Works Published in 2011
Displaying all 16 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
Nature, 476(7361), 450.
Source: ORCID
Added: April 8, 2020
2011 journal article
Mechanistic computational model of steroidogenesis in H295R cells: role of oxysterols and cell proliferation to improve predictability of biochemical response to endocrine active chemical—metyrapone
Toxicological Sciences, 123(1), 80–93.
Source: ORCID
Added: April 8, 2020
2011 journal article
RCW 86: A TYPE Ia SUPERNOVA IN A WIND-BLOWN BUBBLE
ASTROPHYSICAL JOURNAL, 741(2).
author keywords: cosmic rays; dust, extinction; ISM: supernova remnants
iopscience.iop.org (publisher PDF)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Sexually dimorphic expression of hypothalamic estrogen receptors α and β and kiss1 in neonatal male and female rats
The Journal of Comparative Neurology, 519(15), 2954–2977.
author keywords: development; anteroventral periventricular nucleus (AVPV); medial preoptic area (MPOA); arcuate nucleus (ARC); kisspeptin; sex differences
MeSH headings : Animals; Autoradiography; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Hypothalamus / anatomy & histology; Hypothalamus / metabolism; Kisspeptins / genetics; Kisspeptins / metabolism; Male; Neurons / cytology; Neurons / metabolism; Pregnancy; Rats; Sex Characteristics; Signal Transduction / physiology
TL;DR:
Detailed profiles of neonatal Kiss1 and ERs mRNA levels will help elucidate the relative roles each plays in the sex‐specific, estrogen‐dependent organization of gonadotropin signaling pathways and provide evidence that Kiss1 may play a role in the sexual dimorphic organization of the neonatal brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
NATURE, 476(7361), 450–U101.
MeSH headings : Aedes / microbiology; Aedes / physiology; Aedes / virology; Animals; Dengue / prevention & control; Dengue / transmission; Dengue / virology; Dengue Virus / classification; Dengue Virus / isolation & purification; Dengue Virus / physiology; Female; Genetic Fitness; Humans; Insect Vectors / microbiology; Insect Vectors / physiology; Insect Vectors / virology; Male; Pest Control, Biological / methods; Reproduction / physiology; Saliva / virology; Wolbachia / classification; Wolbachia / physiology
TL;DR:
The successful transinfection of A. aegypti with the avirulent wMel strain of Wolbachia, which induces the reproductive phenotype cytoplasmic incompatibility with minimal apparent fitness costs and high maternal transmission, providing optimal phenotypic effects for invasion is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Mechanistic Computational Model of Steroidogenesis in H295R Cells: Role of Oxysterols and Cell Proliferation to Improve Predictability of Biochemical Response to Endocrine Active Chemical-Metyrapone
TOXICOLOGICAL SCIENCES, 123(1), 80–93.
author keywords: endocrine disrupting chemicals; mechanistic computational model; in vitro toxicology; metyrapone; H295R cells; steroid biosynthesis
MeSH headings : Adrenocortical Carcinoma / drug therapy; Adrenocortical Carcinoma / metabolism; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Cholesterol / analogs & derivatives; Cholesterol / metabolism; Computational Biology / methods; Endocrine Disruptors / toxicity; Enzyme Inhibitors / toxicity; Humans; Metyrapone / toxicity; Models, Theoretical; Predictive Value of Tests; Steroids / metabolism
TL;DR:
The improvement of the extended, more biologically realistic model to predict CHOL and steroid concentrations in H295R cells and medium and their dynamic biochemical response to the EAC, MET is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat
REPRODUCTIVE TOXICOLOGY, 31(3), 280–289.
