Works Published in 2010
Displaying works 1 - 20 of 135 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
The Internet and Pet Health Information: Perceptions and Behaviors of Pet Owners and Veterinarians
The Internet Journal of Veterinary Medicine, 8(1).
Source: NC State University Libraries
Added: April 24, 2021
2010 journal article
T1727 Paneth Cells Expand From a Pre-Existing Pool During Repair After Doxorubicin-Induced Damage
Gastroenterology, 138(5), S-566.
Source: Crossref
Added: February 12, 2021
2010 journal article
MS516 Unusual Sterolic Mixture, and 24-isopropylcholesterol, from the sponge Ciocalypta sp. reduce cholesterol uptake and basolateral secretion in Caco2 cells
Atherosclerosis Supplements, 11(2), 213.
Source: Crossref
Added: February 12, 2021
2010 journal article
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure
Nature Medicine, 16(2), 183–190.
MeSH headings : Angiotensin II / physiology; Animals; Blood Pressure / physiology; Guanine Nucleotide Exchange Factors / chemistry; Guanine Nucleotide Exchange Factors / metabolism; Guanine Nucleotide Exchange Factors / physiology; Hypertension / etiology; Hypertension / physiopathology; Janus Kinase 2 / metabolism; Mice; Mice, Knockout; Muscle, Smooth, Vascular / cytology; Muscle, Smooth, Vascular / physiology; Phosphorylation; Proto-Oncogene Proteins / chemistry; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins / physiology; Rho Guanine Nucleotide Exchange Factors; Signal Transduction; Tyrosine / metabolism
TL;DR:
Evidence is provided that Arhgef1 is the RhoA guanine exchange factor specifically responsible for angiotensin II–induced activation of RHoA signaling in arterial smooth muscle cells and identifies Arh gef1 as a potential target for the treatment of hypertension.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1
Nature Cell Biology, 12(5), 477–483.
MeSH headings : Cell Line; Guanine Nucleotide Dissociation Inhibitors / metabolism; Guanine Nucleotide Dissociation Inhibitors / physiology; Homeostasis; Humans; Protein Binding; Protein Folding; Protein Prenylation; Protein Stability; Receptor Cross-Talk; rho GTP-Binding Proteins / metabolism; rho-Specific Guanine Nucleotide Dissociation Inhibitors
TL;DR:
It is found that depletion of RhoGDI1 promotes misfolding and degradation of the cytosolic geranylgeranylated pool of R Ho GTPases while activating the remaining membrane-bound fraction, raising important questions about the conclusions drawn from studies that manipulate Rho protein levels.
(via Semantic Scholar)
europepmc.org (repository)
Source: Crossref
Added: August 28, 2020
2010 journal article
Selective isolation of live/dead cells using contactless dielectrophoresis (cDEP)
Lab on a Chip, 10(4), 438.
MeSH headings : Animals; Cell Death; Cell Line, Tumor; Cell Separation / instrumentation; Cell Separation / methods; Cell Survival; Electric Conductivity; Electrophoresis; Humans
TL;DR:
Two microfluidic devices capable of selectively isolating live human leukemia cells from dead cells utilizing their electrical signatures are presented, achieving greater than 95% removal efficiency and 100% selectivity between live and dead cells.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Electromagnetically Controlled Biological Assembly of Aligned Bacterial Cellulose Nanofibers
Annals of Biomedical Engineering, 38(8), 2475–2484.
author keywords: Acetobacter xylinum; Biological assembly; Directed biofabrication; Electrokinetics
MeSH headings : Air; Bacteria; Cellulose / biosynthesis; Cellulose / ultrastructure; Culture Media; Electricity; Gluconacetobacter xylinus / metabolism; Magnetics; Nanofibers; Oxygen / metabolism
TL;DR:
A new biofabrication process in which the precise control of bacterial motion is used to fabricate customizable networks of cellulose nanofibrils, demonstrating a new concept of bottom up material synthesis by the control of a biological assembly process.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Echinoid regulates tracheal morphology and fusion cell fate in Drosophila
Developmental Dynamics, 239(9), 2509–2519.
author keywords: Drosophila; Echinoid; trachea; morphogenesis; cellular junctions; branch fusion; anastomosis
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Animals; Cell Adhesion Molecules / genetics; Cell Adhesion Molecules / metabolism; Cell Fusion; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / embryology; Embryo, Nonmammalian / anatomy & histology; Embryo, Nonmammalian / physiology; Morphogenesis / physiology; Phenotype; Repressor Proteins / genetics; Repressor Proteins / metabolism; Trachea / anatomy & histology; Trachea / embryology; Wnt1 Protein / metabolism
Source: Crossref
Added: August 28, 2020
2010 journal article
750 Germ Free Mice Show Apoptosis but Dramatically Reduced Overt Mucosal Damage After Doxorubicin
Gastroenterology, 138(5), S-103.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2010 journal article
Heterotaxin: A novel TGF-beta signaling inhibitor identified in a multi-phenotype profiling screen in Xenopus embryos
Developmental Biology, 344(1), 526.
