Works Published in 2015

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Displaying works 141 - 160 of 164 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2015 journal article

Osteogenic Differentiation of Human Mesenchymal Stem Cells in 3-D Zr-Si Organic-Inorganic Scaffolds Produced by Two-Photon Polymerization Technique

PLOS ONE, 10(2).

By: A. Koroleva*, A. Deiwick*, A. Nguyen n, S. Schlie-Wolter*, R. Narayan n, P. Timashev*, V. Popov, V. Bagratashvili, B. Chichkov*

MeSH headings : Adipose Tissue / cytology; Alkaline Phosphatase / metabolism; Calcium / metabolism; Cell Culture Techniques / methods; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chemistry Techniques, Synthetic / methods; Elastic Modulus; Hardness; Humans; Inorganic Chemicals / chemistry; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / ultrastructure; Microscopy, Electron, Scanning; Organic Chemicals / chemistry; Osteocalcin / metabolism; Osteogenesis; Polymerization; Reproducibility of Results; Silicon / chemistry; Stem Cells / cytology; Stem Cells / metabolism; Stem Cells / ultrastructure; Time Factors; Tissue Engineering / methods; Tissue Scaffolds / chemistry; Zirconium / chemistry
TL;DR: Analysis of ALP activity, osteocalcin staining and SEM observations of matrix mineralization reveal that mesenchymal stem cells cultured on 3-D scaffolds without osteogenic stimulation spontaneously differentiate towards osteogenic lineage. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Optimization of Contrast-to-Tissue Ratio Through Pulse Windowing in Dual-Frequency “Acoustic Angiography” Imaging

Ultrasound in Medicine & Biology, 41(7), 1884–1895.

author keywords: Microbubbles; Superharmonic; Harmonic; Pulse shape; Pulse window; High-frequency ultrasound; Acoustic angiography; Contrast agent
TL;DR: In this study, shaped transmit pulses were used to image the higher broadband harmonic echoes of microbubble contrast agents, and the effects of varying pulse window and phasing on microbubbles and tissue harmonic echoes were evaluated using a dual-frequency transducer in vitro and in vivo. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2015 article

Meniscus mechanics and mechanobiology

Donahue, T. L. H., Fisher, M. B., & Maher, S. A. (2015, June 1). JOURNAL OF BIOMECHANICS, Vol. 48, pp. 1341–1342.

By: T. Donahue*, M. Fisher n & S. Maher*

UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Engineering meniscus structure and function via multi-layered mesenchymal stem cell-seeded nanofibrous scaffolds

JOURNAL OF BIOMECHANICS, 48(8), 1412–1419.

By: M. Fisher n, E. Henning*, N. Soeegaard, M. Bostrom*, J. Esterhai* & R. Mauck*

author keywords: Tissue engineering; Meniscus; Nanofibrous scaffold; Electrospinning; Mechanical properties
MeSH headings : Animals; Cattle; Cells, Cultured; Collagen / metabolism; Elastic Modulus; Materials Testing; Menisci, Tibial / pathology; Mesenchymal Stem Cells / physiology; Nanofibers / chemistry; Polyesters / chemistry; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR: This study developed multi-lamellar mesenchymal stem cell-seeded nanofibrous constructs that may serve as functional substitutes for the meniscus as well as test beds to understand the complex mechanical principles that enable meniscUS function. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Characterization of a novel N-acetylneuraminic acid lyase favoring N-acetylneuraminic acid synthesis

SCIENTIFIC REPORTS, 5.

By: W. Ji, W. Sun n, J. Feng*, T. Song*, D. Zhang*, P. Ouyang*, Z. Gu n, J. Xie*

MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Biocatalysis; Cloning, Molecular; Corynebacterium glutamicum / chemistry; Corynebacterium glutamicum / classification; Corynebacterium glutamicum / enzymology; Escherichia coli / enzymology; Escherichia coli / genetics; Gene Expression; Hexosamines / metabolism; Hydro-Lyases / chemistry; Hydro-Lyases / classification; Hydro-Lyases / genetics; Hydro-Lyases / metabolism; Kinetics; Molecular Sequence Data; N-Acetylneuraminic Acid / biosynthesis; Oxo-Acid-Lyases / chemistry; Oxo-Acid-Lyases / genetics; Oxo-Acid-Lyases / metabolism; Phylogeny; Pyruvic Acid / metabolism; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sequence Alignment; Substrate Specificity
TL;DR: The biochemical characterization of a novel NAL from a “GRAS” (General recognized as safe) strain C. glutamicum ATCC 13032 suggests that CgNal might have adopted a unique set of residues for substrates recognition and is a promising biocatalyst for industrial Neu5Ac biosynthesis. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

A neuromechanics-based powered ankle exoskeleton to assist walking post-stroke: a feasibility study

JOURNAL OF NEUROENGINEERING AND REHABILITATION, 12.

