Bioinformatics

Works Published in 2012

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Displaying works 21 - 36 of 36 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2012 journal article

Evaluation of Polymorphisms in the Sulfonamide Detoxification Genes CYB5A and CYB5R3 in Dogs with Sulfonamide Hypersensitivity

JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(5), 1126–1133.

By: J. Funk-Keenan*, J. Sacco *, Y. Wong*, S. Rasmussen*, A. Motsinger-Reif n & L. Trepanier *

author keywords: Genotype; Idiosyncratic; Potentiated sulfonamide; Predisposition
MeSH headings : Animals; Cytochrome-B(5) Reductase / genetics; Cytochrome-B(5) Reductase / immunology; Cytochromes b5 / genetics; Cytochromes b5 / immunology; Dog Diseases / genetics; Dog Diseases / immunology; Dogs; Drug Hypersensitivity / etiology; Drug Hypersensitivity / genetics; Drug Hypersensitivity / immunology; Drug Hypersensitivity / veterinary; Female; Genotype; Liver / enzymology; Liver / immunology; Male; Polymorphism, Genetic; RNA / chemistry; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Sulfonamides / adverse effects
TL;DR: The CYB5R3 729GG variant may contribute to the risk of sulfonamide HS in dogs and functional characterization of this polymorphism, as well as genotyping in a larger number of HS and TOL dogs, is warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Assessing the utility of whole genome amplified DNA as a template for DMET Plus array

Clinical Chemistry and Laboratory Medicine, 50(8), 1329–1334.

By: Y. He, A. Misher, W. Irvin, A. Motsinger-Reif, H. McLeod & J. Hoskins

Source: NC State University Libraries
Added: August 6, 2018

2012 article

Comparison of venous sampling methods for thromboelastography in clinically normal dogs

Walker, J. M., Hanel, R. M., Hansen, B. D., & Motsinger-Reif, A. A. (2012, December). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 1864–1870.

By: J. Walker n, R. Hanel*, B. Hansen* & A. Motsinger-Reif*

MeSH headings : Animals; Blood Platelets / physiology; Dogs / blood; Male; Phlebotomy / methods; Phlebotomy / veterinary; Thrombelastography / methods; Thrombelastography / veterinary
TL;DR: Different sampling methods resulted in small but significant differences in thromboelastographic values, but all of these sampling methods were acceptable for 1-time clinical use. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Ranking Transitive Chemical-Disease Inferences Using Local Network Topology in the Comparative Toxicogenomics Database

PLOS ONE, 7(11).

By: B. King *, A. Davis n, M. Rosenstein*, T. Wiegers n & C. Mattingly n 

MeSH headings : Cluster Analysis; Databases, Factual; Drug-Related Side Effects and Adverse Reactions / genetics; Gene Regulatory Networks; Humans; Protein Interaction Mapping; Toxicogenetics / methods
TL;DR: A statistic to score and rank inferences based on the topology of the local network consisting of the chemical, disease and each of the genes used to make an inference is implemented, which uniquely takes into account the number of common neighbors and the connectivity of each entity involved. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Impaired plasmalogens in patients with schizophrenia

Psychiatry Research, 198(3), 347–352.

By: R. Kaddurah-Daouk, J. McEvoy, R. Baillie, H. Zhu, J. Yao, V. Nimgaonkar, P. Buckley, M. Keshavan, A. Georgiades, H. Nasrallah

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile

Scientific Reports, 2.

By: R. Kaddurah-Daouk, P. Yuan, S. Boyle, W. Matson, Z. Wang, Z. Zeng, H. Zhu, G. Dougherty ...

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Twice-Daily Application of HIV Microbicides Alters the Vaginal Microbiota

MBIO, 3(6).

By: J. Ravel *, P. Gajer*, L. Fu *, C. Mauck *, S. Koenig*, J. Sakamoto *, A. Motsinger-Reif n, G. Doncel*, S. Zeichner *

MeSH headings : Administration, Intravaginal; Adolescent; Adult; Anti-Infective Agents / administration & dosage; Biota; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; DNA, Ribosomal / chemistry; DNA, Ribosomal / genetics; Female; HIV Infections / prevention & control; Human Experimentation; Humans; Metagenome / drug effects; Middle Aged; Placebos / administration & dosage; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA; Vagina / microbiology; Young Adult
TL;DR: The hypothesis that the microbicides negatively affect a critical line of defense against HIV, the vaginal microbiota, is tested, which suggests that molecular evaluation of microbicide effects on vaginal microbiota may be a critical endpoint that should be incorporated in early clinical assessment ofmicrobicide candidates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

CYP2C8*3 predicts benefit/risk profile in breast cancer patients receiving neoadjuvant paclitaxel

BREAST CANCER RESEARCH AND TREATMENT, 134(1), 401–410.

By: D. Hertz*, A. Motsinger-Reif n, A. Drobish, S. Winham  n, H. McLeod *, L. Carey *, E. Dees *

author keywords: Paclitaxel; CYP2C8*3; Pharmacogenetics; Neoadjuvant breast cancer therapy; Clinical complete response
MeSH headings : ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics; Adult; Aged; Antineoplastic Agents, Phytogenic / adverse effects; Antineoplastic Agents, Phytogenic / pharmacology; Antineoplastic Agents, Phytogenic / therapeutic use; Aryl Hydrocarbon Hydroxylases / genetics; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Breast Neoplasms / pathology; Chemotherapy, Adjuvant; Cytochrome P-450 CYP2C8; Female; Gene Frequency; Genetic Association Studies; Haplotypes; Humans; Middle Aged; Multivariate Analysis; Neoadjuvant Therapy; Paclitaxel / adverse effects; Paclitaxel / pharmacology; Paclitaxel / therapeutic use; Polymorphism, Single Nucleotide; Tumor Burden / drug effects
TL;DR: Patients carrying CYP2C8*3 are more likely to achieve clinical complete response from neoadjuvant paclitaxel treatment, but may also be at increased risk of experiencing severe peripheral neurotoxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity

PHARMACOGENETICS AND GENOMICS, 22(10), 733–740.

