College of Sciences Administration

Works Published in 2014

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Displaying works 1 - 20 of 22 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2014 article

Weak Convergence of a Seasonally Forced Stochastic Epidemic Model

ArXiv Preprint ArXiv:1412.0964.

By: A. Lloyd & Y. Zhang

Source: ORCID
Added: April 8, 2020

2014 journal article

Time-varying, serotype-specific force of infection of dengue virus

Proceedings of the National Academy of Sciences, 111(26), E2694–E2702.

By: R. Reiner, S. Stoddard, B. Forshey, A. King, A. Ellis, A. Lloyd, K. Long, C. Rocha ...

Source: ORCID
Added: April 8, 2020

2014 journal article

Recasting the theory of mosquito-borne pathogen transmission dynamics and control

Transactions of the Royal Society of Tropical Medicine and Hygiene, 108(4), 185–197.

Alun Lloyd

Source: ORCID
Added: April 8, 2020

2014 journal article

A global assembly of adult female mosquito mark-release-recapture data to inform the control of mosquito-borne pathogens

Parasit Vectors, 7(1), 276.

By: C. Guerra, R. Reiner, T. Perkins, S. Lindsay, J. Midega, O. Brady, C. Barker, W. Reisen ...

Source: ORCID
Added: April 8, 2020

2014 journal article

Accretion in supergiant High Mass X-ray Binaries

EPJ Web of Conferences, 64, 02006.

By: A. Manousakis*, R. Walter* & J. Blondin n

Ed(s): E. Bozzo, P. Kretschmar, M. Audard, M. Falanga & C. Ferrigno

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Crossref, ORCID
Added: February 21, 2020

2014 journal article

Too big to be noticed: cryptic invasion of Asian camel crickets in North American houses

PEERJ, 2.

By: M. Epps n, H. Menninger n, N. LaSala & R. Dunn n

author keywords: Rhaphidophoridae; Diestrammena; Invasive species; Urban ecology; Citizen science
TL;DR: A continental-scale citizen science campaign is launched to better understand the relative distributions and frequency of native and nonnative camel crickets in human homes across North America and reports the establishment in the northeastern United States of a second exotic species, putatively Diestrammena japanica Blatchley, which was previously undocumented in the literature. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Antipathogen genes and the replacement of disease-vectoring mosquito populations: a model-based evaluation

Evolutionary Applications, 7(10), 1238–1251.

author keywords: Aedes aegypti; antipathogen genes; dengue fever; female-killing; ordinary differential equation model; reduce and replace
TL;DR: A mathematical model is utilized to evaluate impacts on competent Aedes aegypti populations of FK, AP, and R&R releases as well as hybrid strategies that result from combinations of these three approaches and discusses the roles that density dependence and inclusion of females play in the order of efficacy of the strategies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2014 journal article

Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II

CURRENT OPINION IN PHARMACOLOGY, 19, 145–152.

By: D. Filer*, H. Patisaul n, T. Schug*, D. Reif n & K. Thayer*

MeSH headings : Animals; Databases, Factual; Endocrine Disruptors / toxicity; High-Throughput Screening Assays; Humans; Models, Theoretical; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR: Results from this exercise suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated, and that some aspects of endocrine disruption are not fully covered in ToxCast. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Urinary Tetrabromobenzoic Acid (TBBA) as a Biomarker of Exposure to the Flame Retardant Mixture Firemaster ® 550

Environmental Health Perspectives, 122(9), 963–969.

MeSH headings : Adult; Aged; Animals; Biomarkers / metabolism; Bromobenzoates / urine; Dust / analysis; Environmental Exposure / analysis; Environmental Pollutants / urine; Female; Flame Retardants / metabolism; Hand; Humans; Male; Mass Spectrometry / methods; Middle Aged; Organophosphates / urine; Phthalic Acids / urine; Polybrominated Biphenyls / urine; Rats
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Soy but not bisphenol A (BPA) induces hallmarks of polycystic ovary syndrome (PCOS) and related metabolic co-morbidities in rats

REPRODUCTIVE TOXICOLOGY, 49, 209–218.

By: H. Patisaul n, N. Mabrey n, H. Adewale n & A. Sullivan n

author keywords: Phytoestrogens; Genistein; Endocrine disruptors; Ovary; Development
MeSH headings : Animals; Benzhydryl Compounds / adverse effects; Diet / adverse effects; Endocrine Disruptors / adverse effects; Female; Ovary / drug effects; Ovary / pathology; Phenols / adverse effects; Polycystic Ovary Syndrome / chemically induced; Polycystic Ovary Syndrome / pathology; Pregnancy; Rats; Rats, Wistar; Soy Foods / adverse effects; Testosterone / blood
TL;DR: Lifetime exposure to a soy diet, containing endocrine active phytoestrogens, but not developmental exposure to the endocrine disrupting monomer bisphenol A (BPA), can induce key features of PCOS in the rat, results which support the hypothesis that hormonally active diets may contribute to risk when consumed throughout gestation and post-natal life. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

A Novel Model for Neuroendocrine Toxicology: Neurobehavioral Effects of BPA Exposure in a Prosocial Species, the Prairie Vole (Microtus ochrogaster)

ENDOCRINOLOGY, 155(10), 3867–3881.

