Works Published in 2016
Displaying works 1 - 20 of 117 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
Association of breed and histopathological grade in canine mast cell tumours.
Veterinary and Comparative Oncology.
MeSH headings : Age Factors; Animals; Dog Diseases / etiology; Dog Diseases / pathology; Dogs; Female; Male; Mastocytosis, Cutaneous / etiology; Mastocytosis, Cutaneous / pathology; Mastocytosis, Cutaneous / veterinary; Retrospective Studies; Risk Factors; Sex Factors; Skin Neoplasms / etiology; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Species Specificity
TL;DR:
The data indicate that the proportion of high-grade tumours increases with advancing age, and that male and intact dogs have increased odds of developing high- grade tumours, and a genetic association for the development ofhigh-grade MCTs is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 23, 2023
2016 journal article
IGF-1 C domain-modified hydrogel enhances cell therapy for AKI
Journal of the American Society of Nephrology, 27(8), 2357–2369.
Contributors: G. Feng*, J. Zhang *, Y. Li, Y. Nie, D. Zhu* , R. Wang, J. Liu *, J. Gao *
MeSH headings : Acute Kidney Injury / therapy; Adipose Tissue / cytology; Animals; Chitosan; Combined Modality Therapy; Hydrogel, Polyethylene Glycol Dimethacrylate; Insulin-Like Growth Factor I / administration & dosage; Mesenchymal Stem Cell Transplantation; Mice
TL;DR:
In conclusion, IGF-1C immobilized on a chitosan hydrogel provides an artificial microenvironment for ADSCs and may be a promising therapeutic approach for AKI.
(via Semantic Scholar)
europepmc.org (repository)
Source: ORCID
Added: April 19, 2023
2016 journal article
The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling
Genome Biology and Evolution.
Contributors: P. Schaap *, I. Barrantes *, P. Minx, N. Sasaki *, R. Anderson*, M. Beinard, K. Biggar*, N. Buehler
author keywords: Amoebozoa; tyrosine kinase receptor; two-component system; signaling; phytochrome
MeSH headings : Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Evolution, Molecular; Genetic Loci; Genome, Protozoan; Physarum polycephalum / genetics; Protozoan Proteins / genetics; Protozoan Proteins / metabolism; Receptor Protein-Tyrosine Kinases / genetics; Receptor Protein-Tyrosine Kinases / metabolism; Signal Transduction; Transcriptome
TL;DR:
The analysis characterizes P. polycephalum as a prototypical eukaryote with features attributed to the last common ancestor of Amorphea, that is, the Amoebozoa and Opisthokonts, and argues against the later emergence of tyrosine kinase signaling in the opistHokont lineage.
(via Semantic Scholar)
Source: ORCID
Added: February 16, 2022
2016 journal article
Endocrine active contaminants in aquatic systems and intersex in common sport fishes
Environmental Toxicology and Chemistry, 36(4), 959–968.
author keywords: Intersex; Estrogens; Endocrine disruption; Black bass; Sunfish
MeSH headings : Animals; Bass / growth & development; Bass / metabolism; Disorders of Sex Development / chemically induced; Endocrine Disruptors / analysis; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Environmental Monitoring; Female; Male; North Carolina; Oocytes / drug effects; Oocytes / growth & development; Rivers / chemistry; Seasons; Species Specificity; Sports; Testis / drug effects; Testis / growth & development; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
TL;DR:
The authors’ results associate genus‐specific prevalence of intersex with specific EAC classes in common sport fishes having biological, ecological, and conservation implications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2016 journal article
Endothelial Membrane Modulation by OxLDL: Molecular-Scale Effects of Oxidation Products on Model Membranes
Biophysical Journal, 110(3), 81a.
TL;DR:
A molecular-scale investigation of changes induced in endothelial membranes in the presence of various oxidation products using coarse-grained molecular dynamics simulations may begin to clarify some of the molecular mechanisms underlying endothelial cell dysfunction resulting from exposure to OxLDL.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Molecular Dynamics Simulations of Kir2.2-Cholesterol Interactions
Biophysical Journal, 110(3), 186a.
TL;DR:
A computational approach which utilizes coarse-grained molecular dynamics simulations - employing the MARTINI force field - to further investigate the spatial and temporal mechanics of cholesterol binding has allowed for a greater range of binding effects, such as binding time, binding instances, changes in channel conformation, and ion flux through the channel.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn’s disease
Scientific Reports, 6(1).
