Bioinformatics Research Center

Works Published in 2006

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Displaying all 6 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2006 journal article

Dependence among sites in RNA evolution

MOLECULAR BIOLOGY AND EVOLUTION, 23(8), 1525–1537.

author keywords: RNA secondary structure; dependence among sites; substitution rate
MeSH headings : Animals; Computer Simulation; Evolution, Molecular; Markov Chains; Nucleic Acid Conformation; Phylogeny; RNA / chemistry; RNA / genetics; RNA, Ribosomal / chemistry; RNA, Ribosomal / genetics; Sequence Analysis, RNA
TL;DR: An evolutionary model and a Bayesian inference procedure that are aimed at filling the gap in probabilistic models of genotype evolution are proposed and potential applications, including improved ancestral sequence inference and location of functionally interesting sites, are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

A population-based latent variable approach for association mapping of quantitative trait loci

ANNALS OF HUMAN GENETICS, 70, 506–523.

author keywords: association mapping; maximum likelihood; haplotype; latent variable; EM algorithm
MeSH headings : Algorithms; Chromosome Mapping; Computer Simulation; Genetics, Population / methods; Humans; Likelihood Functions; Linkage Disequilibrium / genetics; Models, Genetic; Quantitative Trait Loci; Statistics as Topic
TL;DR: Under a general likelihood framework, an EM‐based algorithm is developed to estimate genetic effects of the QTL and haplotype frequencies of theQTL and markers jointly and provides a joint test for association between a quantitative trait and marker genotypes without requiring adjustment for the multiple testing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Multiple-interval mapping for ordinal traits

GENETICS, 173(3), 1649–1663.

MeSH headings : Algorithms; Chromosome Mapping; Computer Simulation; Crosses, Genetic; Epistasis, Genetic; Models, Statistical; Quantitative Trait Loci
TL;DR: This study extends MIM to ordinal traits on the basis of a threshold model and inherits the properties and advantages of MIM and can fit a model of multiple QTL effects and epistasis on the underlying liability score. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Validation of two major quantitative trait loci for fusarium head blight resistance in Chinese wheat line W14

PLANT BREEDING, 125(1), 99–101.

By: J. Chen n, C. Griffey n, M. Maroof n, E. Stromberg n, R. Biyashev n, W. Zhao n, M. Chappell n, T. Pridgen n, Y. Dong n, Z. Zeng n

author keywords: Triticum aestivum; Fusarium head blight; microsatellite; QTL mapping
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Models and partition of variance for quantitative trait loci with epistasis and linkage disequilibrium

BMC Genetics, 7.

By: T. Wang & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Testing for spatial clustering of amino acid replacements within protein tertiary structure

JOURNAL OF MOLECULAR EVOLUTION, 62(6), 682–692.

author keywords: protein tertiary structure; protein evolution; spatial clustering
MeSH headings : Amino Acid Substitution; Cluster Analysis; Evolution, Molecular; Protein Structure, Tertiary; Statistics, Nonparametric
TL;DR: Two simple and not very parametric hypothesis tests are introduced that help distinguish three possibilities of spatial clustering of amino acid replacements during evolution and these findings need to be reconciled with the common practice of basing evolutionary inferences on models that assume independent change among sites. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

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