Works Published in 2014
Displaying works 81 - 100 of 140 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Bio-lnspired Synthetic Nanovesicles for Glucose-Responsive Release of Insulin
BIOMACROMOLECULES, 15(10), 3495–3502.
MeSH headings : Animals; Blood Glucose / drug effects; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Experimental / metabolism; Drug Delivery Systems / methods; Gluconates / chemistry; Glucose / administration & dosage; Glucose / chemistry; Glucose Oxidase / metabolism; Hydrogen-Ion Concentration; Insulin / administration & dosage; Insulin / chemistry; Male; Mice; Mice, Inbred C57BL; Polymers / administration & dosage; Polymers / chemistry
TL;DR:
In vivo experiments demonstrate that a single injection of the developed nanovesicle facilitated stabilization of the blood glucose levels in the normoglycemic state (<200 mg/dL) for up to 5 days.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Age-Related Effects on the Potency of Human Adipose-Derived Stem Cells: Creation and Evaluation of Superlots and Implications for Musculoskeletal Tissue Engineering Applications
Tissue Engineering Part C: Methods, 20(12), 972–983.
MeSH headings : Adipogenesis; Adipose Tissue / cytology; Adult; Aged; Aged, 80 and over; Aging / physiology; Cell Line; Cell Proliferation; Cell Separation; DNA / metabolism; Female; Humans; Middle Aged; Musculoskeletal System / metabolism; Osteogenesis; Postmenopause; Premenopause; Proteins / metabolism; Reproducibility of Results; Stem Cells / cytology; Tissue Engineering / methods; Young Adult
TL;DR:
In general, superlots effectively represented the average differentiation behavior of each of their contributing cell populations and could provide a powerful tool for increasing experimental throughput to more efficiently utilize resources when studying hASC differentiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2014 journal article
Acoustic Characterization of Contrast-to-issue Ratio and Axial Resolution for Dual-Frequency Contrast-Specific Acoustic Angiography Imaging
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 61(10), 1668–1687.
MeSH headings : Angiography / methods; Animals; Cattle; Contrast Media / chemistry; Iliac Artery / diagnostic imaging; Mice; Microbubbles; Muscles / diagnostic imaging; Particle Size; Pressure; Rats; Rats, Inbred F344; Signal Processing, Computer-Assisted; Signal-To-Noise Ratio; Transducers; Ultrasonography, Interventional / instrumentation; Ultrasonography, Interventional / methods
TL;DR:
CTR dependence on transmit frequency and peak pressure were confirmed through in vivo imaging in two rodents and may lead to improved imaging of vascular remodeling in superficial or luminal cancers such as those of the breast, prostate, and colon.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 review
Review of recent developments in stimulated emission depletion microscopy: Applications on cell imaging
[Review of ]. Journal of Biomedical Optics, 19(8).
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Research into fabrics used in compression therapy and assessment of their impact on treatment regimens
Journal of Wound Care, 23(9), S14–22.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Multiple Scan Rate Voltammetry for Selective Quantification of Real-Time Enkephalin Dynamics
ANALYTICAL CHEMISTRY, 86(15), 7806–7812.
MeSH headings : Animals; Electrodes; Enkephalins / physiology; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley
TL;DR:
This work has developed and characterized a novel voltammetric waveform for the selective quantification of small tyrosine-containing peptides, such as the ENKs, with rapid temporal (subsecond) and precise spatial (10s of micrometers) resolution, and provides a foundation for real-time measurements of endogenous ENK fluctuations in biological locations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 review
Interconnected, microporous hollow fibers for tissue engineering: Commercially relevant, industry standard scale-up manufacturing
[Review of ]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 102(9), 3311–3323.
author keywords: spunbond process; hollow porous fibers; industry standard scale-up manufacturing; tissue engineering; stem cells
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Improving Finite State Impedance Control of Active-Transfemoral Prosthesis Using Dempster-Shafer Based State Transition Rules
Journal of Intelligent & Robotic Systems, 76(3-4), 461–474.
