Works Published in 2015
Displaying works 41 - 60 of 164 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Impact of an energy-conserving strategy on succinate production under weak acidic and anaerobic conditions in Enterobacter aerogenes
Microbial Cell Factories, 14(1), (11 June 2015).
Contributors: Y. Tajima*, Y. Yamamoto *, K. Fukui*, Y. Nishio *, K. Hashiguchi*, Y. Usuda*, K. Sode*
author keywords: Enterobacter aerogenes; Succinate fermentation; Phosphoenolpyruvate carboxykinase; Glucose-PTS; Weak acidity; Anaerobic metabolism
MeSH headings : Adenosine Triphosphate / metabolism; Anaerobiosis; Culture Media / chemistry; Culture Media / metabolism; Enterobacter aerogenes / genetics; Enterobacter aerogenes / metabolism; Fermentation; Hydrogen-Ion Concentration; Metabolic Engineering / methods; Succinic Acid / metabolism
TL;DR:
Focusing on increasing net ATP production during succinate synthesis leads to increased succinate yield and volumetric productivity in E. aerogenes, demonstrating proof-of-concept that bacterium-based succinate fermentation can be improved under weakly acidic conditions.
(via Semantic Scholar)
microbialcellfactories.biomedcentral.com (publisher PDF)
Source: ORCID
Added: October 9, 2020
2015 journal article
Enzyme linking to DNA aptamers via a zinc finger as a bridge
Chemical Communications, 51(57), 11467–11469.
Contributors: K. Abe *, Y. Murakami*, A. Tatsumi*, K. Sumida*, A. Kezuka*, T. Fukaya*, T. Kumagai *, Y. Osawa*, K. Sode* , K. Ikebukuro *
MeSH headings : Animals; Aptamers, Nucleotide / chemistry; Biosensing Techniques; Cattle; Enzyme-Linked Immunosorbent Assay; Humans; Luciferases, Firefly / chemistry; Luminescent Agents / chemistry; Luminescent Measurements; Thrombin / analysis; Vascular Endothelial Growth Factor A / analysis; Zinc Fingers
TL;DR:
A novel enzyme-labeling method for DNA aptamers using enzyme-fused zinc finger proteins that achieved thrombin detection and vascular endothelial growth factor detection using zinc finger-fuse firefly luciferase is proposed.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2015 journal article
Efficient surface-display of autotransporter proteins in cyanobacteria
Algal Research-Biomass Biofuels and Bioproducts, 12, 337–340.
author keywords: Cyanobacteria; Synechocystis; Autotransporter; Cell-surface display; Recombinant expression
TL;DR:
This is the first report of an efficient method for the display of recombinant proteins in cyanobacteria and the complete post-translational processing of the antigen 43 protein was confirmed by Western blot analysis.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2015 article
Crystal structure of Aspergillus flavus FADGDH in complex with D-glucono-1,5-lactone
Worldwide Protein Data Bank.
Contributors: H. Yoshida, G. Sakai, K. Mori, K. Kojima, S. Kamitori & K. Sode*
Source: ORCID
Added: October 9, 2020
2015 article
Crystal structure of Aspergillus flavus FAD glucose dehydrogenase
Worldwide Protein Data Bank.
Contributors: H. Yoshida, G. Sakai, K. Mori, K. Kojima, S. Kamitori & K. Sode*
Source: ORCID
Added: October 9, 2020
2015 journal article
Advancing the development of glycated protein biosensing technology: next-generation sensing molecules.
Journal of Diabetes Science and Technology, 9(2), 183–191.
Contributors: M. Kameya*, A. Sakaguchi-Mikami*, S. Ferri*, W. Tsugawa * & K. Sode*
MeSH headings : Amino Acid Oxidoreductases; Biomarkers / analysis; Biosensing Techniques / methods; Fructosamine; Humans
TL;DR:
Research on FN6K and fructosyl amino acid-binding protein has been opening up new possibilities for the development of highly sensitive and proteolytic-digestion-free biosensing systems for glycated proteins.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2015 journal article
Effects of Eliminating Pyruvate Node Pathways and of Coexpression of Heterogeneous Carboxylation Enzymes on Succinate Production by Enterobacter aerogenes
Applied and Environmental Microbiology, 81(3), 929–937.
