Works Published in 2013

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Displaying works 21 - 40 of 48 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2013 article

ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling

Houck, K. A., Richard, A. M., Judson, R. S., Martin, M. T., Reif, D. M., & Shah, I. (2013, February). High-Throughput Screening Methods in Toxicity Testing, Vol. 2, p. 1–31.

Contributors: K. Houck*, A. Richard*, R. Judson*, M. Martin*, D. Reif* & I. Shah*

Source: ORCID
Added: May 14, 2019

2013 journal article

Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays

Chem. Res. Toxicol., 26(6), 878–895.

Contributors: N. Sipes*, M. Martin*, P. Kothiya*, D. Reif*, R. Judson*, A. Richard*, K. Houck*, D. Dix*, R. Kavlock*, T. Knudsen*

MeSH headings : Animals; Enzymes / metabolism; Guinea Pigs; High-Throughput Screening Assays; Humans; Membrane Transport Proteins / metabolism; Organic Chemicals / toxicity; Rats; Receptors, G-Protein-Coupled / antagonists & inhibitors; Receptors, G-Protein-Coupled / metabolism; Signal Transduction / drug effects
Source: ORCID
Added: May 14, 2019

2013 journal article

Meta-analysis of toxicity and teratogenicity of 133 chemicals from zebrafish developmental toxicity studies.

Reproductive Toxicology, 41, 98–108.

By: N. Ducharme*, L. Peterson*, E. Benfenati*, D. Reif*, C. McCollum*, G. Jå*, M. Bondesson*

co-author countries: Italy 🇮🇹 Sweden 🇸🇪

Contributors: N. Ducharme*, L. Peterson*, E. Benfenati*, D. Reif*, C. McCollum*, J. Gustafsson*, M. Bondesson*

author keywords: Developmental toxicity; Zebrafish; ToxPi; Teratogen; Meta-analysis
MeSH headings : 1-Octanol / chemistry; Animals; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Teratogens / chemistry; Teratogens / toxicity; Toxicity Tests; Water / chemistry; Zebrafish
Source: ORCID
Added: May 14, 2019

2013 journal article

High-throughput models for exposure-based chemical prioritization in the ExpoCast project.

Environmental Science and Technology, 47(15), 8479–8488.

By: J. Wambaugh*, R. Setzer*, D. Reif*, S. Gangwal*, J. Mitchell-Blackwood*, J. Arnot*, O. Joliet*, A. Frame* ...

co-author countries: Canada 🇨🇦

Contributors: J. Wambaugh*, R. Setzer*, D. Reif*, S. Gangwal*, J. Mitchell-Blackwood*, J. Arnot*, O. Joliet*, A. Frame* ...

MeSH headings : Environmental Exposure; Environmental Pollutants / classification; Models, Theoretical
Source: ORCID
Added: May 14, 2019

2013 journal article

Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate.

Toxicological Sciences, 136(2), 308–327.

By: J. Wambaugh*, R. Setzer*, A. Pitruzzello*, J. Liu*, D. Reif*, N. Kleinstreuer*, N. Wang*, N. Sipes* ...

Contributors: J. Wambaugh*, R. Setzer*, A. Pitruzzello*, J. Liu*, D. Reif*, N. Kleinstreuer*, N. Wang*, N. Sipes* ...

author keywords: perfluorooctanoate; perfluorooctanoic acid; perfluorooctanesulfonate; perfluorooctanesulfonic acid; compartment model; saturable resorption model; pharmacokinetics; statistical analysis; Bayesian analysis; ToxCast; in vitro-in vivo extrapolation
MeSH headings : Alkanesulfonic Acids / pharmacokinetics; Alkanesulfonic Acids / toxicity; Animals; Caprylates / pharmacokinetics; Caprylates / toxicity; Dose-Response Relationship, Drug; Female; Fluorocarbons / pharmacokinetics; Fluorocarbons / toxicity; In Vitro Techniques; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley
Source: ORCID
Added: May 14, 2019

2013 journal article

A Computational Model Predicting Disruption of Blood Vessel Development

PLoS Comput Biol, 9(4), e1002996.

By: N. Kleinstreuer*, D. Dix*, M. Rountree*, N. Baker*, N. Sipes*, D. Reif*, R. Spencer*, T. Knudsen*

Contributors: N. Kleinstreuer*, D. Dix*, M. Rountree*, N. Baker*, N. Sipes*, D. Reif*, R. Spencer*, T. Knudsen*

Ed(s): S. Peirce

MeSH headings : Algorithms; Animals; Blood Vessels / embryology; Chemokines / metabolism; Chemotaxis; Computer Simulation; Endothelial Cells / cytology; Endothelium, Vascular / pathology; Humans; Inflammation; Models, Theoretical; Neovascularization, Physiologic; Phenotype; Signal Transduction; Software; Vascular Endothelial Growth Factor A / metabolism
Source: ORCID
Added: May 14, 2019

2013 journal article

ALFAXALONE ANESTHESIA IN BULLFROGS (LITHOBATES CATESBEIANA) BY INJECTION OR IMMERSION

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 44(4), 965–971.

