Works Published in 2018
Displaying works 41 - 60 of 192 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Direct electron transfer (DET) mechanism of FAD dependent dehydrogenase complexes ∼from the elucidation of intra- and inter-molecular electron transfer pathway to the construction of engineered DET enzyme complexes∼
Current Opinion in Electrochemistry.
Contributors: Y. Yamashita *, I. Lee *, N. Loew n & K. Sode n
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 9, 2020
2018 journal article
Esterification of PQQ Enhances Blood-Brain Barrier Permeability and Inhibitory Activity against Amyloidogenic Protein Fibril Formation.
ACS Chemical Neuroscience.
Contributors: K. Tsukakoshi *, W. Yoshida *, M. Kobayashi *, N. Kobayashi *, J. Kim *, T. Kaku*, T. Iguchi*, K. Nagasawa *
author keywords: Pyrroloquinoline quinone trimethylester; alpha-synuclein; amyloid beta; blood-brain barrier permeability
MeSH headings : Amyloid / drug effects; Amyloid beta-Peptides / drug effects; Amyloid beta-Peptides / metabolism; Amyloidogenic Proteins / drug effects; Animals; Blood-Brain Barrier / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Esterification; Esters / chemical synthesis; Esters / pharmacology; Humans; Mice; Neurons / drug effects; Neurons / metabolism; PQQ Cofactor / analogs & derivatives; PQQ Cofactor / chemical synthesis; PQQ Cofactor / pharmacology; Peptide Fragments / drug effects; Peptide Fragments / metabolism; Permeability; Prion Proteins / drug effects; Prion Proteins / metabolism; Protein Aggregation, Pathological / metabolism; alpha-Synuclein / drug effects; alpha-Synuclein / metabolism
TL;DR:
It is shown that an esterified compound of PQQ, P QQ-trimethylester (PQQ-TME), has twice the BBB permeability than PqQ in vitro, and indicated that esterification of PZQ could be a useful approach in developing a novel PQZ-based amyloid inhibitor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 9, 2020
2018 journal article
Engineered fungus derived FAD-dependent glucose dehydrogenase with acquired ability to utilize hexaammineruthenium(III) as an electron acceptor
Bioelectrochemistry, 123, 62–69.
Contributors: M. Okurita*, N. Suzuki*, N. Loew n, H. Yoshida *, W. Tsugawa *, K. Mori*, K. Kojima*, D. Klonoff *, K. Sode n
author keywords: Glucose dehydrogenase; Glucose oxidase; Flavin adenine dinucleotide; Aspergillus flavus; Hexaammineruthenium chloride; Enzyme sensor strip
MeSH headings : Amino Acid Substitution; Aspergillus flavus / enzymology; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Electrochemical Techniques; Electrons; Flavin-Adenine Dinucleotide / metabolism; Glucose 1-Dehydrogenase / genetics; Glucose 1-Dehydrogenase / metabolism; Models, Molecular; Protein Engineering; Ruthenium Compounds / metabolism
TL;DR:
A mutant of Aspergillus flavus-derived FADGDH, capable of utilizing hexaammineruthenium(III) as electron acceptor: AfGDH-H403D, which should lead to the development of sensor strips for blood glucose monitoring with increased accuracy and less stringent packing requirements.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 9, 2020
2018 journal article
Development of an electrochemical detection system for CpG methylation of human genome using methyl CpG binding domain and zinc finger protein
Abstracts of Papers of the American Chemical Society, 256. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000447600001002&KeyUID=WOS:000447600001002
Contributors: J. Lee, W. Yoshida, D. Hiraoka, A. Tatsumi, K. Abe, K. Nakabayashi, H. Wakeda, K. Hata
Source: ORCID
Added: October 9, 2020
2018 journal article
Designer fungus FAD glucose dehydrogenase capable of direct electron transfer.
Biosensors & Bioelectronics.
