College of Sciences Administration

Works Published in 2023

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Displaying works 1 - 20 of 21 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2023 journal article

Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat

TOXICOLOGICAL SCIENCES, 191(2), 357–373.

By: A. Newell n, V. Kapps n, Y. Cai n, M. Rai, G. St Armour n, B. Horman n, K. Rock n, S. Witchey n, A. Greenbaum n, H. Patisaul n

author keywords: neurodevelopment; monoamine; OPFR; OPE; flame retardants; neurotransmitters; neurotoxicity; neurotoxicology; prenatal; reproductive and developmental toxicology; mesocortical dopamine system; tissue clearing light sheet microscopy.
TL;DR: Results indicate maternal exposure to OPFRs alters the development trajectory of the embryonic dopaminergic system and adds to growing evidence of OPFR developmental neurotoxicity. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 12, 2024

2023 journal article

Modeling impact of vaccination on COVID-19 dynamics in St. Louis

JOURNAL OF BIOLOGICAL DYNAMICS, 17(1).

By: A. Lacy*, M. Igoe*, P. Das n, T. Farthing n, A. Lloyd n, C. Lanzas n, A. Odoi*, S. Lenhart*

author keywords: Modeling COVID-19 spread; St. Louis area; SafeGraph movement data; vaccination; differential equations
TL;DR: This work investigates how human mobility, vaccination, and time-varying transmission rates influenced SARS-CoV-2 transmission in five counties in the St. Louis area and predicted the changes in disease spread under scenarios with increased vaccination coverage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID
Added: December 18, 2023

2023 journal article

Uncovering the common factors of chemical exposure and behavior: Evaluating behavioral effects across a testing battery using factor analysis

NEUROTOXICOLOGY, 99, 264–273.

By: W. Marinello n, S. Gillera n, L. Huang n, J. Rollman n, D. Reif n & H. Patisaul n

author keywords: EDCs; Endocrine disruptors; Neurodevelopment; Neurotoxicology; Organophosphate; Flame retardants; Vole; Behavior
Sources: Web Of Science, ORCID
Added: December 18, 2023

2023 journal article

Developmental organophosphate flame retardant exposure disrupts adult hippocampal neurogenesis in Wistar rats

NEUROTOXICOLOGY, 99, 104–114.

By: A. Newell n & H. Patisaul n

author keywords: Neurodevelopment; OPFR; OPE; Flame retardants; Neurotoxicity; Neurotoxicology; Postnatal; Reproductive and developmental toxicology; Hippocampus; Dentate gyrus; Adult hippocampal neurogenesis
TL;DR: Results indicate that developmental OPFR exposure has significant, sex specific impacts on multiple markers of AHN in the dentate gyrus of rats, and further elucidate the developmental neurotoxic properties of OPFRs and highlight the importance of including sex as a biological variable in neurotoxicology research. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: December 11, 2023

2023 journal article

Inapparent infections shape the transmission heterogeneity of dengue

PNAS NEXUS, 2(3).

By: G. Vazquez-Prokopec*, A. Morrison*, V. Paz-Soldan*, S. Stoddard*, W. Koval*, L. Waller*, T. Perkins*, A. Lloyd n ...

author keywords: arbovirus; transmission heterogeneity; mobility; super-spreading
TL;DR: Marked heterogeneity in dengue case distribution, and the role of inapparent infections in defining it, highlight major challenges faced by reactive interventions if those transmission units contributing the most to transmission are not identified, prioritized, and effectively treated. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: October 23, 2023

2023 journal article

Gestational exposure to FireMaster® 550 (FM 550) disrupts the placenta-brain axis in a socially monogamous rodent species, the prairie vole (<i>Microtus ochrogaster</i>)

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 576.

By: W. Marinello n, S. Gillera n, Y. Han*, J. Richardson*, G. St Armour n, B. Horman n, H. Patisaul n

author keywords: Pregnancy; EDCs; Endocrine disruptors; Neurotoxicology; Developmental toxicology; Organophosphate
TL;DR: Prairie voles are used, a monogamous and bi-parental rodent, leveraged for decades to decipher the underpinnings of social behaviors, to examine the impact of fetal FR exposure on gene targets in the mid-gestational placenta and fetal brain and provide insights on the mechanisms by which FRs impair neurodevelopment and later in life social behaviors. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: October 16, 2023

2023 journal article

Direct mosquito feedings on dengue-2 virus-infected people reveal dynamics of human infectiousness

PLOS NEGLECTED TROPICAL DISEASES, 17(9).