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Aldo-Keto Reductase Family 1 Member C3 / metabolism; Caco-2 Cells; Cells, Cultured; Coculture Techniques; Crohn Disease / metabolism; Dinoprost / metabolism; Eicosapentaenoic Acid / analogs & derivatives; Eicosapentaenoic Acid / metabolism; Epithelial Cells / cytology; Epithelial Cells / metabolism; Female; Humans; Hydroxyeicosatetraenoic Acids / metabolism; Intestinal Mucosa / metabolism; Intestines / cytology; Male; Middle Aged; Prostaglandin D2 / analogs & derivatives; Prostaglandin D2 / metabolism; Wound Healing; Young Adult
TL;DR:
CD EGC presented impaired ability to promote IEB functions through defect in L-PGDS-AKR1C3-11βPGF2α dependent pathway, which is similar to that presented by healthy EGC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2016 journal article
Using magnets and magnetic beads to dissect signaling pathways activated by mechanical tension applied to cells
Methods, 94, 19–26.
author keywords: Mechanotransduction; Tension; VE-cadherin; Endothelial cell
MeSH headings : Antigens, CD / physiology; Cadherins / physiology; Electron Spin Resonance Spectroscopy; Human Umbilical Vein Endothelial Cells / physiology; Humans; Magnetic Phenomena; Mechanotransduction, Cellular; Phosphorylation; Protein Processing, Post-Translational; rho GTP-Binding Proteins / physiology
TL;DR:
The methods for analyzing mechanotransduction through VE-cadherin on endothelial cells using both permanent magnets and magnetic tweezers are demonstrated.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2016 journal article
Focal adhesions, stress fibers and mechanical tension
Experimental Cell Research, 343(1), 14–20.
author keywords: Myosin II; RhoA; Integrins; Substratum rigidity
MeSH headings : Animals; Focal Adhesions / physiology; Humans; Models, Biological; Stress Fibers / physiology; Stress, Mechanical
TL;DR:
The evidence for and against the role of mechanical tension in driving the assembly of stress fibers and focal adhesions are discussed, and how their assembly is influenced by the rigidity of the substratum to which cells are adhering is considered.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2016 journal article
Production of Spherical Ablations Using Nonthermal Irreversible Electroporation: A Laboratory Investigation Using a Single Electrode and Grounding Pad
Journal of Vascular and Interventional Radiology, 27(9), 1432–1440.e3.
MeSH headings : Ablation Techniques / instrumentation; Animals; Computer Simulation; Electrodes; Electroporation / instrumentation; Equipment Design; Finite Element Analysis; In Vitro Techniques; Liver / pathology; Liver / surgery; Materials Testing; Numerical Analysis, Computer-Assisted; Swine
TL;DR:
Computer modeling showed that the P+GP configuration for IRE procedures yields ablations that are larger than the 2EP configuration, creating substantial ablation zones with a single electrode placement.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2016 journal article
Molecular organization of cytokinesis nodes and contractile rings by super-resolution fluorescence microscopy of live fission yeast
Proceedings of the National Academy of Sciences, 113(40), E5876–E5885.
author keywords: super resolution; cytokinesis; cytokinetic nodes; contractile ring; fission yeast
MeSH headings : Actin Cytoskeleton / metabolism; Actins / metabolism; Cytokinesis; Interphase; Microscopy, Fluorescence / methods; Models, Molecular; Phenotype; Schizosaccharomyces / cytology; Schizosaccharomyces / metabolism; Schizosaccharomyces pombe Proteins / metabolism
TL;DR:
It is shown that nodes, protein assembly precursors to the contractile ring, are discrete structural units with stoichiometric ratios and distinct distributions of constituent proteins, which establish the organization of the proteins in the functional units of a cytokinetic contractiles ring.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2016 journal article
Tu1850 Direct Regulation of Crypt Autophagy and Intestinal Homeostasis via mRNA Binding Protein Imp1
Gastroenterology, 150(4), S960.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2016 journal article
Use of an Esophagostomy Tube for Management of Traumatic Subtotal Glossectomy in an African Pygmy Hedgehog (Atelerix albiventris)
Journal of Exotic Pet Medicine, 25(3), 231–236.
author keywords: African pygmy hedgehog; Atelerix albiventris; esophagostomy tube; glossectomy; nutrition
TL;DR:
Placement, maintenance, and successful use of this esophagostomy tube to manage severe oral trauma in a novel exotic pet species is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2016 journal article
27 AN IMPROVED LARGE ANIMAL MODEL FOR THE STUDY OF ADULT STEM CELLS
Reproduction, Fertility and Development, 28(2), 143.
