Works Published in 2016
Displaying works 41 - 59 of 59 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives
GREEN CHEMISTRY, 18(16), 4407–4419.
Contributors: F. Grimm*, Y. Iwata*, O. Sirenko*, G. Chappell *, F. Wright n, D. Reif n , J. Braisted *, D. Gerhold *
TL;DR:
An experimental and computational approach to categorizing UVCBs according to chemical and biological similarities is presented.
(via Semantic Scholar)
pubs.rsc.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Use of RNA-seq to identify cardiac genes and gene pathways differentially expressed between dogs with and without dilated cardiomyopathy
AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(7), 693–699.
MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / metabolism; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Down-Regulation; Female; Gene Expression; Heart Ventricles; Male; Myocardium / metabolism; RNA / genetics; Up-Regulation
TL;DR:
Genes involved in cellular energy metabolism, especially metabolism of carbohydrates and fats, were significantly downregulated in dogs with DCM, and Expression of cardiac structural proteins was also altered in affected dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Trust, but Verify II: A Practical Guide to Chemogenomics Data Curation
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 56(7), 1243–1252.
MeSH headings : Consensus; Genomics; Quality Control; Quantitative Structure-Activity Relationship; Reproducibility of Results; Statistics as Topic / standards
TL;DR:
A chemical and biological data curation workflow that relies on existing cheminformatics approaches to flag, and when appropriate, correct possibly erroneous entries in large chemogenomics data sets is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Pharmacometabolomic assessment of metformin in non-diabetic, African Americans
Frontiers in Pharmacology, 7.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Genome-wide association study in immunocompetent patients with delayed hypersensitivity to sulfonamide antimicrobials
PLoS One, 11(6).
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
A genome-wide study of lipid response to fenofibrate in Caucasians: A combined analysis of the GOLDN and ACCORD studies
Pharmacogenetics and Genomics, 26(7), 324–333.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
alpha-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance
DIABETES CARE, 39(6), 988–995.
MeSH headings : Adult; Biomarkers / metabolism; Blood Glucose / metabolism; Cohort Studies; Fasting; Female; Glucose Intolerance / metabolism; Glucose Tolerance Test; Humans; Hydroxybutyrates / metabolism; Male; Metabolomics; Middle Aged; Multivariate Analysis; Oleic Acid / metabolism; Prediabetic State / metabolism; Prospective Studies
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
PCR amplification of a multi-copy mitochondrial gene (cox3) improves detection of Cytauxzoon felis infection as compared to a ribosomal gene (18S)
VETERINARY PARASITOLOGY, 225, 123–130.
Contributors: M. Schreeg n, H. Marr n, E. Griffith n, J. Tarigo n, D. Bird n , M. Reichard *, L. Cohn*, M. Levy n, A. Birkenheuer n
author keywords: Cytauxzoonosis; Cytochrome c oxidase; Piroplasmosis; Mitochondria; Feline; Molecular diagnostic assays
MeSH headings : Animals; Cat Diseases / diagnosis; Cats; DNA, Protozoan / blood; DNA, Protozoan / genetics; Electron Transport Complex IV / genetics; Gene Dosage; Haemosporida / genetics; Polymerase Chain Reaction / standards; Polymerase Chain Reaction / veterinary; Protozoan Infections, Animal / diagnosis; RNA, Ribosomal, 18S / genetics; Sensitivity and Specificity
TL;DR:
A PCR assay targeting the C. felis mitochondrial gene cytochrome c oxidase subunit III (cox3) is designed and demonstrated that the cox3 PCR can detect as low as 1 copy of DNA target and can detect C.Felis during early infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure
REPRODUCTIVE TOXICOLOGY, 62, 92–99.
