Works Published in 2021
Displaying works 161 - 180 of 210 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 journal article
A deleterious mutation in the ALMS1 gene in a naturally occurring model of hypertrophic cardiomyopathy in the Sphynx cat
ORPHANET JOURNAL OF RARE DISEASES, 16(1).
author keywords: Hypertrophic cardiomyopathy; ALMS1; Feline; Mitogenic; Sphynx
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cats / genetics; Cell Cycle Proteins / genetics; Exons; Mice; Mutation / genetics
TL;DR:
This study demonstrates a novel form of cardiomyopathy associated with ALMS1 in the cat, and suggests that variants in genes involved with cardiac development and cell regulation, like the AL MS1 gene, may deserve further consideration for association with familial hypertrophic cardiopathy.
(via Semantic Scholar)
ojrd.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 12, 2021
2021 journal article
Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31
JOURNAL OF NEUROVIROLOGY, 27(2), 302–324.
author keywords: Human immunodeficiency virus; Neurocognitive; Neurotrophin; Therapy; Behavior; Neuroprotection
MeSH headings : Animals; Cats; Cognition Disorders / virology; Feline Acquired Immunodeficiency Syndrome / complications; Immunodeficiency Virus, Feline; Isoleucine / analogs & derivatives; Isoleucine / pharmacology; Morpholines / pharmacology; Neuroprotective Agents / pharmacology; Receptor, Nerve Growth Factor / agonists
TL;DR:
The data indicate that LM11A-31 is likely to be a potent adjunctive treatment for the control of neurodegeneration in HIV infected individuals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 12, 2021
2021 journal article
Time-dependent injection strategies for multilayer Hele-Shaw and porous media flows
PHYSICAL REVIEW FLUIDS, 6(3).
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: April 12, 2021
2021 article
Modeling the role of mortality-based response triggers on the effectiveness of African swine fever control strategies
Machado, G., Farthing, T., Andraud, M., Lopes, F. P. N., & Lanzas, C. (2021, April 6). BioRxiv, Vol. 4.
Contributors: G. MacHado n , T. Farthing n, M. Andraud *, F. Lopes* & C. Lanzas n
TL;DR:
A nested multiscale model for the transmission of ASF is developed, combining spatially explicit network model of animal movements with a deterministic compartmental models for the dynamics of two ASF strains within-pixels of 3 km x 3 km, amongst the pig population in one Brazilian state.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 7, 2021
2021 journal article
Mitotic Figures-Normal, Atypical, and Imposters: A Guide to Identification
VETERINARY PATHOLOGY, 58(2), 243–257.
author keywords: mitotic figure; mitotic count; MC; prophase; prometaphase; metaphase; anaphase; telophase; computational pathology; CPATH; artificial intelligence; AI; whole slide image; WSI; pathology; oncology
MeSH headings : Animals; Eosine Yellowish-(YS); Hematoxylin; Mitotic Index / veterinary; Reproducibility of Results; Software
TL;DR:
Correct identification of MF will improve MC consistency, reproducibility, and accuracy obtained from manual (glass slide or whole-slide imaging) and CPATH approaches.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 5, 2021
2021 journal article
Genetic relatedness of multidrug resistant Escherichia coli isolated from humans, chickens and poultry environments
Antimicrobial Resistance & Infection Control, 10(1).
author keywords: Escherichia coli; Antimicrobial resistance; Prevalence; Chicken; Multidrug resistance; Genetic relatedness; One health; Nigeria
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Chickens / microbiology; Cross-Sectional Studies; Drug Resistance, Multiple, Bacterial / genetics; Escherichia coli / genetics; Escherichia coli / isolation & purification; Farms; Humans; Microbial Sensitivity Tests; Multilocus Sequence Typing; Nigeria; Phylogeny; Plasmids / genetics; Polymorphism, Single Nucleotide; Poultry / microbiology; Whole Genome Sequencing
TL;DR:
The prevalence and genetic relatedness among MDR E. coli isolated from poultry-workers, chickens, and poultry environments in Abuja, Nigeria and the emergence of MDR E.coli with novel ST in two isolates may be plasmid-mediated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: April 5, 2021
2021 journal article
The Potential Distribution of Pythium insidiosum in the Chincoteague National Wildlife Refuge, Virginia
FRONTIERS IN VETERINARY SCIENCE, 8.
