College of Sciences Administration

Works Published in 2018

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Displaying works 1 - 20 of 24 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2018 journal article

Teaching the Concept Effort to Research Faculty

Journal of Abstract Concepts.

Jennifer Williams

Source: ORCID
Added: September 15, 2020

2018 journal article

Contributions from the silent majority dominate dengue virus transmission

PLOS Pathogens, 14(5), e1006965.

By: Q. Bosch, H. Clapham, L. Lambrechts, V. Duong, P. Buchy, B. Althouse, A. Lloyd, L. Waller ...

Source: ORCID
Added: April 8, 2020

2018 journal article

Efficacy of Aedes aegypti control by indoor Ultra Low Volume (ULV) insecticide spraying in Iquitos, Peru

PLoS Neglected Tropical Diseases, 12(4), e0006378.

By: C. Gunning, K. Okamoto, H. Astete, G. Vasquez, E. Erhardt, C. Del Aguila, R. Pinedo, R. Cardenas ...

Source: ORCID
Added: April 8, 2020

2018 journal article

Endocrine disruptors and the developing immune system

Current Opinion in Toxicology, 10, 31–36.

TL;DR: The role of endocrine disruption in DIT is considered and endocrine disrupting chemicals (EDCs) with known DIT effects are highlighted, of special importance are microglia, the resident immune cells of the central nervous system that are highly influenced by endogenous endocrine signals during development and are therefore sensitive to effects from exposure to EDCs. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2018 journal article

The NIEHS TaRGET II Consortium and environmental epigenomics

Nature Biotechnology, 36(3), 225–227.

By: T. Wang*, E. Pehrsson*, D. Purushotham*, D. Li*, X. Zhuo*, B. Zhang, H. Lawson*, M. Province* ...

MeSH headings : Environmental Exposure / adverse effects; Epigenomics; Genome / drug effects; Humans; National Institute of Environmental Health Sciences (U.S.); United States
TL;DR: It is critical to determine whether epigenetic alterations are conserved across tissues in such a way that easily sampled surrogate tissues could be used to assess the impact of environmental exposure on diseaserelevant but inaccessible target tissues. (via Semantic Scholar)
Source: Crossref
Added: January 25, 2020

2018 journal article

Nucleus accumbens core medium spiny neuron electrophysiological properties and partner preference behavior in the adult male prairie vole, Microtus ochrogaster

Journal of Neurophysiology, 119(4), 1576–1588.

By: J. Willett n, A. Johnson n, A. Vogel n, H. Patisaul n, L. McGraw n & J. Meitzen n

author keywords: electrophysiology; medium spiny neuron; nucleus accumbens; rat; vole
MeSH headings : Action Potentials / physiology; Animals; Arvicolinae / physiology; Excitatory Postsynaptic Potentials / physiology; Male; Mating Preference, Animal / physiology; Neurons / physiology; Nucleus Accumbens / physiology; Patch-Clamp Techniques; Social Behavior
TL;DR: It is found that decreases in miniature excitatory postsynaptic current amplitude and the slope of the evoked action potential firing rate to depolarizing current injection weakly associated with increased preference for the partnered female, suggests that exciteatory synaptic strength and neuronal excitability may be decreased in MSNs in males exhibiting stronger preference for a partnered female. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019

2018 journal article

Individual Variation in Social Behaviours of Male Lab-reared Prairie voles (Microtus ochrogaster) is Non-heritable and Weakly Associated with V1aR Density

Scientific Reports, 8(1).

By: A. Vogel, H. Patisaul*, S. Arambula, F. Tiezzi & L. McGraw

MeSH headings : Animals; Arvicolinae / physiology; Basal Forebrain / metabolism; Female; Male; Mating Preference, Animal; Pair Bond; Receptors, Vasopressin / metabolism; Social Behavior
TL;DR: Heritability estimates of variation in partner preference were low, yet heritability estimates for V1aR expression were high, indicating that the extensive variation in Partner preference observed within this population is due largely to environmental plasticity. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 17, 2019

2018 journal article

Environmental Mechanisms of Neurodevelopmental Toxicity

Current Environmental Health Reports, 5(1), 145–157.

