Works Published in 2018

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Displaying works 101 - 120 of 192 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2018 journal article

Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction

ACS APPLIED MATERIALS & INTERFACES, 10(39), 33088–33096.

By: T. Su n, K. Huang n, M. Daniele n, M. Hensley n, A. Young n, J. Tang n, T. Allen n, A. Vandergriff n ...

author keywords: microvessels; hydrodynamic focusing; cardiac stem cells; cardiomyocyte proliferation; angiogenesis; myocardial infarction
MeSH headings : Animals; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Microfluidic Analytical Techniques; Myocardial Infarction / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Rats; Rats, Nude; Stem Cells / cytology; Stem Cells / physiology
TL;DR: It is shown that the endothelialized BMVs mimicked the natural architecture and function of capillaries and that the resultant vascularized cardiac patch (BMV-CSC patch) exhibited equivalent release of paracrine factors compared to those of coculture of genuine human CSCs and HUVECs after 7 days of in vitro culture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 29, 2018

2018 journal article

Biomimetic Microgels with Controllable Deformability Improve Healing Outcomes

ADVANCED BIOSYSTEMS, 2(10).

By: E. Sproul n, S. Nandi n, C. Roosa n, L. Schreck* & A. Brown n

author keywords: biomimetic; fibrin; microgel; synthetic platelet; wound healing
TL;DR: Hollow PLPs with low degrees of shell crosslinking improve some wound healing outcomes in vivo, recapitulating the clot retraction function of platelets, while other particle types do not. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 29, 2018

2018 journal article

Development of a dynamic index finger and thumb model to study impairment

JOURNAL OF BIOMECHANICS, 77, 206–210.

author keywords: Musculoskeletal modelling; Hand; Stroke
MeSH headings : Biomechanical Phenomena; Electromyography; Fingers / physiology; Humans; Kinetics; Mechanical Phenomena; Models, Biological; Thumb / physiology; Torque
TL;DR: This validated model can provide a means for evaluating clinical interventions and predict the effects of activation deficits on pinch force production and revealed that the intrinsic muscles, especially first dorsal interosseous and adductor pollicis, had a substantial impact on the resulting fingertip force. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: October 19, 2018

2018 article

In Vitro Fatigue Evaluation of Chimney Endovascular Aneurysm Repair: A Case Study

Zhang, R., Crawford, S., Forbes, T., Cole, J. H., & King, M. W. (2018, September). JOURNAL OF VASCULAR SURGERY, Vol. 68, pp. E92–E92.

By: R. Zhang n, S. Crawford*, T. Forbes*, J. Cole n & M. King n

TL;DR: Overall, anatomic success was similar between the two procedures, however, there were notable differences in duplex ultrasound findings postoperatively, and this decline in vein diameter is mild and slower than anticipated. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: October 19, 2018

2018 journal article

Probing the role of proline-135 on the structure, stability, and cell proliferation activity of human acidic fibroblast growth factor

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 654, 115–125.

By: J. Davis*, A. Alghanmi*, R. Gundampati*, S. Jayanthi*, E. Fields*, M. Armstrong*, V. Weidling*, V. Shah* ...

author keywords: Fibroblast growth factor; Heparin binding; Charge-reversal; Bioactivity; Stability
MeSH headings : Cell Proliferation / physiology; Fibroblast Growth Factor 1 / chemistry; Fibroblast Growth Factor 1 / genetics; Fibroblast Growth Factor 1 / physiology; Heparin / metabolism; Humans; Mutagenesis, Site-Directed; Proline / physiology; Protein Binding; Protein Stability; Protein Structure, Tertiary; Proton Magnetic Resonance Spectroscopy; Receptors, Fibroblast Growth Factor / metabolism
TL;DR: The results of this study suggest that while heparin is useful for stabilizing hFGF1 on the cell surface, this interaction is not mandatory for activation of the FGF receptor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Replenishable drug depot to combat post-resection cancer recurrence

BIOMATERIALS, 178, 373–382.