Contributors: M. Jara n, K. Holcomb *, X. Wang *, E. Goss * & G. Machado n
TL;DR:
It was found that June, July, and August were the months with the highest suitability for P. insidiosum across the Refuge, while December through March were less favorable months, and significant differences in suitability were observed between the two grazing areas.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 5, 2021
2021 journal article
Replication of Marek's disease vaccines in turkey embryos and their effect on TLR-3 and IFN-gamma transcripts
AVIAN PATHOLOGY, 50(3), 227–233.
author keywords: HVT; TLR-3; IFN-γ turkey; in ovo; vaccination
TL;DR:
It was demonstrated that commercial turkey flocks got exposed to wild type HVT within the first days of life; therefore, there is a potential of interaction between wildtype HVT and rHVT when administered at day of age, and all evaluated vaccines replicated very well in turkey embryonic tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021
2021 journal article
The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence
OSTEOARTHRITIS AND CARTILAGE, 29(3), 402–412.
author keywords: SA-beta-gal; DNA damage; Osteoarthritis; Aging; TGF- beta 1; bFGF
MeSH headings : Animals; Ankle Joint; Cartilage, Articular / cytology; Cartilage, Articular / drug effects; Cartilage, Articular / metabolism; Cellular Senescence / drug effects; Cellular Senescence / genetics; Chemokine CCL2 / drug effects; Chemokine CCL2 / genetics; Chondrocytes / drug effects; Chondrocytes / metabolism; Cyclin-Dependent Kinase Inhibitor p16 / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; DNA Damage / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Histones / drug effects; Histones / metabolism; Horses; Humans; In Vitro Techniques; Inflammation / genetics; Insulin-Like Growth Factor Binding Protein 3 / drug effects; Insulin-Like Growth Factor Binding Protein 3 / genetics; Interleukin-6 / genetics; Matrix Metalloproteinase 13 / drug effects; Matrix Metalloproteinase 13 / genetics; Mitogens / pharmacology; Stifle; Transforming Growth Factor beta1 / pharmacology; beta-Galactosidase / drug effects; beta-Galactosidase / metabolism
TL;DR:
Treatment of cartilage explants with mitogenic stimuli in the context of cellular damage reliably induces high levels of SA-β-gal activity and other senescence markers, which provides a physiologically relevant model system to investigate the mechanisms of senescences induction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 29, 2021
2021 journal article
The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus
Frontiers in Immunology, 12.
author keywords: adaptive immunity; humoral immunity; neutralizing antibodies; IgA; IgG; porcine reproductive and respiratory syndrome virus
MeSH headings : Animals; Antibodies, Neutralizing / blood; Flow Cytometry / methods; Immunity, Humoral / immunology; Immunoglobulin A / analysis; Immunoglobulin A / immunology; Immunoglobulin G / blood; Nasal Mucosa / immunology; Nasal Mucosa / virology; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine respiratory and reproductive syndrome virus / immunology; Swine; Vaccination; Viral Vaccines / immunology; Viremia / immunology; Viremia / virology
TL;DR:
This study improves the understanding of the relationship between local and systemic infections and the humoral immune response induced by PRRSV-2 infection or MLV vaccination and provides novel insights into the timeline of the development of homologous and heterologous NA levels – by bothMLV vaccination or infection with two strains from the currently prevalent PRRSv-2 lineage 1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 29, 2021
2021 journal article
Hematologic and clinical characteristics of dogs with circulating macrophage-like cells
VETERINARY CLINICAL PATHOLOGY, 50(1), 37–44.
author keywords: canine; hepatic lymphoma; histiocytes; histiocytic sarcoma; monocyte; pancytopenia
MeSH headings : Animals; Blood Cell Count / veterinary; Dog Diseases / diagnosis; Dogs; Histiocytic Sarcoma / veterinary; Macrophages; Retrospective Studies
TL;DR:
The hemograms and diagnoses of dogs with ML cells suggest that severe inflammatory conditions or histiocytic and non-histiocytical neoplasia are common causes for circulating ML cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 29, 2021
2021 journal article
The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus
Frontiers in Immunology, 1. http://europepmc.org/abstract/PMC/PMC7985350
Source: ORCID
Added: March 27, 2021
2021 journal article
Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice
PLOS ONE, 16(2).