author keywords: Stroke; Exoskeleton; Gait; Rehabilitation; Ankle
MeSH headings : Aged; Aged, 80 and over; Ankle; Ankle Joint; Artificial Limbs; Biomechanical Phenomena; Bionics; Electromyography; Energy Metabolism; Feasibility Studies; Female; Foot; Humans; Male; Mechanical Phenomena; Middle Aged; Paresis / rehabilitation; Prosthesis Design; Robotics; Stroke Rehabilitation; Walking
TL;DR: This feasibility study demonstrated that the exoskeleton can enhance paretic ankle moment, and appeared to reduce the net metabolic power gradually with each 5 minute repetition, though no statistical significance was found. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Six degree-of-freedom analysis of hip, knee, ankle and foot provides updated understanding of biomechanical work during human walking

JOURNAL OF EXPERIMENTAL BIOLOGY, 218(6), 876–886.

author keywords: Biomechanics; Foot work; Gait analysis; Inverse dynamics; Joint work; Mechanical work
MeSH headings : Adult; Ankle Joint / physiology; Biomechanical Phenomena; Female; Foot / physiology; Hip Joint / physiology; Humans; Knee Joint / physiology; Male; Walking; Young Adult
TL;DR: Six degree-of-freedom (6DOF) analysis of hip–knee–ankle–foot better captures energy changes of the body during gait than conventional 3DOF joint work estimates, revealing increased work contributions from the hip. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Revisiting the mechanics and energetics of walking in individuals with chronic hemiparesis following stroke: from individual limbs to lower limb joints

JOURNAL OF NEUROENGINEERING AND REHABILITATION, 12.

By: D. Farris n, A. Hampton n, M. Lewek* & G. Sawicki n

author keywords: Locomotion; Individual limbs method; Mechanical power; Metabolic power; Joint power; Inverse dynamics; Stroke
MeSH headings : Aged; Ankle Joint / physiopathology; Biomechanical Phenomena; Calorimetry, Indirect; Chronic Disease; Energy Metabolism; Female; Gait; Hip Joint / physiopathology; Humans; Joints / physiopathology; Knee Joint / physiopathology; Locomotion; Lower Extremity / physiopathology; Male; Mechanical Phenomena; Middle Aged; Paresis / etiology; Paresis / physiopathology; Self-Help Devices; Stroke / complications; Stroke / physiopathology
TL;DR: A comparison of the mechanics and energetics of hemiparetic and unimpaired walking at a matched speed highlighted the need to target improving paretic ankle push-off via therapy or assistive technology in order to reduce the metabolic cost of hemIParetic walking. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

NON-INVASIVE IN VIVO CHARACTERIZATION OF HUMAN CAROTID PLAQUES WITH ACOUSTIC RADIATION FORCE IMPULSE ULTRASOUND: COMPARISON WITH HISTOLOGY AFTER ENDARTERECTOMY

ULTRASOUND IN MEDICINE AND BIOLOGY, 41(3), 685–697.

author keywords: Atherosclerosis; Stroke; Plaque characterization; Carotid endarterectomy; Acoustic radiation force impulse; Ultrasound
MeSH headings : Aged; Carotid Artery, Internal / diagnostic imaging; Carotid Stenosis / diagnostic imaging; Carotid Stenosis / surgery; Elasticity Imaging Techniques / methods; Endarterectomy, Carotid; Female; Humans; Male; Middle Aged; Plaque, Atherosclerotic / diagnostic imaging; Predictive Value of Tests; Risk Assessment; Risk Factors; Stroke / prevention & control; Treatment Outcome
TL;DR: In this preliminary study, in vivo ARFI imaging is presented in a case study format for four patients undergoing clinically indicated carotid endarterectomy and compared with histology, illustrating the feasibility and challenges of transcutaneous ARFI for characterizing the material and structural composition of carotids atherosclerotic plaques via mechanical properties, in humans, in vitro. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Microfluidic strategies for design and assembly of microfibers and nanofibers with tissue engineering and regenerative medicine applications

Advanced Healthcare Materials, 4(1).

By: M. Daniele, D. Boyd, A. Adams & F. Ligler

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Micro-elastometry on whole blood clots using actuated surface-attached posts (ASAPs)

LAB ON A CHIP, 15(5), 1385–1393.

By: R. Judith*, J. Fisher*, R. Spero*, B. Fiser*, A. Turner*, B. Oberhardt n, R. Taylor*, M. Falvo*, R. Superfine*

MeSH headings : Blood Coagulation; Humans; Magnetics; Microfluidic Analytical Techniques / instrumentation; Rheology; Stress, Mechanical; Surface Properties
TL;DR: The paper concludes that actuated surface-attached post (ASAP) technology addresses a clinical need for point-of-care and small-volume elastic haemostatic assays and demonstrates its ability to measure stiffness of blood clots as they form. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

CONTRAST-ENHANCED ULTRASOUND IMAGING AND IN VIVO CIRCULATORY KINETICS WITH LOW-BOILING-POINT NANOSCALE PHASE-CHANGE PERFLUOROCARBON AGENTS

ULTRASOUND IN MEDICINE AND BIOLOGY, 41(3), 814–831.

