Works Published in 2018
Displaying works 121 - 140 of 192 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels
COLLOIDS AND SURFACES B-BIOINTERFACES, 166, 89–97.
author keywords: Oligoethylene glycol-based microgels; Platelet-like particles; Fibrin clot; Fibrin-targeting antibodies; Elastic modulus; Permeability
MeSH headings : Elastic Modulus; Fibrin / chemistry; Polyethylene Glycols / chemistry; Polymers / chemistry
TL;DR:
PEG-PLP-reinforced fibrin clots exhibit higher degrees of stiffness as demonstrated by the significantly increased average Younǵs modulus, as measured by AFM force spectroscopy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Ultrananocrystalline diamond-coated nanoporous membranes support SK-N-SH neuroblastoma endothelial cell attachment
INTERFACE FOCUS, 8(3).
author keywords: ultrananocrystalline diamond; nanoporous membrane; reactive ion etching; biocompatibility
TL;DR:
Attachment of SK-N-SH cells onto UNCD membranes on both porous regions and solid surfaces was shown, indicating the potential use of UN CD membranes in biomedical applications such as biosensors and tissue engineering scaffolds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 article
Elucidation of the intra- and inter-molecular electron transfer pathways of glucoside 3-dehydrogenase
Miyazaki, R., Yamazaki, T., Yoshimatsu, K., Kojima, K., Asano, R., Sode, K., & Tsugawa, W. (2018, August). BIOELECTROCHEMISTRY, Vol. 122, pp. 115–122.
Contributors: R. Miyazaki*, T. Yamazaki *, K. Yoshimatsu *, K. Kojima*, R. Asano *, K. Sode n , W. Tsugawa *
author keywords: Glucoside 3 dehydrogenase; Electron transfer pathway; FAD; Fe-S cluster; Heme c
MeSH headings : Agrobacterium tumefaciens / chemistry; Agrobacterium tumefaciens / enzymology; Agrobacterium tumefaciens / genetics; Amino Acid Sequence; Catalytic Domain; Electron Transport; Genes, Bacterial; Glucose Dehydrogenases / chemistry; Glucose Dehydrogenases / genetics; Glucose Dehydrogenases / metabolism; Iron-Sulfur Proteins / chemistry; Iron-Sulfur Proteins / genetics; Iron-Sulfur Proteins / metabolism; Multigene Family; Sequence Alignment
TL;DR:
The results suggested that R. radiobacter G3DH possesses an iron‑sulfur cluster that may play an important role in the electron transfer from FAD to cytochrome c like molecule, which is an external electron acceptor of G3 DH.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Cavitation enhancement increases the efficiency and consistency of chromatin fragmentation from fixed cells for downstream quantitative applications
Biochemistry, 57(19), 2756–2761.
MeSH headings : Animals; Cell Cycle Proteins / chemistry; Cell Cycle Proteins / genetics; Chromatin / radiation effects; Chromatin Immunoprecipitation / methods; DNA / chemistry; DNA / genetics; DNA / radiation effects; DNA Fragmentation / radiation effects; Euchromatin / radiation effects; Heterochromatin / radiation effects; Mice; Nanoparticles / chemistry; Octamer Transcription Factor-3 / chemistry; Octamer Transcription Factor-3 / genetics; Sonication / methods
TL;DR:
It is shown that nanodroplets increase sonication efficiency by 16-fold and provide more consistent levels of chromatin fragmentation, which drastically reduces the amount of processing time and provides consistently fragmented chromatin of high quality for downstream applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Variability in circulating gas emboli after a same scuba diving exposure
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 118(6), 1255–1264.
author keywords: Echocardiography; Venous gas emboli; Ultrasound; Decompression sickness; Microbubble
MeSH headings : Adult; Biological Variation, Individual; Decompression Sickness / diagnostic imaging; Decompression Sickness / etiology; Decompression Sickness / physiopathology; Diving / adverse effects; Diving / physiology; Echocardiography; Embolism, Air / diagnostic imaging; Embolism, Air / etiology; Embolism, Air / physiopathology; Humans; Male; Middle Aged; Veins / diagnostic imaging
TL;DR:
Since VGE evolution post-dive varies between people, more work is clearly needed to isolate contributing factors, and going toward a more continuous evaluation, or developing new means to detect decompression stress markers, may offer the ability to better assess dynamic correlations to other physiological parameters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Unexplored therapeutic opportunities in the human genome
NATURE REVIEWS DRUG DISCOVERY, 17(5), 317–332.