By: Y. Brudno n, M. Pezone, T. Snyder, O. Uzun, C. Moody n, M. Aizenberg, D. Mooney*

author keywords: Biomaterials; Drug delivery; Cancer therapy; Drug depot; Sustained release
MeSH headings : Alginates / chemistry; Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Line, Tumor; Cell Proliferation / drug effects; Click Chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Doxorubicin / therapeutic use; Female; Hydrogels / chemistry; Kinetics; Mice; Neoplasm Recurrence, Local / drug therapy; Neoplasm Recurrence, Local / pathology; Neoplasms / pathology; Neoplasms / surgery; Prodrugs / chemical synthesis; Prodrugs / pharmacology; Prodrugs / therapeutic use; Prodrugs / toxicity; Subcutaneous Tissue / drug effects
TL;DR: A refillable hydrogel depot system based on bioorthogonal click chemistry that captures prodrug refills from the blood and subsequently releases active drugs locally in a sustained manner to improve cancer therapy while eliminating systemic side effects is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 19, 2018

2018 journal article

Advances in transformable drug delivery systems

BIOMATERIALS, 178, 546–558.

By: Q. Hu n, Q. Chen n & Z. Gu n

author keywords: Drug delivery; Stimuli-responsive; Cancer therapy; Transformable formulation
MeSH headings : Animals; Drug Delivery Systems / methods; Extracellular Space / chemistry; Humans; Intracellular Space / chemistry; Microbubbles; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasms / diagnosis; Neoplasms / pathology
TL;DR: This review describes the recently developed intracelluarly and extracellularly transformable DDSs, especially associated with assembly or disassociation of the original formulation units, for achieving various functionalities, including prolonged retention time, inhibited endocytosis and enhanced cytotoxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Orthogonal click reactions enable the synthesis of ECM-mimetic PEG hydrogels without multi-arm precursors

JOURNAL OF MATERIALS CHEMISTRY B, 6(30), 4929–4936.

By: F. Jivan*, N. Fabela*, Z. Davis n & D. Alge*

TL;DR: Characterization and in vitro testing demonstrated that the hydrogels created have highly tunable physicochemical properties and excellent cytocompatiiblity and that stoichiometric control over the crosslinking reaction can be leveraged to leave unreacted norbornene groups in the hydrogram for subsequent hydrogel functionalization via bioorthogonal inverse-electron demand Diels-Alder click reactions with s-tetrazines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: October 19, 2018

2018 journal article

Analysis of Interleukin 8 Secretion by a Stem-Cell-Derived Human-Intestinal-Epithelial-Monolayer Platform

ANALYTICAL CHEMISTRY, 90(19), 11523–11530.

By: Y. Wang*, R. Kim n, S. Hwang*, J. Dutton n, C. Sims* & N. Allbritton n

MeSH headings : Cells, Cultured; Chemokine CCL2 / analysis; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-8 / analysis; Interleukin-8 / metabolism; Intestinal Mucosa / cytology; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Porosity; Stem Cells / cytology; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: Results demonstrate that the described human-intestinal-monolayer platform has the potential for assays and screening of metabolites and compounds that alter the inflammatory response of the intestine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Blind Source Separation-Based Motion Detector for Imaging Super-Paramagnetic Iron Oxide (SPIO) Particles in Magnetomotive Ultrasound Imaging

IEEE TRANSACTIONS ON MEDICAL IMAGING, 37(10), 2356–2366.

author keywords: Blind source separation (BSS); principal component analysis (PCA); motion detection; MMUS imaging; nanoparticles
MeSH headings : Algorithms; Equipment Design; Magnetite Nanoparticles / chemistry; Phantoms, Imaging; Principal Component Analysis; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR: A novel blind source separation-based FPL (BSS-FPL) algorithm is presented for detecting motion using a shorter ensemble length (EL) than FPL and without <inline-formula>, which is an important step toward translating MMUS imaging to <italic>in vivo</italic>, where long tracking ensembles would increase acquisition time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

2018 article

Improving probes for super-resolution

Moore, R. P., & Legant, W. R. (2018, September). NATURE METHODS, Vol. 15, pp. 659–660.

