Works Published in 2015
Displaying works 41 - 53 of 53 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Canine urothelial carcinoma: genomically aberrant and comparatively relevant
CHROMOSOME RESEARCH, 23(2), 311–331.
author keywords: Canine; Urothelial carcinoma; Transitional cell carcinoma; Cytogenetics; Chromosome aberration; Array comparative genomic hybridization; Comparative oncology
MeSH headings : Animals; Biopsy; Carcinoma / veterinary; Chromosome Aberrations; Comparative Genomic Hybridization; Computational Biology / methods; DNA Copy Number Variations; Dogs; Female; Genetic Loci; Genomics / methods; Humans; In Situ Hybridization, Fluorescence; Male; Urologic Neoplasms / veterinary
TL;DR:
It is proposed that common aberrations found in primary canine UC biopsies are indicative of an evolutionarily conserved mechanism of pathogenesis and harbor genes key to urothelial neoplasia, warranting investigation for diagnostic, prognostic, and therapeutic applications.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Roles of Solvent Accessibility and Gene Expression in Modeling Protein Sequence Evolution
EVOLUTIONARY BIOINFORMATICS, 11.
author keywords: protein evolution; protein structure; gene expression; codon usage; scaled selection coefficient; solvent accessibility
TL;DR:
It is come to the biologically plausible conclusion that both RSA and gene expression are related to amino acid frequencies, but, among synonymous codons, the relative probability of a particular codon is more closely related to gene expression than RSA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups
PHARMACOGENOMICS, 16(8), 817–824.
author keywords: drug-induced hypersensitivity; HLA; human leukocyte antigen; pharmacogenetics; pharmacogenomics; risk mitigation
MeSH headings : Black or African American / genetics; Alleles; Asian People / genetics; Drug Hypersensitivity / genetics; Drug Hypersensitivity / pathology; Genotype; HLA-B Antigens / genetics; HLA-DQ alpha-Chains / genetics; Hispanic or Latino / genetics; Humans; Polymorphism, Single Nucleotide / genetics; White People
TL;DR:
This study demonstrates the utility of SNP tagging as a 'real time' approach to predict or exclude the presence of specific HLA alleles of known importance to HSR across diverse ethnic groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
A Multi-Megabase Copy Number Gain Causes Maternal Transmission Ratio Distortion on Mouse Chromosome 2
PLOS GENETICS, 11(2).
MeSH headings : Alleles; Animals; Chromosomes / genetics; Crosses, Genetic; DNA Copy Number Variations / genetics; Female; Genomics; Genotyping Techniques; Haplotypes / genetics; Inheritance Patterns / genetics; Male; Meiosis / genetics; Mice; Mutation
TL;DR:
It is found that transmission ratios in R2d2WSB heterozygous females vary between Mendelian segregation and complete distortion depending on the genetic background, and that TRD is under genetic control of unlinked distorter loci.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer
Chemical Research in Toxicology, 28(6), 1144–1155.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Population-Based in Vitro Hazard and Concentration-Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study
ENVIRONMENTAL HEALTH PERSPECTIVES, 123(5), 458–466.
MeSH headings : Cell Line, Tumor; Genome-Wide Association Study / methods; Genotype; Humans; Risk Assessment; Toxicity Tests / methods
TL;DR:
This experimental approach fills critical gaps unaddressed by recent large-scale toxicity testing programs, providing quantitative, experimentally based estimates of human toxicodynamic variability, and also testable hypotheses about mechanisms contributing to interindividual variation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013
EQUINE VETERINARY JOURNAL, 47(3), 279–284.
author keywords: horse; large colon volvulus; strangulation; pelvic flexure; surgery
MeSH headings : Animals; Biopsy; Colon / pathology; Hemorrhage / pathology; Hemorrhage / veterinary; Horse Diseases / surgery; Horses; Intestinal Volvulus / pathology; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Logistic Models; Retrospective Studies
TL;DR:
Histomorphometric measurements of interstitium-to-crypt ratio and degree of haemorrhage predict short-term outcome in cases of large colon volvulus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Hypothesis testing at the extremes: fast and robust association for high-throughput data
BIOSTATISTICS, 16(3), 611–625.
author keywords: Density approximation; Exact testing; Permutation
MeSH headings : Biostatistics; Breast Neoplasms / genetics; Computer Simulation; Cystic Fibrosis / genetics; Databases, Nucleic Acid / statistics & numerical data; Female; High-Throughput Nucleotide Sequencing / statistics & numerical data; High-Throughput Screening Assays / statistics & numerical data; Humans; Likelihood Functions; Linear Models; Polymorphism, Single Nucleotide; Sample Size; Software
TL;DR:
An approximation to exact association tests of trend that is accurate and fast enough for standard use in high-throughput settings, and can easily provide standard two-sided or doubled [Formula: see text]-values is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Gene Expression in Transformed Lymphocytes Reveals Variation in Endomembrane and HLA Pathways Modifying Cystic Fibrosis Pulmonary Phenotypes
The American Journal of Human Genetics, 96(2), 318–328.
MeSH headings : Cystic Fibrosis / genetics; Cystic Fibrosis / pathology; Endoplasmic Reticulum Stress / genetics; Gene Expression Profiling; Genes, MHC Class I / genetics; Genetic Variation; Humans; Linear Models; Phenotype; Receptors, Lysophosphatidic Acid / genetics; Sequence Deletion / genetics
TL;DR:
Gene expression provided a powerful tool to identify unrecognized heritable variation, complementing ongoing GWASs in this rare disease and enriched for heritable genetic variation and expression quantitative traits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
The Comparative Toxicogenomics Database's 10th year anniversary: update 2015
NUCLEIC ACIDS RESEARCH, 43(D1), D914–D920.
MeSH headings : Databases, Chemical / history; Disease / etiology; Disease / genetics; Genomics / history; History, 21st Century; Internet; Phenotype; Toxicogenetics / history
TL;DR:
The prototype database originally described in its first report has transformed into a sophisticated resource used actively today to help scientists develop and test hypotheses about the etiologies of environmentally influenced diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
An investigation of gene-gene interactions in dose-response studies with Bayesian nonparametrics
Biodata Mining, 8.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain
PeerJ, 3.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Signatures of adaptation to plant parasitism in nematode genomes
PARASITOLOGY, 142, S71–S84.
Contributors: D. Bird* , J. Jones *, C. Opperman, T. Kikuchi * & E. Danchin *
author keywords: nematodes; genomes; plant parasitism; adaptation; convergence
MeSH headings : Adaptation, Physiological; Animals; Genomics; Host-Parasite Interactions; Nematoda / genetics; Nematoda / physiology; Phylogeny; Plants / parasitology
TL;DR:
Overall, nematodes appear to have developed convergent genomic solutions to adapt to plant parasitism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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