Contributors: Y. Tajima*, Y. Yamamoto *, K. Fukui*, Y. Nishio *, K. Hashiguchi*, Y. Usuda*, K. Sode*
MeSH headings : Actinobacillus / enzymology; Actinobacillus / genetics; Corynebacterium glutamicum / enzymology; Corynebacterium glutamicum / genetics; Culture Media / chemistry; Enterobacter aerogenes / enzymology; Enterobacter aerogenes / genetics; Enterobacter aerogenes / metabolism; Gene Deletion; Gene Expression; Glucose / metabolism; Hydrogen-Ion Concentration; Metabolic Engineering; Phosphoenolpyruvate Carboxykinase (ATP) / genetics; Phosphoenolpyruvate Carboxykinase (ATP) / metabolism; Pyruvate Carboxylase / genetics; Pyruvate Carboxylase / metabolism; Pyruvic Acid / metabolism; Succinic Acid / metabolism
TL;DR:
Lowering the pH in bacterium-based succinate fermentation is considered a feasible approach to reduce total production costs and can be applied to identify additional engineering targets to increase succinate production.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2015 journal article
Development of an electrochemical adenosine diphosphate (ADP) sensing principle employing ADP-dependent kinase
Sensors and Materials, 27(9), 839–845.
Contributors: W. Tsugawa, H. Futagami & K. Sode
Source: ORCID
Added: October 9, 2020
2015 journal article
3RD GENERATION CGM SENSOR EMPLOYING DIRECT ELECTRON TRANSFER PRINCIPLE WITH IMPROVED OPERATIONAL CONDITIONS
Diabetes Technology & Therapeutics, 17, A90. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349317500203&KeyUID=WOS:000349317500203
Contributors: S. Sekimoto, K. Shinozaki, Y. Murase, Y. Kusaka, W. Tsugawa & K. Sode
Source: ORCID
Added: October 9, 2020
2015 journal article
Corrigendum to ‘Controlling chitosan-based encapsulation for protein and vaccine delivery’ [Biomaterials 35 (2014) 4382–4389]
Biomaterials, 73, 308.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2015 journal article
Biocompatibility of Tygon® tubing in microfluidic cell culture
Biomedical Microdevices, 17(1).
author keywords: Biomaterial; Cancer cell; Biocompatibility; Toxicity; Polyvinylchloride; Spectroscopy
MeSH headings : Cell Culture Techniques / instrumentation; Cell Culture Techniques / methods; Cell Line, Tumor; Female; Humans; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods
TL;DR:
Results indicate leaching of a chemical species from microbore Tygon® tubing that can affect cell growth in microfluidic devices.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2015 journal article
The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination
Molecular and Cellular Endocrinology, 413, 36–48.
author keywords: Cardiomyocyte; Peroxisome proliferator-activated receptor alpha; Fatty acid metabolism; Cardiac metabolism; Monoubiquitination; Muscle ring finger-1
MeSH headings : Active Transport, Cell Nucleus / genetics; Animals; Cell Nucleus / genetics; Cell Nucleus / metabolism; Cell Nucleus / pathology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Mice; Mice, Knockout; Muscle Proteins / genetics; Muscle Proteins / metabolism; Myocardium / metabolism; Myocardium / pathology; PPAR alpha / genetics; PPAR alpha / metabolism; Tripartite Motif Proteins; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
TL;DR:
An ubiquitin ligase (muscle ring finger-1/MuRF1) that inhibits fatty acid oxidation by inhibiting PPARα, but not PPARβ/δ or PPARγ in cardiomyocytes in vitro is reported.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2015 journal article
Targeted cellular ablation based on the morphology of malignant cells
Scientific Reports, 5(1).
MeSH headings : Animals; Brain Neoplasms / pathology; Brain Neoplasms / therapy; Brain Neoplasms / veterinary; Cell Line, Tumor; Cell Nucleus Size; Cell Shape; Cell Survival; Coculture Techniques; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Electroporation; Finite Element Analysis; Glioblastoma / pathology; Glioblastoma / therapy; Glioblastoma / veterinary; Humans; Hydrogels / chemistry; Single-Cell Analysis
TL;DR:
A physical treatment method based on electrical disruption of cells, whose action depends strongly on cellular morphology, that may be useful in safely targeting the therapy-resistant cell niches that cause recurrence of GBM tumors is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2015 journal article
Bursts of Bipolar Microsecond Pulses Inhibit Tumor Growth
Scientific Reports, 5(1).