By: R. Moore n & W. Legant n

MeSH headings : DNA; Microscopy, Fluorescence; Oligonucleotides
TL;DR: Chemically modified DNA aptamers enable quantitative super-resolution imaging and improve the quality of high-resolution X-ray diffraction analysis in the nucleus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Engineering PD-1-Presenting Platelets for Cancer Immunotherapy

NANO LETTERS, 18(9), 5716–5725.

author keywords: Drug delivery; platelet; immune checkpoint blockade; immunotherapy; nanomedicine
TL;DR: This work genetically engineered platelets from megakaryocyte progenitor cells to express the programmed cell death protein 1 (PD-1) and found that the PD-1 platelet and its derived microparticle could accumulate within the tumor surgical wound and revert exhausted CD8+ T cells, leading to the eradication of residual tumor cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2018

2018 journal article

Comparing Surface and Intramuscular Electromyography for Simultaneous and Proportional Control Based on a Musculoskeletal Model: A Pilot Study

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 26(9), 1735–1744.

By: D. Crouch*, L. Pan n, W. Filer*, J. Stallings n & H. Huang n

Contributors: D. Crouch*, L. Pan n, W. Filer*, J. Stallings n & H. Huang n

author keywords: Musculoskeletal; model; prosthesis; control; virtual reality; electrodes
MeSH headings : Adult; Amputees; Artificial Limbs; Brain-Computer Interfaces; Computer Systems; Electrodes; Electrodes, Implanted; Electromyography / instrumentation; Electromyography / methods; Female; Hand / physiology; Healthy Volunteers; Humans; Male; Models, Biological; Muscle, Skeletal; Musculoskeletal Physiological Phenomena; Pilot Projects; Psychomotor Performance / physiology; Young Adult
TL;DR: While iEMG may permit targeted recording of EMG, its signal characteristics may not be as ideal for SPC as those of sEMG, and the tradeoff between recording specificity and signal characteristics is an important consideration for development and clinical implementation of SPC for neural-machine interfaces. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 article

Mechanical Stimulation of Adipose-Derived Stem Cells for Functional Tissue Engineering of the Musculoskeletal System via Cyclic Hydrostatic Pressure, Simulated Microgravity, and Cyclic Tensile Strain

ADIPOSE-DERIVED STEM CELLS: METHODS AND PROTOCOLS, 2ND EDITION, Vol. 1773, pp. 215–230.

By: R. Nordberg n, J. Bodle n & E. Loboa*

author keywords: Adipose-derived stem cells; Tissue engineering; Mechanical stimulation; Tensile strain; Hydrostatic pressure; Microgravity; Differentiation; Osteogenesis; Chondrogenesis; Adipogenesis; Protocols; Methods
MeSH headings : Adipose Tissue / cytology; Cell Differentiation; Chondrogenesis; Humans; Hydrostatic Pressure; Mesenchymal Stem Cells / cytology; Musculoskeletal System; Osteogenesis; Primary Cell Culture; Stress, Mechanical; Tensile Strength; Tissue Engineering / methods; Weightlessness Simulation
TL;DR: This chapter describes methods for applying mechanical stimuli to hASC to direct differentiation for functional tissue engineering of the musculoskeletal system. (via Semantic Scholar)
Source: Web Of Science
Added: October 16, 2018

2018 journal article

What to Consider in a Culturally Tailored Technology-Based Intervention?

CIN-COMPUTERS INFORMATICS NURSING, 36(9), 424–429.

author keywords: Challenges; Culturally tailored; Discussion; Internet; Intervention; Issues; Technology
MeSH headings : Asian; Breast Neoplasms / ethnology; Cancer Survivors; Computer Literacy; Confidentiality; Cultural Characteristics; Culturally Competent Care / organization & administration; Female; Health Services Accessibility; Humans; Language; Technology
TL;DR: Practical issues found in the research process included those related to technology literacy and preferences, language issues, cultural attitudes, beliefs, and values, and security and confidentiality issues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Source: Web Of Science
Added: October 16, 2018

2018 journal article

Reduced muscle fatigue using kilohertz-frequency subthreshold stimulation of the proximal nerve

JOURNAL OF NEURAL ENGINEERING, 15(6).