Contributors: K. Ito *, J. Okuda-Shimazaki*, K. Mori*, K. Kojima*, W. Tsugawa *, K. Ikebukuro *, C. Lin *, J. La Belle*, H. Yoshida *, K. Sode n
author keywords: Glucose dehydrogenase; Cellobiose dehydrogenase; Direct electron transfer; Designer FADGDH; Fusion protein; Heme b-binding cytochrome domain
MeSH headings : Aspergillus flavus / chemistry; Aspergillus flavus / enzymology; Biosensing Techniques; Blood Glucose / isolation & purification; Catalytic Domain; Electrodes; Electron Transport; Flavin-Adenine Dinucleotide / chemistry; Glucose Dehydrogenases / chemistry; Heme / chemistry
TL;DR:
The designer FADGDH was confirmed to be a novel GDH that possesses electrode DET ability and relevant and consistent findings provide a novel strategic approach for the improvement of the DET properties of designer FadGDH.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 9, 2020
2018 journal article
Comprehensive study of domain rearrangements of single-chain bispecific antibodies to determine the best combination of configurations and microbial host cells
Mabs, 10(6), 854–863.
Contributors: R. Asano *, Y. Kuroki*, S. Honma, M. Akabane, S. Watanabe, S. Mayuzumi*, S. Hiyamuta*, I. Kumagai*, K. Sode n
author keywords: Brevibacillus choshinensis; cancer immunotherapy; CD3; diabody; effective domain order; epidermal growth factor receptor; host cell; Pichia pastoris; small bispecific antibody; tandem scFv
MeSH headings : Antibodies, Bispecific / genetics; Antibodies, Bispecific / immunology; Binding Sites / genetics; Binding Sites / immunology; Brevibacillus / genetics; Cell Line, Tumor; Cell Survival / immunology; Electrophoresis, Polyacrylamide Gel; Escherichia coli / genetics; Genetic Variation; Humans; Pichia / genetics; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / immunology; Recombinant Fusion Proteins / metabolism; Single-Chain Antibodies / genetics; Single-Chain Antibodies / immunology
TL;DR:
This study designed all possible domain orders for scDb and taFv with identical Fv pairs and individually expressed all 16 variants using Escherichia coli, Pichia pastoris, and Brevibacillus choshinensis, finding a promising candidate that exhibited high activity and productivity.
(via Semantic Scholar)
www.tandfonline.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 9, 2020
2018 journal article
Biomolecular engineering of redox enzymes: Alteration of the electron acceptor preference; from oxygen to direct electron transfer
Abstracts of Papers of the American Chemical Society, 255. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000435537700584&KeyUID=WOS:000435537700584
Contributors: K. Sode
Source: ORCID
Added: October 9, 2020
2018 journal article
Affinity sensor for haemoglobin A1c based on single-walled carbon nanotube field-effect transistor and fructosyl amino acid binding protein.
Biosensors & Bioelectronics.
Contributors: M. Hatada*, T. Tran*, W. Tsugawa *, K. Sode n & A. Mulchandani *
author keywords: Single-walled carbon nanotube; Field-effect transistor; Haemoglobin A1c; Fructosyl amino acid binding protein; SocA; Fructosyl valine
MeSH headings : Agrobacterium tumefaciens / chemistry; Bacterial Proteins / chemistry; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Equipment Design; Glycated Hemoglobin / analysis; Humans; Nanotubes, Carbon / chemistry; Proteolysis; Transistors, Electronic; Valine / analogs & derivatives; Valine / analysis
TL;DR:
The label-free affinity sensor for HbA1c is reported based on the chemiresistor-type field-effect transistor, which has the ability to measure as low as 1.2 nM FV, which is 14-fold more sensitive compared to the previously reported fluorescence-based sensor using SocA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 9, 2020
2018 journal article
A Disposable Tear Glucose Biosensor-Part 5: Improvements in Reagents and Tear Sampling Component.
Journal of Diabetes Science and Technology, 12(4), 842–846.
