Works Published in 2022
Displaying works 161 - 180 of 212 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2022 journal article
Tissue-reactive drugs enable materials-free local depots
JOURNAL OF CONTROLLED RELEASE, 343, 142–151.
author keywords: Sustained release; Materials-free delivery; Paclitaxel; Pancreatic cancer; Extracellular matrix; N-hydroxysuccinimide ester
MeSH headings : Animals; Cell Line, Tumor; Drug Delivery Systems; Drug Liberation; Hydrogels; Mice; Paclitaxel; Pancreatic Neoplasms / drug therapy
TL;DR:
It is demonstrated that locally injected TRAPs create dispersed, stable intratumoral depots deep within mouse and human pancreatic tumor tissues, and had better solubility than free paclitaxel and enabled sustained in vitro and in vivo drug release.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022
2022 article
Platelet-mimicking procoagulant nanoparticles: Potential strategies for mitigating blood shortages
Nellenbach, K., & Brown, A. C. (2022, April 19). JOURNAL OF THROMBOSIS AND HAEMOSTASIS.
MeSH headings : Blood Platelets; Humans; Nanoparticles; Platelet Activation
TL;DR:
A new study has demonstrated the creation of plateletmimicking procoagulant nanoparticles (PPNs) that have advanced platelet function compared with prior designs, and the implications for these new findings in the field of synthetic platelet design are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 2, 2022
2022 journal article
In Vitro Continuous 3 Months Operation of Direct Electron Transfer Type Open Circuit Potential Based Glucose Sensor: Heralding the Next CGM Sensor
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY, 16(5), 1107–1113.
author keywords: FADGDH; direct electron transfer (DET); 3(rd) generation glucose sensor; continuous glucose monitoring (CGM); Open circuit potential (OCP); long-term operation
MeSH headings : Humans; Biosensing Techniques / methods; Blood Glucose; Blood Glucose Self-Monitoring; Electrodes; Electrons; Flavin-Adenine Dinucleotide; Glucose; Gold
TL;DR:
The results suggest that the DET-type OCP glucose sensor is far more stable than the sensor constructed based on the amperometric principle, and is ideal for next generation CGM’s, especially in long duration implantable use cases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 27, 2022
2022 review
Hand function development of children with hemiplegic cerebral palsy: A scoping review
[Review of ]. JOURNAL OF PEDIATRIC REHABILITATION MEDICINE, 15(1), 211–228.
author keywords: Hand function; assessment methods; hemiplegia; cerebral palsy; upper limb
MeSH headings : Biomechanical Phenomena; Cerebral Palsy; Child; Hand; Hemiplegia / etiology; Humans; Physical Therapy Modalities; Upper Extremity
TL;DR:
While several studies have evaluated hand function in children with hCP, the majority relied on clinical scales, assessments, or qualitative descriptions and further assessments of kinematics, kinetics, and muscle activation patterns are needed to identify the underlying impairment mechanisms that should be targeted for treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 25, 2022
2022 article
In Vivo Compositional Changes in the Articular Cartilage of the Patellofemoral Joint Following Anterior Cruciate Ligament Reconstruction
Boling, M. C., Dupell, M., Pfeiffer, S. J., Wallace, K., Lalush, D., Spang, J. T., … Pietrosimone, B. (2022, April 13). ARTHRITIS CARE & RESEARCH.
MeSH headings : Adolescent; Adult; Anterior Cruciate Ligament Injuries / surgery; Anterior Cruciate Ligament Reconstruction / methods; Cartilage, Articular / diagnostic imaging; Cartilage, Articular / surgery; Female; Humans; Knee Joint / surgery; Magnetic Resonance Imaging / methods; Male; Patellofemoral Joint / diagnostic imaging; Patellofemoral Joint / surgery; Young Adult
TL;DR:
To compare T1ρ relaxation times of the medial and lateral regions of the patella and femoral trochlea at 6 and 12 months following anterior cruciate ligament reconstruction (ACLR) on the ACLR and contralateral extremity, a comparison of proteoglycan density of articular cartilage is conducted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: April 25, 2022
2022 review
Non-invasive transcranial ultrasound stimulation for neuromodulation
[Review of ]. CLINICAL NEUROPHYSIOLOGY, 135, 51–73.
