed to fenitrothion, suggesting that fen itrothion may have mixed endocrine effects on the developing brain.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation
American Journal of Industrial Medicine, 50(10), 772–778.
author keywords: parkinsonism; neurochemistry; inhalation; macaca mulatta; manganese
MeSH headings : 3,4-Dihydroxyphenylacetic Acid / metabolism; Animals; Basal Ganglia / drug effects; Basal Ganglia / metabolism; Disease Models, Animal; Dopamine / metabolism; Glutamic Acid / metabolism; Hydroxyindoleacetic Acid / metabolism; Inhalation; Macaca mulatta; Manganese Compounds / analysis; Neurotransmitter Agents / analysis; Neurotransmitter Agents / metabolism; Norepinephrine / metabolism; Parkinsonian Disorders / physiopathology; Serotonin / metabolism; Sulfates / analysis; Sulfates / toxicity; gamma-Aminobutyric Acid / metabolism
TL;DR:
Despite the presence of increased tissue manganese concentrations, high-dose exposure to MnSO4 was associated with relatively few changes in basal ganglial neurotransmitter concentrations.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Unintentional Injury Risk in Children with Externalizing Behavior Disorders at Summer Camp
Journal of Clinical Psychology in Medical Settings, 14(2), 145–151.
author keywords: injury; safety; attention-deficit; hyperactivity disorder (ADHD); oppositional defiant disorder (ODD); externalizing behavior
TL;DR:
Symptoms of ODD and CD—violations and intentional aggression in particular—were related to injury incidence but symptoms of ADHD were not, consistent with a growing body of evidence that oppositional, noncompliant, and aggressive behavior patterns might be primarily responsible for increased risk for injury among children with externalizing behavior disorders.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2007 journal article
Radial Glial Dependent and Independent Dynamics of Interneuronal Migration in the Developing Cerebral Cortex
PLoS ONE, 2(8), e794.
Ed(s): T. Chan-Ling
MeSH headings : Animals; Cell Differentiation; Cell Movement / physiology; Cell Polarity; Cells, Cultured; Cerebral Cortex / cytology; Cerebral Cortex / embryology; Cerebral Cortex / physiology; Embryo, Mammalian / metabolism; Immunohistochemistry; Interneurons / cytology; Interneurons / metabolism; Mice; Mice, Transgenic; Neuroglia / cytology; Neuroglia / metabolism
TL;DR:
The observations suggest that interactions with radial glial scaffold and localized migration within the expanding cerebral wall may play essential roles in the guidance and placement of interneurons in the developing cerebral cortex.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2007 journal article
Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice
American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(5), G1013–G1022.
author keywords: intestinal stem cells; intestinal resection; crypt fission; label retention
MeSH headings : Acclimatization; Animals; Cecum / surgery; Cell Division; Ileum / surgery; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Jejunum / cytology; Jejunum / physiology; Male; Mice; Mice, Inbred C57BL; Regeneration; Stem Cells / cytology; Stem Cells / physiology
TL;DR:
These studies support that expansion of ISC occurs following ICR, leading to an overall increase number of crypts through a process of fission and intestinal dilation.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2007 journal article
Rapid expansion of intestinal secretory lineages following a massive small bowel resection in mice
American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(1), G215–G222.
author keywords: intestinal adaptation; intestinal failure; Paneth cells; goblet cells
MeSH headings : Anastomosis, Surgical; Animals; DNA Primers; Ileum / anatomy & histology; Ileum / physiology; Ileum / surgery; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; Intestinal Mucosa / surgery; Intestine, Small / metabolism; Intestine, Small / physiology; Intestine, Small / surgery; Male; Mice; Mice, Inbred C57BL; Microvilli / physiology; Microvilli / ultrastructure; RNA / genetics; RNA / isolation & purification; Reverse Transcriptase Polymerase Chain Reaction; Sucrase-Isomaltase Complex / genetics
TL;DR:
It is speculated that early expansion of intestinal secretory lineages within the epithelium of the ileum occurs following SBR, possibly serving to amplify the signal responsible for initiating and sustaining intestinal adaptation.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2007 chapter
Detecting Network Motifs in Gene Co-expression Networks Through Integration of Protein Domain Information
In Methods of Microarray Data Analysis V (pp. 89–102).
author keywords: graph algorithms; microarray analysis; clustering; network motif; gene expression; protein domain; protein interaction; data integration
TL;DR:
This work developed algorithms for constructing gene co-expression networks labeled with corresponding protein sequence domain combinations, and detected recurring network motifs with similar protein domain memberships within these labeled networks, and applied this approach to the malaria transcriptome.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 20, 2019
2007 journal article
Simulation of miscible diffusive mixing in microchannels
Sensors and Actuators B: Chemical, 123(2), 1142–1152.
Contributors: S. Sullivan*, B. Akpa* , S. Matthews*, A. Fisher *, L. Gladden * & M. Johns *
author keywords: microchannel; analyte; LB; lattice Boltzmann; miscible; simulation
Sources: Crossref, ORCID
Added: July 20, 2019
2007 journal article
Study of miscible and immiscible flows in a microchannel using magnetic resonance imaging.
Analytical Chemistry, 79(16), 6128–6134.
Contributors: B. Akpa* , S. Matthews*, A. Sederman *, K. Yunus*, A. Fisher *, M. Johns *, L. Gladden *
MeSH headings : Diffusion; Magnetic Resonance Imaging / methods; Microfluidic Analytical Techniques / methods; Microfluidics
TL;DR:
MRI has been used for the first time to obtain both cross-sectional velocity and concentration maps of flow through an optically opaque Y-shaped microfluidic sensor via the multidimensional spatial resolution of flow and mass transfer.
(via Semantic Scholar)
Source: ORCID
Added: May 18, 2019
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