Works Published in 2013

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Displaying works 1 - 20 of 116 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2013 journal article

A multiphase model for three-dimensional tumor growth

New Journal of Physics, 15(1), 015005.

TL;DR: This model can predict and optimize the efficacy of anticancer therapeutic strategies and be further developed to answer questions on tumor biophysics, related to the effects of ECM stiffness and cell adhesion on TC proliferation. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 31, 2023

2013 journal article

Fibroblasts Derived from Human Pluripotent Stem Cells Activate Angiogenic Responses In Vitro and In Vivo

PLoS ONE, 8(12), e83755.

By: Y. Shamis*, E. Silva*, K. Hewitt*, Y. Brudno*, S. Levenberg*, D. Mooney*, J. Garlick*

Ed(s): C. Egles

MeSH headings : Angiogenesis Inducing Agents / metabolism; Angiogenesis Inducing Agents / pharmacology; Animals; Biomarkers / metabolism; Cell Differentiation; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Extremities / blood supply; Extremities / pathology; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; Ischemia / metabolism; Ischemia / pathology; Ischemia / therapy; Mice; Neovascularization, Physiologic; Pericytes / metabolism; Pluripotent Stem Cells / cytology; Pluripotent Stem Cells / metabolism; Proteome; Stem Cell Transplantation
TL;DR: It is demonstrated that stable populations of pericyte-like angiogenic cells can be generated with high efficiency from hESC and hiPSC using a directed differentiation approach, which provides new cell sources and opportunities for vascular tissue engineering and for the development of novel strategies in regenerative medicine. (via Semantic Scholar)
Source: ORCID
Added: July 8, 2023

2013 journal article

Tissue-Engineered Constructs of Human Oral Mucosa Examined by Raman Spectroscopy

Tissue Engineering Part C-Methods, 19(4), 299–306.

By: A. Khmaladze*, A. Ganguly*, S. Kuo*, M. Raghavan*, R. Kainkaryam, J. Cole*, K. Izumi*, C. Marcelo*, S. Feinberg*, M. Morris*

Contributors: A. Khmaladze*, A. Ganguly*, S. Kuo*, M. Raghavan*, R. Kainkaryam, J. Cole*, K. Izumi*, C. Marcelo*, S. Feinberg*, M. Morris*

MeSH headings : Calcium / metabolism; Glucose / metabolism; Humans; Mouth Mucosa; Sirolimus / pharmacology; Spectrum Analysis, Raman / methods; Tissue Engineering
TL;DR: The application of near-infrared Raman spectroscopy to in vitro monitoring of EVPOMEs during their manufacturing process is demonstrated, with the ultimate goal of applying this technology in situ to monitor the grafted EVPomes. (via Semantic Scholar)
Source: ORCID
Added: April 4, 2022

2013 journal article

Oxygen-Dependent Mineralization Differences with High Intrinsic Aerobic Capacity are Associated with Osteoblast Extracellular Matrix Gene Expression

Journal of Bone and Mineral Research, 28(Suppl 1), SA0218. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000332035803130&KeyUID=WOS:000332035803130

By: J. Cole, K. Graf, P. Patel, L. Koch, S. Britton, A. Alford, R. Zernicke, K. Kozloff

Contributors: J. Cole, K. Graf, P. Patel, L. Koch, S. Britton, A. Alford, R. Zernicke, K. Kozloff

Source: ORCID
Added: April 4, 2022

2013 journal article

Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery

Advanced Materials, 25(33), 4641–4645.

By: Y. Zhang*, J. Pelet*, D. Heller*, Y. Dong*, D. Chen*, Z. Gu*, B. Joseph*, J. Wallas*, D. Anderson*

author keywords: siRNA; drug delivery; nanoparticle; gene knockdown; aminoglycoside
MeSH headings : Aminoglycosides / chemistry; Animals; Gene Transfer Techniques; HeLa Cells; Humans; Lipids / chemistry; Mice; RNA, Small Interfering / chemistry; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism
TL;DR: Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. (via Semantic Scholar)
Source: Crossref
Added: April 3, 2022

2013 journal article

Drug Delivery: Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery (Adv. Mater. 33/2013)

Advanced Materials, 25(33), 4680–4680.

By: Y. Zhang*, J. Pelet*, D. Heller*, Y. Dong*, D. Chen*, Z. Gu*, B. Joseph*, J. Wallas*, D. Anderson*

Source: Crossref
Added: April 3, 2022

2013 journal article

Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug

Biomaterials, 34(23), 5792–5801.