author keywords: Neurodevelopment; Neurotoxicity; Xenobiotic; Neuroendocrine; Neuroimmune
MeSH headings : Brain / drug effects; Brain / growth & development; Environmental Exposure / adverse effects; Humans; Immune System / drug effects; Neurodevelopmental Disorders / chemically induced; Neurosecretory Systems / drug effects; Oxidative Stress / drug effects
TL;DR: Recent findings regarding novel mechanisms of developmental neurotoxicity are reported on and emerging areas of interest include neuroendocrine and immune disruption, as well as indirect toxicity via actions on other organs such as the gut and placenta are highlighted. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 17, 2019

2018 journal article

CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems

Basic & Clinical Pharmacology & Toxicology, 10.

author keywords: Bisphenol A; CLARITY-BPA; endocrine disruptor; endocrine-disrupting chemical; oestrogen
MeSH headings : Animals; Benzhydryl Compounds / toxicity; Congresses as Topic; Disease Models, Animal; Ecotoxicology / methods; Ecotoxicology / standards; Endocrine Disruptors / toxicity; Environmental Exposure / adverse effects; Environmental Pollutants / toxicity; Female; Fetal Development / drug effects; Guidelines as Topic; Humans; National Institute of Environmental Health Sciences (U.S.) / standards; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / prevention & control; Rats, Sprague-Dawley; Risk Assessment / methods; Risk Assessment / standards; Toxicity Tests / methods; Toxicity Tests / standards; United States; United States Food and Drug Administration / standards
TL;DR: The findings highlighted herein corroborate a significant body of evidence that documents adverse effects of BPA at doses relevant to human exposures and emphasizes the need for updated risk assessment analysis. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 17, 2019

2018 journal article

Novel unconditioned prosocial behavior in prairie voles (Microtus ochrogaster) as a model for empathy

BMC Research Notes, 11(1).

By: L. Stetzik*, A. Sullivan n, H. Patisaul n & B. Cushing*

MeSH headings : Animals; Arginine Vasopressin / genetics; Arginine Vasopressin / metabolism; Arvicolinae / physiology; Arvicolinae / psychology; Behavior, Animal / physiology; Cooperative Behavior; Dopaminergic Neurons / cytology; Dopaminergic Neurons / metabolism; Empathy / physiology; Female; Gene Expression; Humans; Hypothalamus / cytology; Hypothalamus / metabolism; Male; Models, Animal; Oxytocin / genetics; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / cytology; Paraventricular Hypothalamic Nucleus / metabolism; Tyrosine 3-Monooxygenase / genetics; Tyrosine 3-Monooxygenase / metabolism
TL;DR: The consistency between neuroanatomical mechanisms linked to empathy, and the durations of time spent engaging in empathic contact, support the prediction that the empathy contact in this test is a distinct prosocial behavior, lacking prior behavioral training or the naturally occurring ethological relevance of other prosocial behaviors, and is a measure of empathy. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 17, 2019

2018 journal article

IR-MALDESI mass spectrometry imaging of underivatized neurotransmitters in brain tissue of rats exposed to tetrabromobisphenol A

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410(30), 7979–7986.

By: M. Bagley n, M. Ekelof n, K. Rock n, H. Patisaul n & D. Muddiman n

author keywords: IR-MALDESI; Neurotransmitters; Mass spectrometry imaging; Exposomics; Orbitrap
MeSH headings : Animals; Brain; Female; Infrared Rays; Neurotransmitter Agents / chemistry; Polybrominated Biphenyls / toxicity; Rats; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: This study serves as a demonstration of a new application of IR-MALDESI, namely that neurotransmitter distributions can be confidently and rapidly imaged without derivatization, and is used for the analysis of neurotransmitters in the brains of rats exposed to TBBPA in gestation and lactation through their mothers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 3, 2018

2018 journal article

An approach to periodic, time-varying parameter estimation using nonlinear filtering

Inverse Problems, 34(10), 105005.

author keywords: time-varying parameter estimation; periodic structure; nonlinear filtering; ensemble Kalman filter (EnKF); FitzHugh-Nagumo; measles transmission
TL;DR: An approach to estimating periodic, time-Varying parameters that imposes periodic structure by treating the time-varying parameter as a piecewise function with unknown coefficients is presented, allowing the resulting parameter estimate more flexibility in shape than prescribing a specific functional form to model its behavior. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: October 19, 2018

2018 journal article

Investigating the Structure of Vela X

ASTROPHYSICAL JOURNAL, 865(2).

author keywords: acceleration of particles; ISM: individual objects (Vela X); ISM: supernova remnants; shock waves
Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 journal article

Efficacy of Aedes aegypti control by indoor Ultra Low Volume (ULV) insecticide spraying in Iquitos, Peru

PLOS Neglected Tropical Diseases, 12(4), e0006378.

