Works Published in 2017
Displaying works 81 - 100 of 203 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2017 journal article
Self-renewing monolayer of primary colonic or rectal epithelial cells
Cellular and Molecular Gastroenterology and Hepatology, 4(1), 165-.
Source: NC State University Libraries
Added: August 6, 2018
2017 review
Rise of the Pigs: Utilization of the Porcine Model to Study Musculoskeletal Biomechanics and Tissue Engineering During Skeletal Growth
[Review of ]. TISSUE ENGINEERING PART C-METHODS, 23(11), 763–780.
author keywords: animal models; ligament and tendon; cartilage; bone; skeletal muscle
MeSH headings : Animals; Biomechanical Phenomena; Bone Development; Models, Animal; Musculoskeletal Physiological Phenomena; Regenerative Medicine; Sus scrofa; Tissue Engineering
TL;DR:
This review explores the publication history of the use of pig models in biomechanics and TERM discuss interspecies comparative studies, highlight studies on the effect of skeletal growth and other biological considerations in the porcine model, and present challenges and emerging opportunities for using this model to study functional TERM.
(via Semantic Scholar)
www.ncbi.nlm.nih.gov (repository)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Quantifying center of pressure variability in chondrodystrophoid dogs
VETERINARY JOURNAL, 226, 26–31.
author keywords: Locomotion; Kinematics; Center of gravity
MeSH headings : Animals; Biomechanical Phenomena; Cartilage / growth & development; Dog Diseases / physiopathology; Dogs / anatomy & histology; Dogs / physiology; Gait; Species Specificity; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary
TL;DR:
In conclusion, COP variability can be measured consistently in dogs, and a range of COP variability for normal chondrodystrophoid dogs has been determined to provide a baseline for future studies on dogs with spinal cord injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment
ACS NANO, 11(9), 9223–9230.
author keywords: drug delivery; microneedle patch; obesity; browning agent; adipose tissue
MeSH headings : Adipocytes, White / drug effects; Adipose Tissue, White / drug effects; Animals; Anti-Obesity Agents / administration & dosage; Anti-Obesity Agents / therapeutic use; Drug Delivery Systems / instrumentation; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / therapeutic use; Male; Mice, Inbred C57BL; Obesity / drug therapy; Rosiglitazone / administration & dosage; Rosiglitazone / therapeutic use; Transdermal Patch
TL;DR:
A transcutaneous browning agent patch is developed to locally induce adipose tissue transformation and reduces treated fat pad size, increases whole body energy expenditure, and improves type-2 diabetes in vivo in a diet-induced obesity mouse model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
KO of 5-InsP(7) kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(45), 11968–11973.
author keywords: bioenergetics; signaling; inositol pyrophosphates
MeSH headings : Adenosine Triphosphate / metabolism; CRISPR-Cas Systems; Cell Line, Tumor; Colonic Neoplasms / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / biosynthesis; G1 Phase Cell Cycle Checkpoints / genetics; Gene Knockout Techniques; Glycolysis / genetics; Glycolysis / physiology; HCT116 Cells; HEK293 Cells; Humans; Inositol Phosphates / metabolism; Mitochondria / metabolism; Phosphotransferases (Phosphate Group Acceptor) / genetics; Phosphotransferases (Phosphate Group Acceptor) / metabolism; Signal Transduction; Tumor Suppressor Protein p53 / biosynthesis
TL;DR:
It is concluded that 5-InsP7 regulates p53 expression, whereas 1,5-Insp8 regulates ATP levels, which attribute hitherto unsuspected functionality for 1-5- InsP8 to bioenergetic homeostasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Creation and Evaluation of New Porcine Model for Investigation of Treatments of Surgical Site Infection
TISSUE ENGINEERING PART C-METHODS, 23(11), 795–803.
author keywords: surgical site infection; porcine model; antimicrobial scaffold; silver; electrospinning; MRSA
MeSH headings : Animals; Anti-Infective Agents / pharmacology; Anti-Infective Agents / therapeutic use; Disease Models, Animal; Female; Methicillin-Resistant Staphylococcus aureus / drug effects; Nanofibers / chemistry; Nanofibers / ultrastructure; Polyesters / chemistry; Porosity; Surgical Wound Infection / drug therapy; Surgical Wound Infection / microbiology; Surgical Wound Infection / pathology; Sus scrofa; Tissue Scaffolds / chemistry
TL;DR:
A porcine full-thickness incision model to investigate SSI caused by methicillin-resistant Staphylococcus aureus is developed, and the potential of silver releasing nanofibrous scaffolds for treatment/prevention of SSI is confirmed, and a new porcines model is introduced for in vivo evaluation of additional SSI treatment approaches are introduced.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 review
Bioresponsive transcutaneous patches
[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 48, 28–32.
