Works Published in 2018
Displaying works 81 - 100 of 192 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 article
Optimized Path Planning for Soft Tissue Resection via Laser Vaporization
CLINICAL AND TRANSLATIONAL NEUROPHOTONICS 2018, Vol. 10480.
author keywords: laser ablation; neurosurgery; automation; robotic surgery; surgical planning; genetic algorithm; optimization
TL;DR:
A novel approach to generating a cutting path for the volumetric resection of tissue using a computer-guided laser scalpel and the ability to control depth and smoothness of cut using genetic algorithms to optimize the ablation parameters and cutting path is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 14, 2019
2018 journal article
Improved osseointegration with as-built electron beam melted textured implants and improved peri-implant bone volume with whole body vibration
MEDICAL ENGINEERING & PHYSICS, 58, 64–71.
author keywords: Additive manufactured implants; Textured implant; Electron beam melting; Bone-implant interface; Osseointegration of Transcutaneous; Prostheses; Whole Body Vibration
TL;DR:
The EBM textured implants exhibited significantly improved mechanical stability independent of vibration, highlighting the benefits of using EBM to produce custom textured surfaces.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 7, 2019
2018 journal article
Cardiac cell-integrated microneedle patch for treating myocardial infarction
SCIENCE ADVANCES, 4(11).
MeSH headings : Animals; Cells, Cultured; Microtechnology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Needles; Rats; Rats, Inbred WKY; Regeneration; Stromal Cells / cytology; Stromal Cells / transplantation; Swine; Tissue Engineering / instrumentation
TL;DR:
The microneedle patch integrated with cardiac stromal cells (MN-CSCs) represents an innovative approach delivering therapeutic cells for heart regeneration and polymeric MNs are used to create “channels” between host myocardium and therapeutic CSCs to promote heart repair.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 31, 2018
2018 review
Blood sampling using microneedles as a minimally invasive platform for biomedical diagnostics
[Review of ]. APPLIED MATERIALS TODAY, 13, 144–157.
author keywords: Blood sampling; Microneedle; Minimally invasive; Hemotological analysis; Point-of-care test
TL;DR:
This review highlights the characteristics of skin structures and the existing blood sampling techniques in clinics and in nature, focusing on several critical aspects of microneedle platforms for transdermal blood extraction and analysis, including materials composition, actuator fabrication, sensing methods and the future prospects toward clinical translation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 31, 2018
2018 journal article
Propylene Glycol in Free-Ranging Green Sea Turtle Plasma
JOURNAL OF FISH AND WILDLIFE MANAGEMENT, 9(2), 598–604.
author keywords: antifreeze; cold adaptation; green sea turtles; metabolomics; nuclear magnetic resonance spectroscopy; propylene glycol
TL;DR:
The presence of propylene glycol in plasma of free-ranging apparently healthy green sea turtles Chelonia mydas and individuals impacted by cold stun syndrome is demonstrated and serves as a starting point for future characterization of lipid metabolism and glycolysis in green sea Turtles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: December 31, 2018
2018 journal article
Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 315(6), G966–G979.
author keywords: adherens junction; chloride channel ClC-2; colonic homeostasis; colonic tumorigenicity; colonoids
MeSH headings : Adherens Junctions / metabolism; Adherens Junctions / pathology; Animals; CLC-2 Chloride Channels; Carcinogenesis / genetics; Carcinogenesis / metabolism; Chloride Channels / genetics; Chloride Channels / metabolism; Colitis, Ulcerative / complications; Colonic Neoplasms / etiology; HT29 Cells; Homeostasis; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Mice; Mice, Inbred C57BL; Signal Transduction; beta Catenin / metabolism
TL;DR:
Disruption of adherens junctions in the absence of chloride channel protein-2 revealed critical functions of these junctional structures, including maintenance of colonic homeostasis and differentiation as well as driving tumorigenicity by regulating β-catenin signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 31, 2018
2018 journal article
The Functional Utilization of Propulsive Capacity During Human Walking
JOURNAL OF APPLIED BIOMECHANICS, 34(6), 474–482.
author keywords: impeding forces; biomechanics; gait; elderly; push-off
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: December 31, 2018
2018 journal article
Muscle Fatigue Post-stroke Elicited From Kilohertz-Frequency Subthreshold Nerve Stimulation
FRONTIERS IN NEUROLOGY, 9.
author keywords: transcutaneous electrical nerve stimulation; electromyography; muscle fatigue; stroke; kilohertz-frequency
TL;DR:
The results indicated that the HF nerve stimulation technique can reduce muscle fatigue in stroke survivors by maintaining a higher efficiency of muscle activations compared with the LF stimulation.