By: T. Dang*, A. Thai*, J. Cohen*, J. Slosberg*, K. Siniakowicz*, J. Doloff*, M. Ma*, J. Hollister-Lock* ...

author keywords: Anti-inflammatory drugs; Curcumin; Encapsulated islets; Diabetes; Fibrotic overgrowth; Host response
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use; Capsules / chemistry; Cathepsins / metabolism; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Experimental / therapy; Fibrosis; Islets of Langerhans / drug effects; Islets of Langerhans / immunology; Islets of Langerhans Transplantation; Lactic Acid / chemistry; Male; Mice; Mice, Inbred C57BL; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species / metabolism; Small Molecule Libraries / pharmacology; Small Molecule Libraries / therapeutic use
TL;DR: Results showed that localized administration of anti-inflammatory drug can improve the longevity of encapsulated islets and may facilitate the translation of this technology toward a long-term cure for type I diabetes. (via Semantic Scholar)
Source: Crossref
Added: April 3, 2022

2013 journal article

Degradable polymeric nanocapsule for efficient intracellular delivery of a high molecular weight tumor-selective protein complex

Nano Today, 8(1), 11–20.

By: M. Zhao*, B. Hu*, Z. Gu*, K. Joo*, P. Wang* & Y. Tang*

author keywords: Nanogel; Core-shell; Redox-responsive; Apoptosis; Breast cancer
TL;DR: Intracellularly released apoptin induced tumor-specific apoptosis in several cancer cell lines and inhibited tumor growth in vivo, demonstrating the potential of this polymer–protein combination as an anticancer therapeutic. (via Semantic Scholar)
Source: Crossref
Added: April 3, 2022

2013 journal article

Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions

The Journal of Pathology, 229(1), 25–35.

author keywords: idiopathic pulmonary fibrosis; epithelial-to-mesenchymal transition; fibrosis; stiffness; cell contractility; alveolar epithelial cell
MeSH headings : Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Biomechanical Phenomena; Bleomycin; Cells, Cultured; Cellular Microenvironment; Coculture Techniques; Disease Models, Animal; Elastic Modulus; Epithelial-Mesenchymal Transition; Fibronectins / metabolism; Integrins / metabolism; Laminin / metabolism; Lung / metabolism; Lung / pathology; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Microscopy, Atomic Force; Mink; Nanotechnology; Phenotype; Pulmonary Fibrosis / metabolism; Pulmonary Fibrosis / pathology; Rats; Rats, Sprague-Dawley; Thrombin / metabolism; Time Factors; Transforming Growth Factor beta / metabolism
TL;DR: In vitro research finds that stiff, but not soft, fibronectin substrates induce EMT, a response dependent on cell contraction‐mediated integrin activation of TGFβ. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: October 23, 2021

2013 journal article

Colloid-matrix assemblies in regenerative medicine

Current Opinion in Colloid & Interface Science, 18(5), 393–405.

By: K. Clarke, A. Douglas, A. Brown*, T. Barker & L. Lyon

author keywords: Extracellular matrix; Fibrin; Colloids; Composites; Tissue engineering; Regenerative medicine
TL;DR: This review describes a variety of strategies aimed at reproducing and also simplifying the ECM, and focuses on colloidal particles as potential artificial ECM components that could increase the complexity as modular building blocks. (via Semantic Scholar)
Source: Crossref
Added: October 23, 2021

2013 journal article

The Mechanical Properties of Modified Fibrin Fibers: Blocking the B-b Knob-Pocket Interaction

Biophysical Journal, 104(2), 512a–513a.

By: S. Baker*, A. Carson Brown, T. Barker* & M. Guthold*

TL;DR: Fibrin clot formation was studied to determine the mechanical properties of fibrin fibers modified by blocking the B-b knob-pocket interaction and it was found that the density and lateral aggregation of fibers was hindered byblocking the b-pockets with the synthetic B-knobs. (via Semantic Scholar)
Source: Crossref
Added: October 23, 2021

2013 journal article

Saturated control of an uncertain nonlinear system with input delay

Automatica, 49(6), 1741–1747.

By: N. Fischer*, A. Dani*, N. Sharma* & W. Dixon*

Contributors: N. Fischer*, A. Dani*, N. Sharma* & W. Dixon*

author keywords: Saturated control; Input delay; Nonlinear control; Lyapunov-Krasovskii functional
TL;DR: A Lyapunov-based stability analysis utilizing LyapUNov-Krasovskii (LK) functionals is provided to prove uniformly ultimately bounded tracking despite uncertainties in the dynamics. (via Semantic Scholar)
Source: ORCID
Added: August 12, 2021

2013 conference paper

Optimized control of different actuation strategies for FES and orthosis aided gait

ASME 2013 Dynamic Systems and Control Conference, DSCC 2013, 1.

