Works Published in 2012
Displaying works 181 - 200 of 202 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
The Toxicology Education Summit: Building the Future of Toxicology Through Education
TOXICOLOGICAL SCIENCES, 127(2), 331–338.
author keywords: toxicology; education
MeSH headings : Cooperative Behavior; Curriculum / trends; Education, Professional / trends; Fellowships and Scholarships / trends; Forecasting; Humans; Interinstitutional Relations; Needs Assessment / trends; Professional Competence; Research Support as Topic / trends; Toxicology / education; Toxicology / trends
TL;DR:
This report summarizes the outcomes of the Toxicology Educational Summit, presents examples of successful programs that advance toxicology education, and concludes with strategies that will insure the future of toxicology through advanced educational initiatives.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Synthesis and Biological Response of Size-Specific, Monodisperse Drug-Silica Nanoconjugates
ACS NANO, 6(5), 3954–3966.
author keywords: silica nanoparticle; nanoconjugates; chemotherapeutics; nanomedicine; drug delivery; cancer therapy; tumor penetration; cell uptake; nanoparticle biodistribution
MeSH headings : Animals; Female; HeLa Cells; Humans; Kinetics; Mice; Mice, Inbred C57BL; Nanoconjugates; Pharmaceutical Preparations / chemistry; Silicon Dioxide / chemistry
TL;DR:
20 nm NCs are superior to their 50 and 200 nm NC analogues by 2-5- and 10-20-fold, respectively, with regard to tumor accumulation and penetration and cellular internalization, which underscores the importance and necessity of further miniaturizing nanomedicine size for optimized drug delivery applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Long-Term Efficacy Following Readministration of an Adeno-Associated Virus Vector in Dogs with Glycogen Storage Disease Type Ia
HUMAN GENE THERAPY, 23(4), 407–418.
MeSH headings : Animals; Dependovirus / genetics; Dogs; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Glycogen Storage Disease Type I / genetics; Glycogen Storage Disease Type I / metabolism; Glycogen Storage Disease Type I / therapy; Hypoglycemia / genetics; Hypoglycemia / metabolism; Hypoglycemia / therapy; Liver / metabolism
TL;DR:
Preclinical data support the further translation of AAV vector-mediated gene therapy in GSD-Ia and support the demonstrated risk for recurrent hypoglycemia and mortality from waning efficacy of the AAV2/9 vector.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Identification of Bartonella henselae in 2 Cats With Pyogranulomatous Myocarditis and Diaphragmatic Myositis
VETERINARY PATHOLOGY, 49(4), 608–611.
author keywords: Bartonella; cats; diaphragmatic myositis; myocarditis
MeSH headings : Animals; Bartonella Infections / microbiology; Bartonella Infections / pathology; Bartonella Infections / veterinary; Bartonella henselae; Cat Diseases / microbiology; Cat Diseases / pathology; Cats; Fatal Outcome; Female; Male; Myocarditis / pathology; Myocarditis / veterinary; Myositis / pathology; Myositis / veterinary
TL;DR:
This study supports a potential association between B. henselae and what has been historically described as “transmissible myocarditis and diaphragmitis” of undetermined cause in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
A Serosurvey for Brucella suis, Classical Swine Fever Virus, Porcine Circovirus Type 2, and Pseudorabies Virus in Feral Swine (Sus scrofa) of Eastern North Carolina
JOURNAL OF WILDLIFE DISEASES, 48(2), 462–466.
author keywords: Brucella suis; classical swine fever; feral swine; North Carolina; porcine circovirus type 2; pseudorabies virus; Sus scrofa
MeSH headings : Animals; Animals, Wild / microbiology; Animals, Wild / virology; Antibodies, Bacterial / blood; Antibodies, Viral / blood; Brucella suis / immunology; Brucellosis / epidemiology; Brucellosis / veterinary; Circoviridae Infections / epidemiology; Circoviridae Infections / veterinary; Circovirus / immunology; Classical Swine Fever / epidemiology; Classical Swine Fever Virus / immunology; Female; Herpesvirus 1, Suid / immunology; Male; North Carolina / epidemiology; Pseudorabies / epidemiology; Seroepidemiologic Studies; Sus scrofa / blood; Swine; Swine Diseases / epidemiology
TL;DR:
The detection of feral Swine with antibodies to B. suis for the first time in North Carolina warrants increased surveillance of the feral swine population to evaluate speed of disease spread and to establish the potential risk to commercial swine and humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Uterine artery blood flow remains unchanged in pregnant mares in response to short-term administration of pentoxifylline
THERIOGENOLOGY, 77(2), 430–436.