MeSH headings : Administration, Cutaneous; Animals; Drug Delivery Systems / methods; Drug Monitoring / methods; Humans; Needles; Skin; Transdermal Patch
TL;DR:
Recent advances in the development and use of bioresponsive transcutaneous patches for on-demand smart and precise drug delivery, exploiting different physiological signals including pH, serum glucose levels, and enzyme activity are surveyed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model
TISSUE ENGINEERING PART C-METHODS, 23(11), 745–753.
author keywords: subchondral bone; cartilage; microfracture; skeletal maturity
MeSH headings : Aging / physiology; Animals; Bone Remodeling; Cartilage, Articular / diagnostic imaging; Cartilage, Articular / pathology; Cartilage, Articular / surgery; Collagen Type II / metabolism; Disease Models, Animal; Fluoroscopy; Immunohistochemistry; Male; Proteoglycans / metabolism; Swine; Swine, Miniature; Wound Healing; X-Ray Microtomography
TL;DR:
The significant impact of skeletal maturity on the propensity of subchondral bone to remodel as a result of chondral injury is shown to improve selection criteria for animal models for studying cartilage injury, repair, and treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 review
Tailoring non-viral delivery vehicles for transporting genome-editing tools
[Review of ]. Science China-Materials, 60(6), 511–515.
TL;DR:
The recent advances in the development of non-viral delivery systems for CRISPR-Cas9 are surveyed and challenges and future directions in this field are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Shear Shock Waves Observed in the Brain
PHYSICAL REVIEW APPLIED, 8(4).
TL;DR:
An ultrasound imaging technique that is developed has a combination of penetration, frame-rate, and motion detection accuracy required to directly observe, for the first time, the formation and evolution of shear shock waves in the brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis
STEM CELLS TRANSLATIONAL MEDICINE, 6(10), 1905–1916.
author keywords: Fibrosis; Pulmonary; Syngeneic; Allogeneic; Stem cells
MeSH headings : Animals; Bleomycin / toxicity; Cells, Cultured; Female; Lung / cytology; Pulmonary Fibrosis / etiology; Pulmonary Fibrosis / therapy; Rats; Rats, Wistar; Spheroids, Cellular / transplantation; Stem Cell Transplantation / adverse effects; Stem Cell Transplantation / methods; Transplantation, Homologous / adverse effects; Transplantation, Homologous / methods
TL;DR:
It is found that infusion of allogeneic LSCs reduces the progression of inflammation and fibrotic manifestation and preserves epithelial and endothelial health without eliciting significant immune rejection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Motor Unit Activity during Fatiguing Isometric Muscle Contraction in Hemispheric Stroke Survivors
FRONTIERS IN HUMAN NEUROSCIENCE, 11.
author keywords: motor unit; stroke; isometric fatigue; surface EMG decomposition; motor unit action potential; motor unit firing rate
TL;DR:
Evidence of both central and peripheral fatigue at the MU level during isometric fatiguing contraction for the first time in stroke survivors is presented, which may suggest that central mechanisms observed here as changes in firing rate are the dominant processes leading to task failure on the affected side.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
In Vitro Generation of Mouse Colon Crypts
ACS BIOMATERIALS SCIENCE & ENGINEERING, 3(10), 2502–2513.
author keywords: intestinal epithelial stem cells; differentiation; intestine-on-a-chip; microfabrication; gradient; tissue mimics
TL;DR:
A new approach combining microengineered scaffolds, native chemical gradients, and biophysical cues to control primary epithelium ex vivo can serve as a highly functional and physiologically relevant in vitro tissue model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Glucose-responsive insulin by molecular and physical design
NATURE CHEMISTRY, 9(10), 937–943.