By: C. Gunning n, K. Okamoto n, H. Astete*, G. Vasquez*, E. Erhardt*, C. Del Aguila*, R. Pinedo*, R. Cardenas* ...

Ed(s): R. Barrera

MeSH headings : Aedes / drug effects; Aedes / physiology; Animals; Female; Insect Vectors / drug effects; Insect Vectors / physiology; Insecticides / analysis; Insecticides / toxicity; Male; Mosquito Control / methods; Peru; Pyrethrins / analysis; Pyrethrins / toxicity
TL;DR: The results demonstrate that densities of adult Ae. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2018 journal article

Animal models of endocrine disruption

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 32(3), 283–297.

author keywords: vole; peromyscus; toxicology; neurosciences; collaborative cross; PFOA
MeSH headings : Animals; Disease Models, Animal; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Endocrine System Diseases / chemically induced; Endocrine System Diseases / pathology; Environmental Exposure / adverse effects; Environmental Illness / chemically induced; Environmental Illness / pathology; Humans; Reproducibility of Results; Reproduction / drug effects; Reproduction / physiology
TL;DR: Advances in genomics, neuroimaging and other tools are making a wider range of animal models more widely available to EDC researchers, and a greater diversity of species are used to effectively model more subtle but significant outcomes such as changes in pubertal timing, mammary gland development, and social behaviors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Invasion and migration of spatially self-limiting gene drives: A comparative analysis

Evolutionary Applications, 11(5), 794–808.

By: S. Dhole n, M. Vella n, A. Lloyd n & F. Gould n

author keywords: Cas9; CRISPR; daisy-chain drive; gene drive; population alteration; underdominance
TL;DR: Differences in the minimum release size required for successfully driving a payload into a population and in the extent of population alteration are found, which could affect the suitability of each gene drive for specific applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2018 article

Introduction to the special issue on endocrine disrupting chemicals and behavior

Barrett, E. S., & Patisaul, H. B. (2018, May). HORMONES AND BEHAVIOR, Vol. 101, pp. 1–2.

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Contributions from the silent majority dominate dengue virus transmission

PLOS Pathogens, 14(5), e1006965.

Ed(s): N. Ferguson

MeSH headings : Aedes / virology; Animals; Dengue / diagnosis; Dengue / transmission; Dengue / virology; Dengue Virus / pathogenicity; Disease Reservoirs / virology; Host-Pathogen Interactions; Humans; Models, Biological; Mosquito Vectors / virology; Viremia / diagnosis; Viremia / transmission; Viremia / virology
TL;DR: The need to reorient current practices for outbreak response to adoption of pre-emptive strategies that account for contributions of undetected infections in surveillance programs, when assessing intervention impact, and when modeling mosquito-borne virus transmission is emphasized. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2018 journal article

Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study

NEUROTOXICOLOGY, 65, 207–220.

By: S. Arambula n, D. Jima n & H. Patisaul n

author keywords: Endocrine disruptor; EDC; Brain; Oxytocin; Sex difference; Estrogen; Androgen
MeSH headings : Amygdala / drug effects; Amygdala / metabolism; Animals; Animals, Newborn; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Ethinyl Estradiol / pharmacology; Female; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / metabolism; Rats; Sex Characteristics; Signal Transduction / drug effects; Transcriptome / drug effects
TL;DR: It is demonstrated that that prenatal BPA exposure can disrupt the transcriptome of the neonate amygdala, at doses below the FDA No Observed Adverse Effect Level (NOAEL), in a sex‐specific manner and indicate that the female amygdala may be more sensitive to BPA Exposure during fetal development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 personal communication

The NIEHS TaRGET II Consortium and environmental epigenomics

By: T. Wang, E. Pehrsson, D. Purushotham, D. Li, X. Zhuo, B. Zhang, H. Lawson, M. Province ...

Source: NC State University Libraries
Added: August 6, 2018

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