author keywords: Uterine blood flow; Equine pregnancy; Placentitis; Pentoxifylline; Color Doppler ultrasound; Horse
MeSH headings : Animals; Female; Gestational Age; Horses / physiology; Pentoxifylline / administration & dosage; Pregnancy; Pulsatile Flow / drug effects; Regional Blood Flow / drug effects; Ultrasonography, Doppler, Color / veterinary; Uterine Artery / diagnostic imaging; Uterine Artery / drug effects; Uterine Artery / physiology; Vascular Resistance / drug effects; Vasodilator Agents / administration & dosage
TL;DR:
It was concluded that any immediate benefits of pentoxifylline administration in the pregnant mare were not mediated through enhanced uterine artery blood flow.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Quantum dot penetration into viable human skin
NANOTOXICOLOGY, 6(2), 173–185.
author keywords: Nanoparticles; exposure; nanotoxicology; surface chemistry
MeSH headings : Diffusion Chambers, Culture; Female; Humans; Hydrogen-Ion Concentration; Microscopy, Confocal; Nanoparticles; Particle Size; Polyethylene Glycols / metabolism; Polyethylene Glycols / pharmacology; Quantum Dots; Skin / chemistry; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Tissue Culture Techniques
TL;DR:
Systematic studies probing the effects of nanoparticle surface modification and formulation pH are important in nanotoxicology and nanomedicine and this study uses laser-scanning fluorescence confocal microscopy to evaluate nanoparticle penetration in viable excised human skin that was intact or tape-stripped.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Neoplastic and Nonneoplastic Liver Lesions Induced by Dimethylnitrosamine in Japanese Medaka Fish
VETERINARY PATHOLOGY, 49(2), 372–385.
author keywords: Japanese medaka; Oryzias latipes; hepatocarcinogenesis; dimethylnitrosamine; aquatic animal models; comparative carcinogenesis; alternative animal models
MeSH headings : Animals; Animals, Genetically Modified; Biliary Tract Neoplasms / chemically induced; Biliary Tract Neoplasms / pathology; Biliary Tract Neoplasms / veterinary; Biomarkers / metabolism; Carcinogenicity Tests; Carcinogens / toxicity; Carcinoma, Hepatocellular / chemically induced; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / veterinary; Cell Proliferation / drug effects; Chemical and Drug Induced Liver Injury / pathology; Chemical and Drug Induced Liver Injury / veterinary; Dimethylnitrosamine / toxicity; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fish Diseases / chemically induced; Fish Diseases / pathology; Liver / drug effects; Liver Neoplasms / chemically induced; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Male; Mutagenicity Tests; Oryzias; Rats; Signal Transduction; Species Specificity; Transforming Growth Factor beta / metabolism
TL;DR:
Small fish models have been used for decades in carcinogenicity testing, but the pre-neoplastic and neoplastic commonalities between the two models are largely unknown, with special emphasis on the TGF-β pathway and its corresponding role in DMN-induced hepatic neoplasia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 article
Necropsy or Autopsy? It's All About Communication!
Law, M., Stromberg, P., Meuten, D., & Cullen, J. (2012, March). VETERINARY PATHOLOGY, Vol. 49, pp. 271–272.
MeSH headings : Animals; Autopsy; Communication; Humans; Pathology, Veterinary / methods; Terminology as Topic
TL;DR:
Several of us have decided that communication is more important than tradition and postmortem examination of nonhumans was proscribed from using the term and was designated ‘‘necropsy’.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Molecular Characterization of Salmonella enterica Serotype Enteritidis Isolates from Humans by Antimicrobial Resistance, Virulence Genes, and Pulsed-Field Gel Electrophoresis
FOODBORNE PATHOGENS AND DISEASE, 9(3), 232–238.