author keywords: Soy; Estrogen; Phytoestrogens; Endocrine disruptors; Development; Reproductive; Fertility; Ovary
MeSH headings : Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Arcuate Nucleus of Hypothalamus / pathology; Female; Gene Expression Regulation, Developmental / drug effects; Genistein / toxicity; Hypothalamus / drug effects; Hypothalamus / metabolism; Immunohistochemistry; In Situ Hybridization; Kisspeptins; Midline Thalamic Nuclei / drug effects; Midline Thalamic Nuclei / metabolism; Midline Thalamic Nuclei / pathology; Ovary / drug effects; Ovary / growth & development; Phytoestrogens / toxicity; Proteins / genetics; Proteins / metabolism; RNA, Messenger / analysis; Rats; Rats, Long-Evans; Rats, Wistar; Sex Factors; Sexual Maturation / drug effects; Sexual Maturation / physiology; Signal Transduction / drug effects
TL;DR:
Female rats exposed to the phytoestrogen genistein, estradiol benzoate, or vehicle from post natal day (P) 0-3 via subcutaneous injection were exposed to estrogenic endocrine disrupting compounds to establish sex specific development of KISS gene expression, cell number and neural fiber density across peripuberty.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Gene-drive into insect populations with age and spatial structure: a theoretical assessment
EVOLUTIONARY APPLICATIONS, 4(3), 415–428.
author keywords: age and spatial structure; engineered underdominance; gene drive; release threshold; theoretical assessment
TL;DR:
This study demonstrates that to determine the best method of spatial release, and the total number of engineered insects that must be released, it is important to take into account the age and sex of the released insects and spatial structure of the population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Evaluation of Location-Specific Predictions by a Detailed Simulation Model of Aedes aegypti Populations
PLoS ONE, 6(7), e22701.
Ed(s): E. Ooi
MeSH headings : Aedes; Animals; Argentina; Female; Models, Theoretical; Population Dynamics; Stochastic Processes; Time Factors
TL;DR:
The results show that Skeeter Buster replicates specific population dynamics and spatial structure of Ae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2011 journal article
MEDEA SELFISH GENETIC ELEMENTS AS TOOLS FOR ALTERING TRAITS OF WILD POPULATIONS: A THEORETICAL ANALYSIS
EVOLUTION, 65(4), 1149–1162.
author keywords: Dengue; introgression; malaria; maternal effect; mosquito; population replacement
MeSH headings : Animals; Culicidae / genetics; Disease Transmission, Infectious / prevention & control; Female; Fertility / genetics; Genetic Fitness / genetics; Genetics, Population; Genotype; Insect Vectors / genetics; Male; Models, Genetic; Repetitive Sequences, Nucleic Acid / genetics; Transgenes / genetics
TL;DR:
This work derives equations that describe the conditions under which Medea elements with fitness costs will spread, and the equilibrium allele frequencies are achieved, and suggests that medea elements can drive population replacement under a wide range of conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 article
On the Need for a National (US) Research Program to Elucidate the Potential Risks to Human Health and the Environment Posed by Contaminants of Emerging Concern
Novak, P. J., Arnold, W. A., Blazer, V. S., Halden, R. U., Klaper, R. D., Kolpin, D. W., … Swackhamer, D. L. (2011, May 1). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 45, pp. 3829–3830.
MeSH headings : Animals; Environmental Health / trends; Environmental Pollutants / adverse effects; Environmental Pollution / adverse effects; Humans; Public Health / trends; Research / trends; United States
TL;DR:
This dissertation aims to provide a history of sustainable water management practices in the United States from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including World War II.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness
Hormones and Behavior, 60(2), 185–194.
author keywords: Sex behavior; Endocrine disruptor; Genistein; Estrogen receptor; Partner preference; DPN; Estrogen; Masculinization; Virility; Soy
MeSH headings : Animals; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / agonists; Estrogen Receptor beta / metabolism; Estrogens / pharmacology; Genistein / pharmacology; Male; Mating Preference, Animal / drug effects; Nitriles / pharmacology; Phenols / pharmacology; Phytoestrogens / pharmacology; Propionates / pharmacology; Pyrazoles / pharmacology; Rats; Rats, Long-Evans; Sexual Behavior, Animal / drug effects
TL;DR:
DPN had a greater adverse impact than PPT on reproductive behavior, suggesting a functional role for ERβ in the organization of these male-specific behaviors and EB exposure significantly lowered the testis to body weight ratio, and circulating testosterone levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2011 article
Gender differences in salary and practice ownership expectations of matriculating veterinary students
Bristol, D. G. (2011, August 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 239, pp. 329–334.