By: P. Sheeran n, J. Rojas n, C. Puett n, J. Hjelmquist n, C. Arena n & P. Dayton n

author keywords: Acoustic droplet vaporization; Perfluoropropane; Perfluorobutane; Microbubble; Ultrasound; Contrast agent; Phase change
MeSH headings : Animals; Contrast Media / chemistry; Contrast Media / pharmacokinetics; Fluorocarbons / chemistry; Fluorocarbons / pharmacokinetics; Kidney / blood supply; Kidney / diagnostic imaging; Kinetics; Microbubbles; Phase Transition; Rats; Rats, Inbred F344; Transducers; Ultrasonography / methods
TL;DR: Low-boiling-point nanoscale PCCAs evaluated in vivo can produce contrast enhancement similar to that of microbubbles and can be designed to circulate for as much as 3.3 times longer than microbubble. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

BIOMATERIALS, 50, 67–74.

By: R. Mo n, T. Jiang n, W. Sun n & Z. Gu n

author keywords: ATP responsive; Graphene oxide; DNA; Drug delivery; Nanomedicine
MeSH headings : Adenosine Triphosphate / pharmacology; Antineoplastic Agents / pharmacology; Cell Death / drug effects; DNA, Single-Stranded / chemistry; Doxorubicin / pharmacology; Drug Delivery Systems; Endocytosis / drug effects; Graphite / chemistry; HeLa Cells; Humans; Intracellular Space / metabolism; Nanoparticles / chemistry; Particle Size; Spectrometry, Fluorescence
TL;DR: This study applied adenosine-5'-triphosphate (ATP), the primary "energy molecule", as a trigger for enhanced release of preloaded drugs responding to the intracellular ATP concentration that is significantly higher than the extracellular level, for targeted on-demand delivery of anticancer drugs inside specific cells. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

A temperature microsensor for measuring laser-induced heating in gold nanorods

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(3), 719–725.

author keywords: Microsensor; Gold nanorods; Temperature; Nanoparticles; Microfluidics
MeSH headings : Chemistry Techniques, Analytical / instrumentation; Chemistry Techniques, Analytical / methods; Equipment Design; Gold; Heating; Hot Temperature; Lasers; Microtechnology; Nanotubes / analysis
TL;DR: The results demonstrate the suitability of this simple temperature microsensor for determining laser-induced heating profiles of metallic nanomaterials; such measurements will be essential for optimizing therapeutic and catalytic applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 article

More is not always better: Modeling the effects of elastic exoskeleton compliance on underlying ankle muscle-tendon dynamics (vol 9, 046018, 2014)

Bioinspiration & Biomimetics, Vol. 10.

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Continuous liquid interface production of 3D objects

SCIENCE, 347(6228), 1349–1352.

By: J. Tumbleston, D. Shirvanyants, N. Ermoshkin, R. Janusziewicz*, A. Johnson n, D. Kelly, K. Chen, R. Pinschmidt ...

TL;DR: The continuous generation of monolithic polymeric parts up to tens of centimeters in size with feature resolution below 100 micrometers is demonstrated and critical control parameters are delineated and shown that complex solid parts can be drawn out of the resin at rates of hundreds of millimeters per hour. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

A real-time, practical sensor fault-tolerant module for robust EMG pattern recognition

JOURNAL OF NEUROENGINEERING AND REHABILITATION, 12(1).

By: X. Zhang* & H. Huang n

Contributors: X. Zhang* & H. Huang n

author keywords: Sensor fault-tolerant; EMG pattern recognition; Real-time; Signal disturbance; Practical; Robust; Outlier detection; Self-recovery
MeSH headings : Algorithms; Amputees; Arm; Artificial Limbs; Bioengineering / instrumentation; Bioengineering / methods; Electromyography / instrumentation; Electromyography / methods; Female; Humans; Pattern Recognition, Automated / methods; Time Factors
TL;DR: The results of the real-time tests suggested that the SFTM was able to handle different types of disturbances investigated in this study and significantly improve the classification performance when one or multiple EMG signals were disturbed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 review

Programmable nanomedicine: synergistic and sequential drug delivery systems

[Review of ]. NANOSCALE, 7(8), 3381–3391.

By: D. Pacardo n, F. Ligler n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; DNA / chemistry; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Resistance, Neoplasm; Humans; Microscopy, Electron, Transmission; Nanomedicine / methods; Nanoparticles / chemistry; Neoplasms / drug therapy; Neoplasms / pathology
TL;DR: This minireview discusses the current advances in programmable nanocarriers for cancer therapy with particular emphasis on synergistic and sequential drug delivery systems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 review

Glucose-responsive synthetic closed-loop insulin delivery systems

[Review of ]. Progress in Chemistry, 27(1), 11–26.

By: Y. Zhang, J. Yu, Q. Shen & Z. Gu

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

A laser ultrasound transducer using carbon nanofibers-polydimethylsiloxane composite thin film

APPLIED PHYSICS LETTERS, 106(2).

By: B. Hsieh n, J. Kim n, J. Zhu n, S. Li n, X. Zhang n & X. Jiang n

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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