MeSH headings : Animals; Cell Line, Tumor; Disease Models, Animal; Electroporation / methods; Male; Mice; Neoplasms / pathology; Neoplasms / therapy; Tumor Burden; Xenograft Model Antitumor Assays
TL;DR:
This work explored the pulse-duration space between 250 ns and 100 μs and determined the lethal electric field intensity for specific H-FIRE protocols using a 3D tumor mimic, showing the potential for H- FIRE to be used as a focal therapy and merits its investigation in larger pre-clinical models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2015 journal article
On-demand drug delivery from local depots
Journal of Controlled Release, 219, 8–17.
author keywords: Drug delivery; Depot; Polymer; Therapeutic; On-demand; Ultrasound; Magnetic; Electric; Light; Pharmaceutical; Nucleic acid; Stimulated
MeSH headings : Delayed-Action Preparations / administration & dosage; Delayed-Action Preparations / chemistry; Drug Delivery Systems; Humans; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / chemistry; Polymers / administration & dosage; Polymers / chemistry
TL;DR:
This review highlights recent advances in the development of polymeric systems engineered for releasing therapeutic molecules through physical and pharmacological stimulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2015 journal article
In Vivo Targeting through Click Chemistry
ChemMedChem, 10(4), 617–620.
author keywords: bioorthogonal chemistry; click chemistry; drug delivery; drug targeting; gels
MeSH headings : Alginates / chemistry; Alkynes / administration & dosage; Alkynes / chemistry; Animals; Azides; Benzene Derivatives / administration & dosage; Benzene Derivatives / chemistry; Click Chemistry / methods; Cyclooctanes / administration & dosage; Cyclooctanes / chemistry; Drug Delivery Systems / methods; Fluorescent Dyes / chemistry; Glucuronic Acid / chemistry; Heterocyclic Compounds, 1-Ring / chemistry; Hexuronic Acids / chemistry; Hydrogels / chemistry; Mice; Muscles / metabolism
TL;DR:
It is demonstrated that bioorthogonal click chemistry can be used to target circulating small molecules to hydrogels resident intramuscularly in diseased tissues and that small molecules can be repeatedly targeted to the diseased area over the course of at least one month.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2015 journal article
Virtual Immersion for Post-Stroke Hand Rehabilitation Therapy
Annals of Biomedical Engineering, 43(2), 467–477.
author keywords: Stroke; Rehabilitation; Virtual reality; Interactive environments; Upper extremity
MeSH headings : Adult; Aged; Arm / physiology; Exercise Therapy / instrumentation; Exercise Therapy / methods; Female; Hand / physiopathology; Humans; Male; Middle Aged; Paresis / etiology; Paresis / physiopathology; Paresis / rehabilitation; Stroke / complications; Stroke / physiopathology; Stroke Rehabilitation; User-Computer Interface
TL;DR:
A virtual reality (VR) system in order to encourage repetitive task practice for stroke survivors with hemiparesis by furthering engagement in the rehabilitation exercises and future expansion to multi-user virtual environments may extend the benefits.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Intravesical chitosan/interleukin-12 immunotherapy induces tumor-specific systemic immunity against murine bladder cancer
Cancer Immunology, Immunotherapy, 64(6), 689–696.
author keywords: Intravesical immunotherapy; Bladder cancer; Interleukin-12; Chitosan
MeSH headings : Administration, Intravesical; Animals; Cell Line, Tumor; Chitosan / administration & dosage; Chitosan / immunology; Dose-Response Relationship, Immunologic; Female; Immunotherapy / methods; Interleukin-12 / administration & dosage; Interleukin-12 / immunology; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Random Allocation; Urinary Bladder Neoplasms / drug therapy; Urinary Bladder Neoplasms / immunology
TL;DR:
In an advanced bladder cancer model, intravesical CS/IL-12 immunotherapy controlled simultaneous orthotopic and subcutaneous tumors in 70 % of treated mice and Protective immunity was durable, lasting for at least 18 months after immunotherapy.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Reprint of: Extracellular matrix as a biological scaffold material: Structure and function
Acta Biomaterialia, 23, S17–S26.
TL;DR:
An overview of the composition and structure of selected ECM scaffolding materials, the effects of manufacturing methods upon the structural properties and resulting mechanical behavior of the scaffold materials, and the in vivo degradation and remodeling of ECm scaffolds with an emphasis on tissue function is provided.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Controlled release of cytokines using silk-biomaterials for macrophage polarization
Biomaterials, 73, 272–283.
author keywords: Macrophage; Polarization; Silk; Cytokine
MeSH headings : Aniline Compounds / chemistry; Animals; Biocompatible Materials / chemistry; Cytokines / metabolism; Delayed-Action Preparations / metabolism; Humans; Interferon-gamma / administration & dosage; Interleukin-4 / administration & dosage; Macrophages / cytology; Macrophages / metabolism; Mice; Microscopy, Electron, Scanning; Phenotype; Protein Structure, Secondary; Real-Time Polymerase Chain Reaction; Silk / chemistry; Solubility; Time Factors; Water / chemistry
TL;DR:
The silk biomaterials were able to release enough IFN-γ or IL-4 to repolarize the macrophage from M1 to M2 and vice versa, demonstrating the well-established plasticity of macrophages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: February 24, 2020
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