Works Published in 2017
Displaying works 41 - 60 of 203 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2017 journal article
Red Blood Cells for Drug Delivery
Small Methods, 1(12), 1700270.
author keywords: interface engineering; layer-by-layer assembly; multilayer thin films; optoelectronic devices
TL;DR:
The loading methods and loading therapeutics by RBC carriers are surveyed, and recent advances in the design of stimuli-triggered R BC carriers highlighted, and an outlook is presented.
(via Semantic Scholar)
Source: Crossref
Added: December 19, 2020
2017 journal article
Insulin-Responsive Glucagon Delivery for Prevention of Hypoglycemia
Small, 13(19), 1603028.
MeSH headings : Animals; Blood Glucose / metabolism; Glucagon / metabolism; Humans; Hypoglycemia / metabolism; Insulin / therapeutic use; Mice
TL;DR:
This study reports an insulin-responsive glucagon delivery method based on a microneedle (MN)-array patch that is able to prevent hypoglycemia following a high-dose insulin injection in a chemically induced type 1 diabetic mouse model.
(via Semantic Scholar)
rss.onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: December 19, 2020
2017 journal article
Inside Cover: Anaerobe-Inspired Anticancer Nanovesicles (Angew. Chem. Int. Ed. 10/2017)
Angewandte Chemie International Edition, 56(10), 2516–2516.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: December 19, 2020
2017 journal article
Nanosilver-PMMA composite coating optimized to provide robust antibacterial efficacy while minimizing human bone marrow stromal cell toxicity
Toxicology in Vitro, 44, 248–255.
author keywords: PMMA; Silver nanoparticles; Antibacterial; Pulsed laser deposition (PLD); Metal leaching
MeSH headings : Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Apoptosis / drug effects; Biocompatible Materials / administration & dosage; Biocompatible Materials / chemistry; Cell Survival / drug effects; Drug Liberation; Escherichia coli / drug effects; Escherichia coli / growth & development; Humans; Mesenchymal Stem Cells / drug effects; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Scanning; Necrosis / chemically induced; Polymethyl Methacrylate / administration & dosage; Polymethyl Methacrylate / chemistry; Silver / administration & dosage; Silver / chemistry
TL;DR:
Examining both leachates and direct cell contact allowed us to develop an in vitro cytotoxicity test method and optimize a novel device material and coating to be nontoxic and bactericidal during both potential initial implantation and external use.
(via Semantic Scholar)
Source: Crossref
Added: December 15, 2020
2017 journal article
Additive manufacturing for regenerative medicine: Where do we go from here?
Current Opinion in Biomedical Engineering, 2, iii-v.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
9. Industry, Innovation and Infrastructure
(Web of Science)
Source: Crossref
Added: December 15, 2020
2017 journal article
Thrombin-Responsive Transcutaneous Patch for Auto-Anticoagulant Regulation
Advanced Materials, 29(4), 1604043.
MeSH headings : Anticoagulants; Blood Coagulation; Heparin; Skin; Thrombin / administration & dosage
TL;DR:
A thrombin-responsive closed-loop patch is developed for prolonged heparin delivery in a feedback-controlled manner that can sustainably regulate blood coagulation in response toThrombin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: December 11, 2020
2017 journal article
Leveraging H2O2Levels for Biomedical Applications
Advanced Biosystems, 1(9), 1700084.
author keywords: diagnosis; drug delivery; H2O2-responsive; oxidation-responsive; polymers
TL;DR:
The development of H2O2‐responsive functional groups for constructing H1N1‐responsive formulations, as well as the guidance for designing suitable formulations to treat each specific pathological condition are overviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: November 30, 2020
2017 chapter
Minimally invasive microneedle array electrodes employing direct electron transfer type glucose dehydrogenase for the development of continuous glucose monitoring sensors
In Biosensors 2016 (Vol. 27, pp. 208–209).
Contributors: S. Sharma *, E. Takagi*, T. Cass*, W. Tsugawa * & K. Sode*
author keywords: continuous glucose monitoring; minimally invasive sensors; direct electron transfer; microneedles
TL;DR:
This work reports on the marriage of minimally invasive, continuous glucose sensors and a direct electron transfer type glucose dehydrogenase enzymatic system, which allows operation of the electrochemical sensor at lower potentials to minimize the effect of interference.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2017 journal article
Mediator Preference of Two Different FAD-Dependent Glucose Dehydrogenases Employed in Disposable Enzyme Glucose Sensors
Sensors, 17(11).