(via Semantic Scholar)
Source: Web Of Science
Added: December 17, 2018
2018 journal article
Deferoxamine-Soaked Suture Improves Angiogenesis and Repair Potential After Acute Injury of the Chicken Achilles Tendon
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE, 6(10).
author keywords: growth factors/healing enhancement; biology of tendon healing of cartilage; Achilles tendon; shoulder; rotator cuff; tendinosis
TL;DR:
A significant increase in hemoglobin content as well as articular zone vessel density in the DFO group compared with the CTL group is evidence of increased angiogenesis in the fibrocartilaginous region of the tendon exposed to DFO.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 10, 2018
2018 journal article
A Monolayer of Primary Colonic Epithelium Generated on a Scaffold with a Gradient of Stiffness for Drug Transport Studies
ANALYTICAL CHEMISTRY, 90(22), 13331–13340.
MeSH headings : Animals; Atenolol / metabolism; Biological Transport / physiology; Caco-2 Cells; Chickens; Collagen / chemistry; Colon / physiology; Epithelium / physiology; Humans; Mice; Propranolol / metabolism; Rhodamine 123 / metabolism; Riboflavin / metabolism; Tissue Engineering / methods
TL;DR:
A collagen scaffold, in which the degree of collagen cross-linking was present as a gradient, was developed to support the proliferation of primary colonic cells, and it is anticipated that this platform of primary Colonic epithelium will find utility in drug development and physiological studies, since the tissue possesses high integrity and active transporters and metabolism similar to that in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 10, 2018
2018 journal article
Mixing and delivery of multiple controlled oxygen environments to a single multiwell culture plate
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 315(5), C766–C775.
author keywords: cell culture; cycling hypoxia; finite element analysis; oxygen diffusion; permeability
MeSH headings : Caco-2 Cells; Cell Culture Techniques / instrumentation; Cell Hypoxia / genetics; Cell Proliferation / genetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / chemistry; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; MCF-7 Cells; Oxygen / chemistry; Oxygen / metabolism
TL;DR:
A 96-well plate-based device that is capable of delivering eight static or dynamically changing oxygen environments to different rows on a single plate that is amenable to multiwell Plate-based molecular assays or drug dose-response studies in static or cycling hypoxia conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 10, 2018
2018 journal article
Analysis of the structural and mechanical effects of procoagulant agents on neonatal fibrin networks following cardiopulmonary bypass
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 16(11), 2159–2167.
author keywords: activated factor VII; cardiopulmonary bypass; fibrin; neonatal coagulation; prothrombin complex concentrate; transfusion
MeSH headings : Blood Coagulation; Blood Coagulation Factors / therapeutic use; Blood Coagulation Tests; Blood Transfusion; Cardiopulmonary Bypass; Coagulants / therapeutic use; Factor VIIa / therapeutic use; Fibrin / chemistry; Fibrinogen / chemistry; Fibrinolysis; Hemorrhage; Hemostatics / therapeutic use; Humans; Infant, Newborn; Neonatology; Recombinant Proteins / therapeutic use; Risk
TL;DR:
Compared neonatal clots formed with cryoprecipitate (SOC) to two procoagulant therapies, which resulted in clots with increased stiffness and decreased fibrinolytic properties may be a viable alternative to SOC treatment for neonatal bleeding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 3, 2018
2018 journal article
Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy
NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.
MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
TL;DR:
It is shown that systemically delivered blood platelets decorated with anti-PD-1 antibodies and conjugated to haematopoietic stem cells reduce the growth and recurrence of leukaemia in mice and significantly augment the therapeutic efficacy of checkpoint blockade.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 26, 2018
2018 journal article
Intestinal Metabolism and Bioaccumulation of Sucralose In Adipose Tissue In The Rat
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 81(18), 913–923.
MeSH headings : Adipose Tissue / metabolism; Animals; Chromatography, High Pressure Liquid; Feces / chemistry; Female; Intestinal Mucosa / metabolism; Male; Rats; Rats, Sprague-Dawley; Sucrose / analogs & derivatives; Sucrose / metabolism; Sucrose / urine; Sweetening Agents / metabolism; Tandem Mass Spectrometry; Time Factors
TL;DR:
New findings of metabolism of sucralose in the gastrointestinal tract (GIT) and its accumulation in adipose tissue were not part of the original regulatory decision process for this agent and indicate that it now may be time to revisit the safety and regulatory status of this organochlorine artificial sweetener.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: November 26, 2018
2018 journal article
Carbon-Fiber Microbiosensor for Monitoring Rapid Lactate Fluctuations in Brain Tissue Using Fast-Scan Cyclic Voltammetry
ANALYTICAL CHEMISTRY, 90(21), 12994–12999.
