Works Published in 2018

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Displaying works 21 - 40 of 192 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2018 conference paper

An Active-Subspace-Based Algorithm for Reducing Redundancy in a Hybrid Neuroprosthesis

2018 IEEE Conference on Decision and Control (CDC), 2018-December, 4849–4854.

By: F. Moore-Clingenpeel*, V. Molazadeh* & N. Sharma*

Contributors: F. Moore-Clingenpeel*, V. Molazadeh* & N. Sharma*

Event: 2018 IEEE Conference on Decision and Control (CDC) at Miami, FL on December 17-19, 2018

TL;DR: This work has developed a novel technique based on active subspaces to reduce the dimensionality of the redundant control system and shows that by using this algorithm, synergies can be calculated more quickly than performing dynamic optimization. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 23, 2021

2018 journal article

A Control Scheme That Uses Dynamic Postural Synergies to Coordinate a Hybrid Walking Neuroprosthesis: Theory and Experiments

Frontiers in Neuroscience, 12(APR).

By: N. Alibeji*, V. Molazadeh*, B. Dicianno* & N. Sharma*

Contributors: N. Alibeji*, V. Molazadeh*, B. Dicianno* & N. Sharma*

author keywords: hybrid neuroprosthesis; synergy; nonlinear control; neuromuscular stimulation; Lyapunov
TL;DR: A muscle synergy-inspired control framework is used to derive the controller and is motivated mainly to address the actuator redundancy issue and was demonstrated experimentally on an able-bodied subject and person with an incomplete spinal cord injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 23, 2021

2018 conference paper

Hybrid Dynamical System Model and Robust Control of a Hybrid Neuroprosthesis Under Fatigue Based Switching

2018 Annual American Control Conference (ACC), 2018-June, 1446–1451.

By: Z. Sheng*, V. Molazadeh* & N. Sharma*

Contributors: Z. Sheng*, V. Molazadeh* & N. Sharma*

Event: 2018 Annual American Control Conference (ACC)

TL;DR: A hybrid neuroprosthesis controller that integrates a modified PD-based robust controller to compensate for electromechanical delay during functional electrical stimulation and a variable structure controller to control a powered exoskeleton is developed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 23, 2021

2018 conference paper

A Within-Stride Switching Controller for Walking with Virtual Constraints: Application to a Hybrid Neuroprosthesis

2018 Annual American Control Conference (ACC), 2018-June, 5286–5291.

By: V. Molazadeh*, Z. Sheng* & N. Sharma*

Contributors: V. Molazadeh*, Z. Sheng* & N. Sharma*

Event: 2018 Annual American Control Conference (ACC)

TL;DR: This paper investigated if a switching controller and optimal virtual constraint design for a class of walking exoskeleton with redundant actuation can achieve a stable walking limit cycle and found it proven to achieve exponential stability despite arbitrary switching. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 23, 2021

2018 journal article

Model-Based Dynamic Control Allocation in a Hybrid Neuroprosthesis

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 26(1), 224–232.

By: N. Kirsch*, X. Bao*, N. Alibeji*, B. Dicianno* & N. Sharma*

Contributors: N. Kirsch*, X. Bao*, N. Alibeji*, B. Dicianno* & N. Sharma*

author keywords: Hybrid neuroprosthesis; model predictive control; dynamic control allocation; functional electrical stimulation; muscle fatigue; medical control systems
MeSH headings : Adult; Algorithms; Biomechanical Phenomena; Computer Systems; Electric Stimulation Therapy; Exoskeleton Device; Gait Disorders, Neurologic / rehabilitation; Humans; Leg; Male; Models, Neurological; Muscle Fatigue; Muscle, Skeletal / physiopathology; Neural Prostheses; Paraplegia / rehabilitation; Prosthesis Design; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / rehabilitation
TL;DR: A model predictive control-based dynamic control allocation (DCA) is used to allocate control between FES and the electric motor that simultaneously maintain a desired knee angle and validate the hybrid technology’s potential use in walking rehabilitation. (via Semantic Scholar)
Source: ORCID
Added: August 12, 2021

2018 journal article

Drug-Bearing Supramolecular MMP Inhibitor Nanofibers for Inhibition of Metastasis and Growth of Liver Cancer

Advanced Science, 5(8), 1700867.

By: Y. Ji*, Y. Xiao*, L. Xu*, J. He*, C. Qian*, W. Li*, L. Wu*, R. Chen* ...

author keywords: doxorubicin; liver cancer; metastasis; matrix metalloproteinase (MMP) inhibitor; peptide drug conjugates
TL;DR: This hexapeptide‐based supermolecule system represents a promising nanoscale platform to sustain drug release with high loading capacity for intratumoral administration and simultaneously inhibits metastasis and tumor growth to achieve synergistic effects for metastatic HCC therapy. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2018 journal article

ROS-Responsive Microneedle Patch for Acne Vulgaris Treatment (Adv. Therap. 3/2018)

Advanced Therapeutics, 1(3), 1870006.