By: A. Sullivan n, E. Beach*, L. Stetzik*, A. Perry*, . Alyssa S. D'Addezio n, B. Cushing*, H. Patisaul n

MeSH headings : Affect / drug effects; Animals; Arvicolinae / physiology; Arvicolinae / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Defense Mechanisms; Endocrine Disruptors / toxicity; Environmental Exposure; Environmental Pollutants / toxicity; Female; Male; Models, Animal; Motor Activity / drug effects; Neurosecretory Systems / drug effects; Phenols / toxicity; Social Behavior; Toxicity Tests
TL;DR: The hypothesis that BPA alters affective behaviors, potentially via disruption of OT/AVP pathways, is supported in the prairie vole, which is more prosocial than lab rats or mice. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Investigation of the Effects of Subchronic Low Dose Oral Exposure to Bisphenol A (BPA) and Ethinyl Estradiol (EE) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus

TOXICOLOGICAL SCIENCES, 140(1), 190–203.

By: M. Rebuli n, J. Cao n, E. Sluzas n, K. Delclos*, L. Camacho*, S. Lewis*, M. Vanlandingham*, H. Patisaul n

author keywords: brain; endocrine disruptor; endocrine disruption; hypothalamus; development; subchronic exposure; sexually dimorphic; ethinyl estradiol; bisphenol A
MeSH headings : Aging / metabolism; Animals; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Estrogen Receptor alpha / genetics; Estrogen Receptor beta / genetics; Ethinyl Estradiol / toxicity; Female; Gene Expression / drug effects; Hypothalamus / drug effects; Hypothalamus / embryology; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / metabolism; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Sex Characteristics
TL;DR: The impact of subchronic exposure from gestation to adulthood to oral doses of BPA below the current no-observed-adverse-effect level (NOAEL) of 5 mg/kg body weight (bw)/day on estrogen receptor (ESR) expression in sexually dimorphic brain regions of prepubertal and adult female rats is examined. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Hypoxia induced changes in expression of proteins involved in iron uptake and storage in cultured lens epithelial cells

EXPERIMENTAL EYE RESEARCH, 125, 135–141.

By: M. Goralska n, L. Fleisher n & M. McGahan n

author keywords: lens; iron; iron proteins; hypoxia
MeSH headings : Animals; Cell Hypoxia / physiology; Cells, Cultured; Dogs; Epithelial Cells / metabolism; Ferritins / metabolism; Gene Expression Regulation; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Oxidative Stress / physiology; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction; Receptors, Transferrin / metabolism; Transferrin / metabolism
TL;DR: Changes in expression of ferritin and Tf/TfR1 in LEC cultured under hypoxic conditions are examined to better protect LEC against oxidative stress by limiting iron-catalyzed ROS formation in the low oxygen environment in which the lens resides. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Hypoxia controls iron metabolism and glutamate secretion in retinal pigmented epithelial cells

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1840(10), 3138–3144.

By: J. Harned n, S. Nagar n & M. McGahan n

author keywords: Iron transport; Glutamate; Hypoxia; Blood-ocular barriers
MeSH headings : Animals; Cell Hypoxia; Cells, Cultured; Dogs; Epithelial Cells / metabolism; Epithelial Cells / pathology; Glutamic Acid / metabolism; Humans; Iron / metabolism; Oxidation-Reduction; Retinal Pigment Epithelium / metabolism; Retinal Pigment Epithelium / pathology; Stroke / metabolism; Stroke / pathology
TL;DR: Iron, a key catalyst of free radical generation, is removed from RPE under hypoxic conditions which may help protect RPE from oxidative stress and indicate the importance of using polarized tight junctional cells as more physiologically relevant models for blood-barrier-like systems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Feasible Introgression of an Anti-pathogen Transgene into an Urban Mosquito Population without Using Gene-Drive

PLOS NEGLECTED TROPICAL DISEASES, 8(7).

MeSH headings : Aedes / genetics; Animals; Animals, Genetically Modified / genetics; Communicable Disease Control / methods; Insect Vectors / genetics; Mosquito Control / methods; Peru; Transgenes / genetics
TL;DR: It is found that releasing mosquitoes carrying only an anti-pathogen construct can substantially decrease vector competence of a natural population, even at release ratios well below that required for the two currently feasible alternatives that rely on population reduction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Time-varying, serotype-specific force of infection of dengue virus

Proceedings of the National Academy of Sciences, 111(26), E2694–E2702.