MeSH headings : Animals; Biosensing Techniques / methods; Carbon Fiber / chemistry; Electrochemical Techniques / instrumentation; Electrochemical Techniques / methods; Enzymes, Immobilized / chemistry; Lactic Acid / analysis; Limit of Detection; Male; Microelectrodes; Mixed Function Oxygenases / chemistry; Neostriatum / metabolism; Rats, Sprague-Dawley; Sensitivity and Specificity
TL;DR:
There is evidence that striatal lactate availability increases biphasically in response to electrical stimulation of the dopaminergic midbrain in the anesthetized rat, and this new tool for real-time detection of lactate dynamics promises to improve understanding of how lactateavailability underscores neuronal function and dysfunction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 26, 2018
2018 journal article
Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltage in vitro and in vivo
LAB ON A CHIP, 18(19), 2985–2993.
MeSH headings : Blood Coagulation; Electricity; Hemostasis; Humans; Microtechnology / instrumentation
TL;DR:
A novel surface treatment using an interdigitated microelectronic device that creates rapid hemostasis in both in vitro and in vivo bleeding models with low applied voltages is reported, representing a new and novel class of hemostatic agents that are electrically-based.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 19, 2018
2018 journal article
Delivery Strategies for Immune Checkpoint Blockade
ADVANCED HEALTHCARE MATERIALS, 7(20).
author keywords: biomaterials; cancer therapy; drug delivery; immune checkpoint blockade; immunotherapy
MeSH headings : Autoimmune Diseases / immunology; Autoimmune Diseases / therapy; Humans; Immunotherapy / methods; Neoplasms / immunology; Neoplasms / therapy
TL;DR:
A brief review summarizes strategies to increase the antitumor immunity, including the local and targeted delivery of checkpoint inhibitors, and a combination of different checkpoint inhibitors or with other therapeutic treatments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 19, 2018
2018 journal article
IN VIVO VISCOELASTIC RESPONSE (VISR) ULTRASOUND FOR CHARACTERIZING MECHANICAL ANISOTROPY IN LOWER-LIMB SKELETAL MUSCLES OF BOYS WITH AND WITHOUT DUCHENNE MUSCULAR DYSTROPHY
ULTRASOUND IN MEDICINE AND BIOLOGY, 44(12), 2519–2530.
author keywords: Viscoelastic response (VisR) ultrasound; Acoustic radiation force; Duchenne muscular dystrophy; Viscoelasticity; Anisotropy; Transverse isotropy
TL;DR:
The results suggest that Viscoelastic Response RE and RV measures reflect differences in mechanical anisotropy associated with functional impairment with dystrophic degeneration that are relevant to monitoring DMD clinically.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 19, 2018
2018 journal article
Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines
BREAST CANCER RESEARCH, 20.
author keywords: Breast cancer vaccine; Autologous tumor cell vaccine; MDSCs; Breast cancer immunogenicity
MeSH headings : Animals; Breast / pathology; Breast Neoplasms / immunology; Breast Neoplasms / pathology; Breast Neoplasms / therapy; CRISPR-Cas Systems; Cancer Vaccines / administration & dosage; Cancer Vaccines / immunology; Cell Line, Tumor / immunology; Cell Line, Tumor / radiation effects; Cell Line, Tumor / transplantation; Disease Models, Animal; Female; Gene Deletion; Granulocyte Colony-Stimulating Factor / genetics; Granulocyte Colony-Stimulating Factor / immunology; Humans; Immunogenicity, Vaccine; Mice; Mice, Inbred BALB C; Neoplasm Recurrence, Local / immunology; Neoplasm Recurrence, Local / prevention & control; Treatment Outcome
TL;DR:
This study demonstrates that genetic ablation of immunosuppressive cytokines, such as G-CSF, can enhance the immunogenicity of breast cancer cell-based vaccines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 12, 2018
2018 journal article
Viscoelastic properties of microgel thin films control fibroblast modes of migration and pro-fibrotic responses
BIOMATERIALS, 185, 371–382.
author keywords: Microgels; Colloidal thin film; Fibroblasts; Mechanotransduction; Self-healing
MeSH headings : Biocompatible Materials / chemistry; Cell Adhesion; Cell Differentiation; Cell Line; Cell Movement; Elastic Modulus; Fibroblasts / cytology; Fibrosis / etiology; Gels / chemistry; Humans; Mechanotransduction, Cellular; Viscosity
TL;DR:
Using microgel thin films with controllable non-linear elastic properties for investigating the role of material loss tangent on cell adhesion, migration, and myofibroblastic differentiation indicates that slight changes in tissue viscoelasticity following injury could contribute to early initiation of fibrotic related responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 12, 2018
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