TL;DR:
A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a novel pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2010 journal article
CT myelography in a dog with intramedullary intervertebral disc herniation
Veterinary Radiology & Ultrasound, 52(2), 185–187.
author keywords: computed tomography; interverebral disc; intramedullary; myelography
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dogs; Female; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Lumbar Vertebrae / diagnostic imaging; Myelography / veterinary; Spinal Cord Injuries / diagnostic imaging; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary; Thoracic Vertebrae / diagnostic imaging; Tomography, X-Ray Computed / veterinary
TL;DR:
Based on the findings in this patient, intramedullary disc herniation should be considered a cause for focal intramingullary contrast medium accumulation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019
2010 journal article
Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation
Molecular and Cellular Neuroscience, 43(1), 157–163.
author keywords: Resiniferotoxin; TrpV1; Nociception; Pain; Thermal sensation
MeSH headings : Analgesics / pharmacology; Animals; Capsaicin / pharmacology; Diterpenes / pharmacology; Male; Mechanoreceptors / drug effects; Mechanoreceptors / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nociceptors / cytology; Nociceptors / drug effects; Nociceptors / metabolism; Pain / physiopathology; Pain Measurement; Plant Oils / pharmacology; Sensory System Agents / pharmacology; Stress, Mechanical; TRPV Cation Channels / agonists; TRPV Cation Channels / genetics; TRPV Cation Channels / metabolism; Thermosensing / drug effects; Thermosensing / physiology; Trigeminal Nerve / drug effects; Trigeminal Nerve / metabolism
TL;DR:
The data demonstrate that TrpV1 neurons are selectively tuned nociceptors that mediate responses to thermal but not mechanical pain and insinuate a labeled line model for somatosensory coding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2019
2010 journal article
Parvalbumin Deficiency and GABAergic Dysfunction in Mice Lacking PGC-1α
Journal of Neuroscience, 30(21), 7227–7235.
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Biophysics; Cells, Cultured; DNA-Binding Proteins / metabolism; Electric Stimulation / methods; GTP Phosphohydrolases / metabolism; Gene Expression Regulation, Developmental / genetics; Glutamate Decarboxylase / metabolism; Heart; High Mobility Group Proteins / metabolism; Hippocampus / cytology; Humans; Inhibitory Postsynaptic Potentials / drug effects; Inhibitory Postsynaptic Potentials / genetics; Interneurons / metabolism; Long-Term Potentiation / drug effects; Long-Term Potentiation / genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium / metabolism; Parvalbumins / deficiency; Patch-Clamp Techniques / methods; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; RNA, Messenger / metabolism; Shaw Potassium Channels / metabolism; Trans-Activators / deficiency; Trans-Activators / metabolism; Transcription Factors / metabolism; Transfection / methods; gamma-Aminobutyric Acid / metabolism
TL;DR:
Findings indicate that PGC-1α is a novel regulator of interneuron gene expression and function and a potential therapeutic target for neurological disorders associated with Interneuron dysfunction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: September 9, 2019
2010 journal article
Heart to Heart
Circulation, 121(18), 1981–1984.
author keywords: Editorials; heart; regenerative medicine; stem cells
MeSH headings : Bone Marrow Cells / cytology; Hematopoietic Stem Cell Transplantation; Humans; Myocardial Ischemia / therapy; Myocytes, Cardiac / cytology; Regeneration
TL;DR:
In conclusion, injection of autologous BMCs as adjunctive treatment for convalescent myocardial infarction has proven to be remarkably safe and the overall efficacy is modest, but certain subgroups do experience clinically meaningful increments in ejection fraction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2010 journal article
Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing Their Enhanced Functional Potency for Myocardial Repair
STEM CELLS, 28(11), 2088–2098.