By: J. Sacco *, M. Abouraya*, A. Motsinger-Reif n, S. Yale *, C. McCarty * & L. Trepanier *

author keywords: cytochrome b(5); drug hypersensitivity; hydroxylamine; N-acetyltransferase; potentiated sulfonamides; sulfamethoxazole
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Arylamine N-Acetyltransferase / genetics; Child; Child, Preschool; Cytochrome-B(5) Reductase / genetics; Cytochrome-B(5) Reductase / metabolism; Cytochromes b5 / genetics; Drug Hypersensitivity / genetics; Female; Gene Frequency; Genetic Association Studies; Humans; Inactivation, Metabolic / genetics; Infant; Male; Middle Aged; Polymorphism, Genetic; Sulfonamides / pharmacokinetics
TL;DR: No association of NAT2 coding alleles with sulfonamide hypersensitivity (predominantly cutaneous eruptions) in this adult Caucasian population is found. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 article

Effects of acepromazine maleate on platelet function assessed by use of adenosine diphosphate activated- and arachidonic acid-activated modified thromboelastography in healthy dogs

Conner, B. J., Hanel, R. M., Hansen, B. D., Motsinger-Reif, A. A., Asakawa, M., & Swanson, C. R. (2012, May). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 595–601.

By: B. Conner  n, R. Hanel n, B. Hansen n, A. Motsinger-Reif n, M. Asakawa n & C. Swanson n

MeSH headings : Acepromazine / administration & dosage; Acepromazine / adverse effects; Adenosine Diphosphate / chemistry; Animals; Arachidonic Acid / chemistry; Blood Platelets / drug effects; Blood Platelets / physiology; Cross-Over Studies; Dogs / physiology; Female; Hemostasis / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / adverse effects; Injections, Intravenous / veterinary; Thrombelastography / methods; Thrombelastography / veterinary
TL;DR: Platelet function in dogs, as assessed by use of a modified thromboelastography assay, was not inhibited by acepromazine at doses of 0.05 or 0.1 mg/kg, IV, in contrast to previous reports in which it was suggested that ace Promazine may alter platelet function via inhibition of ADP and AA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

A novel N-terminal domain may dictate the glucose response of Mondo proteins

PLoS One, 7(4).

By: L. McFerrin & W. Atchley

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics

PHARMACOGENETICS AND GENOMICS, 22(4), 247–253.

By: R. Abo n, S. Hebbring n, Y. Ji  n, H. Zhu n, Z. Zeng n, A. Batzler  n, G. Jenkins  n, J. Biernacka  n ...

author keywords: 1000 Genomes; HapMap; imputation; major depressive disorder; pharmacometabolomics; pharmacogenomics; selective serotonin reuptake inhibitors; tag single-nucleotide polymorphisms
MeSH headings : Citalopram / adverse effects; Citalopram / therapeutic use; Depressive Disorder / drug therapy; Depressive Disorder / genetics; Genome-Wide Association Study / methods; Glycine / biosynthesis; Glycine / genetics; Glycine / metabolism; Glycine Dehydrogenase / genetics; HapMap Project; Haplotypes; Humans; Metabolic Networks and Pathways / genetics; Metabolomics; Pharmacogenetics; Polymorphism, Single Nucleotide / genetics; Selective Serotonin Reuptake Inhibitors / metabolism
TL;DR: The results indicate that the use of GWAS data to impute SNPs for genes in pathways identified by other ‘omics’ approaches makes it possible to rapidly and cost efficiently identify SNP markers to ‘broaden’ and accelerate pharmacogenomic studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Global models of ant diversity suggest regions where new discoveries are most likely are under disproportionate deforestation threat

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(19), 7368–7373.

By: B. Guenard n, M. Weiser n & R. Dunn n 

author keywords: biogeography; Formicidae
MeSH headings : Animals; Ants / classification; Ants / growth & development; Biodiversity; Conservation of Natural Resources / methods; Ecosystem; Environmental Monitoring / methods; Geography; Models, Biological
TL;DR: A database representing about 13,000 records for ant generic distribution from over 350 regions that cover much of the globe is assembled, finding that the hotspots of discovery are also the regions in which biodiversity is the most threatened by habitat destruction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

A predictive model for Efavirenz dosing

Pharmacogenomics, 13(2), 137–138.

By: C. Brown, N. Oki, G. Hariani & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Energy, taxonomic aggregation, and the geography of ant abundance

Ecography, 35(1), 65–72.

By: M. Kaspari & M. Weiser

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Strong influence of regional species pools on continent-wide structuring of local communities

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 279(1727), 266–274.

By: J. Lessard *, M. Borregaard *, J. Fordyce *, C. Rahbek *, M. Weiser n, R. Dunn n , N. Sanders *

author keywords: regional species pool; community assembly; phylogenetics; tropical niche conservatism; diversity gradients; Formicidae
MeSH headings : Animals; Ants / physiology; Biodiversity; Climate; North America; Phylogeny; Population Dynamics; Temperature
TL;DR: It is found that the average phylogenetic relatedness of species in ant communities decreases from tropical to temperate regions, but the strength of this relationship depends on the level of ecological realism in the definition of source pools. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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