By: N. Kirsch*, N. Alibeji* & N. Sharma*

Contributors: N. Kirsch*, N. Alibeji* & N. Sharma*

TL;DR: It is shown that dynamic optimization can be used to compute stimulation/torque profiles and their corresponding joint angle trajectories which minimize electrical stimulation and walker push or pull forces. (via Semantic Scholar)
Source: ORCID
Added: August 12, 2021

2013 conference paper

Control of functional electrical stimulation in the presence of electromechanical and communication delays

International IEEE/EMBS Conference on Neural Engineering, NER, 299–302.

By: N. Alibeji*, N. Kirsch* & N. Sharma*

Contributors: N. Alibeji*, N. Kirsch* & N. Sharma*

TL;DR: The experimental results obtained with the new automatic control method, designed to achieve position tracking between a user and the remote manipulator device, show its superior performance in comparison to the proportional integral derivative (PID) controller. (via Semantic Scholar)
Source: ORCID
Added: August 12, 2021

2013 journal article

Adaptive inverse optimal neuromuscular electrical stimulation

IEEE Transactions on Cybernetics, 43(6), 1710–1718.

Contributors: Q. Wang*, N. Sharma*, M. Johnson*, C. Gregory* & W. Dixon*

author keywords: Functional electrical stimulation (FES); inverse optimal control; Lyapunov stability; neural network (NN); neuromuscular electrical stimulation; nonlinear system control
MeSH headings : Adaptation, Physiological / physiology; Adult; Algorithms; Biofeedback, Psychology / methods; Biofeedback, Psychology / physiology; Electric Stimulation Therapy / methods; Humans; Knee Joint / physiology; Male; Muscle Contraction / physiology; Muscle, Skeletal / physiology; Range of Motion, Articular / physiology; Therapy, Computer-Assisted / methods
Source: ORCID
Added: August 12, 2021

2013 journal article

Role of substrate crystallographic characteristics on structure and properties of rutile TiO2 epilayers

Journal of Applied Physics, 114(4), 044314.

By: M. Bayati n, R. Molaei n, J. Budai*, R. Narayan n & J. Narayan n

UN Sustainable Development Goal Categories
Source: Crossref
Added: January 14, 2021

2013 journal article

Prevention of Ultraviolet (UV)-Induced Surface Damage and Cytotoxicity of Polyethersulfone Using Atomic Layer Deposition (ALD) Titanium Dioxide

JOM, 65(4), 550–556.

TL;DR: The results indicate that ALD of TiO2 thin films is a useful technique to protect polymers from UV damage and to retain low cytotoxicity to macrophages and other types of cells that are involved in wound healing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Crossref
Added: January 14, 2021

2013 journal article

Ultrafast switching in wetting properties of TiO2/YSZ/Si(001) epitaxial heterostructures induced by laser irradiation

Journal of Applied Physics, 113(6), 063706.

By: M. Bayati n, S. Joshi*, R. Molaei n, R. Narayan n & J. Narayan n

UN Sustainable Development Goal Categories
Source: Crossref
Added: January 14, 2021

2013 journal article

Biomaterial-mediated delivery of degradative enzymes to improve meniscus integration and repair

Acta Biomaterialia, 9(5), 6393–6402.

By: F. Qu*, J. Lin*, J. Esterhai*, M. Fisher* & R. Mauck*

author keywords: Drug delivery; Enzyme; Meniscus tear; Nanofibrous scaffold; Wound healing
MeSH headings : Animals; Biocompatible Materials; Cattle; Enzymes / administration & dosage; Enzymes / metabolism; Knee Joint / pathology; Microscopy, Electron, Scanning
TL;DR: An innovative approach to targeted enzyme delivery may aid the many patients that exhibit meniscal tears by promoting integration of the defect, thereby circumventing the pathologic consequences of partial meniscus removal, and may find widespread application in the treatment of injuries to a variety of dense connective tissues. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2013 journal article

Organized nanofibrous scaffolds that mimic the macroscopic and microscopic architecture of the knee meniscus

Acta Biomaterialia, 9(1), 4496–4504.

By: M. Fisher*, E. Henning*, N. Söegaard*, J. Esterhai* & R. Mauck*

author keywords: Tissue engineering; Meniscus; Nanofibrous scaffold; Electrospinning; Mechanical properties
MeSH headings : Materials Testing; Menisci, Tibial / anatomy & histology; Menisci, Tibial / ultrastructure; Microscopy, Electron, Scanning; Molecular Mimicry; Nanostructures; Tissue Engineering; Tissue Scaffolds
TL;DR: A novel electrospinning method to produce scaffolds composed of circumferentially aligned (CircAl) nanofibers, quantified their structure and mechanics, and compared them with traditional linearly aligned (LinAl) scaffolds will enable the formation of functional anatomic meniscus constructs. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

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