By: Y. Zheng n & X. Hu n

author keywords: transcutaneous electrical nerve stimulation; finger function; electromyography; muscle fatigue; kilohertz frequency; functional electrical stimulation
MeSH headings : Adult; Electric Stimulation / methods; Electromyography; Female; Fingers / physiology; Healthy Volunteers; Humans; Male; Median Nerve / physiology; Motor Neurons / physiology; Muscle Fatigue / physiology; Muscle Fibers, Skeletal / physiology; Peripheral Nerves / physiology; Transcutaneous Electric Nerve Stimulation; Ulnar Nerve / physiology; Young Adult
TL;DR: The findings revealed that the subthreshold kilohertz nerve stimulation can induce temporally and spatially dispersed activation of different motor units with more efficient activation patterns and can potentially reduce muscle fatigue. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: October 16, 2018

2018 journal article

Delayed fatigue in finger flexion forces through transcutaneous nerve stimulation

JOURNAL OF NEURAL ENGINEERING, 15(6).

By: H. Shin n, R. Chen & X. Hu*

author keywords: muscle fatigue; neuromuscular electrical stimulation; nerve stimulation; hand function; muscle activation pattern
MeSH headings : Adult; Algorithms; Electrodes; Electromyography; Fatigue / prevention & control; Female; Fingers / physiology; Healthy Volunteers; Humans; Male; Muscle Contraction / physiology; Muscle Fatigue; Muscle Fibers, Skeletal / physiology; Muscle, Skeletal / physiology; Transcutaneous Electric Nerve Stimulation / methods; Young Adult
TL;DR: The findings demonstrated that the stimulation of the proximal nerve bundles can elicit sustained force output and delayed decrease in the rate of force decline, potentially due to a spatially distributed activation of the muscle fibers, compared with the traditional motor point stimulation. (via Semantic Scholar)
Source: Web Of Science
Added: October 16, 2018

2018 article

Electronic Taste and Smell: The Case for Performance Standards

Nagle, H. T., & Schiffman, S. S. (2018, September). PROCEEDINGS OF THE IEEE, Vol. 106, pp. 1471–1478.

By: H. Nagle n & S. Schiffman n

TL;DR: Why standards for e-noses and e-tongues are needed is described, and IEEE volunteers are called for to participate and collaborate on technical standards development to ensure that machine olfaction and taste provide reliable and reproducible results that are comparable to human smell and taste. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 journal article

Phosphorylcholine-based stealthy nanocapsules decorating TPGS for combatting multi-drug-resistant cancer

ACS Biomaterials-Science & Engineering, 4(5), 1679–1686.

By: G. Liu, H. Tsai, X. Zeng, W. Cheng, L. Jiang, H. Chen, X. Zhang, J. Zhang, L. Mei

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

LITE microscopy: Tilted light-sheet excitation of model organisms offers high resolution and low photobleaching

JOURNAL OF CELL BIOLOGY, 217(5), 1869–1882.

By: T. Fadero*, T. Gerbich*, K. Rana*, A. Suzuki*, M. DiSalvo n, K. Schaefer*, J. Heppert*, T. Boothby* ...

MeSH headings : Animals; Arabidopsis / cytology; Cell Line; Cell Nucleus / metabolism; Fluorescence; Fungi / cytology; Humans; Imaging, Three-Dimensional; Light; Microscopy, Fluorescence / methods; Models, Biological; Photobleaching; Reproducibility of Results; Time-Lapse Imaging
TL;DR: A novel live-cell LSFM method, lateral interference tilted excitation (LITE), in which a tilted light sheet illuminates the detection objective focal plane without a sterically limiting illumination scheme, which is compatible with any detection objective, including oil immersion, without an upper NA limit. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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