MeSH headings : Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Blood Glucose / analysis; Contact Lenses; Glucose 1-Dehydrogenase; Humans; Indicators and Reagents; Tears / chemistry
TL;DR:
A tear glucose (TG) sensor with an integrated tear sampler can provide a noninvasive method for calibrating the continuous TG contact lens and monitoring glucose and suggests that using enzymes with lower Km may be advantageous when operating in low glucose environments like tears.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2018 journal article
Synergistically Enhancing the Therapeutic Effect of Radiation Therapy with Radiation Activatable and Reactive Oxygen Species-Releasing Nanostructures
ACS Nano, 12(5), 4946–4958.
author keywords: radiation/chemotherapy; radio sensitizer; reactive oxygen species; gold-titanium oxide nanoparticles; heterogeneous interface; triple-negative breast cancers
MeSH headings : Animals; Apoptosis; Biocompatible Materials / chemistry; Cell Line, Tumor; Cell Survival; Female; Gold / chemistry; Humans; Metal Nanoparticles / chemistry; Mice, Nude; Neoplasm Transplantation; Polyethylene Glycols / chemistry; Radiation-Sensitizing Agents / chemistry; Radiation-Sensitizing Agents / therapeutic use; Reactive Oxygen Species / metabolism; Tissue Distribution; Titanium / chemistry; Triple Negative Breast Neoplasms / metabolism; Triple Negative Breast Neoplasms / radiotherapy
TL;DR:
Significant tumor growth suppression and overall improvement in survival rate in a TNBC tumor model have been successfully demonstrated under DAT uptake for a radio-sensitized radiation therapy.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2018 journal article
Optimization of a single insertion electrode array for the creation of clinically relevant ablations using high-frequency irreversible electroporation
Computers in Biology and Medicine, 95, 107–117.
author keywords: Focal ablation; HFIRE; Cancer therapy; Non-thermal; Device modeling; Finite element model
MeSH headings : Animals; Cattle; Electrodes; Electroporation / methods; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Models, Theoretical
TL;DR:
Numerical simulations develop numerical simulations that demonstrate the potential for clinically relevant ablations with H-FIRE delivered via a single insertion technique comprised of an expandable array and a distally placed grounding pad and indicate that in vivo investigation of asingle insertion array and grounding pad are warranted.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 24, 2020
2018 journal article
Effect of extension of the heparin binding pocket on the structure, stability, and cell proliferation activity of the human acidic fibroblast growth factor
Biochemistry and Biophysics Reports, 13, 45–57.
author keywords: Fibroblast growth factor; Heparin binding; Stability; Cell proliferation
TL;DR:
The results of this study clearly demonstrate that heparin binding affinity of hFGF1 is not strongly correlated to its cell proliferation activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2018 journal article
Quadriceps weakness is associated with lesser proteoglycan density in the medial femoral cartilage six-months following anterior cruciate ligament reconstruction
Osteoarthritis and Cartilage, 26, S372–S373.
Source: Crossref
Added: February 24, 2020
2018 journal article
Electrochemical Selectivity Achieved Using a Double Voltammetric Waveform and Partial Least Squares Regression: Differentiating Endogenous Hydrogen Peroxide Fluctuations from Shifts in pH
Analytical Chemistry, 90(3), 1767–1776.
MeSH headings : Animals; Brain / metabolism; Electrochemical Techniques / methods; Hydrogen Peroxide / metabolism; Hydrogen-Ion Concentration; Least-Squares Analysis; Male; Principal Component Analysis; Rats, Sprague-Dawley
TL;DR:
The data demonstrate that the double waveform PLSR model is a powerful tool that can be used to disambiguate and evaluate naturally occurring H2O2 fluctuations in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2018 journal article
Quantitative Comparison of Enzyme Immobilization Strategies for Glucose Biosensing in Real-Time Using Fast-Scan Cyclic Voltammetry Coupled with Carbon-Fiber Microelectrodes
ChemPhysChem, 19(10), 1197–1204.
author keywords: biosensing; carbon-fiber microelectrodes; cyclic voltammetry; dopamine; glucose
MeSH headings : Animals; Biosensing Techniques; Carbon / chemistry; Electrochemical Techniques; Enzymes, Immobilized; Glucose / analysis; Glucose Oxidase / metabolism; Male; Microelectrodes; Rats; Rats, Sprague-Dawley; Time Factors
TL;DR:
Comparing three approaches to enzyme immobilization on the microelectrode surface-physical adsorption, hydrogel entrapment, andEntrapment in electrospun nanofibers suggests that each of these methods can be used to create functional microbiosensors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2018 journal article
Strategies of Combination Drug Delivery for Immune Checkpoint Blockades
Advanced Healthcare Materials, 1801099.
