Works Published in 2011
Displaying works 41 - 60 of 113 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Modeling and development of a low frequency contactless dielectrophoresis (cDEP) platform to sort cancer cells from dilute whole blood samples
Biosensors and Bioelectronics, 30(1), 13–20.
author keywords: Electrokinetics; Enrichment; Selective isolation; Cancer detection; Lab on a chip
MeSH headings : Biosensing Techniques / instrumentation; Blood Component Removal / instrumentation; Cell Separation / instrumentation; Computer Simulation; Computer-Aided Design; Conductometry / instrumentation; Electrophoresis / instrumentation; Equipment Design; Equipment Failure Analysis; Microfluidic Analytical Techniques / instrumentation; Models, Theoretical; Neoplasms / pathology
TL;DR:
This work presents a continuous sorting device which is the first cDEP design capable of exploiting the Clausius-Mossotti factor at frequencies where it is both positive and negative for mammalian cells.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Contactless dielectrophoretic spectroscopy: Examination of the dielectric properties of cells found in blood
ELECTROPHORESIS, 32(22), 3164–3171.
author keywords: Cancer detection; Clausius-Mossotti factor; Dielectrophoresis; Microfluidics; Sample isolation
MeSH headings : Cell Line, Tumor; Cell Separation / instrumentation; Cell Separation / methods; Computer Simulation; Electrophoresis / instrumentation; Humans; Neoplastic Cells, Circulating / chemistry; Spectrum Analysis / instrumentation
TL;DR:
By first establishing the dielectrophoretic responses of cancerous cells within this cDEP device, conditions to detect and enrich tumor cells from mixtures with non‐transformed cells can be determined providing further information to develop methods to isolate these rare cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Selective concentration of human cancer cells using contactless dielectrophoresis
ELECTROPHORESIS, 32(18), 2523–2529.
author keywords: Clausius-Mossotti factor; Dielectrophoresis; Enrichment; Microfluidics; Sample isolation
MeSH headings : Cell Line, Tumor; Cell Separation / instrumentation; Cell Separation / methods; Electrodes; Electrophoresis / instrumentation; Electrophoresis / methods; Humans; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Neoplasms / chemistry; Neoplasms / pathology
TL;DR:
This work is the first to demonstrate the ability of contactless dielectrophoresis (cDEP) to isolate target cell species from a heterogeneous sample of live cells and could provide a workbench for clinicians to detect transformed cells at their earliest stage, screen drug therapies prior to patient treatment, increasing the probability of success, and eliminate unsuccessful treatment options.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
Nature, 473(7347), 394–397.
MeSH headings : 5-Methylcytosine / analogs & derivatives; Animals; Biotinylation; Cell Line; Cytosine / analogs & derivatives; Cytosine / analysis; Cytosine / isolation & purification; Cytosine / metabolism; DNA Methylation; Embryonic Stem Cells / metabolism; Exons / genetics; Gene Expression Regulation, Developmental / genetics; Genome / genetics; Glucose / metabolism; Mice; Periodic Acid / metabolism; Promoter Regions, Genetic / genetics; Sequence Analysis, DNA / methods; Transcription Initiation Site; Transcription, Genetic / genetics
TL;DR:
The results indicate that 5hmC has a probable role in transcriptional regulation, and suggest a model in which5hmC contributes to the ‘poised’ chromatin signature found at developmentally-regulated genes in ES cells.
(via Semantic Scholar)
research-repository.uwa.edu.au (repository)
Sources: Crossref, ORCID
Added: August 28, 2020
2011 journal article
Effect of a serotonin antagonist on delay in grip muscle relaxation for persons with chronic hemiparetic stroke
Clinical Neurophysiology, 122(4), 796–802.
author keywords: Stroke; Hand grip; Hyperexcitability; Muscle relaxation; EMG
MeSH headings : Adult; Aged; Aged, 80 and over; Brain Stem / physiology; Cyproheptadine / pharmacology; Efferent Pathways / physiology; Electromyography; Female; Fingers / physiology; Hand / physiology; Hand Strength / physiology; Humans; Male; Middle Aged; Motor Neurons / physiology; Muscle Relaxation / drug effects; Paresis / etiology; Paresis / physiopathology; Serotonin Antagonists / pharmacology; Spinal Cord / cytology; Spinal Cord / physiology; Stroke / complications; Stroke / physiopathology
TL;DR:
The findings support the supposition that monoaminergic brainstem pathways may be disinhibited following stroke, thereby resulting in increased delays in muscle relaxation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Use of Visual Force Feedback to Improve Digit Force Direction During Pinch Grip in Persons With Stroke: A Pilot Study
Archives of Physical Medicine and Rehabilitation, 92(1), 24–30.