TL;DR:
How the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 article
Towards Enhancing Skin Drug Delivery
Gu, Z., & Chen, X. (2018, March 1). ADVANCED DRUG DELIVERY REVIEWS, Vol. 127, pp. 1–2.
MeSH headings : Administration, Cutaneous; Animals; Drug Delivery Systems; Humans; Skin / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
The mechanism of lauric acid-modified protein nanocapsules escape from intercellular trafficking vesicles and its implication for drug delivery
Drug Delivery, 25(1), 985–994.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
The electrochemical behavior of a FAD dependent glucose dehydrogenase with direct electron transfer subunit by immobilization on self-assembled monolayers
Bioelectrochemistry, 121, 1–6.
Contributors: I. Lee *, N. Loew*, W. Tsugawa *, C. Lin *, D. Probst *, J. La Belle*, K. Sode n
MeSH headings : Biosensing Techniques / methods; Blood Glucose / analysis; Blood Glucose / metabolism; Burkholderia cepacia / enzymology; Electrochemical Techniques / methods; Electron Transport; Enzymes, Immobilized / metabolism; Flavin-Adenine Dinucleotide / metabolism; Glucose / analysis; Glucose / metabolism; Glucose 1-Dehydrogenase / metabolism; Humans
TL;DR:
The results indicate the feasibility of controlling the immobilization state of the enzymes on the electrode surface, and the current generated from DET-FADGDH electrodes decreased with increasing length of SAM, suggesting that the DET ability can be affected by the distance between the enzyme and the electrode.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Selective Osmotic Shock for Islet Isolation in the Cadaveric Canine Pancreas
CELL TRANSPLANTATION, 27(3), 542–550.
author keywords: islet isolation; selective osmotic shock; GLUT2; canine; cadaveric
MeSH headings : Animals; Cell Death / physiology; Cell Survival / physiology; Dogs; Female; Glucose / pharmacology; Glucose Transporter Type 2 / metabolism; Islets of Langerhans / metabolism; Male; Osmotic Pressure / drug effects; Osmotic Pressure / physiology
TL;DR:
A novel islet isolation protocol utilizing high concentrations of glucose to cause selective osmotic shock (SOS) provides a widely available means for researchers to isolate canine islets for use in islet transplantation or in studies of canine islet physiology.
(via Semantic Scholar)
journals.sagepub.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Reduction of Muscle Contractions during Irreversible Electroporation Therapy Using High-Frequency Bursts of Alternating Polarity Pulses: A Laboratory Investigation in an Ex Vivo Swine Model
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 29(6), 893–898.
MeSH headings : Animals; Electroporation / methods; Female; In Vitro Techniques; Liver / pathology; Models, Animal; Muscle Contraction / physiology; Swine
TL;DR:
H-FIRE appears to be an effective technique to mitigate the muscle contractions associated with traditional IRE pulses, which may enable the use of voltages greater than 3,000 V necessary for the creation of large ablations in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 review
Potential Synergistic Effects of Stem Cells and Extracellular Matrix Scaffolds
[Review of ]. ACS BIOMATERIALS SCIENCE & ENGINEERING, 4(4), 1208–1222.
Contributors: L. Gaffney n, E. Wrona n & D. Freytes n
author keywords: extracellular matrix (ECM); stem cells; pluripotent stem cells (PSCs); wound healing; macrophage polarization
TL;DR:
This work has shown that extracellular matrix-derived biomaterials, used as scaffolds to help regenerate diseased or damaged tissues, provide a scaffold material with native-like composition and structure through several mechanisms that include chemotactic properties, growth factor release, and modulation of the immune response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 review
Polymeric microneedles for transdermal protein delivery
[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 127, 106–118.
author keywords: Drug delivery; Transdermal; Microneedle; Protein delivery; Vaccine
MeSH headings : Administration, Cutaneous; Drug Delivery Systems; Humans; Microinjections; Needles; Polymers / chemistry; Proteins / administration & dosage; Proteins / metabolism; Proteins / pharmacokinetics; Skin / metabolism
TL;DR:
This review surveys the current design and use of polymeric MNs for transdermal protein delivery and discusses the clinical potential and future translation of MNs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Myoelectric Control Based on a Generic Musculoskeletal Model: Toward a Multi-User Neural-Machine Interface
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 26(7), 1435–1442.
