Bioinformatics Research Center

Works Published in 2008

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Displaying all 8 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2008 journal article

Statistical Methods for Mapping Multiple QTL

International Journal of Plant Genomics, 2008, 1–8.

TL;DR: This article focuses the discussion on the statistical methods for mapping multiple QTL by maximum likelihood and Bayesian methods and also on determining appropriate thresholds for the analysis. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2008 journal article

Quantitative Trait Loci Mapping and The Genetic Basis of Heterosis in Maize and Rice

GENETICS, 180(3), 1707–1724.

MeSH headings : Chromosome Mapping; Crosses, Genetic; Epistasis, Genetic; Hybrid Vigor / genetics; Models, Genetic; Oryza / genetics; Quantitative Trait Loci; Zea mays / genetics
TL;DR: The results show that heterosis in maize is mainly due to dominant gene action, although overdominance of individual QTL could not completely be ruled out due to the mapping resolution and limitations of NC design III. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Basing population genetic inferences and models of molecular evolution upon desired stationary distributions of DNA or protein sequences

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 363(1512), 3931–3939.

author keywords: variable-length Markov model; profile hidden Markov model; insertion-deletion model; scaled selection coefficient; fitness; Pfam
MeSH headings : Computer Simulation; DNA / genetics; Evolution, Molecular; Genetics, Population; INDEL Mutation / genetics; Markov Chains; Models, Genetic; Population Density; Proteins / genetics; Selection, Genetic
TL;DR: This work explores how to construct time-reversible evolutionary models that yield stationary distributions of sequences that match given target distributions, and introduces an insertion–deletion model that describes selectively neutral evolutionary changes to DNA. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Rates of nucleotide substitution in Cornaceae (Cornales)-Pattern of variation and underlying causal factors

MOLECULAR PHYLOGENETICS AND EVOLUTION, 49(1), 327–342.

author keywords: Comus; Cornaceae; Divergence time; Rate of molecular evolution; Rate of morphological evolution; Speciation
MeSH headings : Bayes Theorem; Chloroplasts / genetics; Cornus / anatomy & histology; Cornus / classification; Cornus / genetics; DNA, Chloroplast / genetics; DNA, Plant / genetics; Evolution, Molecular; Fossils; Genes, Plant; Genetic Speciation; Genome, Chloroplast; Models, Genetic; Nucleotides / genetics; Phylogeny; Sequence Analysis, DNA
TL;DR: This study examined the rate and pattern of molecular evolution for five DNA regions over a phylogeny of Cornus, the single genus of Cornaceae, and suggested a possible localized link between species richness and rate of nonsynonymous nucleotide substitution for the combined cpDNA regions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Does strong linkage disequilibrium guarantee redundant association results?

GENETIC EPIDEMIOLOGY, 32(6), 546–552.

author keywords: linkage disequilibrium; association mapping; negative correlation; case control; transmission disequilibrium
MeSH headings : Computer Simulation; Gene Frequency; Genetic Markers; Genome, Human; Haplotypes; Humans; Linkage Disequilibrium; Models, Genetic; Models, Statistical; Phenotype; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable
TL;DR: This work finds that in the null hypothesis situation, where there is no association between the markers and the phenotype, the relationship between LD and the correlation between association test outcomes is clear, though it is not always ideal. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants

BMC Genomics, 9.

By: L. Huang, A. Heinloth, Z. Zeng, R. Paules & P. Bushel

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

From classical genetics to quantitative genetics to systems biology: Modeling epistasis

PLoS Genetics, 4(3).

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Measuring and partitioning the high-order linkage disequilibrium by multiple order Markov chains

GENETIC EPIDEMIOLOGY, 32(4), 301–312.

author keywords: multilocus linkage disequilibrium; multiple order Markov chains; partition of multilocus LID
MeSH headings : Biometry; Databases, Genetic; Epidemiologic Methods; Gene Frequency; Haplotypes; Humans; Likelihood Functions; Linkage Disequilibrium; Markov Chains; Models, Genetic
TL;DR: Non‐homogeneous, multiple order Markov Chain models are employed as a statistical framework to measure and partition the LD among multiple markers into components due to different orders of marker associations and the results reveal that the most LD in the HapMap data is attributed to the LD between adjacent pairs of markers across the whole region. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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