MeSH headings : Diabetes Mellitus / drug therapy; Diabetes Mellitus / metabolism; Glucose / metabolism; Humans; Insulin / metabolism; Insulin / therapeutic use; Models, Biological
TL;DR:
A forward-looking viewpoint is provided, which asks if there are new approaches that could spur innovation in this area as well as to encourage synthetic chemists and chemical engineers to address the challenges and promises offered by this therapeutic approach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Exploration of Hand Grasp Patterns Elicitable Through Non-Invasive Proximal Nerve Stimulation
SCIENTIFIC REPORTS, 7.
MeSH headings : Adult; Electric Stimulation; Female; Fingers / physiology; Hand / physiology; Hand Strength / physiology; Humans; Male; Muscle, Skeletal / physiology; Range of Motion, Articular / physiology; Young Adult
TL;DR:
This study provides initial evidence on the feasibility of a proximal nerve stimulation technique in controlling a variety of finger movements and grasp patterns and could also be developed into a rehabilitative/assistive tool that can result in flexible movements of the fingers.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2017 article
Strategic Directions in Immunoresponsive Biomaterials in Tissue Engineering INTRODUCTION
Zaharoff, D. A., & Jewell, C. M. (2017, October). TISSUE ENGINEERING PART A, Vol. 23, pp. 1042–1043.
MeSH headings : Biocompatible Materials / adverse effects; Biocompatible Materials / chemistry; Cell Survival / drug effects; Humans; Regenerative Medicine / methods; Tissue Engineering / methods
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Piecewise parabolic method for simulating one-dimensional shear shock wave propagation in tissue-mimicking phantoms
SHOCK WAVES, 27(6), 879–888.
author keywords: Shear shock waves; Traumatic brain injury; Piecewise parabolic method; Nonlinear shear waves
TL;DR:
This work presents a piecewise parabolic method-based solver for one-dimensional linearly polarized nonlinear shear wave in a homogeneous medium and with empirical frequency-dependent attenuation, which is expected to be a starting point for the development of a two- and three-dimensional full-wave code for the propagation of non linear shear waves in heterogeneous media.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Performance of acoustic radiation force impulse ultrasound imaging for carotid plaque characterization with histologic validation
JOURNAL OF VASCULAR SURGERY, 66(6), 1749-+.
MeSH headings : Aged; Area Under Curve; Calcium / analysis; Carotid Arteries / chemistry; Carotid Arteries / diagnostic imaging; Carotid Arteries / pathology; Carotid Artery Diseases / diagnostic imaging; Carotid Artery Diseases / pathology; Collagen / analysis; Elasticity Imaging Techniques; Female; Fibrosis; Hemorrhage / diagnostic imaging; Hemorrhage / pathology; Humans; Male; Middle Aged; Necrosis; Observer Variation; Pilot Projects; Plaque, Atherosclerotic; Predictive Value of Tests; Prognosis; Prospective Studies; ROC Curve; Reproducibility of Results; Vascular Calcification / diagnostic imaging; Vascular Calcification / pathology
TL;DR:
The performance of acoustic radiation force impulse (ARFI) imaging, a noninvasive ultrasound elasticity imaging method, for delineating the composition of human carotid plaque in vivo with histologic validation is suggested to be capable of distinguishing soft from stiff atherosclerotic plaque components and delineating FC thickness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Origins of Common Neural Inputs to Different Compartments of the Extensor Digitorum Communis Muscle
SCIENTIFIC REPORTS, 7.
MeSH headings : Adult; Central Nervous System / physiology; Electromyography; Female; Fingers / innervation; Humans; Male; Muscle, Skeletal / innervation; Young Adult
TL;DR:
Overall, the common input shared across different fingers are found to be at low to moderate levels, in comparison with the total input, which allows dexterous control of individual digits with some degree of coordinated control of multiple digits.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Orientation changes in the cruciate ligaments of the knee during skeletal growth: A porcine model
JOURNAL OF ORTHOPAEDIC RESEARCH, 35(12), 2725–2732.
author keywords: anterior cruciate ligament; posterior cruciate ligament; adolescent; porcine; MRI
MeSH headings : Animals; Anterior Cruciate Ligament / diagnostic imaging; Anterior Cruciate Ligament / growth & development; Female; Magnetic Resonance Imaging; Posterior Cruciate Ligament / diagnostic imaging; Posterior Cruciate Ligament / growth & development; Swine
TL;DR:
The age‐dependent properties of the ACL and PCL in the female pig mirrored results found in female human patients, suggesting that the porcine model may provide a pre‐clinical platform to study the cruciate ligaments during skeletal growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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