Works Published in 2014
Displaying works 121 - 140 of 140 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Microfluidic fabrication of multiaxial microvessels via hydrodynamic shaping
RSC ADVANCES, 4(45), 23440–23446.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Inkjet printing for pharmaceutical applications
MATERIALS TODAY, 17(5), 247–252.
TL;DR:
Piezoelectric inkjet printing may be used to load microneedles and other drug delivery devices with pharmacologic agents and showed biodegradation and antifungal activity against the organism Candida albicans on Sabouraud dextrose agar using an in vitro agar plating method.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Dynamics and evolution of beta-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening
INTEGRATIVE BIOLOGY, 6(7), 673–684.
MeSH headings : Cell Line, Tumor; Clone Cells; Humans; Image Processing, Computer-Assisted; Kinetics; Luminescent Proteins / chemistry; Luminescent Proteins / metabolism; Microscopy, Fluorescence / methods; Wnt Proteins / metabolism; Wnt Signaling Pathway; beta Catenin / metabolism
TL;DR:
A generational-dependent trend in Wnt signaling in A375 cells is revealed that provides insight into the pathway's mechanisms of positive feedback and self-inhibition, which is seen as a challenge to be overcome in the development of novel cell lines and reporter-based assays.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Cytotoxic evaluation of nanostructured zinc oxide (ZnO) thin films and leachates
TOXICOLOGY IN VITRO, 28(6), 1144–1152.
author keywords: Zinc oxide (ZnO); Surface toxicity; Metal leaching; Nanoroughness; Pulsed laser deposition; Macrophage
MeSH headings : Animals; Apoptosis / drug effects; Cell Line; Cell Survival / drug effects; Mice; Nanostructures / chemistry; Nanostructures / toxicity; Necrosis; Zinc Oxide / chemistry; Zinc Oxide / toxicity
TL;DR:
ZnO coatings may produce gradual ion release which becomes toxic after a certain level and should be evaluated using both direct exposure and extraction methods, indicating a tolerable concentration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Cyclic Tensile Strain Enhances Osteogenesis and Angiogenesis in Mesenchymal Stem Cells from Osteoporotic Donors
TISSUE ENGINEERING PART A, 20(1-2), 67–78.
MeSH headings : Aged, 80 and over; Calcium / metabolism; Cell Differentiation; Cell Proliferation; Cell Separation; Female; Gene Expression Regulation; Gene Regulatory Networks; Humans; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / pathology; Neovascularization, Physiologic / genetics; Oligonucleotide Array Sequence Analysis; Osteogenesis / genetics; Osteoporosis, Postmenopausal / genetics; Osteoporosis, Postmenopausal / pathology; Proto-Oncogene Mas; Real-Time Polymerase Chain Reaction; Signal Transduction / genetics; Stress, Mechanical; Tensile Strength; Tissue Donors; White People
TL;DR:
It is demonstrated that hMSC from aged, osteoporotic donors are capable of enhanced osteogenic differentiation in response to 10% cyclic tensile strain with significant increases in the expression of genes associated with enhanced cell proliferation, musculoskeletal development, and angiogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
pH-Responsive and near-infrared-emissive polymer nanoparticles for simultaneous delivery, release, and fluorescence tracking of doxorubicin in vivo
CHEMICAL COMMUNICATIONS, 50(36), 4699–4702.
MeSH headings : Animals; Doxorubicin / administration & dosage; Doxorubicin / analysis; Doxorubicin / pharmacokinetics; Drug Delivery Systems / methods; Fluorescence Resonance Energy Transfer / methods; Fluorescent Dyes / administration & dosage; Fluorescent Dyes / analysis; Fluorescent Dyes / pharmacokinetics; Hydrogen-Ion Concentration; Mice; Nanoparticles / administration & dosage; Nanoparticles / analysis; Nanoparticles / metabolism; Polymers / administration & dosage; Polymers / analysis; Polymers / pharmacokinetics; Spectroscopy, Near-Infrared / methods; Xenograft Model Antitumor Assays / methods
TL;DR:
Dextran modified with pendant acetals is used to load doxorubicin and a near-infrared-emissive conjugated polymer (BTTPF), and this aims to provide selective drug release at therapeutic targets including tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Simultaneous Detection of Dopamine, Ascorbic Acid and Uric Acid at Lithographically-Defined 3D Graphene Electrodes
ELECTROANALYSIS, 26(1), 52–56.
author keywords: Dopamine; Ascorbic acid; Uric acid; Graphene electrodes
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Phase change events of volatile liquid perfluorocarbon contrast agents produce unique acoustic signatures
PHYSICS IN MEDICINE AND BIOLOGY, 59(2), 379–401.
MeSH headings : Acoustics; Contrast Media / chemistry; Fluorocarbons / chemistry; Volatilization
TL;DR:
This study demonstrates through high-speed video microscopy and US interrogation that PCCAs composed of highly volatile perfluorocarbons (PFCs) exhibit unique acoustic behavior that can be detected and differentiated from standard microbubble contrast agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Noninvasive In Vivo Magnetic Resonance Measures of Glutathione Synthesis in Human and Rat Liver as an Oxidative Stress Biomarker
HEPATOLOGY, 59(6), 2321–2330.
