Works Published in 2018
Displaying works 61 - 80 of 192 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases
Nature Communications, 9(1).
MeSH headings : Amino Acid Sequence; Animals; Apoptosis Regulatory Proteins / metabolism; CRISPR-Cas Systems; Calcium-Binding Proteins / metabolism; Caspase Activation and Recruitment Domain; Female; Gene Editing; Genetic Therapy; Inflammasomes / genetics; Inflammation / therapy; Male; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Peritonitis / immunology; Protein Conformation
TL;DR:
This study inactivate NLRP3 in macrophages using CRISPR/Cas9 encapsulated in nanoparticles, and shows that administration in mice is effective in preventing septic shock and peritonitis, and in improving diabetes-associated inflammation and insulin resistance.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 19, 2020
2018 journal article
Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery
ACS Nano, 12(3), 2466–2473.
MeSH headings : Animals; Blood Glucose / analysis; Blood Glucose / metabolism; Delayed-Action Preparations / metabolism; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Diabetes Mellitus, Type 1 / metabolism; Drug Delivery Systems / instrumentation; Enzymes, Immobilized / metabolism; Equipment Design; Humans; Hydrogels / metabolism; Hydrogen Peroxide / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / therapeutic use; Insulin / administration & dosage; Insulin / therapeutic use; Male; Mice; Mice, Inbred C57BL; Needles; Transdermal Patch
TL;DR:
It is demonstrated that this smart insulin patch with a bioresponsive core and protective shell could effectively regulate the blood glucose levels within a normal range with improved biocompatibility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 19, 2020
2018 journal article
Leverage physiology for precision medications
Nanomedicine: Nanotechnology, Biology and Medicine, 14(5), 1883–1884.
Source: Crossref
Added: January 19, 2020
2018 journal article
Glucose-responsive oral insulin delivery for postprandial glycemic regulation
Nano Research, 12(7), 1539–1545.
author keywords: diabetes; drug delivery; glucose-responsive; insulin; nanomedicine
TL;DR:
In vivo studies on chemically-induced type 1 diabetic mice show this oral glucose-responsive delivery approach can effectively reduce postprandial blood glucose excursions, and is the first demonstration of an oral insulin delivery system directly triggered by increasing postPRandial glucose concentrations in the intestine to provide an on-demand insulin release with ease of administration.
(via Semantic Scholar)
Source: Crossref
Added: January 19, 2020
2018 journal article
Nanomedicine for obesity treatment
Science China Life Sciences, 61(4), 373–379.
author keywords: drug delivery; nanomedicine; obesity; browning; fat absorption; energy expenditure
MeSH headings : Anti-Obesity Agents / pharmacology; Anti-Obesity Agents / therapeutic use; Drug Delivery Systems / trends; Energy Metabolism / drug effects; Humans; Models, Biological; Nanomedicine; Obesity / drug therapy; Obesity / metabolism
TL;DR:
Recent advances in nanomedicine are surveyed as an emerging strategy for obesity treatment with an emphasis on the enhanced therapeutic efficiency and minimized side effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 19, 2020
2018 conference paper
Visual Terrain Identification and Surface Inclination Estimation for Improving Human Locomotion with a Lower-Limb Prosthetic
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018-July, 1817–1820.
Contributors: J. Diaz, R. Da Silva n, B. Zhong n, H. Huang* & E. Lobaton n
Event: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
MeSH headings : Amputees; Artificial Limbs; Humans; Locomotion; Lower Extremity
TL;DR:
This work developed a terrain identification and surface inclination estimation system for a prosthetic leg using visual and inertial sensors and built a dataset from which images with high sharpness are selected using the IMU signal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 14, 2020
2018 conference paper
Characterizing Residual Muscle Properties in Lower Limb Amputees Using High Density EMG Decomposition: A Pilot Study*
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018-January, 5974–5977.
Event: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
MeSH headings : Amputees; Artificial Limbs; Electrodes; Electromyography; Humans; Lower Extremity; Muscle Contraction; Muscle, Skeletal / physiology; Pilot Projects
TL;DR:
Results indicate that surface EMG signals recorded from residual muscles present modified signal features from intact shank muscles, which should be considered when implementing myoelectric control schemes.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 14, 2020
2018 conference paper
A Practical Approach for Evaluation of Socket Pistoning for Lower Limb Amputees
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018-July, 3938–3941.