author keywords: Cardiac stem cells; Stem cell niche; Extracellular-matrix molecules; Adhesion molecule
MeSH headings : Animals; Blotting, Western; Cells, Cultured; Echocardiography; Extracellular Matrix / metabolism; Flow Cytometry; Histone Deacetylase 2 / metabolism; Humans; Insulin-Like Growth Factor I / metabolism; Integrin alpha2 / metabolism; Laminin / metabolism; Mice; Mice, SCID; Myocardial Infarction / metabolism; Myocardial Infarction / therapy; Myocardium / cytology; Myocardium / metabolism; Oxidative Stress / physiology; Polymerase Chain Reaction; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism; Telomerase / metabolism
TL;DR:
Growth of cardiac‐derived cells as cardiospheres mimics stem cell niche properties with enhanced “stemness” and expression of ECM and adhesion molecules underlie an increase in cell survival and more potent augmentation of global function following implantation into the infarcted heart.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2010 journal article
Exploring cellular adhesion and differentiation in a micro-/nano-hybrid polymer scaffold
Biotechnology Progress, 26(3), 838–846.
author keywords: tissue engineering; scaffold; stem cell; micro-/nano-fabrication; adhesion
MeSH headings : Cell Adhesion; Cell Differentiation; Cells, Cultured; Fibroblasts / cytology; Humans; Materials Testing; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Nanostructures / chemistry; Nanostructures / ultrastructure; Neurons / cytology; Porosity; Shear Strength; Stem Cells / cytology; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
This study represents a systematic comparison of cellular activities on micro‐only, nano‐only and micro/nano combined scaffolds, and demonstrates the unique advantages of the later.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2010 journal article
Dedifferentiation and Proliferation of Mammalian Cardiomyocytes
PLoS ONE, 5(9), e12559.
Ed(s): A. Kowaltowski
MeSH headings : Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; GATA4 Transcription Factor / genetics; GATA4 Transcription Factor / metabolism; Homeobox Protein Nkx-2.5; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Male; Mice; Mice, Transgenic; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats; Rats, Inbred WKY; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
Contradicting the prevailing view that they are terminally-differentiated, postnatal mammalian cardiomyocytes are instead capable of substantial plasticity.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2010 journal article
Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair
Cardiovascular Research, 89(1), 157–165.
author keywords: Physiological oxygen; Ex vivo expansion; Cardiac stem cells
MeSH headings : Adult; Adult Stem Cells / cytology; Adult Stem Cells / physiology; Adult Stem Cells / transplantation; Aneuploidy; Animals; Cell Differentiation; Cell Proliferation; Cellular Senescence; DNA Damage; Humans; In Vitro Techniques; Male; Mice; Mice, SCID; Muscle Development / physiology; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / cytology; Oxidative Stress; Oxygen / physiology; Reactive Oxygen Species / metabolism; Regeneration / physiology; Transplantation, Heterologous
TL;DR:
The expansion of human adult cardiac stem cells in low oxygen increased cell yield, and the resulting cells were superior by various key in vitro and in vivo metrics of cell quality.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2010 journal article
Magnetic Targeting Enhances Engraftment and Functional Benefit of Iron-Labeled Cardiosphere-Derived Cells in Myocardial Infarction
Circulation Research, 106(10), 1570–1581.
author keywords: cardiac progenitor cells; cell transplantation; myocardial infarction; targeted cell delivery
MeSH headings : Animals; Cell Differentiation; Cell Survival; Echocardiography; Female; Genes, sry; In Situ Nick-End Labeling; Inflammation / physiopathology; Iron; Male; Mesenchymal Stem Cell Transplantation / methods; Myocardial Infarction / diagnostic imaging; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / surgery; Polymerase Chain Reaction; Rats; Rats, Inbred WKY
Source: Crossref
Added: July 28, 2019
2010 journal article
Neuronal Inactivation of Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Protects Mice from Diet-induced Obesity and Leads to Degenerative Lesions
Journal of Biological Chemistry, 285(50), 39087–39095.
MeSH headings : Animal Feed; Animals; Brain / metabolism; Constriction, Pathologic; Gene Expression Regulation; Liver / metabolism; Mice; Mice, Transgenic; Neurodegenerative Diseases / metabolism; Neurons / metabolism; Obesity / genetics; Oxygen Consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Trans-Activators / metabolism; Transcription Factors; Transcription, Genetic; Triglycerides / metabolism
TL;DR:
A physiological role for neuronal PGC-1α in the control of energy balance is demonstrated and CaMKIIα-positive neurons as an important part of the neural circuitry that governs energy expenditure in vivo are implicate.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
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