Contributors: N. Loew*, W. Tsugawa *, D. Nagae*, K. Kojima* & K. Sode*
author keywords: glucose dehydrogenase; flavin adenine dinucleotide; Aspergillus flavus; Burkholderia cepacia; enzyme sensor strip; mediated electron transfer; potassium ferricyanide; methoxy phenazine methosulfate; hexaammineruthenium chloride
MeSH headings : Biosensing Techniques; Flavin-Adenine Dinucleotide; Glucose / analysis; Glucose Dehydrogenases
TL;DR:
Results show that access of even very small mediators with strong charges to a buried active center can be almost completely blocked by the protein.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2017 journal article
X-ray structures of fructosyl peptide oxidases revealing residues responsible for gating oxygen access in the oxidative half reaction
Scientific Reports, 7(1).
Contributors: T. Shimasaki*, H. Yoshida *, S. Kamitori * & K. Sode*
MeSH headings : Amino Acid Oxidoreductases / chemistry; Amino Acid Oxidoreductases / genetics; Amino Acid Oxidoreductases / metabolism; Amino Acid Substitution; Amino Acids / chemistry; Amino Acids / genetics; Amino Acids / metabolism; Binding Sites; Crystallography, X-Ray; Flavin-Adenine Dinucleotide / chemistry; Flavin-Adenine Dinucleotide / metabolism; Glycated Hemoglobin / metabolism; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxygen / chemistry; Oxygen / metabolism; Protein Conformation; Structure-Activity Relationship
TL;DR:
Results reveal that Asn56 in PnFPOX is essential for maintaining an effective oxygen accession path, and support the role of Asp54 as a gate keeper that cooperates with Lys274 to enable oxygen to reach the active site properly.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: October 9, 2020
2017 journal article
Novel fungal FAD glucose dehydrogenase derived from Aspergillus niger for glucose enzyme sensor strips
Biosensors & Bioelectronics, 87, 305–311.
Contributors: K. Sode* , N. Loew*, Y. Ohnishi*, H. Tsuruta*, K. Mori*, K. Kojima*, W. Tsugawa *, J. LaBelle*, D. Klonoff *
author keywords: FAD-dependent glucose dehydrogenase; Aspergillus niger; Aspergillus flavus; Glucose specificity; Xylose; BG Monitor
MeSH headings : Aspergillus niger / chemistry; Aspergillus niger / enzymology; Aspergillus niger / metabolism; Biosensing Techniques / methods; Flavin-Adenine Dinucleotide / metabolism; Glucose / analysis; Glucose / metabolism; Glucose Dehydrogenases / chemistry; Glucose Dehydrogenases / metabolism; Humans; Models, Molecular; Substrate Specificity; Xylose / metabolism
TL;DR:
This is the first report of an enzyme sensor strip using a fungus derived FADGDH, which did not show any positive bias at a therapeutic level xylose concentration on the signal for a glucose sample, which clearly indicates the superiority of AnGDH over other conventionally used fungi derived F ADGDHs in the application for SMBG sensor strips.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2017 journal article
Development of an electrochemical detection system for measuring DNA methylation levels using methyl CpG-binding protein and glucose dehydrogenase-fused zinc finger protein
Biosensors & Bioelectronics, 93, 118–123.
Contributors: J. Lee *, W. Yoshida *, K. Abe *, K. Nakabayashi *, H. Wakeda*, K. Hata *, C. Marquette *, L. Blum*, K. Sode* , K. Ikebukuro *
author keywords: DNA methylation; Electrochemical detection; Diagnosis; Zinc finger protein; Glucose dehydrogenase; Methyl-CpG binding domain
MeSH headings : Biosensing Techniques; CpG Islands / genetics; DNA / chemistry; DNA Methylation / genetics; DNA-Binding Proteins / chemistry; Glucose 1-Dehydrogenase / chemistry; Glucose 1-Dehydrogenase / genetics; Humans; Promoter Regions, Genetic
TL;DR:
A simple electrochemical detection system for DNA methylation using methyl CpG-binding domain (MBD) and a glucose dehydrogenase (GDH)-fused zinc finger protein is developed and the methylation levels at the promoter region of the androgen receptor gene are measured.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2017 journal article
Characterization of Electron Mediator Preference of Aerococcus viridans-Derived Lactate Oxidase for Use in Disposable Enzyme Sensor Strips
Sensors and Materials, 29(12), 1703–1711.
Contributors: N. Loew, M. Fitriana, K. Hiraka, K. Sode & W. Tsugawa
author keywords: lactate oxidase; screen-printed carbon electrode; electron mediator; 1-methoxy-5-methyl phenazinium methyl sulfate; potassium ferricyanide; hexaammineruthenium(III) chloride; biomedical engineering
TL;DR:
The protein scaffold of Av LOx can almost completely block the access to the co-factor for very small electron acceptors, depending on their charge.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2017 journal article
Applying a riboregulator as a new chromosomal gene regulation tool for higher glycogen production in Synechocystis sp PCC 6803
Applied Microbiology and Biotechnology, 101(23-24), 8465–8474.