By: L. Posner n, K. Bailey n, E. Richardson n, A. Motsinger-Reif n & C. Harms n

author keywords: Alfaxalone; Alfaxan (R); anesthesia; bullfrogs; immersion; intramuscular
MeSH headings : Anesthetics / administration & dosage; Anesthetics / pharmacology; Animals; Drug Administration Routes; Pregnanediones / administration & dosage; Pregnanediones / pharmacology; Rana catesbeiana
Source: Web Of Science
Added: August 6, 2018

2013 journal article

De novo Sequencing, Characterization, and Comparison of Inflorescence Transcriptomes of Cornus canadensis and C. florida (Cornaceae)

PLOS ONE, 8(12).

co-author countries: China 🇨🇳
MeSH headings : Chromosome Mapping; Cornus / genetics; Cornus / growth & development; DNA, Complementary / chemistry; Flowers / genetics; Flowers / growth & development; Gene Library; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Transcriptome
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Tracing the Rise of Ants - Out of the Ground

PLOS ONE, 8(12).

co-author countries: Japan 🇯🇵
MeSH headings : Animals; Ants; Ecosystem; Evolution, Molecular; Hot Temperature; Phylogeny; Plant Leaves; Soil; Statistics as Topic
Source: Web Of Science
Added: August 6, 2018

2013 article

Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine

Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). PHARMACOGENOMICS, Vol. 14, pp. 1929–1931.

author keywords: cancer; canine model; chemotherapy; clinical trials
MeSH headings : Animals; Disease Models, Animal; Dogs; Humans; Neoplasms / drug therapy; Neoplasms / pathology; Pharmacogenetics / methods
Source: Web Of Science
Added: August 6, 2018

2013 journal article

A CTD-Pfizer collaboration: manual curation of 88 000 scientific articles text mined for drug-disease and drug-phenotype interactions

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: A. Davis n, T. Wiegers n, P. Roberts n, B. King n, J. Lay n, K. Lennon-Hopkins n, D. Sciaky n, R. Johnson n ...

MeSH headings : Cooperative Behavior; Data Mining; Databases, Factual; Disease; Drug Industry; Humans; Pharmaceutical Preparations / metabolism; Phenotype; Publications; Toxicogenetics
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Localization, morphology and transcriptional profile of Aspergillus flavus during seed colonization

MOLECULAR PLANT PATHOLOGY, 14(9), 898–909.

By: A. Dolezal n, G. Obrian n, D. Nielsen n, C. Woloshuk*, R. Boston n & G. Payne n

MeSH headings : Aspergillus flavus / genetics; Aspergillus flavus / growth & development; Aspergillus flavus / pathogenicity; Chromosomes, Fungal / genetics; Colony Count, Microbial; DNA, Fungal / isolation & purification; Electrophoresis, Agar Gel; Endosperm / microbiology; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genes, Fungal / genetics; Humans; Seeds / cytology; Seeds / microbiology; Transcription Factors / metabolism; Transcription, Genetic; Zea mays / cytology; Zea mays / microbiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Genomic architecture of adaptive color pattern divergence and convergence in Heliconius butterflies

GENOME RESEARCH, 23(8), 1248–1257.

co-author countries: Colombia 🇨🇴 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Panama 🇵🇦
MeSH headings : Adaptation, Biological / genetics; Animal Distribution; Animals; Base Sequence; Bayes Theorem; Butterflies / genetics; Conserved Sequence; Evolution, Molecular; Genetic Speciation; Genome, Insect; Genotype; Haplotypes; High-Throughput Nucleotide Sequencing; Likelihood Functions; Models, Genetic; Molecular Sequence Annotation; Molecular Sequence Data; Panama; Phenotype; Phylogeny; Pigmentation / genetics; Sequence Analysis, DNA; South America; Synteny; Transcriptome; Wings, Animal / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas

PLACENTA, 34(7), 599–605.

co-author countries: China 🇨🇳
author keywords: Placenta; Preeclampsia; IUGR; MiR-194; MiR-149
MeSH headings : Down-Regulation; Female; Fetal Growth Retardation / genetics; Fetal Growth Retardation / metabolism; Humans; MicroRNAs / biosynthesis; Placenta / metabolism; Pre-Eclampsia / genetics; Pre-Eclampsia / metabolism; Pregnancy; Transcriptome
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Alterations in metabolic pathways and networks in Alzheimer’s disease

Translational Psychiatry, 3(4), e244–e244.

