Works Published in 2019

search works

Displaying works 41 - 60 of 215 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2019 journal article

Engineering Multifunctional Gold Decorated Dendritic Mesoporous Silica/Tantalum Oxide Nanoparticles for Intraperitoneal Tumor-Specific Delivery

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 36(4).

By: R. Kashfi-Sadabad*, L. Gonzalez-Fajardo*, D. Hargrove*, B. Ahmadi*, D. Munteanu*, S. Shahbazmohamadi*, M. Jay n, X. Lu*

author keywords: contrast agents; gold nanoparticles; intraperitoneal injection; metastatic ovarian cancer; tantalum oxides
TL;DR: This study demonstrates that after intraperitoneal administration, rationally designed bimetallic NPs can simultaneously serve as targeted contrast agents for imaging tumors and to enhance radiation therapy in metastatic ovarian cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 20, 2020

2019 journal article

An improved hybrid continuum-atomistic four-way coupled model for electrokinetics in nanofluidics

ELECTROPHORESIS, 40(12-13), 1678–1690.

By: S. Jahromi*, E. Amani* & S. Movahed*

author keywords: Continuum-atomistic; Electrokinetics; Eulerian-Lagrangian; Ion transport; Nanofluidics
TL;DR: The validation of the proposed model with the results of Molecular Dynamics simulations suggests that this model can be a promising approach for studying the electrokinetic phenomena in more complicated geometries where the Molecular Dynamics approach is computationally prohibitive. (via Semantic Scholar)
Source: Web Of Science
Added: April 20, 2020

2019 journal article

IN VIVO MOLECULAR IMAGING USING LOW-BOILING-POINT PHASE-CHANGE CONTRAST AGENTS: A PROOF OF CONCEPT STUDY

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(1), 177–191.

By: J. Rojas n & P. Dayton n

author keywords: Ultrasound molecular imaging; Molecular targeting; Phase-change contrast agents; Acoustic droplet vaporization
MeSH headings : Animals; Contrast Media; Disease Models, Animal; Feasibility Studies; Fibrosarcoma / diagnostic imaging; Image Enhancement / methods; Molecular Imaging / methods; Proof of Concept Study; Rats; Rats, Inbred F344; Ultrasonography / methods
TL;DR: Data indicate that PCCA-specific imaging is more sensitive to small numbers of bound agents than conventional contrast imaging, however, data also revealed that contrast from targeted microbubbles was greater than that provided by PCCAs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 20, 2020

2019 journal article

VAPORIZATION DETECTIONIMAGING: A TECHNIQUE FOR IMAGING LOW-BOILING-POINTPHASE-CHANGE ONTRAST AGENTS WITH A HIGH DEPTH OF PENETRATION AND CONTRAST-TO-TISSUERATIO

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(1), 192–207.

By: J. Rojas n & P. Dayton n

author keywords: Phasechange; Contrast agents; Acoustic droplet vaporization; Vaporization detection; Perfluorobutane; Perfluoropropane; Nanodroplet
MeSH headings : Animals; Contrast Media; Kidney / diagnostic imaging; Models, Animal; Rats; Rats, Inbred F344; Signal Processing, Computer-Assisted; Ultrasonography; Volatilization
TL;DR: This work explores the effect of pulse length and concentration on the vaporization signal of PCCAs and a new technique to capture and use the signals to make high contrast-to-tissue ratio images in vivo and indicates that using a short pulse may be ideal for imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 20, 2020

2019 journal article

Multi-compartment Microfluidic Device Geometry and Covalently Bound Poly-D-Lysine Influence Neuronal Maturation

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 7.

By: J. Kamande*, T. Nagendran*, J. Harris* & A. Taylor*

author keywords: neuron; human stem cells; standard neuron device; multi-compartment devices; microfluidic chambers; silicone chambers; glutamatergic neurons; compartmentalized microfluidic platform
TL;DR: It is found that covalently bound PDL greatly improved the differentiation and maturation of stem cell-derived neurons within the devices, and experimental paradigms using the multi-compartment platform show that axons of human stem cell derived neurons intrinsically regenerate in the absence of inhibitory cues. (via Semantic Scholar)
Source: Web Of Science
Added: April 20, 2020

2019 journal article

Ankle Rotation and Muscle Loading Effects on the Calcaneal Tendon Moment Arm: An In Vivo Imaging and Modeling Study

ANNALS OF BIOMEDICAL ENGINEERING, 47(2), 590–600.