author keywords: Biofeedback, psychology; Fingers; Hand; Rehabilitation; Feedback, sensory; Stroke; Touch
MeSH headings : Adult; Aged; Feedback, Sensory; Female; Fingers; Hand Strength; Humans; Male; Middle Aged; Paresis / rehabilitation; Physical Therapy Modalities; Pilot Projects; Stroke Rehabilitation; Thumb
TL;DR:
Repeated practice of pinch with visual feedback of force direction improved grip force control in persons with stroke and Visual feedback of pinch forces may prove valuable as a rehabilitation paradigm for improving hand function.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines
Biomaterials, 32(3), 926–932.
author keywords: Chitosan; Drug delivery; Immunostimulation; Interleukin 12; Polysaccharide; Vaccine
MeSH headings : Adjuvants, Immunologic / metabolism; Animals; CD4-Positive T-Lymphocytes / metabolism; Chitosan / immunology; Enzyme-Linked Immunosorbent Assay; Interferon-gamma / metabolism; Interleukin-12 / immunology; Mice; Mice, Inbred C57BL; Proteins / immunology; Vaccines / immunology
TL;DR:
A vaccine adjuvant system using a viscous chitosan solution and interleukin (IL)-12, a Th1-inducing cytokine, promoted the generation of a Th 1 immune response to a model protein vaccine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
549 Perfusion/Decellularization of Large Animal Lungs
The Journal of Heart and Lung Transplantation, 30(4), S184–S185.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Hybrid Gel Composed of Native Heart Matrix and Collagen Induces Cardiac Differentiation of Human Embryonic Stem Cells without Supplemental Growth Factors
Journal of Cardiovascular Translational Research, 4(5), 605–615.
author keywords: Tissue engineering; Cardiac differentiation; Human embryonic stem cells; Biomaterial; Native cardiac matrix
MeSH headings : Animals; Biomarkers / metabolism; Cell Differentiation; Cells, Cultured; Coculture Techniques; Collagen Type I / metabolism; Connexin 43 / metabolism; Embryonic Stem Cells / metabolism; Embryonic Stem Cells / transplantation; Extracellular Matrix / metabolism; Humans; Hydrogels; Myocardial Contraction; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / transplantation; Regenerative Medicine / methods; Swine; Time Factors; Tissue Engineering; Tissue Scaffolds; Troponin I / metabolism; Troponin T / genetics; Up-Regulation
TL;DR:
The ability of native ECM hydrogel to induce cardiac differentiation of hESCs without the addition of soluble factors makes it an attractive biomaterial system for basic studies of cardiac development and potentially for the delivery of therapeutic cells into the heart.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Optofluidic characterization of marine algae using a microflow cytometer
Biomicrofluidics, 5(3), 032009.
author keywords: band-pass filters; biological techniques; bioMEMS; bio-optics; fluorescence; light scattering; marine pollution; microchannel flow; microorganisms; molecular biophysics; optical fibres; optical filters; photomultipliers; proteins
TL;DR:
The design and fabrication of a Microflow Cytometer for characterization of phytoplankton was demonstrated and the effect of the sheath-to-sample flow-rate ratio on the light scatter and fluorescence of these marine microorganisms was investigated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
UV polymerization of hydrodynamically shaped fibers
Lab on a Chip, 11(6), 1157.
TL;DR:
Passive hydrodynamic focusing and UV polymerization of a shaped acrylate stream produced metre-long fibers for structural and mechanical characterization.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Microflow Cytometer for optical analysis of phytoplankton
Biosensors and Bioelectronics, 26(11), 4263–4269.
author keywords: Flow cytometry; Microfluidics; Optical sensing; Hydrodynamic focusing; Phytoplankton
MeSH headings : Diatoms / chemistry; Diatoms / classification; Diatoms / cytology; Equipment Design; Flow Cytometry / instrumentation; Fluorescence; Microfluidic Analytical Techniques / instrumentation; Optical Devices; Optical Phenomena; Phytoplankton / chemistry; Phytoplankton / classification; Phytoplankton / cytology; Scattering, Radiation; Species Specificity; Synechococcus / chemistry
TL;DR:
The Microflow Cytometer proved sensitive enough to detect and characterize picoplankton with diameter approximately 1 μm and larger phytoplankton of up to 80 μm in length and the wide range in size discrimination coupled with detection of intrinsic fluorescent pigments suggests that this MicroflowCytometer will be able to distinguish different populations of phy toplankon on unmanned underwater vehicles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Optimization of antibody-conjugated magnetic nanoparticles for target preconcentration and immunoassays
Analytical Biochemistry, 410(1), 124–132.
