Works Published in 2014
Displaying works 21 - 40 of 46 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Bayesian neural networks for detecting epistasis in genetic association studies
BMC Bioinformatics, 15.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
RNA-seq analysis pipeline based on oshell environment
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 11(5), 973–978.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Evaluation of thromboelastography for prediction of clinical bleeding in thrombocytopenic dogs after total body irradiation and hematopoietic cell transplantation
AMERICAN JOURNAL OF VETERINARY RESEARCH, 75(5), 425–432.
MeSH headings : Animals; Bone Marrow Transplantation / veterinary; Cohort Studies; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Hemorrhage / diagnosis; Hemorrhage / physiopathology; Hemorrhage / veterinary; Hemostasis / physiology; Kaolin; Lymphoma / physiopathology; Lymphoma / veterinary; Male; Platelet Count / veterinary; Prospective Studies; Thrombelastography / methods; Thrombelastography / veterinary; Thrombocytopenia / physiopathology; Thrombocytopenia / veterinary; Whole-Body Irradiation / veterinary
TL;DR:
Compared with buccal mucosal bleeding time and platelet count, thromboelastography was more reliable at identifying thrombocytopenic dogs with a low risk of bleeding and could be considered to help guide the use of transfusion products in dogs undergoing TBI and BMT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Structural properties of the minimum cut of partially-supplied graphs
DISCRETE APPLIED MATHEMATICS, 177, 152–157.
author keywords: Graph theory; Minimum cut; Tree reconstruction
TL;DR:
This work considers pairs of graphs G and H, with respective Laplacian matrices L and M, and calls H partially supplied provided M is a Schur complement of L.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Single-Nucleotide Polymorphism Data Support the General Unrelatedness of the Males in the Agricultural Health Study
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 23(10), 2192–2195.
MeSH headings : Agriculture; Case-Control Studies; Cohort Studies; Consanguinity; Gene-Environment Interaction; Humans; Male; Occupational Exposure; Polymorphism, Single Nucleotide; Principal Component Analysis; Research Design
TL;DR:
This analysis rejects the hypothesis that individuals in the case–control study of prostate cancer exhibit cryptic relatedness, and these findings are important for all subsequent analyses of gene–environment interactions in the AHS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Relationship Between Mechanical Thresholds and Limb Use in Dogs With Coxofemoral Joint OA-Associated Pain and the Modulating Effects of Pain Alleviation From Total Hip Replacement on Mechanical Thresholds
VETERINARY SURGERY, 43(5), 542–548.
MeSH headings : Animals; Arthroplasty, Replacement, Hip / veterinary; Coccyx; Dog Diseases / physiopathology; Dog Diseases / surgery; Dogs; Female; Femur; Gait; Hip Joint / physiopathology; Joint Instability / physiopathology; Joint Instability / veterinary; Male; Pain Measurement / veterinary; Prospective Studies; Recovery of Function
TL;DR:
Successful unilateral THR results in decreased central sensitization after 12 months in dogs and there were no significant correlations between mQSTvF data and age, bodyweight or the GRF variables.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Positive association between a glutathione-S-transferase polymorphism and lymphoma in dogs
VETERINARY AND COMPARATIVE ONCOLOGY, 12(3), 227–236.
author keywords: cancer risk; canine; carcinogens; glutathione; lymphosarcoma; polymorphisms
MeSH headings : Animals; Case-Control Studies; Dog Diseases / enzymology; Dog Diseases / genetics; Dogs; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Glutathione Transferase / genetics; Glutathione Transferase / metabolism; Lymphoma / enzymology; Lymphoma / genetics; Lymphoma / veterinary; Point Mutation; Polymorphism, Genetic
TL;DR:
This intronic variant was predicted to perturb GSTT1 mRNA splicing, and may increase lymphoma risk by impairing detoxification of environmental chemicals, and confirmation of this finding in a larger population of dogs may support the inclusion of GSTT 1 genotyping in epidemiologic studies of canine lymph cancer risk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma
CHROMOSOME RESEARCH, 22(3), 305–319.
author keywords: canine; chromosome; hemangiosarcoma; comparative genomic hybridization (CGH)
MeSH headings : Animals; Breeding; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dog Diseases / genetics; Dogs; Gene Amplification; Gene Expression Profiling; Genetic Heterogeneity; Genome; Hemangiosarcoma / genetics; Hemangiosarcoma / veterinary; Penetrance; Vascular Endothelial Growth Factor A / genetics
TL;DR:
Analysis of genome-wide microarray-based somatic DNA copy number profiling of 75 primary intra-abdominal hemangiosarcomas from five popular dog breeds supports prior transcriptional studies suggesting that the clinical heterogeneity of this cancer may reflect the existence of multiple, molecularly distinct subtypes of canine hemangiusarcoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Aspergillus flavus infection induces transcriptional and physical changes in developing maize kernels
Frontiers in Microbiology, 5.
author keywords: Aspergillus flavus; maize; transcription; genetic; aflatoxins; pathogenesis
TL;DR:
Data indicate that infection of the maize kernel by A. flavus induced metabolic changes in the kernel, including the production of a defense response, as well as a disruption in kernel development, which indicates host response to infection by the fungus.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2014 journal article
Lymphoblastoid Cell Lines Models of Drug Response: Successes and Lessons from this Pharmacogenomic Model
CURRENT MOLECULAR MEDICINE, 14(7), 833–840.