By: Y. Zhang, P. Feng, J. Yu, J. Yang, J. Zhao, J. Wang, Q. Shen, Z. Gu*

Source: Crossref
Added: December 19, 2020

2018 journal article

ROS-Responsive Microneedle Patch for Acne Vulgaris Treatment

Advanced Therapeutics, 1(3), 1800035.

author keywords: acne vulgaris; drug delivery; microneedle patch; stimuli responsive
TL;DR: A new method of drug administration using a reactive oxygen species (ROS)‐responsive microneedle (MN) patch for anti‐acne therapy and in vivo studies demonstrated this bioresponsive patch with adsorption capability could efficiently reduce the skin swelling and inhibit the bacterial growth. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: December 19, 2020

2018 journal article

Cancer Immunotherapy: PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy (Adv. Mater. 22/2018)

Advanced Materials, 30(22), 1870152.

By: X. Zhang n, C. Wang n, J. Wang n, Q. Hu n, B. Langworthy*, Y. Ye n, W. Sun n, J. Lin* ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: December 19, 2020

2018 journal article

Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade

Advanced Materials, 30(28), 1801527.

author keywords: checkpoint blockade; drug delivery; hydrogel; immunotherapy; stimuli responsive
MeSH headings : Gels; Humans; Immunotherapy; Melanoma; Tumor Microenvironment
TL;DR: A combination immunotherapy strategy is developed based on a thermogelling reactive oxygen species‐responsive polypeptide gel for sustained release of anti‐programmed cell death‐ligand 1 antibody and dextro‐1‐methyl tryptophan with leveraging the ROS level in the tumor microenvironment to enhance anti‐melanoma efficacy in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: December 19, 2020

2018 journal article

Editorial

Medical Devices & Sensors, 1(1), e10009.

By: R. Narayan n

Source: Crossref
Added: December 15, 2020

2018 journal article

Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic

ACS Nano, 12(8), 7826–7837.

author keywords: microgels; myocardial infarction; fibrin; fibrinolytic; fibrosis; ischemia reperfusion; drug delivery
MeSH headings : Acrylic Resins / chemical synthesis; Acrylic Resins / chemistry; Acrylic Resins / therapeutic use; Animals; Fibrosis / complications; Fibrosis / drug therapy; Fibrosis / metabolism; Ischemia / complications; Ischemia / drug therapy; Ischemia / metabolism; Myocardial Infarction / drug therapy; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Nanogels; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polyethylene Glycols / therapeutic use; Polyethyleneimine / chemical synthesis; Polyethyleneimine / chemistry; Polyethyleneimine / therapeutic use; Rats
TL;DR: In vivo and in vitro, FSNs localize to fibrin in injured heart tissue and, when loaded with tPA and Y-27632, showed significant improvement in left ventricular ejection fraction 2 and 4 weeks post-I/R as well as significantly decreased infarct size, α-smooth muscle actin expression, and connective tissue growth factor expression 4 weeks after the I/R. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: November 29, 2020

2018 journal article

Wearable and implantable biosensing technologies based on the direct electron transfer principle

Abstracts of Papers of the American Chemical Society, 256. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000447600001124&KeyUID=WOS:000447600001124

By: K. Sode, N. Loew, I. Lee, Y. Ito & W. Tsugawa

Contributors: K. Sode, N. Loew, I. Lee, Y. Ito & W. Tsugawa

Source: ORCID
Added: October 9, 2020

2018 journal article

Synthesis of a hemin-containing copolymer as a novel immunostimulator that induces IFN-gamma production

International Journal of Nanomedicine, 13, 4461–4472.

author keywords: hemin copolymer; immunostimulator; adjuvant; radical polymerization; NIPAM; toll-like receptor 9; T-helper 1; inflammasome
MeSH headings : Acrylic Resins / chemical synthesis; Acrylic Resins / chemistry; Cell Death / drug effects; Cell Line; Hemin / pharmacology; Humans; Immunologic Factors / pharmacology; Interferon-gamma / biosynthesis; Interleukin-6 / biosynthesis; NF-kappa B / metabolism; Polymers / chemical synthesis; Polymers / chemistry; Signal Transduction / drug effects; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Toll-Like Receptors / metabolism
TL;DR: It is found that NIPAM-hemin induced IL-6 and IFN-γ production in immune cells without any cytotoxic effects, and has potential therapeutic applications as a Th1-type adjuvant. (via Semantic Scholar)
Source: ORCID
Added: October 9, 2020

2018 journal article

Smart aptamers forming G-quadruplex: Structural and functional change of aptamers forming G-quadruplex in response to surrounding conditions and its regulation with the ligands

Abstracts of Papers of the American Chemical Society, 256. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000447600001223&KeyUID=WOS:000447600001223