author keywords: Immunoassay; Magnetic nanoparticles; Total internal reflection fluorescence; Array Biosensor; Protein microarrays
MeSH headings : Analytic Sample Preparation Methods / methods; Animals; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Fluorescent Dyes / chemistry; Immunoassay / instrumentation; Immunoassay / methods; Immunoglobulin G / chemistry; Immunoglobulin G / immunology; Limit of Detection; Magnetics; Nanoparticles / chemistry; Spectrometry, Fluorescence
TL;DR:
The results demonstrate the impact of magnetic extraction using the MNPs labeled with fluorescent proteins both for target preconcentration and for subsequent integration into immunoassays performed under flow conditions for enhanced signal generation.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Parameters affecting the shape of a hydrodynamically focused stream
Microfluidics and Nanofluidics, 11(2), 119–128.
author keywords: Flow focusing; Angle of confluence; Converging channels; Inertial effects; Laminar flow; Symmetric
Source: Crossref
Added: August 28, 2020
2011 journal article
Erratum to: Hydrodynamic and electrical considerations in the design of a four-electrode impedance-based microfluidic device
Analytical and Bioanalytical Chemistry, 400(9), 3177–3177.
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Hydrodynamic and electrical considerations in the design of a four-electrode impedance-based microfluidic device
Analytical and Bioanalytical Chemistry, 400(5), 1347–1358.
author keywords: Hydrodynamic focusing; Impedance spectroscopy; Nyquist plot; Bode impedance; Bode phase; Microfluidics
MeSH headings : Biosensing Techniques / instrumentation; Cytological Techniques / instrumentation; Electric Impedance; Electrodes; Equipment Design; Hydrodynamics; Microfluidic Analytical Techniques / instrumentation
TL;DR:
A four-electrode sensor with hydrodynamic focusing to confine that the current was characterized for tunable sensitivity was designed and analyzed for optimization and to resolve issues that would impact sensitivity and reproducibility in subsequent biosensor applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Non-invasive Monitoring of L-2-Oxothiazolidine-4-Carboxylate Metabolism in the Rat Brain by In vivo 13C Magnetic Resonance Spectroscopy
Neurochemical Research, 36(3), 443–451.
author keywords: Magnetic resonance; Metabolism; Cysteine; Glutathione; Taurine
MeSH headings : Animals; Brain / metabolism; Female; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular / methods; Oxidative Stress; Pyrrolidonecarboxylic Acid / metabolism; Rats; Rats, Inbred F344; Thiazolidines / metabolism
TL;DR:
These studies demonstrate the utility of in vivo magnetic resonance for non-invasive monitoring of antioxidant uptake and metabolism in intact brain and evaluate the efficacy of various interventions for maintenance of brain glutathione.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref
Added: August 27, 2020
2011 journal article
LIFT: A new framework of learning from testing data for face recognition
Neurocomputing, 74(6), 916–929.
author keywords: Face recognition; Semi-supervised learning; One-against-all; Feature extraction; Data quality
TL;DR:
A novel learning methodology for face recognition, LearnIng From Testing data (LIFT) framework, where neural networks and support vector machines are used as the base learning models and the one-against-all technique is integrated into the learning system.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 19, 2020
2011 journal article
Continuous Locomotion-Mode Identification for Prosthetic Legs Based on Neuromuscular–Mechanical Fusion
IEEE Transactions on Biomedical Engineering, 58(10), 2867–2875.
Contributors: H. Huang* , F. Zhang *, L. Hargrove *, Z. Dou *, D. Rogers* & K. Englehart *
author keywords: Data fusion; electromyography (EMG); pattern recognition; prosthesis; surface electromyography
MeSH headings : Amputees / rehabilitation; Artificial Limbs; Electromyography / methods; Humans; Locomotion / physiology; Muscle, Skeletal / physiology; Signal Processing, Computer-Assisted; Support Vector Machine; Thigh
TL;DR:
An algorithm based on neuromuscular-mechanical fusion to continuously recognize a variety of locomotion modes performed by patients with transfemoral (TF) amputations outperformed methods that used only EMG signals or mechanical information.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 19, 2020
2011 journal article
Towards Design of a Stumble Detection System for Artificial Legs
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 19(5), 567–577.
Contributors: F. Zhang *, . S.E. D'andrea, M. Nunnery, S. Kay * & H. Huang*
author keywords: Detection; electromyographic (EMG); lower limb amputees; prosthetics; stumble
MeSH headings : Acceleration; Accidental Falls / prevention & control; Adult; Algorithms; Amputation, Surgical; Artificial Limbs; Electromyography; Electronic Data Processing; Female; Foot / physiology; Gait / physiology; Humans; Male; Middle Aged; Muscle Strength / physiology; Postural Balance / physiology; Prosthesis Design; Walking / physiology
TL;DR:
The results showed that the acceleration of prosthetic foot can accurately detect the tested stumbling events 140-240 ms before the critical timing of falling and precisely classify the stumble type, however, the detector based on foot acceleration produced high false alarm rates, which challenged its real application.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 19, 2020
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