Contributors: M. Liu n, F. Zhang n, P. Datseris* & H. Huang n
author keywords: Impedance control; Finite state machine; Uncertainty; Amputee gait
TL;DR:
This study aimed to generate more robust FSI control of ATP against these variations by using Dempster-Shafer theory (DST)-based transition rules, which yielded enhanced accuracy in state transition timing and reduced control errors when intra- and inter-subject variations were presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Evaluation of chirp reversal power modulation sequence for contrast agent imaging
Physics in Medicine & Biology, 59(17), 5101–5117.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Evaluation of bias voltage modulation sequence for nonlinear contrast agent imaging using a capacitive micromachined ultrasonic transducer array
PHYSICS IN MEDICINE AND BIOLOGY, 59(17), 4879–4896.
author keywords: amplitude modulation; bias voltage; cMUT; multi-pulse sequence; contrast agent imaging; harmonic; nonlinear behavior
MeSH headings : Algorithms; Contrast Media; Humans; Microbubbles; Phantoms, Imaging; Transducers; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR:
A new contrast imaging sequence, called bias voltage modulation (BVM), specifically developed for cMUTs to suppress their inherent nonlinear behavior is proposed, revealing that the problem of cM UT nonlinearity can be addressed, thus expanding the potential of this new transducer technology for nonlinear contrast agent detection and imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Vascular channels formed by subpopulations of PECAM1+ melanoma cells
Nature Communications, 5(1).
MeSH headings : Angiogenesis Inhibitors / chemistry; Animals; Cell Line, Tumor; Female; Flow Cytometry; Green Fluorescent Proteins / metabolism; Humans; Melanoma / metabolism; Melanoma, Experimental / metabolism; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic / metabolism; Platelet Endothelial Cell Adhesion Molecule-1 / metabolism; RNA, Small Interfering / metabolism; Skin Neoplasms / metabolism; Transcription Factor AP-2 / metabolism; Up-Regulation; Vascular Endothelial Growth Factor A / metabolism; Vascular Endothelial Growth Factor Receptor-2 / metabolism
TL;DR:
VM-competent subpopulations, rather than all cells within a tumour, may instigate VM, supplant host-derived endothelium, and form PECAM1-dependent conduits that are not diminished by neutralizing VEGF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2014 review
Stimuli-responsive nanomaterials for therapeutic protein delivery
[Review of ]. JOURNAL OF CONTROLLED RELEASE, 194, 1–19.
author keywords: Stimuli-response; Nanomaterials; Protein/peptide therapeutics; Drug delivery; Nanomedicine
MeSH headings : Animals; Drug Delivery Systems; Humans; Nanomedicine / trends; Nanostructures / chemistry; Proteins / administration & dosage; Proteins / therapeutic use
TL;DR:
This review surveys recent advances in controlled protein delivery of proteins or peptides using stimuli-responsive nanomaterials and strategies utilizing both physiological and external stimuli are introduced and discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 article
Recent progress in multidrug delivery to cancer cells by liposomes
Mo, R., Jiang, T., & Gu, Z. (2014, June). NANOMEDICINE, Vol. 9, pp. 1117–1120.
author keywords: chemotherapy; co-delivery; combination cancer therapy; drug delivery; gene therapy; liposome; protein therapy
MeSH headings : Antineoplastic Agents / administration & dosage; Drug Delivery Systems; Genetic Therapy; Humans; Liposomes / chemistry; Neoplasms / drug therapy; Neoplasms / therapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
In vitro dermal and epidermal cellular response to titanium alloy implants fabricated with electron beam melting
MEDICAL ENGINEERING & PHYSICS, 36(10), 1367–1372.
author keywords: Keratinocyte; Fibroblast; Additive manufacturing; Electron beam melting; Titanium alloy; Biocompatibility
MeSH headings : Alloys; Cell Proliferation / drug effects; Cell Survival / drug effects; Dermis / cytology; Electrons; Epidermal Cells; Fibroblasts / cytology; Fibroblasts / drug effects; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Materials Testing; Osseointegration / drug effects; Phase Transition; Prostheses and Implants; Surface Properties; Titanium / chemistry; Titanium / pharmacology
TL;DR:
Electron beam melting EBM Ti6Al4V discs exhibited an acceptable biocompatibility profile compared to solid titanium alloy discs from a commercial source for dermal and epidermal cells, and may be considered as an option for fabrication of custom transdermal implants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Clickable Protein Nanocapsules for Targeted Delivery of Recombinant p53 Protein
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(43), 15319–15325.