By: J. Franz n, A. Khanchandani*, H. McKenny n & W. Clark n

author keywords: Ultrasound; Plantarflexor; Triceps surae; OpenSim; Dynamometry
MeSH headings : Achilles Tendon / diagnostic imaging; Achilles Tendon / physiology; Adult; Ankle Joint / diagnostic imaging; Ankle Joint / physiology; Diagnostic Imaging; Female; Humans; Isometric Contraction / physiology; Isotonic Contraction / physiology; Male; Models, Biological; Movement / physiology; Muscle, Skeletal / diagnostic imaging; Muscle, Skeletal / physiology; Rotation; Weight-Bearing / physiology
TL;DR: It is found that muscle loading independently increased the CTma by up to 8% and attenuated the effects of ankle joint rotation, the latter likely through changes in tendon slack and tendon curvature, which contribute to improving the understanding of the physiology of ankle moment and power generation. (via Semantic Scholar)
Source: Web Of Science
Added: April 20, 2020

2019 article

Wound Healing and the Host Response in Regenerative Engineering

ENCYCLOPEDIA OF BIOMEDICAL ENGINEERING, VOL 1, pp. 707–718.

By: D. Chester n, E. Marrow n, M. Daniele n & A. Brown n

TL;DR: The purpose of this book chapter is to highlight the cellular processes and bioactive agents that encompass the wound healing process and to discuss how these processes change in the presence of a biomaterial. (via Semantic Scholar)
Source: Web Of Science
Added: April 14, 2020

2019 journal article

Adipocytes as Anticancer Drug Delivery Depot

MATTER, 1(5), 1203–1214.

TL;DR: The lipid metabolism is exploited to engineer adipocytes that serve as a depot to deliver cancer therapeutics at the tumor site, promoting antitumor efficacy and downregulation of PD-L1 expression is observed in tumor cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 6, 2020

2019 article

3D Printing in the Biomedical Field

ENCYCLOPEDIA OF BIOMEDICAL ENGINEERING, VOL 2, pp. 275–280.

By: A. Nguyen n, R. Narayan n & A. Shafiee*

TL;DR: 3D printing encompasses multiple fabrication technologies and materials ranging from extrusion to laser processing, and materials such as live cells or metal powders can be processed for applications ranging from soft tissue to rigid prosthetics. (via Semantic Scholar)
Source: Web Of Science
Added: March 30, 2020

2019 journal article

Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity

Journal of Biological Chemistry, 294(12), 4412–4424.

By: K. Nguyen n, F. Gillam n, J. Hopkins n, S. Jayanthi*, R. Gundampati*, G. Su*, J. Bear*, G. Pilkington* ...

author keywords: heparin; interleukin; glycosaminoglycan; cytokine; immunology; heparan sulfate; heparin-binding cytokine; IL-12
MeSH headings : Animals; Biophysical Phenomena; Calorimetry; Cytokines / biosynthesis; Dose-Response Relationship, Drug; Female; Flow Cytometry; HEK293 Cells; Heparin / chemistry; Heparin / pharmacology; Heparitin Sulfate / metabolism; Humans; Interleukin-12 / metabolism; Interleukin-12 / pharmacology; Mice; Mice, Inbred C57BL; Protein Binding; Receptors, Interleukin-2 / metabolism; Recombinant Proteins / metabolism; Recombinant Proteins / pharmacology; Signal Transduction / drug effects; T-Lymphocytes / drug effects; T-Lymphocytes / metabolism
TL;DR: Heparin-dependent modulation of hIL-12 function correlates with several of heparin's biophysical characteristics, including chain length, sulfation level, and concentration, which provide a foundation for further investigation of heParin's interactions with IL-12 family cytokines and for the use of he parin as an immunomodulatory agent. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2019 journal article

Biomimetics: Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury (Adv. Funct. Mater. 4/2019)

Advanced Functional Materials, 29(4), 1970019.

By: T. Su n, K. Huang n, H. Ma*, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen n ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2019 journal article

Biomechanical Function and Size of the Anteromedial and Posterolateral Bundles of the ACL Change Differently with Skeletal Growth in the Pig Model

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 477(9), 2161–2174.

By: S. Cone n, E. Lambeth, H. Ru*, L. Fordham, J. Piedrahita*, J. Spang, M. Fisher*

MeSH headings : Aging / physiology; Animals; Anterior Cruciate Ligament / physiology; Biomechanical Phenomena; Cadaver; Models, Animal; Musculoskeletal Development / physiology; Range of Motion, Articular / physiology; Rotation; Swine; Tibia / physiology; Torque
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: February 17, 2020

2019 journal article

Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells

ADVANCED THERAPEUTICS, 2(10).