By: L. Lambrechts*, R. Reiner*, M. Briesemeister*, P. Barrera*, K. Long*, W. Elson*, A. Vizcarra*, H. Astete* ...

TL;DR: It is concluded that mildly ill DENV-infected humans with similar levels of viremia during the first two days after symptom onset will be most infectious to mosquitoes on the second day of their illness. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: October 16, 2023

2023 article

Evidence for a prehistoric multifault rupture along the southern Calico fault system, Eastern California Shear Zone, USA

Vadman, M. J., Garvue, M. M., Spotila, J. A., Bemis, S. P., Stamps, D. S., Owen, L. A., & Figueiredo, P. M. (2023, September 8). GEOSPHERE.

By: M. Vadman*, M. Garvue*, J. Spotila*, S. Bemis*, D. Stamps*, L. Owen n, P. Figueiredo n

Source: Web Of Science
Added: October 16, 2023

2023 journal article

Skeletal effects following developmental flame-retardant exposure are specific to sex and chemical class in the adult Wistar rat

FRONTIERS IN TOXICOLOGY, 5.

author keywords: endocrine disrupting chemicals; flame retardants; sex difference; osteotoxicology; computed tomography; bone
TL;DR: Although sex specificity was expected due to the sexual dimorphic nature of skeletal physiology, the mechanisms accounting for the male- and female-specific phenotypes remain to be determined and future work aims to clarify these unresolved issues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023

2023 journal article

CRISPR/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukii

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 120(25).

By: A. Yadav n, C. Butler n, A. Yamamoto n, A. Patil n, A. Lloyd n & M. Scott n

author keywords: gene drive; CRISPR; Drosophila suzukii; spotted wing Drosophila; doublesex
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 21, 2023

2023 review

Leveraging eco-evolutionary models for gene drive risk assessment

[Review of ]. TRENDS IN GENETICS, 39(8), 609–623.

By: M. Combs*, A. Golnar*, J. Overcash*, A. Lloyd n, K. Hayes*, . David A. O'Brochta*, K. Pepin*

TL;DR: This work synthesizes gene drive dynamic modeling studies to highlight research trends, knowledge gaps, and emergent principles, organized around their genetic, demographic, spatial, environmental, and implementation features. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 14, 2023

2023 article

New insights into the paleoseismic history of the Mae Hong Son Fault, Northern Thailand (vol 10, 921049, 2022)

Chansom, C., Jitmahantakul, S., Owen, L. A. A., Wiwegwin, W., & Charusiri, P. (2023, June 8). FRONTIERS IN EARTH SCIENCE, Vol. 11.

By: C. Chansom*, S. Jitmahantakul*, L. Owen n, W. Wiwegwin & P. Charusiri*

author keywords: active fault; paleoearthquake; Mae Hong Son Fault; Mae Hong Son Basin; Mae Sariang Basin; OSL dating
Source: Web Of Science
Added: July 31, 2023

2023 article

Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure

Newell, A. J., Jima, D., Reading, B., & Patisaul, H. B. (2023, July 3). TOXICOLOGICAL SCIENCES, Vol. 7.

By: A. Newell n, D. Jima n, B. Reading n & H. Patisaul n

author keywords: artificial intelligence; toxicogenomics; neurodevelopment; OPFR; OPE; flame retardants; neurotoxicology; hippocampus; cortex; placenta
TL;DR: It is shown how machine learning can complement more traditional analytical approaches to identify vulnerable "signature" pathways disrupted by chemical exposures and biomarkers of exposure. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: July 24, 2023

2023 journal article

Fusing an agent-based model of mosquito population dynamics with a statistical reconstruction of spatio-temporal abundance patterns

PLOS COMPUTATIONAL BIOLOGY, 19(4).

By: S. Cavany*, G. Espana*, A. Lloyd n, G. Vazquez-Prokopec*, H. Astete*, L. Waller*, U. Kitron*, T. Scott* ...