author keywords: Cytotoxics; genetic association mapping; genome wide association analysis; lymphoplastoid cell lines; pharmacogenomics
MeSH headings : Cell Line, Transformed; Cost-Benefit Analysis; Genome-Wide Association Study / economics; Genome-Wide Association Study / methods; Humans; Lymphocytes / drug effects; Lymphocytes / metabolism; Models, Biological; Models, Genetic; Pharmacogenetics / economics; Pharmacogenetics / methods; Polymorphism, Single Nucleotide; RNA Interference; Reproducibility of Results; Translational Research, Biomedical / economics; Translational Research, Biomedical / methods
TL;DR:
The advantages, limitations, and opportunities for using lymphoblastoid cell lines (LCL) as a model system for human pharmacogenomic studies, including multivariate concentration response modeling, issues with multiple testing, and successful examples of the 'triangle model' to identify candidate variants are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Pathway-Guided Identification of Gene-Gene Interactions
ANNALS OF HUMAN GENETICS, 78(6), 478–491.
author keywords: Pathway analysis; gene-gene interactions; bio-knowledge-guided
MeSH headings : Computer Simulation; Epistasis, Genetic; Genotype; Humans; Linear Models; Models, Genetic; Polymorphism, Single Nucleotide; Principal Component Analysis; Regression Analysis
TL;DR:
A regression model with pathway‐guided regularization for detecting interactions among genes using the principal components to summarize the SNP‐SNP interactions between a gene pair, and an L1 penalty that incorporates adaptive weights based on biological guidance and trait supervision to identify important main and interaction effects is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Integrative gene set analysis of multi-platform data with sample heterogeneity
BIOINFORMATICS, 30(11), 1501–1507.
MeSH headings : Breast Neoplasms / genetics; DNA Copy Number Variations; DNA Methylation; Female; Gene Expression Profiling; Genes; Genomics / methods; Humans; Sequence Analysis, RNA; Statistics, Nonparametric
TL;DR:
The proposed multi-platform Mann-Whitney statistics method has higher power for heterogeneous samples and comparable performance for homogeneous samples when compared with the existing methods, and is able to identify novel pathways that are missed by other strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Genetic Regulation of Zfp30, CXCL1, and Neutrophilic Inflammation in Murine Lung
GENETICS, 198(2), 735–U376.
author keywords: asthma; CXCL1; neutrophil; expression quantitative trait locus (eQTL); systems genetics; complex traits; Multiparent Advanced Generation Inter-Cross (MAGIC); multiparental populations; MPP
MeSH headings : Animals; Chemokine CXCL1 / genetics; Chemokine CXCL1 / metabolism; DNA-Binding Proteins / physiology; Gene Expression; Gene Expression Regulation / immunology; Lung / immunology; Lung / pathology; Male; Mice, Transgenic; Neutrophil Infiltration; Pneumonia / genetics; Quantitative Trait Loci; Trachea / immunology; Trachea / pathology; Transcription Factors / physiology
TL;DR:
It is shown that Zfp30 is expressed in airway epithelia in the normal mouse lung and that altering ZFP30 expression in vitro affects CXCL1 responses to an immune stimulus, providing strong evidence that Z FP30 is a novel regulator of neutrophilic airway inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?
BRITISH JOURNAL OF HAEMATOLOGY, 167(1), 110–120.
author keywords: immune thrombocytopenia; canine; interleukin-8; animal model
MeSH headings : Animals; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / immunology; Blood Platelets / immunology; Blood Platelets / metabolism; Cytokines / blood; Cytokines / metabolism; Disease Models, Animal; Dogs; Hemorrhage / immunology; Phenotype; Platelet Count; Purpura, Thrombocytopenic, Idiopathic / blood; Purpura, Thrombocytopenic, Idiopathic / diagnosis; Purpura, Thrombocytopenic, Idiopathic / immunology
TL;DR:
Evaluation of cytokine profiles led to the identification of platelets as a potential source of serum interleukin‐8 (IL8) in dogs, suggesting that platelet IL8 may be a previously unrecognized modulator of platelet‐neutrophil crosstalk in humans with ITP.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Heritability and genomics of gene expression in peripheral blood
Nature Genetics, 46(5), 430–437.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Convergence of sample eigenvalues, eigenvectors, and principal component scores for ultra-high dimensional data
BIOMETRIKA, 101(2), 484–490.
author keywords: High-dimension low sample size data; Principal component analysis; Random matrix
TL;DR:
This paper investigates principal component analysis under the ultra-high dimensional regime, where both the number of features and the sample size increase as the ratio of the two quantities also increases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Canine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24
PLoS Genet, 10(2), e1003991.
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Web services-based text-mining demonstrates broad impacts for interoperability and process simplification
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.
MeSH headings : Data Mining / methods; Databases, Chemical; Databases, Genetic; Disease / genetics; Genes; Internet; Time Factors; Toxicogenetics
TL;DR:
A description of the challenge and summary of results are presented, demonstrating how curation groups can effectively use interoperable NER technologies to simplify text-mining pipeline implementation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
BioC interoperability track overview
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.
MeSH headings : Biomedical Research; Computational Biology; Data Mining; Database Management Systems; Databases, Factual; Internet; Natural Language Processing; Software
TL;DR:
The interoperability track at the BioCreative IV workshop featured contributions using or highlighting the BioC format, which included additional implementations of BioC, many new corpora in the format, biomedical NLP tools consuming and producing the format and online services using the format.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
An adaptive permutation approach for genome-wide association study: Evaluation and recommendations for use
Biodata Mining, 7.
Source: NC State University Libraries
Added: August 6, 2018
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