MeSH headings : Animals; Body Weight / drug effects; Cecum / microbiology; Feces / microbiology; Female; Gastrointestinal Microbiome / drug effects; Ileum / microbiology; Male; Metabolome / drug effects; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, G-Protein-Coupled / metabolism; Ursodeoxycholic Acid / administration & dosage; Ursodeoxycholic Acid / pharmacology; Weight Loss / drug effects
TL;DR:
This study is the first to provide a comprehensive view of how exogenously administered ursodiol shapes the healthy gastrointestinal ecosystem in conventional mice and how these changes in turn modify the host physiologic response are important.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 22, 2021
2021 journal article
Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes
FRONTIERS IN VETERINARY SCIENCE, 8.
author keywords: canine papillomavirus type 2; E6; p53; LncRNA-p21; bak; bax
TL;DR:
It is determined that cutaneousCPV2 E6 does not degrade p53, or interfere with the upregulation of p53-regulated genes p21, Bax, Bak, or lncRNA-p21, suggesting that CPV2 may use a p53 -independent mechanism to contribute to oncogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: March 22, 2021
2021 journal article
Unlocking the Role of a Genital Herpesvirus, Otarine Herpesvirus 1, in California Sea Lion Cervical Cancer
ANIMALS, 11(2).
author keywords: California sea lion; cancer; urogenital carcinoma; herpesvirus; oncogenic virus; RNA in situ hybridization; Basescope(®)
TL;DR:
The hypothesis that OtHV1 plays a significant role in the development of sea lion urogenital carcinoma is supported and there is an underlying trigger or event that causes the virus to induce cancer in some infected sea lions and not others.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 15, 2021
2021 journal article
Comparative Genomics of Atypical Enteropathogenic Escherichia coli from Kittens and Children Identifies Bacterial Factors Associated with Virulence in Kittens
INFECTION AND IMMUNITY, 89(3).
author keywords: enteropathogenic E. coli; EPEC; animal model; phylogenetic analysis
MeSH headings : Adolescent; Animals; Cats / genetics; Child; Child, Preschool; Enteropathogenic Escherichia coli / genetics; Escherichia coli Infections / genetics; Escherichia coli Infections / microbiology; Escherichia coli Proteins / genetics; Female; Genetic Variation; Genomics; Humans; Infant; Infant, Newborn; Male; Serogroup; Serotyping; Virulence / genetics
TL;DR:
Kittens are identified as a host for aEPEC where intestinal epithelial colonization was associated with diarrheal disease and death and may provide a needed comparative animal model for the study of aEP EC pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 15, 2021
2021 journal article
Antimicrobial resistance and interspecies gene transfer in Campylobacter coli and Campylobacter jejuni isolated from food animals, poultry processing, and retail meat in North Carolina, 2018-2019
PLOS ONE, 16(2).
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Campylobacter coli / drug effects; Campylobacter coli / genetics; Campylobacter coli / isolation & purification; Campylobacter jejuni / drug effects; Campylobacter jejuni / genetics; Campylobacter jejuni / isolation & purification; Drug Resistance, Bacterial; Gene Transfer, Horizontal; Meat / microbiology; North Carolina; Poultry / microbiology
TL;DR:
Evidence of C. coli and C. jejuni interspecies genomic exchange may aid pathogen adaption, lead to higher AMR and increase Campylobacter persistence in food processing is investigated to track evolving risks to public health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: March 15, 2021
2021 journal article
Impact of Ceftiofur Administration in Steers on the Prevalence and Antimicrobial Resistance of Campylobacter spp.
MICROORGANISMS, 9(2).
author keywords: ceftiofur; CCFA; CHCL; cattle; Campylobacter; antibiotic resistance
TL;DR:
It is suggested that CCFA or CHCL may be preferable due to the lower likelihood of temporary increases in Campylobacter prevalence and ceftiofur minimum inhibitory concentration (MIC) for C. jejuni, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 15, 2021
2021 review
Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against Clostridioides difficile by Commensal Clostridium
[Review of ]. MICROORGANISMS, 9(2).
author keywords: Clostridioides difficile; Clostridium scindens; secondary bile acids; deconjugation; dehydroxylation; epimerization; short-chain fatty acids; proline; hydroxyproline
TL;DR:
Understanding the mechanisms of colonization resistance against C. difficile is important for elucidating the mechanisms by which the pathogen is able to colonize the gut after antibiotics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 15, 2021
2021 journal article
Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(6).
author keywords: Lactobacillus; Acidophilus; gasseri; bile salt hydrolase; bile acid
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Ecosystem; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Genetic Fitness / genetics; Host-Pathogen Interactions / genetics; Humans; Lactobacillus / enzymology; Lactobacillus / genetics; Probiotics / pharmacology; Substrate Specificity / genetics
TL;DR:
It is shown that BA type and BSH substrate preferences affect in vitro and in vivo growth of both species and that BSH enzymatic preferences and the intrinsic chemical features of various BAs determine the toxicity of these molecules during Lactobacillus growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 15, 2021
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