author keywords: Transcranial ultrasound stimulation; Neuromodulation; Plasticity; Non-invasive brain stimulation
MeSH headings : Animals; Brain / cytology; Brain / physiology; Evoked Potentials; Humans; Neuronal Plasticity; Neurons / metabolism; Neurons / physiology; Neurons / radiation effects; Ultrasonic Waves; Ultrasonography, Interventional / methods
TL;DR:
This review provides up-to-date information on the physical and neurophysiological mechanisms of TUS, available readouts for its neural and behavioral effects, insights gained from animal models and human studies, potential clinical applications, and safety considerations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 25, 2022
2022 review
Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review
[Review of ]. NANOMATERIALS, 12(7).
author keywords: glucose detection; biosensors; blood; urine; sweat; saliva; tears; interstitial fluid; breath
TL;DR:
This literature review provides a comprehensive update on the recent advances in the field of biofluid-based sensors for glucose level detection in terms of methods, methodology and materials used.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 25, 2022
2022 review
Multimodal Diagnostic Approaches to Advance Precision Medicine in Sarcopenia and Frailty
[Review of ]. NUTRIENTS, 14(7).
author keywords: sarcopenia; sarcopenic obesity; precision medicine; intramuscular fat
MeSH headings : Aged; Aging; Frailty / complications; Frailty / diagnosis; Humans; Obesity; Precision Medicine; Quality of Life; Sarcopenia / complications; Sarcopenia / diagnosis; Sarcopenia / therapy; Syndrome
TL;DR:
Clinical, radiographic, and biological data can be used to evaluate older adults with sarcopenia and sarcopenic obesity and to further the understanding of the mechanisms leading to declines in physical function and frailty.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 25, 2022
2022 journal article
An Iterative Learning Controller for a Switched Cooperative Allocation Strategy During Sit-to-Stand Tasks with a Hybrid Exoskeleton
IEEE Transactions on Control Systems Technology, 30(3), 1021–1036.
author keywords: Iron; Muscles; Exoskeletons; Resource management; Switches; Knee; Control systems; Functional electrical stimulation (FES); hybrid exoskeleton; iterative learning control; neural networks (NNs); powered exoskeleton; virtual constraints
Sources: ORCID, Web Of Science
Added: April 20, 2022
2022 journal article
Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics
PHARMACEUTICS, 14(3).
author keywords: long-acting; in situ; injectable; biodegradable; implants; PLGA; controlled release; drug delivery; ultrasound; pharmacokinetics
TL;DR:
There was no statistical difference in drug exposure regardless of the route of administration or number of injections, and dolutegravir-loaded ISFIs along the range of injection volumes tested were present at 90 days post-injection, suggesting that DTG can prolong ISFI degradation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 18, 2022
2022 article
Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells
Agarwalla, P., Ogunnaike, E. A., Ahn, S., Froehlich, K. A., Jansson, A., Ligler, F. S., … Brudno, Y. (2022, March 24). NATURE BIOTECHNOLOGY, Vol. 3.
MeSH headings : Animals; Antigens, CD19; B-Lymphocytes; Humans; Immunotherapy, Adoptive / methods; Leukocytes, Mononuclear / metabolism; Mice; Receptors, Antigen, T-Cell; T-Lymphocytes
TL;DR:
An implantable Multifunctional Alginate Scaffold for T Cell Engineering and Release (MASTER) that streamlines in vivo CAR-T cell manufacturing and reduces processing time to a single day is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022
2022 journal article
Location of brachial plexus birth injury affects functional outcomes in a rat model
Journal of Orthopaedic Research, 9.
author keywords: brachial plexus; forelimb; gait; musculoskeletal model; rat model
MeSH headings : Animals; Birth Injuries / complications; Brachial Plexus / injuries; Brachial Plexus Neuropathies / complications; Range of Motion, Articular / physiology; Rats; Rotator Cuff; Shoulder Joint
TL;DR:
The results suggest the presence of compensatory motor control strategies during locomotion following BPBI and support emphasis on functional movement analysis in treatment of BPBI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: April 4, 2022
2022 journal article
Is there a trade-off between economy and task goal variability in transfemoral amputee gait?
JOURNAL OF NEUROENGINEERING AND REHABILITATION, 19(1).