MeSH headings : Adult; Animals; Biomarkers / metabolism; Carbon Isotopes; Glutathione / biosynthesis; Glycine; Humans; Liver / metabolism; Magnetic Resonance Imaging; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Translational Research, Biomedical
TL;DR:
In vivo 13C‐labeling and detection of GSH as a biomarker of tissue OS defenses, detecting chronic and acute OS insults are demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Micropallet arrays for the capture, isolation and culture of circulating tumor cells from whole blood of mice engrafted with primary human pancreatic adenocarcinoma
BIOSENSORS & BIOELECTRONICS, 54, 476–483.
author keywords: Microfabrication; Surface functionalization; Cell array; Circulating tumor cells; Cell sorting; Pancreatic cancer
MeSH headings : Adenocarcinoma / blood; Adenocarcinoma / pathology; Animals; Biosensing Techniques / instrumentation; Cell Line, Tumor; Cell Separation / instrumentation; Equipment Design; Female; Humans; Mice; Neoplastic Cells, Circulating / pathology; Pancreatic Neoplasms / blood; Pancreatic Neoplasms / pathology; Tissue Array Analysis / instrumentation
TL;DR:
Clinical utility of this technology was shown through the capture, isolation and successful culture of CTCs from the blood of mice engrafted with primary human pancreatic tumors and direct capture and isolation of living tumor cells from blood followed by analysis or culture will be a valuable tool for cancer cell characterization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Exploiting elasticity: Modeling the influence of neural control on mechanics and energetics of ankle muscle-tendons during human hopping
JOURNAL OF THEORETICAL BIOLOGY, 353, 121–132.
author keywords: Plantarflexors; Locomotion; Muscle mechanics; Metabolic cost; Elastic mechanisms
MeSH headings : Ankle / physiology; Basal Metabolism; Biomechanical Phenomena; Elasticity; Energy Metabolism / physiology; Humans; Models, Biological; Motor Activity / physiology; Muscle Contraction / physiology; Muscle, Skeletal / physiology; Nervous System Physiological Phenomena; Tendons / physiology
TL;DR:
Frequency and amplitude of stimulation both played integral roles in determining CE F-L operating point, with both higher frequency and amplitude generally corresponding to lower CE strains, reduced injury risk, and elimination of the need for passive force generation in the CE parallel elastic element (PEE).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Response of single leukemic cells to peptidase inhibitor therapy across time and dose using a microfluidic device
INTEGRATIVE BIOLOGY, 6(2), 164–174.
MeSH headings : Cell Survival / drug effects; Dose-Response Relationship, Drug; Glycine / administration & dosage; Glycine / analogs & derivatives; Glycine / pharmacology; Humans; Hydroxamic Acids / administration & dosage; Hydroxamic Acids / pharmacology; Leukemia, Myeloid, Acute / drug therapy; Leukemia, Myeloid, Acute / enzymology; Longitudinal Studies; Microscopy, Fluorescence; Peptide Hydrolases / metabolism; Protease Inhibitors / administration & dosage; Protease Inhibitors / pharmacology; Regression Analysis; U937 Cells
TL;DR:
The results suggest that additional enzymes may become inhibited at doses >1 μM and >2 μM, demonstrating the utility of single-cell data to yield novel biological hypotheses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Enhanced Anticancer Efficacy by ATP-Mediated Liposomal Drug Delivery
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(23), 5815–5820.
author keywords: ATP; drug delivery; liposomes; nanomedicine; stimuli-responsive materials
MeSH headings : Adenosine Triphosphate / metabolism; Animals; Drug Delivery Systems / methods; Humans; Liposomes / metabolism; MCF-7 Cells; Mice; Nanomedicine / methods
TL;DR:
Directly delivering extrinsic liposomal ATP promoted the drug release from the fusogenic liposome in the acidic intracellular compartments upon a pH-sensitive membrane fusion and anticancer efficacy was enhanced both in vitro and in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Engineered cytidine triphosphate synthetase with reduced product inhibition
Protein Engineering Design & Selection, 27(7), 225–233.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Biochemical Properties of Tissue-Engineered Cartilage
JOURNAL OF CRANIOFACIAL SURGERY, 25(1), 111–115.
author keywords: Mesenchymal stem cells; chondrogenesis; microtia; nanofibers; tissue engineering; fibrillin; elastin
MeSH headings : Calcium / chemistry; Calcium-Binding Proteins / chemistry; Cartilage / chemistry; Chondrogenesis / physiology; Collagen Type I / chemistry; Collagen Type II / chemistry; Collagen Type X / chemistry; Ear Auricle / abnormalities; Ear Cartilage / chemistry; Elastin / chemistry; Extracellular Matrix Proteins / chemistry; Fibrillins; Glycosaminoglycans / chemistry; Humans; Image Processing, Computer-Assisted / methods; Mesenchymal Stem Cells / physiology; Microfilament Proteins / chemistry; Ribs / chemistry; Tissue Engineering / methods; Umbilical Cord / cytology
TL;DR:
TE cartilage appears to recapitulate the embryonic development of fibrillin III, which is not expressed in adult tissue, possibly providing a strategy to control TE elastic cartilage phenotype.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Ultrasound Molecular Imaging of Secreted Frizzled Related Protein-2 Expression in Murine Angiosarcoma
PLOS ONE, 9(1).