Contributors: K. Ueno*, Y. Sakai*, C. Shono*, I. Sakamoto*, K. Tsukakoshi *, Y. Hihara *, K. Sode* , K. Ikebukuro *
author keywords: Riboregulator; Synechocystis sp PCC 6803; Cyanobacteria; cyabrB2; Gene regulation; Glycogen production
MeSH headings : Gene Expression Regulation, Bacterial; Genes, Regulator; Glycogen / biosynthesis; Metabolic Engineering / methods; Synechocystis / genetics; Synechocystis / metabolism; Transcription, Genetic
TL;DR:
Phenotypic similarities between the cyabrB2 expression-repressed mutant and the ΔcyabRB2 mutant suggest that the riboregulator can potentially be used as a new chromosomal gene regulation tool in cyanobacteria.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2017 journal article
Development of a screen-printed carbon electrode based disposable enzyme sensor strip for the measurement of glycated albumin
Biosensors & Bioelectronics, 88, 167–173.
Contributors: M. Hatada*, W. Tsugawa *, E. Kamio*, N. Loew*, D. Klonoff * & K. Sode*
author keywords: Diabetes mellitus; Glycated albumin; Fructosyl amino acid oxidase; Hemoglobin A1c; Point-of-care testing; Screen-printed carbon electrode
MeSH headings : Amino Acid Oxidoreductases / chemistry; Biosensing Techniques / instrumentation; Carbon / chemistry; Electrodes; Equipment Design; Glycation End Products, Advanced; Humans; Limit of Detection; Point-of-Care Systems; Reagent Strips / analysis; Serum Albumin / analysis; Glycated Serum Albumin
TL;DR:
The development of a sensing system for measuring GA by combining an enzyme analysis method, which is already used in clinical practice, with electrochemical principles is reported, which shows a clear correlation between the GA concentration and the resulting current.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2017 journal article
Continuous operation of an ultra-low-power microcontroller using glucose as the sole energy source
Biosensors & Bioelectronics, 93, 335–339.
Contributors: I. Lee *, T. Sode*, N. Loew*, W. Tsugawa *, C. Lowe* & K. Sode*
author keywords: Microcontroller; BioCapacitor; Enzyme fuel cell; Direct electron transfer; Implantable artificial organs; Self-powered; Glucose sensor
MeSH headings : Artificial Organs; Bioelectric Energy Sources; Biosensing Techniques; Electrodes; Glucose / chemistry; Glucose 1-Dehydrogenase / chemistry; Humans
TL;DR:
The success in operating a microcontroller using glucose as the sole energy source indicated the probability of realizing implantable self-powered autonomously operated artificial organs, such as artificial pancreas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: October 9, 2020
2017 journal article
Irreversible electroporation for the ablation of pancreatic malignancies: A patient‐specific methodology
Journal of Surgical Oncology, 115(6), 711–717.
author keywords: finite element analysis; impedance; IRE; pancreatic adenocarcinoma; real-time feedback; treatment planning
MeSH headings : Ablation Techniques / methods; Aged; Electroporation / methods; Finite Element Analysis; Humans; Male; Models, Anatomic; Pancreatic Neoplasms / diagnostic imaging; Pancreatic Neoplasms / surgery; Precision Medicine / methods
TL;DR:
This group sought to address the challenge of predicting the ablation volume with IRE for pancreatic procedures with a novel, scalable, and scalable approach that addresses the need for real-time information about the volume of ablation activity during surgery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2017 journal article
“Data characterizing microfabricated human blood vessels created via hydrodynamic focusing”
“Data characterizing microfabricated human blood vessels created via hydrodynamic focusing.” Data in Brief, 14, 156–162.
author keywords: Microfluidics; Ge1MA; Endothelial cell; Blood vessel; Microvessel; Organ-on-chip
TL;DR:
Data is reported regarding the construction of blood vessels including cellular composition and cell positioning within the engineered vascular construct as well as functional aspects of the tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2017 journal article
Asymmetric Waveforms Decrease Lethal Thresholds in High Frequency Irreversible Electroporation Therapies
Scientific Reports, 7(1).
MeSH headings : Cell Line, Tumor; Electroporation / methods; Humans; Radio Waves; Spheroids, Cellular; Tumor Cells, Cultured
TL;DR:
This study shows that asymmetric H-FIRE waveforms can be used to create ablation volumes equivalent to standard IRE treatments, and predicts that in vivo investigation of asymmetric waveforms is warranted.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2017 journal article
A Comprehensive Characterization of Parameters Affecting High-Frequency Irreversible Electroporation Lesions
Annals of Biomedical Engineering, 45(11), 2524–2534.
author keywords: Focal ablation; Non-thermal therapy; H-FIRE; Tissue phantom
MeSH headings : Cell Death; Electroporation / methods; Finite Element Analysis; Phantoms, Imaging; Solanum tuberosum
TL;DR:
H-FIRE treatment protocols can be optimized to produce clinically relevant lesions while maintaining the benefits of a non-thermal ablation technique, as shown in a potato tissue phantom model.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
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