author keywords: cancer immunity circles; cancer immunotherapy; combination delivery; drug delivery; immune checkpoint blockades
MeSH headings : Animals; Antigens, Neoplasm / immunology; Antigens, Neoplasm / therapeutic use; Drug Delivery Systems; Humans; Immunotherapy; Lymphocyte Activation / drug effects; Neoplasms / immunology; Neoplasms / pathology; Neoplasms / therapy; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Cytotoxic / pathology
TL;DR:
Recent advances in combination of immune checkpoint blockades with therapies that participate in different stages of cancer immune cycle, including tumor antigen release, tumor antigen presentation, T‐cell activation, recognition of cancer cells by T‐cells, and tumor‐killing activity are summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 19, 2020
2018 journal article
Biodegradable Gelatin Methacryloyl Microneedles for Transdermal Drug Delivery
Advanced Healthcare Materials, 8(3), 1801054.
author keywords: gelatin methacryloyl; microneedle; sustained release; transdermal drug delivery
MeSH headings : Administration, Cutaneous; Animals; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Doxorubicin / chemistry; Doxorubicin / pharmacology; Gelatin / chemistry; Gelatin / pharmacology; Hydrogels / chemistry; Hydrogels / pharmacology; Melanoma, Experimental / drug therapy; Melanoma, Experimental / metabolism; Melanoma, Experimental / pathology; Mice; Needles; Skin Neoplasms / drug therapy; Skin Neoplasms / metabolism; Skin Neoplasms / pathology
TL;DR:
An innovative biodegradable MNs patch for the sustained delivery of drugs using a polymer patch, which can adjust delivery rates based on its crosslinking degree, is reported.
(via Semantic Scholar)
Source: Crossref
Added: January 19, 2020
2018 journal article
PDT-Driven Highly Efficient Intracellular Delivery and Controlled Release of CO in Combination with Sufficient Singlet Oxygen Production for Synergistic Anticancer Therapy
Advanced Functional Materials, 28(41), 1804324.
author keywords: carbon monoxide; combination therapy; nanogels; peptide dendrimers; photodynamic therapy
TL;DR:
Along with the simultaneous generation of large amounts of 1O2 and CO in cells, the combination of PDT and CO gas therapy offers significant synergistic anticancer effects and superior therapeutic safety both in vitro and in vivo.
(via Semantic Scholar)
Source: Crossref
Added: January 19, 2020
2018 journal article
Cationic lipid-assisted nanoparticles for delivery of mRNA cancer vaccine
Biomaterials Science, 6(11), 3009–3018.
MeSH headings : Animals; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / immunology; Cancer Vaccines / chemistry; Cancer Vaccines / genetics; Cancer Vaccines / immunology; Cell Line; Dendritic Cells / cytology; Dendritic Cells / immunology; Drug Carriers / chemistry; Lipids / chemistry; Lymphoma / pathology; Lymphoma / prevention & control; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA, Messenger / immunology
TL;DR:
Investigation of cationic lipid-assisted nanoparticles (CLAN) found that CLAN encapsulating mRNA encoding antigen could effectively stimulate the maturation of dendritic cells and promote the activation and proliferation of antigen-specific T cells both in vitro and in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 19, 2020
2018 journal article
Local generation of hydrogen for enhanced photothermal therapy
Nature Communications, 9(1).
MeSH headings : Catalysis; Hydrogen / chemistry; Nanoparticles / chemistry; Nanostructures / chemistry; Photoacoustic Techniques; Phototherapy / methods; Spectroscopy, Near-Infrared
TL;DR:
The authors demonstrate the anticancer effects of cubic Pd hydride nanocrystals with photoacoustic imaging properties that can release hydrogen under an NIR trigger and have photothermal effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 19, 2020
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