TL;DR:
The generation of a porcine stem cell reporter line using the combination of transcription activator-like effector nucleases and somatic cell NT, which represents significant progress toward the study of adult stem cells, their progenitors, and the stem cell niche, using a large animal model with an anatomy, physiology, and ability to recapitulate human disease that overcomes the current limitations of rodent models.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2016 journal article
1 GENERATION OF A STABLE TRANSGENIC SWINE MODEL FOR CELL TRACKING AND CHROMOSOME DYNAMIC STUDIES
Reproduction, Fertility and Development, 28(2), 130.
TL;DR:
The first transgenic porcine H2B-GFP model via CRISPR-CAS9 mediated recombination and somatic cell nuclear transfer (SCNT) is developed, representing an improved platform for regenerative medicine and chromosome dynamic and cancer biology studies.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2016 journal article
A comparison of serum and plasma cytokine values using a multiplexed assay in cats
Veterinary Immunology and Immunopathology, 182, 69–73.
author keywords: Biomarker; Immunoassay; Feline
MeSH headings : Animals; Biomarkers / blood; Blood Chemical Analysis / methods; Cats / blood; Cats / immunology; Cytokines / blood; Immunoassay / methods; Plasma / immunology
TL;DR:
While serum and plasma agreement was generally good, detection was improved using serum samples, and alterations of cytokine concentrations have been associated with joint deterioration and pain in humans, similar changes have not been investigated in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2016 journal article
Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis
Gut Microbes, 7(5), 414–423.
author keywords: apoptosis; bacteria; damage; doxorubicin; germ free; intestine
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / adverse effects; Apoptosis / drug effects; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Female; Gastrointestinal Microbiome / drug effects; Germ-Free Life; Goblet Cells / drug effects; Goblet Cells / microbiology; Intestines / cytology; Intestines / drug effects; Intestines / microbiology; Mice; Mice, Inbred C57BL; Paneth Cells / drug effects; Paneth Cells / microbiology
TL;DR:
Findings provide evidence that manipulation and/or depletion of the enteric microbiota may have clinical significance in limiting chemotherapy-induced mucositis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 21, 2020
2016 journal article
Constitutive KIT Activity and IL-6 Production in Mast Cells Alters Levels of Reactive Oxygen Species (ROS) and the Scavenger Protein DJ-1 in Mastocytosis
Journal of Allergy and Clinical Immunology, 137(2), AB281.
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2016 chapter
Recovery of horses from general anesthesia following induction with either propofol or midazolam followed by ketamine
In Journal of the American Veterinary Medical Association (Vol. 253, pp. 101–107).
MeSH headings : Anesthesia Recovery Period; Anesthesia, General / veterinary; Anesthetics, Intravenous / administration & dosage; Anesthetics, Intravenous / pharmacokinetics; Animals; Female; Horses / blood; Ketamine / administration & dosage; Ketamine / pharmacokinetics; Male; Midazolam / administration & dosage; Midazolam / pharmacokinetics; Propofol / administration & dosage; Propofol / pharmacokinetics; Prospective Studies; Random Allocation; Treatment Outcome
TL;DR:
It is suggested that for horses undergoing short periods of general anesthesia, recovery quality may be better following induction with propofol and ketamine, compared with midazolam and ketamines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: NC State University Libraries
Added: September 8, 2019
2016 journal article
Multimodal and Site-Specific Plasticity of Amygdala Parvalbumin Interneurons after Fear Learning
Neuron, 91(3), 629–643.
MeSH headings : Amygdala / cytology; Amygdala / metabolism; Amygdala / physiology; Animals; Conditioning, Psychological / physiology; Fear; Interneurons / physiology; Male; Mice; Neural Pathways / physiology; Neuronal Plasticity / physiology; Neurons / physiology; Parvalbumins / metabolism; gamma-Aminobutyric Acid / metabolism
TL;DR:
Examining synaptic connections between afferent pathways, PV-INs, and principal excitatory neurons in the basolateral amygdala reveals previously overlooked specializations of amygdala PV-Ins and indicates specific circuit mechanisms for inhibitory plasticity during the encoding of associative fear memories.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
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