MeSH headings : Amino Acid Sequence; Azides / chemistry; Cell Survival / drug effects; Click Chemistry; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Carriers / toxicity; Drug Liberation; Gonadotropin-Releasing Hormone / chemistry; HeLa Cells; Humans; Ligands; Nanocapsules / chemistry; Nanocapsules / toxicity; Peptide Fragments / chemistry; Peptide Fragments / metabolism; Polyethylene Glycols / chemistry; Recombinant Proteins / chemistry; Single-Chain Antibodies / chemistry; Single-Chain Antibodies / metabolism; Surface Properties; Tumor Suppressor Protein p53 / chemistry
TL;DR:
The results validate a general approach for targeted protein delivery into tumor cells using cellular-responsive nanocarriers, opening up new opportunities for the development of intracellular protein-based anticancer treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia
Biomicrofluidics, 8(5), 054117.
TL;DR:
This work presents the design and characterization of a microfluidic device that can simultaneously mimic the oxygenation conditions observed within the tumor and model the cell migration and intravasation processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2014 journal article
Single-cell sphingosine kinase activity measurements in primary leukemia
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 406(27), 7027–7036.
author keywords: Single-cell analysis; Sphingosine kinase; Capillary electrophoresis; Leukemia; Primary cells
MeSH headings : Electrophoresis, Capillary; Humans; K562 Cells; Leukemia / enzymology; Phosphotransferases (Alcohol Group Acceptor) / metabolism
TL;DR:
The variability in SK signaling may have important implications for SK inhibitors as therapeutics for leukemia and demonstrates the value of single-cell analysis in characterizing the nature of oncogenic signaling in cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Pulse sequences for uniform perfluorocarbon droplet vaporization and ultrasound imaging
ULTRASONICS, 54(7), 2024–2033.
author keywords: Phase-change; Ultrasound contrast agent; Perfluorocarbon; Vaporization
MeSH headings : Acoustics; Animals; Contrast Media / chemistry; Fluorocarbons / chemistry; Kidney / diagnostic imaging; Microbubbles; Rats; Rats, Inbred F344; Transducers; Ultrasonography; Volatilization
TL;DR:
The development and evaluation of protocols for PCCA-enhanced ultrasound imaging using a commercial array transducer are described and pulse sequences designed to manipulate the geometries of discrete microbubble clouds using electronic steering and cloud spacing were tailored to build a uniform vaporization field.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Primary cilium mechanotransduction of tensile strain in 3D culture: Finite element analyses of strain amplification caused by tensile strain applied to a primary cilium embedded in a collagen matrix
JOURNAL OF BIOMECHANICS, 47(9), 2211–2217.
author keywords: Primary cilia; Finite element analysis; Mechanotransduction; Tensile strain; Ciliary membrane; Mechanobiology; Ciliary pocket; Adipose derived stem cells
MeSH headings : Adipose Tissue / cytology; Cells, Cultured; Cilia / physiology; Collagen; Finite Element Analysis; Humans; Mechanotransduction, Cellular; Models, Biological; Osteogenesis / physiology; Stem Cells / cytology; Stress, Mechanical
TL;DR:
This is the first study to model the effects of tensile strain on the primary cilium and provides newfound insight into the potential role of thePrimary cilia as a mechanosensor, particularly in Tensile strain and potentially a multitude of other mechanical stimuli beyond fluid shear.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Magnetic targeting of cardiosphere-derived stem cells with ferumoxytol nanoparticles for treating rats with myocardial infarction
BIOMATERIALS, 35(30), 8528–8539.
author keywords: Cardiac stem cells; Magnetic targeting; Myocardial infarction; Ferumoxytol; MRI; Superparamagnetic iron oxide nanoparticles
MeSH headings : Animals; Apoptosis / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Female; Ferrosoferric Oxide / pharmacology; Ferrosoferric Oxide / therapeutic use; Finite Element Analysis; Heart Function Tests; Heparin / pharmacology; Humans; Inflammation / pathology; Iron Overload / pathology; Magnetic Phenomena; Male; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Nanoparticles / therapeutic use; Nanoparticles / ultrastructure; Neovascularization, Physiologic / drug effects; Protamines / pharmacology; Rats; Rats, Inbred WKY; Spheroids, Cellular / drug effects; Spheroids, Cellular / pathology
TL;DR:
FHP labeling is safe to cardiac stem cells and facilitates magnetically-targeted stem cell delivery into the heart which leads to augmented cell engraftment and therapeutic benefit, and magnetic targeting increased cardiac retention of transplanted FHP-rCDCs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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