Contributors: V. Vempala*, M. Liu, D. Kamper * & H. Huang*
Event: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
MeSH headings : Amputees; Artificial Limbs; Humans; Lower Extremity; Prosthesis Design; Walking
TL;DR:
Results demonstrate that this procedure, which does not rely on radiography unlike some existing methods, can be used to evaluate the fit of amputees' everyday sockets.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 14, 2020
2018 conference paper
Coordination of Voluntary Residual Muscle Contractions in Transtibial Amputees: a Pilot Study
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018-July, 2128–2131.
Contributors: A. Fleming n, S. Huang n & H. Huang n
Event: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
MeSH headings : Amputees; Artificial Limbs; Biomechanical Phenomena; Electromyography; Humans; Muscle Contraction; Pilot Projects
TL;DR:
The results suggest that amputees have altered ability to coordinate muscle post-amputation; however, all subjects can improve the task performance and learn to reduce EMG coordination patterns that led to task failure.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 14, 2020
2018 conference paper
Merged Haptic Sensation in the Hand during Concurrent Non-Invasive Proximal Nerve Stimulation
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018-July, 2186–2189.
Contributors: L. Vargas *, H. Huang* , Y. Zhu n & X. Hu *
Event: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
MeSH headings : Artificial Limbs; Electric Stimulation; Feedback, Sensory; Hand; Humans; Sensation; Transcutaneous Electric Nerve Stimulation
TL;DR:
The preliminary results showed that the spatial distribution of the haptic sensation was largely a direct summation/merge of the sensation regions from the individual nerve stimulation when comparing the regions to that of the concurrent double stimulation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 14, 2020
2018 conference paper
A Reliable Multi-User EMG Interface Based on A Generic-Musculoskeletal Model against Loading Weight Changes *
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018-July, 2104–2107.
Event: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
MeSH headings : Artificial Limbs; Electromyography; Movement; Reproducibility of Results; Weight-Bearing
TL;DR:
The results demonstrated that the multi-user EMG interface was reliable against the different loading weights, indicating it has potential to promote the myoelectric control into clinical applications.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 14, 2020
2018 article
Additive Manufacturing for Tissue Engineering
3D PRINTING AND BIOFABRICATION, pp. 3–54.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 21, 2019
2018 journal article
Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure
ACS Nano, 12(7), 6536–6544.
Contributors: H. Liang n, K. Huang n, T. Su n, Z. Li n, S. Hu n, P. Dinh n, E. Wrona n, C. Shao *
author keywords: mesenchymal stem cells; red blood cells; biomimetic; nanoparticles; membrane cloaking; liver failure
MeSH headings : Animals; Apoptosis; Biomimetic Materials / chemistry; Biomimetic Materials / therapeutic use; Carbon Tetrachloride; Cell Line; Cell Proliferation; Disease Models, Animal; Erythrocyte Membrane / chemistry; Humans; Liver Failure, Acute / chemically induced; Liver Failure, Acute / pathology; Liver Failure, Acute / physiopathology; Liver Failure, Acute / therapy; Liver Regeneration; Male; Mesenchymal Stem Cells / chemistry; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / therapeutic use
TL;DR:
This work fabricated a nanoparticle that carries the beneficial regenerative factors from mesenchymal stem cells and further coated it with the membranes of red blood cells to increase blood stability and promote liver cell proliferation in vitro and have lower internalization by macrophage cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: September 10, 2019
2018 article
Locality Adaptive Multi-modality GANs for High-Quality PET Image Synthesis
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION - MICCAI 2018, PT I, Vol. 11070, pp. 329–337.
MeSH headings : Algorithms; Electrons; Magnetic Resonance Imaging / methods; Multimodal Imaging / methods; Neural Networks, Computer; Positron-Emission Tomography / methods; Reproducibility of Results; Sensitivity and Specificity
TL;DR:
A locality adaptive multi-modality generative adversarial networks model (LA-GANs) is proposed to synthesize the full-dose PET image from both the low-dose one and the accompanying T1-weighted MRI to incorporate anatomical information for better PET image synthesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 19, 2019
2018 journal article
Response Changes During Insertion of a Cochlear Implant Using Extracochlear Electrocochleography
EAR AND HEARING, 39(6), 1146–1156.