By: K. Huang*, Z. Li n, T. Su n, D. Shen*, S. Hu n & K. Cheng n

author keywords: bispecific antibodies; immunotherapy; myocardial infarction; stem cells
TL;DR: In vivo studies in a mouse model with heart ischemia/reperfusion injury demonstrate the safety and therapeutic potency of SCRD BsAb, which supports cardiac recovery by reducing scarring, promoting angiomyogenesis, and boosting cardiac function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 27, 2020

2019 journal article

In Situ Joint Stiffness Increases During Skeletal Growth but Decreases Following Partial and Complete Anterior Cruciate Ligament Injury

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 141(12).

By: S. Cone n, J. Piedrahita n, J. Spang* & M. Fisher n

TL;DR: This work furthers the understanding of the interaction between joint biomechanics and ACL function throughout growth and the impact of ACL injury in the skeletally immature joint. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: January 27, 2020

2019 journal article

Stroke Prevents Exercise-Induced Gains in Bone Microstructure But Not Composition in Mice

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 141(12).

By: N. Hanne n, A. Steward n, M. Sessions n, H. Thornburg n, H. Sheng* & J. Cole n

author keywords: stroke; bone; exercise; microstructure; composition; gait; adaptation
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020

2019 journal article

Design of a thrombin resistant human acidic fibroblast growth factor (hFGF1) variant that exhibits enhanced cell proliferation activity

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 518(2), 191–196.

By: R. Kerr*, S. Agrawal*, S. Maity*, B. Koppolu n, S. Jayanthi*, G. Kumar*, R. Gundampati*, D. McNabb*, D. Zaharoff n, T. Kumar*

author keywords: Fibroblast growth factor; Cell signaling; Stability; Heparin; Binding affinity; Cell proliferation
MeSH headings : Animals; Cell Proliferation; Fibroblast Growth Factor 1 / chemistry; Fibroblast Growth Factor 1 / genetics; Fibroblast Growth Factor 1 / metabolism; Humans; Mice; Models, Molecular; Mutagenesis, Site-Directed; NIH 3T3 Cells; Point Mutation; Protein Conformation; Thrombin / metabolism
TL;DR: The R136E variant due to its increased thermal stability, resistance to proteases, and enhanced cell proliferation activity are expected to provide valuable clues for the development of hFGF1- based therapeutics for the management of chronic diabetic wounds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 21, 2020

2019 journal article

Drug Delivery: A Dual‐Bioresponsive Drug‐Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade (Adv. Mater. 17/2019)

Advanced Materials, 31(17), 1970120.

Source: Crossref
Added: January 19, 2020

2019 journal article

Cancer Stem Cell-Platelet Hybrid Membrane-Coated Magnetic Nanoparticles for Enhanced Photothermal Therapy of Head and Neck Squamous Cell Carcinoma

Advanced Functional Materials, 29(10), 1807733.

author keywords: cancer stem cell; hybrid mimic membrane; magnetic resonance imaging; photothermal therapy; platelet
TL;DR: A platelet–cancer stem cell (CSC) hybrid membrane‐coated iron oxide magnetic nanoparticle (MN) {CSC‐P]MN is presented for the first time for the enhanced photothermal therapy of head and neck squamous cell carcinoma (HNSCC). (via Semantic Scholar)
Source: Crossref
Added: January 19, 2020

2019 journal article

Engineering Protein Delivery Depots for Cancer Immunotherapy

Bioconjugate Chemistry, 30(3), 515–524.

MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / therapeutic use; Antigens / administration & dosage; Antigens / therapeutic use; Cancer Vaccines / administration & dosage; Cancer Vaccines / therapeutic use; Cytokines / administration & dosage; Cytokines / therapeutic use; Humans; Immunotherapy / methods; Neoplasms / therapy; Proteins / administration & dosage; Proteins / therapeutic use
TL;DR: This Topical Review highlights the recent studies on depot-mediated delivery of protein/peptide therapeutics for cancer immunotherapy and discusses the opportunities and challenges in this field. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: January 19, 2020

2019 journal article

Platelet for drug delivery

Current Opinion in Biotechnology, 58, 81–91.

MeSH headings : Blood Platelets; Drug Delivery Systems; Hemostasis; Humans; Inflammation; Neoplasms
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: January 19, 2020

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.