MeSH headings : Animals; Mosquito Vectors / physiology; Population Dynamics; Zika Virus; Yellow fever virus; Chikungunya virus; Aedes; Zika Virus Infection; Dengue / epidemiology
TL;DR: An approach which fuses mechanistic realism and statistical flexibility into a single model that is able to accurately reproduce abundance patterns in Iquitos and produce a realistic response to adulticide spraying, while retaining sufficient flexibility to be applied across a range of settings is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: May 30, 2023

2023 article

Human occupation, site formation, and chronostratigraphy of a mid-Holocene archaeological site at the eastern Pampa-Patagonia transition, Argentina

Martinez, G., Martinez, G. A., & Owen, L. A. (2023, April 12). QUATERNARY RESEARCH.

author keywords: Hunter-gatherers; Geoarchaeology; Mid-Holocene; OSL; Dunes; Arid/Semiarid landscapes; Taphonomic and geologic bias; Eastern Pampa-Patagonia Transition; Argentina
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: Web Of Science
Added: May 22, 2023

2023 journal article

Quantifying heterogeneities in arbovirus transmission: Description of the rationale and methodology for a prospective longitudinal study of dengue and Zika virus transmission in Iquitos, Peru (2014-2019)

PLOS ONE, 18(2).

By: A. Morrison*, V. Paz-Soldan*, G. Vazquez-Prokopec*, L. Lambrechts*, W. Elson*, P. Barrera*, H. Astete*, V. Briesemeister* ...

MeSH headings : Humans; Zika Virus; Longitudinal Studies; Dengue Virus; Dengue; Prospective Studies; Peru / epidemiology; Zika Virus Infection / epidemiology; Arboviruses
TL;DR: This manuscript provides the rationale and comprehensive, integrated description of the methodology for a five-year longitudinal cohort study based in the tropical city of Iquitos, in the heart of the Peruvian Amazon to better determine the type and extent of effort needed to better prevent virus transmission and disease. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: May 15, 2023

2023 journal article

Widespread glacier advances across the Tian Shan during Marine Isotope Stage 3 not supported by climate-glaciation simulations

FUNDAMENTAL RESEARCH, 3(1), 102–110.

author keywords: Glacier modeling; Glacier sensitivity; MIS 3; MIS 2; Tian Shan; Paleoclimate modeling
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: Web Of Science
Added: March 13, 2023

2023 journal article

A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement

ENVIRONMENTAL HEALTH, 21(SUPPL 1).

By: T. Woodruff*, S. Rayasam*, D. Axelrad*, P. Koman*, N. Chartres*, D. Bennett*, L. Birnbaum*, P. Brown* ...

author keywords: Chemicals; Conflicts of Interest; Environmental Health; Environmental Justice; EPA; Hazard Identification; Health Equity; Risk Assessment; TSCA
MeSH headings : Humans; Environmental Exposure / adverse effects; Environmental Exposure / prevention & control; Environmental Health; Environmental Pollutants / analysis; Public Health; Risk Assessment; Consensus Development Conferences as Topic
TL;DR: Consensus recommendations for health-protective, scientific approaches to reduce harmful chemical exposures are developed, which can be applied to current US policies governing industrial chemicals and environmental pollutants. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: March 6, 2023

2023 review

Advancing the science on chemical classes

[Review of ]. ENVIRONMENTAL HEALTH, 21(SUPPL 1).

By: M. Maffini*, S. Rayasam, D. Axelrad*, L. Birnbaum*, C. Cooper, S. Franjevic, P. MacRoy, K. Nachman* ...

author keywords: Chemical class; Regulation; Decision-making; Toxic chemicals; Risk assessment; Chemical grouping; Ortho-phthalates
MeSH headings : Humans; Hazardous Substances / toxicity; Risk Assessment / methods
TL;DR: Evaluation of how classes of chemicals are defined and used identified commonalities and differences based on regulatory frameworks, risk assessments, and business strategies and identified that using a class-based approach could result in a more efficient process to reduce exposures to multiple hazardous chemicals and, ultimately, reduce health risks. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: March 6, 2023

2023 journal article

A simple model for viral decay dynamics and the distribution of infected cell life spans in SHIV-infected infant rhesus macaques

MATHEMATICAL BIOSCIENCES, 356.

author keywords: Modified Gompertz model; HIV viral decay; SHIV; Stochastic modeling; Infected cell lifespan; Uncertainty quantification
MeSH headings : Animals; Macaca mulatta; HIV Infections; Simian Immunodeficiency Virus; HIV-1; Longevity; Viral Load
TL;DR: The Gompertz model is modified to include a linear term that modulates the decay rate, and it is found that the dynamics of viral decay in this model of infant HIV infection and treatment may be explained by a distribution of cell lifespans, rather than two distinct cell types. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: February 27, 2023

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