MeSH headings : Attitude; Career Choice; Data Collection; Female; Humans; Job Satisfaction; Male; Ownership; Salaries and Fringe Benefits; Sex Factors; Students / psychology; Surveys and Questionnaires; Veterinarians / psychology; Veterinary Medicine
TL;DR:
There was no significant difference in initial salary expectations between male and female students, but men had higher expectations for salary increases over the course of their career, so that expected salary was significantly higher for men than for women 5 years after graduation.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat
NEUROTOXICOLOGY, 32(1), 38–49.
author keywords: Xenoestrogen; Endocrine disruption; Brain; Sexual differentiation; Development; Estrogen receptor; Neuroendocrine
MeSH headings : Age Factors; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / growth & development; Benzhydryl Compounds; Body Weight / drug effects; Body Weight / physiology; Female; Phenols / toxicity; Preoptic Area / drug effects; Preoptic Area / growth & development; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Behavior, Animal / drug effects; Sexual Behavior, Animal / physiology; Ventromedial Hypothalamic Nucleus / drug effects; Ventromedial Hypothalamic Nucleus / growth & development
TL;DR:
The results of this and a prior study indicate that the impact of neonatal BPA Exposure within the female rat hypothalamus is region specific and support the hypothesis that developmental BPA exposure may adversely affect reproductive development in females.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Endocrine Disruption of Brain Sexual Differentiation by Developmental PCB Exposure
ENDOCRINOLOGY, 152(2), 581–594.
MeSH headings : Animals; Estrogen Receptor alpha / metabolism; Female; Gonadotropin-Releasing Hormone / metabolism; Immunohistochemistry; Insulin-Like Growth Factor I / genetics; Kisspeptins; Male; Neurosecretory Systems / drug effects; Polychlorinated Biphenyls / pharmacology; Polymerase Chain Reaction; Pregnancy; Preoptic Area; Proteins / metabolism; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Androgen / genetics; Receptors, N-Methyl-D-Aspartate / genetics; Sex Differentiation / drug effects; Transforming Growth Factor beta / genetics
TL;DR:
The hypothesis that perinatal exposure to polychlorinated biphenyls (PCBs) that disrupt hormonal pathways would perturb reproductive maturation and the sexually dimorphic development of neuroendocrine systems in the preoptic area (POA) is tested and data suggest that developmental PCBs profoundly impair the sexual differentiation of the female hypothalamus.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 333(2), 151–159.
author keywords: Dioxin; Ahr; Antiestrogen; Prl; LH; Estradiol
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / genetics; Aryl Hydrocarbon Hydroxylases / metabolism; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A1 / metabolism; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 CYP1A2 / metabolism; Cytochrome P-450 CYP1B1; Estradiol / pharmacology; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Female; Gene Expression Regulation / drug effects; Glycoprotein Hormones, alpha Subunit / genetics; Glycoprotein Hormones, alpha Subunit / metabolism; Gonadotrophs / cytology; Gonadotrophs / drug effects; Gonadotrophs / metabolism; Immunohistochemistry; In Situ Hybridization; Lactotrophs / cytology; Lactotrophs / drug effects; Lactotrophs / metabolism; Luteinizing Hormone, beta Subunit / genetics; Luteinizing Hormone, beta Subunit / metabolism; Pituitary Gland / cytology; Pituitary Gland / drug effects; Pituitary Gland / enzymology; Polychlorinated Dibenzodioxins / pharmacology; Prolactin / genetics; Prolactin / metabolism; Protein Precursors / genetics; Protein Precursors / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon / genetics; Receptors, Aryl Hydrocarbon / metabolism
TL;DR:
It is found that TCDD upregulated known AhR target genes, cytochrome p450 1a1 (Cyp1a1), Cyp1a2 and Cyp1b1 in the rat pituitary gland, and complex interactions between Ahr and Esr alter Prl and luteinizing hormone (LH) synthesis by direct actions in lactotropes and gonadotropes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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