Contributors: L. Pan n, D. Crouch n & H. Huang n
author keywords: Electromyography (EMG); multi-user; neural-machine interface; musculoskeletal model; transradial amputee
TL;DR:
The results suggested that it is possible to design an EMG-driven NMI based on a musculoskeletal model that could fit multiple users, including upper limb amputees, for predicting coordinated MCP and wrist motion.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2018 review
Material Strategies for Modulating Epithelial to Mesenchymal Transitions
[Review of ]. ACS BIOMATERIALS SCIENCE & ENGINEERING, 4(4), 1149–1161.
author keywords: epithelial to mesenchymal transition; EMT; mechanotransduction; fibrosis; development; transforming growth factor beta; EndoMT
TL;DR:
Drivers of the similar process of endothelial to mesenchymal transition (EndoMT) are discussed and corresponding material strategies for controlling EndoMT are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Genetic variants in CPA6 and PRPF31 are associated with variation in response to metformin in individuals with type 2 diabetes
Diabetes, 67(7), 1428–1440.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
EVALUATING RENAL TRANSPLANT STATUS USING VISCOELASTIC RESPONSE (VISR) ULTRASOUND
ULTRASOUND IN MEDICINE AND BIOLOGY, 44(8), 1573–1584.
author keywords: Kidney transplant; Renal rejection; Chronic kidney disease; Viscoelastic response (VisR); Viscoelasticity; Acoustic radiation force impulse; Ultrasound
MeSH headings : Adult; Elasticity; Elasticity Imaging Techniques / methods; Female; Humans; Image Processing, Computer-Assisted / methods; Kidney / diagnostic imaging; Kidney Transplantation; Male; Middle Aged; Postoperative Complications / diagnostic imaging; Prospective Studies; Viscosity
TL;DR:
It is suggested that allografts with scarring and vascular disease can be identified using non-invasive VisR RE and RV metrics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Do triceps surae muscle dynamics govern non-uniform Achilles tendon deformations?
PeerJ, 6.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Development toward a novel integrated tear lactate sensor using Schirmer test strip and engineered lactate oxidase
SENSORS AND ACTUATORS B-CHEMICAL, 270, 525–529.
Contributors: C. Lin *, K. Hiraka *, D. Matloff*, J. Johns*, A. Deng*, K. Sode n , J. La Belle*
author keywords: Tear lactate; Schirmer's test strip; Integrated sensor; Lactate oxidase; Oxygen interference
TL;DR:
The proposed tear lactate (TL) sensor exhibited potential usefulness in providing an alternative noninvasive method of measuring lactate and in calibrating the continuous lactate contact lens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Development of a glucose sensor employing quick and easy modification method with mediator for altering electron acceptor preference
BIOELECTROCHEMISTRY, 121, 185–190.
Contributors: M. Hatada*, N. Loew n, Y. Inose-Takahashi*, J. Okuda-Shimazaki*, W. Tsugawa *, A. Mulchandani *, K. Sode n
author keywords: 2.5th generation biosensor; Electrochemical enzyme sensor; Mediator modification of enzymes; Glucose dehydrogenase; Glucoside 3-dehydrogenase; Lactate oxidase
MeSH headings : Aerococcus / enzymology; Agrobacterium tumefaciens / enzymology; Biosensing Techniques / methods; Blood Glucose / analysis; Botrytis / enzymology; Electron Transport; Enzymes, Immobilized / chemistry; Glucose / analysis; Glucose 1-Dehydrogenase / chemistry; Glucose Dehydrogenases / chemistry; Humans; Mixed Function Oxygenases / chemistry; Phenazines / chemistry; Recombinant Proteins / chemistry
TL;DR:
Various kinds of diagnostic enzymes can achieve quasi-DET ability simply by modification with arPES, suggesting that continuous monitoring systems based on the 2.5th generation principle can be developed for various target molecules.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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