author keywords: Cochlear implant; Electrocochleography; Hearing preservation; Intraoperative monitoring
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Audiometry, Evoked Response; Child; Child, Preschool; Cochlear Implantation / methods; Cochlear Implants; Female; Humans; Male; Middle Aged; Monitoring, Intraoperative; Monitoring, Physiologic; Round Window, Ear; Young Adult
TL;DR:
Monitoring the electrocochleography during CI insertion from an extracochlear site reveals insertions that are potentially atraumatic, show interaction with cochlear structures followed by response recovery, or show interactions such that response losses persist to the end of recording.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 18, 2019
2018 journal article
Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair
ACS NANO, 12(12), 12193–12200.
author keywords: pretargeting; bioorthogonal click chemistry; heart repair; endogenous stem cells; engineered antibodies
MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / metabolism; Blood Vessels / metabolism; Blood Vessels / pathology; Cells, Cultured; Click Chemistry; Collagen / chemistry; Collagen / metabolism; Disease Models, Animal; Endothelial Progenitor Cells / cytology; Endothelial Progenitor Cells / metabolism; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Mice; Mice, Inbred C57BL; Molecular Structure; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
TL;DR:
In a mouse model of acute myocardial infarction, the in vivo results of cardiac function, heart morphometry, and immunohistochemistry assessment all confirmed effective heart repair by the PTBC system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 14, 2019
2018 journal article
A Dual-Frequency Colinear Array for Acoustic Angiography in Prostate Cancer Evaluation
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 65(12), 2418–2428.
author keywords: Harmonic analysis; in vivo; oncology; ultrasonic imaging; ultrasonic transducer arrays
MeSH headings : Abdomen / blood supply; Abdomen / diagnostic imaging; Angiography / methods; Animals; Contrast Media; Humans; Image Interpretation, Computer-Assisted / methods; Male; Microbubbles; Models, Biological; Phantoms, Imaging; Prostate / blood supply; Prostate / diagnostic imaging; Prostatic Neoplasms / blood supply; Prostatic Neoplasms / diagnostic imaging; Rats; Transducers; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR:
The development of a dual frequency, dual-layer colinear array transducer for transrectal acoustic angiography and identification of regions of neovascularization for the guidance of prostate biopsies are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 14, 2019
2018 article
Creation of an optically tunable, solid tissue phantom for use in cancer detection
CLINICAL AND TRANSLATIONAL NEUROPHOTONICS 2018, Vol. 10480.
author keywords: Phantom; Fluorophore; Cancer; Spectroscopy; Machine Learning
TL;DR:
An optically tunable, solid tissue phantom was developed in order to aid in the verification and validation of non-destructive cancer detection technologies based on fluorescence spectroscopy and was shown to be tunable; thus, indicating that these phantoms could be used to tailor specific optical conditions that mimic cancerous and healthy tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 14, 2019
2018 journal article
Adaptive Multifocus Beamforming for Contrast-Enhanced-Super-Resolution Ultrasound Imaging in Deep Tissue
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 65(12), 2255–2263.
author keywords: Adaptive beamforming; sensitivity; super-resolution imaging
MeSH headings : Abdomen / diagnostic imaging; Animals; Contrast Media; Databases, Factual; Female; Humans; Image Processing, Computer-Assisted / methods; Microbubbles; Muscles / diagnostic imaging; Phantoms, Imaging; Swine; Ultrasonography / methods
TL;DR:
An “adaptive multifocus” sequence is proposed, a new ultrasound imaging sequence that combines the high frame rate feature of a plane wave with the increased bubble detection sensitivity of a focused beam, retaining a high frame rates, yet achieving improved sensitivity to microbubbles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 14, 2019
2018 journal article
Articular cartilage gene expression patterns in the tissue surrounding the impact site following applications of shear and axial loads
BMC MUSCULOSKELETAL DISORDERS, 19.
author keywords: Osteoarthritis; Porcine; Articular injury
MeSH headings : Animals; Cartilage, Articular / metabolism; Cartilage, Articular / pathology; Collagen Type II / genetics; Collagen Type II / metabolism; Gene Expression Profiling / methods; Gene Expression Regulation, Enzymologic; Osteoarthritis, Knee / genetics; Osteoarthritis, Knee / metabolism; Osteoarthritis, Knee / pathology; Patella / metabolism; Patella / pathology; Stress, Mechanical; Sus scrofa; Time Factors; Tissue Culture Techniques; Transcriptome; fas Receptor / genetics; fas Receptor / metabolism
TL;DR:
The results suggest that a more physiologically valid shear load may induce more damage to surrounding articular cartilage than a normal load alone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 14, 2019
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