Works Published in 2000
Displaying 1 work
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2000 journal article
Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
MOLECULAR AND CELLULAR BIOLOGY, 20(2), 672–683.
MeSH headings : Animals; Binding Sites; Carrier Proteins; Cell Cycle Proteins; Cell Transformation, Neoplastic / pathology; Cyclin D1 / antagonists & inhibitors; Cyclin D1 / genetics; Cyclin D1 / metabolism; DNA-Binding Proteins / metabolism; E2F Transcription Factors; E2F1 Transcription Factor; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mammary Glands, Animal / metabolism; Mammary Glands, Animal / pathology; Mice; Mice, Nude; Mice, Transgenic; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Monomeric GTP-Binding Proteins / genetics; Monomeric GTP-Binding Proteins / metabolism; Mutation / genetics; Promoter Regions, Genetic / genetics; Proto-Oncogene Mas; RNA, Antisense / genetics; RNA, Antisense / physiology; Receptor, ErbB-2 / antagonists & inhibitors; Receptor, ErbB-2 / genetics; Receptor, ErbB-2 / metabolism; Retinoblastoma-Binding Protein 1; Sp1 Transcription Factor / metabolism; Sp3 Transcription Factor; Transcription Factor DP1; Transcription Factors / metabolism; Transcriptional Activation; Tumor Cells, Cultured
TL;DR:
It is demonstrated that E2F-1 mediates a Neu-signaling cascade tocyclin D1 and identify cyclin D 1 as a critical downstream target of neu-induced transformation.
(via Semantic Scholar)
mcb.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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