MeSH headings : Ampicillin / pharmacology; Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; DNA Fingerprinting; Disease Outbreaks; Disk Diffusion Antimicrobial Tests; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Eggs / microbiology; Electrophoresis, Gel, Pulsed-Field; Humans; Molecular Typing; North Carolina / epidemiology; Phylogeny; Salmonella Food Poisoning / epidemiology; Salmonella Food Poisoning / microbiology; Salmonella enteritidis / drug effects; Salmonella enteritidis / genetics; Salmonella enteritidis / isolation & purification; Salmonella enteritidis / pathogenicity; Seasons; United States / epidemiology; Virulence; Virulence Factors / genetics; Virulence Factors / metabolism
TL;DR:
A genotypic similar S. Enteritidis population is identified based on antimicrobial susceptibility, virulence gene, and PFGE fingerprint profiles for the human outbreak due to consumption of contaminated eggs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Hematologic Changes After Total Body Irradiation and Autologous Transplantation of Hematopoietic Peripheral Blood Progenitor Cells in Dogs With Lymphoma
VETERINARY PATHOLOGY, 49(2), 341–343.
Contributors: C. Escobar n, C. Grindem n, J. Neel n & S. Suter n
author keywords: clinical pathology; laboratory medicine; dog; hematopoietic; oncology
MeSH headings : Animals; Antigens, CD34 / metabolism; Blood Cell Count / veterinary; Bone Marrow / radiation effects; Dog Diseases / therapy; Dogs; Graft Survival; Hematopoietic Stem Cell Transplantation / methods; Hematopoietic Stem Cell Transplantation / veterinary; Lymphoma / therapy; Lymphoma / veterinary; Transplantation, Autologous; Whole-Body Irradiation / adverse effects; Whole-Body Irradiation / veterinary
TL;DR:
This study documents the hematologic toxicities of total body irradiation in 10 dogs and the subsequent recovery of the affected cell lines after peripheral blood progenitor cell transplant, indicating successful CD34+ engraftment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Evaluation of a Multiplex Real-Time Polymerase Chain Reaction for the Quantification of Escherichia coli O157 in Cattle Feces
FOODBORNE PATHOGENS AND DISEASE, 9(1), 79–85.
MeSH headings : Animals; Bacterial Shedding; Carbohydrate Epimerases / genetics; Cattle; Cattle Diseases / diagnosis; Colony Count, Microbial; DNA Primers / genetics; DNA, Bacterial / genetics; Escherichia coli Infections / diagnosis; Escherichia coli Infections / veterinary; Escherichia coli O157 / genetics; Escherichia coli O157 / isolation & purification; Escherichia coli Proteins / genetics; Feces / microbiology; Multiplex Polymerase Chain Reaction; Real-Time Polymerase Chain Reaction; Sensitivity and Specificity; Shiga Toxin 1 / genetics; Shiga Toxin 2 / genetics; Transaminases / genetics
TL;DR:
The mqPCR quantifying E. coli O157 in cattle feces using stx1, stx2, and rfbE gene targets may have use in detecting and quantifying super shedders, but is not applicable for quantification in animals shedding low concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development
CELL CYCLE, 11(2), 335–342.
author keywords: cell cycle; D-type cyclins; skin; carcinogenesis; epidermis
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1 / genetics; Cyclin D1 / metabolism; Cyclin D2 / metabolism; Cyclin D3 / genetics; Cyclin D3 / metabolism; Gene Expression Regulation; Mice; Mice, Transgenic; Oncogene Protein p21(ras) / genetics; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tumor Burden
TL;DR:
Modulation of the levels of particular members of the D-type cyclin family could be useful to inhibit tumor development and, in particular, ras-mediated tumorigenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Associations Between Multidrug Resistance, Plasmid Content, and Virulence Potential Among Extraintestinal Pathogenic and Commensal Escherichia coli from Humans and Poultry
FOODBORNE PATHOGENS AND DISEASE, 9(1), 37–46.