By: R. Kaddurah-Daouk*, H. Zhu*, S. Sharma*, M. Bogdanov, S. Rozen*, W. Matson*, N. Oki n, A. Motsinger-Reif n ...

co-author countries: Singapore 🇸🇬
author keywords: Alzheimer's disease; metabolomics; partial network reconstruction; pathway analysis
MeSH headings : Aged; Aged, 80 and over; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / metabolism; Biomarkers / cerebrospinal fluid; Case-Control Studies; Chromatography, Liquid; Cognitive Dysfunction / cerebrospinal fluid; Cognitive Dysfunction / metabolism; Female; Humans; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Neuropsychological Tests; Prospective Studies
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

Molecular phylogenetic analysis suggests paraphyly and early diversification of Philadelphus (Hydrangeaceae) in western North America: New insights into affinity with Carpenteria

Journal of Systematics and Evolution, 51(5), 545–563.

By: Y. Guo n, A. Pais n, A. Weakley & Q. Xiang n

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL

CANCER RESEARCH, 73(16), 5029–5039.

By: K. Richards n, A. Motsinger-Reif n, H. Chen n, Y. Fedoriw n, C. Fan n, D. Nielsen n, G. Small n, R. Thomas n ...

co-author countries: Italy 🇮🇹 Japan 🇯🇵 Netherlands 🇳🇱
MeSH headings : Adolescent; Animals; Child; Child, Preschool; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Disease Models, Animal; Dogs; Female; Gene Expression Profiling / methods; Germinal Center / metabolism; Germinal Center / pathology; Humans; Immunoglobulin Heavy Chains / genetics; Immunoglobulin Heavy Chains / metabolism; Interferon Regulatory Factors / genetics; Interferon Regulatory Factors / metabolism; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / pathology; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Male; Mutation; NF-kappa B / genetics; NF-kappa B / metabolism; Proto-Oncogene Proteins c-bcl-6; Transcriptome
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

A Novel Candidate Vaccine for Cytauxzoonosis Inferred from Comparative Apicomplexan Genomics

PLOS ONE, 8(8).

By: J. Tarigo n, E. Scholl n, D. Bird n, C. Brown*, L. Cohn*, G. Dean n, M. Levy n, D. Doolan* ...

co-author countries: Australia 🇦🇺

Contributors: J. Tarigo n, E. Scholl n, D. Bird n, C. Brown*, L. Cohn*, G. Dean n, M. Levy n, D. Doolan* ...

MeSH headings : Animals; Antigens, Protozoan / genetics; Antigens, Protozoan / immunology; Cat Diseases / immunology; Cat Diseases / parasitology; Cat Diseases / prevention & control; Cats; Cattle; Conserved Sequence; Genome, Protozoan; Genomics; Immune Sera / immunology; Piroplasmida / genetics; Piroplasmida / immunology; Protozoan Infections, Animal / immunology; Protozoan Infections, Animal / parasitology; Protozoan Infections, Animal / prevention & control; Protozoan Proteins / genetics; Protozoan Proteins / immunology; Protozoan Vaccines / genetics; Protozoan Vaccines / immunology; Recombinant Proteins / genetics; Recombinant Proteins / immunology; Synteny; Theileria parva / genetics; Theileria parva / immunology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel

ANNALS OF ONCOLOGY, 24(6), 1472–1478.

By: D. Hertz*, S. Roy, A. Motsinger-Reif n, A. Drobish, L. Clark, H. McLeod*, L. Carey*, E. Dees*

author keywords: chemotherapy-induced peripheral neuropathy; cytochrome P450 2C8*3; paclitaxel; pharmacogenetics; race
MeSH headings : Adult; Black or African American / genetics; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic / therapeutic use; Aryl Hydrocarbon Hydroxylases / genetics; Breast Neoplasms / drug therapy; Breast Neoplasms / enzymology; Breast Neoplasms / genetics; Cohort Studies; Cytochrome P-450 CYP2C8; Female; Genetic Variation / genetics; Humans; Middle Aged; Paclitaxel / adverse effects; Paraneoplastic Polyneuropathy / chemically induced; Paraneoplastic Polyneuropathy / enzymology; Paraneoplastic Polyneuropathy / genetics; Risk Factors; Treatment Outcome; White People / genetics; Young Adult
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction

Biodata Mining, 6.

By: H. Dai, R. Charnigo, M. Becker, J. Leeder & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

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