By: R. Reiner*, S. Stoddard*, B. Forshey*, A. King*, A. Ellis*, A. Lloyd n, K. Long*, C. Rocha* ...

author keywords: disease ecology; emerging infections; arthropod-borne virus
MeSH headings : Dengue / epidemiology; Dengue / transmission; Dengue Virus / genetics; Humans; Longitudinal Studies; Models, Biological; Peru / epidemiology; Public Health Surveillance / methods; Time Factors
TL;DR: The first time-varying (daily), serotype-specific estimates of DENV FoIs are presented using a spline-based fitting procedure designed to examine a 12-y, longitudinal DENV serological dataset from Iquitos, Peru, providing a basis for understanding the persistence of this rapidly emerging pathogen and improving disease prevention programs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

Recasting the theory of mosquito-borne pathogen transmission dynamics and control

Transactions of the Royal Society of Tropical Medicine and Hygiene, 108(4), 185–197.

By: D. Smith*, T. Perkins*, R. Reiner*, C. Barker*, T. Niu*, L. Chaves*, A. Ellis*, D. George* ...

author keywords: Dengue; Filariasis; Malaria; Mosquito-borne pathogen transmission; Vector control; West Nile virus
MeSH headings : Animals; Culicidae; Humans; Insect Vectors; Models, Biological; Models, Theoretical; Parasitic Diseases / prevention & control; Parasitic Diseases / transmission
TL;DR: Novel mathematical approaches show how heterogeneity arises from the biology and the landscape on which the processes of mosquito biting and pathogen transmission unfold, and point to the capacity to model heterogeneous, focal transmission as the most important but relatively unexplored component in current theory. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

A global assembly of adult female mosquito mark-release-recapture data to inform the control of mosquito-borne pathogens

Parasites & Vectors, 7(1), 276.

By: C. Guerra*, R. Reiner*, T. Perkins*, S. Lindsay*, J. Midega*, O. Brady*, C. Barker*, W. Reisen* ...

author keywords: Mosquito; Vector; Mark-release-recapture; Database; Pathogen transmission models
MeSH headings : Animals; Communicable Diseases / transmission; Culicidae / microbiology; Culicidae / parasitology; Culicidae / physiology; Female; Global Health; Humans; Insect Vectors; Male; Mosquito Control; Population Dynamics; Species Specificity
TL;DR: A comprehensive database describing adult female MMRR experiments involving 58 vector mosquito species from the three main genera of importance to human health, revealing patterns associated with geography as well as mosquito genus consistent with bionomics varying by species-specific life history and ecological context. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 article

Sex-specific Esr2 mRNA expression in the rat hypothalamus and amygdala is altered by neonatal bisphenol A exposure

Cao, J., Joyner, L., Mickens, J. A., Leyrer, S. M., & Patisaul, H. B. (2014, April). REPRODUCTION, Vol. 147, pp. 537–554.

By: J. Cao*, L. Joyner, J. Mickens*, S. Leyrer & H. Patisaul*

MeSH headings : Amygdala / drug effects; Amygdala / growth & development; Amygdala / metabolism; Animals; Animals, Newborn; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Gene Expression Regulation, Developmental / drug effects; Hypothalamus / drug effects; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Rats; Rats, Long-Evans; Sex Factors; Sexual Behavior, Animal / drug effects; Social Behavior
TL;DR: Testing the hypothesis that neonatal bisphenol A exposure can alter sex-specific postnatal Esr2 (Erβ) expression in brain regions fundamental to sociosexual behavior in rat demonstrates that region- and sex- specific EsR2 expression is vulnerable to neonatal BPA exposure in regions of the developing brain critical to socIosexual behavior. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components

TOXICOLOGY LETTERS, 228(2), 93–102.

By: S. Belcher*, C. Cookman*, H. Patisaul n & H. Stapleton*

author keywords: Apoptosis Endocrine disruptor; Flame retardant; Nuclear receptors; Obesity; Peroxisome proliferator-activated receptor
MeSH headings : Adipocytes / drug effects; Animals; CHO Cells; Caspase 3 / metabolism; Cell Survival / drug effects; Cricetinae; Cricetulus; Endocrine Disruptors / toxicity; Flame Retardants / toxicity; Humans; Ligands; Organophosphates / chemistry; Organophosphates / toxicity; Organotin Compounds / toxicity; PPAR gamma / drug effects; PPAR gamma / metabolism; Receptors, Cytoplasmic and Nuclear / drug effects; Transcriptional Activation / drug effects
TL;DR: The resulting data indicated that the primary metabolic disruptive effects of FM 550 were likely mediated by the activity of the triarylphosphates at PPARγ, and have identified TPP as a candidate metabolic disruptor that also acts as a cytotoxicant. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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