MeSH headings : Animals; Anti-Infective Agents / pharmacology; Chickens; DNA, Bacterial / genetics; Drug Resistance, Multiple, Bacterial / genetics; Escherichia coli / drug effects; Escherichia coli / genetics; Escherichia coli / isolation & purification; Escherichia coli / pathogenicity; Escherichia coli Infections / microbiology; Feces / microbiology; Female; Genotype; Humans; Infant, Newborn; Meat / microbiology; Microbial Sensitivity Tests; Phylogeny; Plasmids / genetics; Poultry Diseases / microbiology; Replicon / genetics; Turkeys; Virulence Factors / genetics
TL;DR:
In extraintestinal E. coli, MDR is most commonly associated with plasmid types, and that these plasmids are frequently found among avian-source E. Escherichia coli from poultry production systems.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 review
Things your dog doesn't want you to know: 11 courageous canines tell you what your dog won't
[Review of ]. Library Journal, 137(2), 81–81.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Successful treatment of a novel generalized variant of canine discoid lupus erythematosus with oral hydroxychloroquine
VETERINARY DERMATOLOGY, 23(1), 65–E16.
MeSH headings : Administration, Oral; Animals; Antirheumatic Agents / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Female; Hydroxychloroquine / therapeutic use; Lupus Erythematosus, Discoid / drug therapy; Lupus Erythematosus, Discoid / pathology; Lupus Erythematosus, Discoid / veterinary; Treatment Outcome
TL;DR:
A generalized variant of canine DLE successfully treated with the antimalarial immunomodulator hydroxychloroquine (HCQ) mirrored the generalized discoid variant of chronic cutaneous lupus erythematosus of humans, and the apparent benefit of HCQ, its safety and low cost warrant future investigations of its use for treatment of canine cutaneouslupus variants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(1), 52–58.
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Cross-Over Studies; Female; Half-Life; Horses / blood; Horses / metabolism; Injections, Intramuscular; Injections, Intravenous; Male
TL;DR:
Buprenorphine has a moderate T(1/2) in the horse and was detected at concentrations expected to be therapeutic in other species after i.v. and i.m. administration of 0.005 mg/kg.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Experimental infection by capillary tube feeding of Rhipicephalus sanguineus with Bartonella vinsonii subspecies berkhoffii
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 35(1), 9–15.
author keywords: Bartonella vinsonii subspecies berkhoffii; Rhipicephalus sanguineus; Artificial infection; Transmission
MeSH headings : Animals; Arachnid Vectors / microbiology; Bacterial Typing Techniques; Bartonella / genetics; Bartonella / physiology; Bartonella Infections / microbiology; Bartonella Infections / transmission; Bartonella Infections / veterinary; DNA, Bacterial / genetics; Dog Diseases / microbiology; Dog Diseases / transmission; Dogs; Feces / microbiology; Female; Polymerase Chain Reaction; Rabbits; Rhipicephalus sanguineus / microbiology
TL;DR:
To determine whether adult R. sanguineus ticks can be infected with a B. v. berkhoffii genotype II isolate via capillary tube feeding and whether the infection can then be transmitted from adult females to their eggs via trans-ovarial transmission, tick fecal material was collected and screened as a possible source of infectious inoculum for canine infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Cathepsin K Expression and Activity in Canine Osteosarcoma
JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(1), 126–134.
author keywords: Bone resorption; Cysteine protease; Malignant osteolysis; Surrogate marker
MeSH headings : Animals; Blotting, Western / veterinary; Bone Density Conservation Agents / pharmacology; Bone Neoplasms / enzymology; Bone Neoplasms / veterinary; Cathepsin K / biosynthesis; Cathepsin K / genetics; Cell Line, Tumor; Collagen Type I / metabolism; Dog Diseases / enzymology; Dogs; Immunohistochemistry / veterinary; Osteosarcoma / enzymology; Osteosarcoma / veterinary; Prospective Studies; RNA / chemistry; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Transforming Growth Factor beta1 / pharmacology
TL;DR:
Canine OS is associated with pathologic bone resorption, and CatK inhibitors might aid in the management of canine OS-related malignant osteolysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
A pilot study to assess markers of renal damage in the rodent kidney after exposure to 7 MHz ultrasound pulse sequences designed to cause microbubble translation and disruption
Ultrasound in Medicine and Biology, 38(1), 168–172.
Source: NC State University Libraries
Added: August 6, 2018
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