Contributors: I. Lee n, B. Fylstra n, M. Liu n, T. Lenzi * & H. Huang n
author keywords: Mechanical energy; Goal equivalent manifold; Transfemoral amputee; Energy recovery rate; Walking
MeSH headings : Amputees; Artificial Limbs; Gait / physiology; Goals; Humans; Walking / physiology
TL;DR:
This study investigated how unilateral transfemoral amputees regulate step and stride variability based on the task to achieve energy economy and found a negative relationship between energy recovery rate and non-goal-equivalent variability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 4, 2022
2022 article
Immunomodulation Strategies for the Successful Regeneration of a Tissue-Engineered Vascular Graft
Zhang, F., & King, M. W. (2022, March 27). ADVANCED HEALTHCARE MATERIALS, Vol. 3.
author keywords: immune response; immunomodulation; macrophage; tissue engineering; tissue-engineered vascular grafts
MeSH headings : Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Humans; Immunity; Immunomodulation; Tissue Engineering
TL;DR:
In this review, the basic concepts of vascular tissue engineering and immunoengineering are considered, the state‐of‐art of TEVGs is summarized and the role of macrophages in TEVG regeneration is analyzed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 31, 2022
2022 journal article
Development of an electrochemical impedance spectroscopy based biosensor for detection of ubiquitin C-Terminal hydrolase L1
BIOSENSORS & BIOELECTRONICS, 208.
author keywords: Traumatic brain injury; Ubiquitin C-Terminal hydrolase L1 (UCH-L1); Electrochemical impedance spectroscopy; Point-of-care testing; Immunosensor
MeSH headings : Biomarkers; Biosensing Techniques; Brain Injuries, Traumatic / diagnosis; Dielectric Spectroscopy; Humans; Ubiquitin Thiolesterase
TL;DR:
This system could detect UCH-L1 within 5 min, without a washing step nor bound/free separation, and had resolution across concentrations ranging from 1 pM to 1000 pM within an artificial serum sample, which makes this platform an attractive candidate for scale-up as a device for rapid, on-site detection of TBI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 30, 2022
2022 journal article
Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy
NATIONAL SCIENCE REVIEW, 9(3).
author keywords: drug delivery; CAR T therapy; microneedle patch; solid tumor treatment; cell delivery
TL;DR:
A porous microneedle patch is implemented that accommodates CAR T cells and allows in situ penetration-mediated seeding ofCAR T cells when implanted in the tumor bed or in the post-surgical resection cavity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 28, 2022
2022 article
EMBER: multi-label prediction of kinase-substrate phosphorylation events through deep learning
Kirchoff, K. E., & Gomez, S. M. (2022, February 14). BIOINFORMATICS.
MeSH headings : Phosphorylation; Deep Learning; Phylogeny; Phosphotransferases; Proteins
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 21, 2022
2022 article
Effect of perfluorocarbon composition on activation of phase-changing ultrasound contrast agents
Mitcham, T. M., Nevozhay, D., Chen, Y., Nguyen, L. D., Pinton, G. F., Lai, S. Y., … Bouchard, R. R. (2022, March 7). MEDICAL PHYSICS.
author keywords: high-frequency ultrasound; nanodroplets; perfluorocarbon contrast agents; ultrasound activation
MeSH headings : Acoustics; Animals; Contrast Media; Fluorocarbons; Mice; Microbubbles; Ultrasonography / methods
TL;DR:
C6‐core PNCAs can provide high‐contrast US imaging with minimal nonspecific activation in phantom and in vivo environments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 21, 2022
2022 article
Development of a Robotic Shear Wave Elastography System for Noninvasive Staging of Liver Disease in Murine Models
Czernuszewicz, T. J., Aji, A. M., Moore, C. J., Montgomery, S. A., Velasco, B., Torres, G., … Gessner, R. C. (2022, February 24). HEPATOLOGY COMMUNICATIONS.
MeSH headings : Animals; Disease Models, Animal; Elasticity Imaging Techniques / methods; Female; Liver Cirrhosis / diagnostic imaging; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease / diagnostic imaging; Reproducibility of Results; Robotic Surgical Procedures
TL;DR:
Robotic SWE in small animals is feasible and sensitive to small changes in liver disease state, facilitating in vivo staging of rodent liver disease with minimal sonographic expertise.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 7, 2022
2022 journal article
An Amine-Reactive Phenazine Ethosulfate (arPES)-A Novel Redox Probe for Electrochemical Aptamer-Based Sensor
SENSORS, 22(5).
author keywords: aptamer; redox probe; amine-reactive phenazine ethosulfate; electrochemical sensor
TL;DR:
The use of amine-reactive phenazine ethosulfate (arPES) for E-AB through its conjugation to the terminus of thrombin-binding aptamer revealed the potential application of arPES for a simultaneous multianalyte detection system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 25, 2022
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