By: K. Tsukakoshi, M. Nishio, I. Sasaki, Y. Ma, K. Nagasawa, Y. Kato, C. Nakamura, K. Sode, K. Ikebukuro

Contributors: K. Tsukakoshi, M. Nishio, I. Sasaki, Y. Ma, K. Nagasawa, Y. Kato, C. Nakamura, K. Sode, K. Ikebukuro

Source: ORCID
Added: October 9, 2020

2018 journal article

Self-powered, wireless continuous glucose sensing system based direct electron transfer

Abstracts of Papers of the American Chemical Society, 256. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000447600000887&KeyUID=WOS:000447600000887

By: I. Lee, N. Loew, W. Tsugawa, K. Ikebukuro & K. Sode

Contributors: I. Lee, N. Loew, W. Tsugawa, K. Ikebukuro & K. Sode

Source: ORCID
Added: October 9, 2020

2018 journal article

Quasi-direct electron transfer-type glucose sensor based on engineered glucose oxidase

Abstracts of Papers of the American Chemical Society, 256. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000447600001209&KeyUID=WOS:000447600001209

By: N. Loew, N. Suzuki, W. Tsugawa, Y. Inose-Takahashi, M. Hatada, K. Mori, K. Sode

Contributors: N. Loew, N. Suzuki, W. Tsugawa, Y. Inose-Takahashi, M. Hatada, K. Mori, K. Sode

Source: ORCID
Added: October 9, 2020

2018 journal article

Minimizing the effects of oxygen interference on L-lactate sensors by a single amino acid mutation in Aerococcus viridans L-lactate oxidase

Biosensors & Bioelectronics, 103, 163–170.

By: K. Hiraka*, K. Kojima*, C. Lin*, W. Tsugawa*, R. Asano*, J. La Belle*, K. Sode*

Contributors: K. Hiraka*, K. Kojima*, C. Lin*, W. Tsugawa*, R. Asano*, J. La Belle*, K. Sode*

author keywords: L-lactate oxidase; L-lactate; Oxygen; Screen-printed carbon electrode; Site-directed mutagenesis; Biomedical engineering
MeSH headings : Amino Acids / chemistry; Biosensing Techniques; Lactic Acid / chemistry; Lactic Acid / isolation & purification; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / genetics; Mutation; Oxidation-Reduction; Oxygen / chemistry
TL;DR: This study provided significant insight into the enzymatic reaction mechanism of AvLOx and presented a novel approach to minimize oxygen interference in sensor applications, which will enable accurate detection of l-lactate concentrations. (via Semantic Scholar)
Source: ORCID
Added: October 9, 2020

2018 journal article

Improving the induction fold of riboregulators for cyanobacteria

Rna Biology, 15(3), 353–358.

By: I. Sakamoto*, K. Abe*, S. Kawai*, K. Tsukakoshi*, Y. Sakai*, K. Sode*, K. Ikebukuro*

Contributors: I. Sakamoto*, K. Abe*, S. Kawai*, K. Tsukakoshi*, Y. Sakai*, K. Sode*, K. Ikebukuro*

author keywords: Cyanobacteria; post-transcriptional gene; regulation; riboregulator; RNA engineering; synthetic biology
MeSH headings : Gene Expression Regulation, Bacterial; Genetic Engineering / methods; Models, Molecular; Nucleic Acid Conformation; Promoter Regions, Genetic; RNA / chemistry; RNA / genetics; Synechocystis / genetics; Synechocystis / growth & development; Transcriptional Activation
TL;DR: An improved riboregulator is improved by designing two RNA species, taRNA and crRNA, to enhance its induction fold and inserting nucleotides into the crRNA loop to enhance intermolecular hybridization and successfully improved its induction Fold. (via Semantic Scholar)
Source: ORCID
Added: October 9, 2020

2018 journal article

Glycogen Production in Marine Cyanobacterial Strain Synechococcus sp NKBG 15041c

Marine Biotechnology, 20(2), 109–117.

By: A. Badary*, S. Takamatsu*, M. Nakajima*, S. Ferri*, P. Lindblad* & K. Sode*

Contributors: A. Badary*, S. Takamatsu*, M. Nakajima*, S. Ferri*, P. Lindblad* & K. Sode*

author keywords: Marine cyanobacteria; Synechococcus; Glycogen; Bioprocess; Carbohydrate production
MeSH headings : Biofuels; Glycogen / biosynthesis; Nitrogen / metabolism; Seawater; Synechococcus / genetics; Synechococcus / growth & development; Synechococcus / metabolism; Transcription, Genetic; Transcriptome
TL;DR: The transcriptional analyses revealed that glycogen production in NKBG15041c under nitrogen-depleted conditions can be explained by the contribution of both increased carbon flux towards glycogen synthesis, similar to PCC6803 and PCC7002, and increased transcriptional levels of genes responsible for glycogens synthesis, resulting in a relatively high amount of glycogen under ambient conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: October 9, 2020

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