MeSH headings : Animals; Antibodies / chemistry; Biomarkers, Tumor / chemistry; Biomarkers, Tumor / genetics; Biotinylation; Cell Line, Tumor; Contrast Media / pharmacokinetics; Gene Expression; Hemangiosarcoma / blood supply; Hemangiosarcoma / diagnosis; Hemangiosarcoma / diagnostic imaging; Hemangiosarcoma / pathology; Male; Membrane Proteins / chemistry; Membrane Proteins / genetics; Mice; Mice, Nude; Microbubbles; Molecular Imaging / methods; Neoplasm Transplantation; Skin Neoplasms / blood supply; Skin Neoplasms / diagnosis; Skin Neoplasms / diagnostic imaging; Skin Neoplasms / pathology; Streptavidin / chemistry; Ultrasonography
TL;DR:
Molecularly-targeted imaging of SFRP2 visualizes angiosarcoma vessels, but not normal vessels, and intensity increases with tumor size, which may provide a rapid, non-invasive method to monitor tumor regression during therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Facile Fabrication of Color Tunable Film and Fiber Nanocomposites via Thiol Click Chemistry
MACROMOLECULES, 47(2), 695–704.
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Ex Vivo Chemical Cytometric Analysis of Protein Tyrosine Phosphatase Activity in Single Human Airway Epithelial Cells
ANALYTICAL CHEMISTRY, 86(2), 1291–1297.
MeSH headings : Bronchi / cytology; Bronchi / drug effects; Bronchi / enzymology; Cell Line; Electrophoresis, Capillary; Enzyme Inhibitors / pharmacology; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / enzymology; Half-Life; Humans; Hydrolysis; Microinjections; Naphthoquinones / pharmacology; Phosphoproteins / administration & dosage; Phosphoproteins / metabolism; Primary Cell Culture; Protein Tyrosine Phosphatases / analysis; Protein Tyrosine Phosphatases / antagonists & inhibitors; Protein Tyrosine Phosphatases / metabolism; Single-Cell Analysis; Vanadates / pharmacology
TL;DR:
The utility and applicability of the microinjection of a fluorescent phosphopeptide that is hydrolyzed specifically by PTPs for ex vivo quantification of PTP activity in small, heterogeneous, human cells and tissues are demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Loading and knee flexion after stroke: Less does not equal more
JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY, 24(1), 172–177.
author keywords: Stroke; Gait; Force feedback; Stiff-knee gait; Rehabilitation
MeSH headings : Adult; Aged; Biomechanical Phenomena; Chronic Disease; Feedback, Physiological / physiology; Female; Gait / physiology; Gait Disorders, Neurologic / etiology; Gait Disorders, Neurologic / physiopathology; Gait Disorders, Neurologic / rehabilitation; Humans; Knee / physiopathology; Male; Middle Aged; Muscle, Skeletal / physiology; Orthotic Devices; Paresis / etiology; Paresis / physiopathology; Paresis / rehabilitation; Quadriceps Muscle / physiopathology; Reflex, Stretch / physiology; Stroke / complications; Stroke / physiopathology; Stroke Rehabilitation; Weight-Bearing / physiology
TL;DR:
The role of limb loading on knee extensor excitability during the late stance/early swing phase of gait in persons post-stroke was determined and it appears that adjusting limb loading during rehabilitation may not be an effective tool to address stiff-knee gait following stroke.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Computational Sensitivity Analysis to Identify Muscles That Can Mechanically Contribute to Shoulder Deformity Following Brachial Plexus Birth Palsy
JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 39(2), 303–311.
author keywords: Biomechanics; brachial plexus; deformity; shoulder; simulation
MeSH headings : Artificial Intelligence; Biomechanical Phenomena / physiology; Birth Injuries / diagnosis; Birth Injuries / physiopathology; Computer Simulation; Humans; Imaging, Three-Dimensional; Infant, Newborn; Joint Deformities, Acquired / physiopathology; Magnetic Resonance Imaging; Models, Theoretical; Muscle Strength; Muscle, Skeletal / innervation; Muscle, Skeletal / physiopathology; Paresis / diagnosis; Paresis / physiopathology; Posture / physiology; Range of Motion, Articular / physiology; Shoulder Dislocation / physiopathology; Shoulder Joint / innervation; Shoulder Joint / physiopathology
TL;DR:
The infraspinatus, subscapularis, latissimus dorsi, long head of biceps, anterior deltoid, pectoralis major, and longHead of triceps were identified in this computational study as being the most capable of producing shoulder forces that may contribute to shoulder deformity following brachial plexus birth palsy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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