Contributors: G. Zhang n, S. Marvel n, L. Truong *, R. Tanguay * & D. Reif n
author keywords: Developmental neurotoxicology; Chemical biology; Morphology; Zebrafish; High throughput screening; ToxCast; Multiplexed assays
MeSH headings : Animals; Embryo, Nonmammalian; Entropy; Flame Retardants / toxicity; High-Throughput Screening Assays; Models, Theoretical; Phenotype; Teratogens / toxicity; Zebrafish / embryology
TL;DR:
An information-theoretic method named Aggregate Entropy (AggE) is proposed and applied to scoring multiplexed, phenotypic endpoints measured in developing zebrafish across a broad concentration-response profile for a diverse set of 1060 chemicals, identifying chemicals with significant morphological effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes
ARCHIVES OF TOXICOLOGY, 90(6), 1459–1470.
Contributors: D. Reif n , L. Truong *, D. Mandrell*, S. Marvel n, G. Zhang n & R. Tanguay *
author keywords: Developmental neurotoxicology; Alternative testing; Chemical biology; Behavior; Zebrafish; High-throughput screening; Bioinformatics; Data integration; ToxCast; Bioactivity
MeSH headings : Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / physiopathology; Hazardous Substances / toxicity; High-Throughput Screening Assays; Predictive Value of Tests; Teratogens / toxicity; Zebrafish / abnormalities; Zebrafish / embryology
TL;DR:
This high-throughput screening system using a vertebrate organism can provide rapid characterization of chemical-elicited behavioral responses at an early developmental stage that are predictive of observable adverse effects later in life.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database
PLOS ONE, 11(5).
MeSH headings : Computational Biology; Databases, Genetic; Disease / genetics; Drug Repositioning; Gene Ontology; Humans; Toxicogenetics
TL;DR:
This inference set should aid researchers, bioinformaticists, and pharmaceutical drug makers in finding commonalities in disease mechanisms, which in turn could help identify new therapeutics, new indications for existing pharmaceuticals, potential disease comorbidities, and alerts for side effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
A comparison of DMET Plus microarray and genome-wide technologies by assessing population substructure
PHARMACOGENETICS AND GENOMICS, 26(4), 147–153.
author keywords: admixture; Affymetrix; cryptic relatedness; DMET Plus; inbreeding coefficients; metabolism; pharmacogenomics; population stratification; principal component analysis; transporters
TL;DR:
The DMET Plus pharmacogenomics genotyping chip is effective in quantifying population substructure across the three continental populations and inferring the presence of an admixed population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
A Phylogenetic Approach Finds Abundant Interlocus Gene Conversion in Yeast
MOLECULAR BIOLOGY AND EVOLUTION, 33(9), 2469–2476.
author keywords: interlocus gene conversion; multigene family evolution
MeSH headings : Base Sequence / genetics; Biological Evolution; Evolution, Molecular; Gene Conversion; Models, Genetic; Multigene Family; Nucleotides / genetics; Phylogeny; Point Mutation; Saccharomyces cerevisiae; Sequence Analysis, DNA / methods; Yeasts / genetics
TL;DR:
This work estimated the percentage of nucleotide substitutions that originate with an IGC event rather than a point mutation in 14 groups of yeast ribosomal protein-coding genes, and found values ranging from 20% to 38%.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
The projack: a resampling approach to correct for ranking bias in high-throughput studies
Biostatistics (Oxford, England), 17(1), 54–64.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
QSAR Modeling and Prediction of Drug-Drug Interactions
MOLECULAR PHARMACEUTICS, 13(2), 545–556.
author keywords: drug-drug interactions; QSAR modeling; simplex descriptors; GUSAR; QNA; DDI; toxicity; adverse drug reactions; mixtures
MeSH headings : Algorithms; Cytochrome P-450 Enzyme System / chemistry; Cytochrome P-450 Enzyme System / metabolism; Databases, Factual; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Models, Biological; Models, Molecular; Quantitative Structure-Activity Relationship
TL;DR:
This work generated virtually all possible binary combinations of marketed drugs and employed QSAR models to identify drug pairs predicted to be instances of DDI, and 4500 of these predicted DDIs that were not found in the training sets were confirmed by data from the DrugBank database.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Computer-aided design of carbon nanotubes with the desired bioactivity and safety profiles
NANOTOXICOLOGY, 10(3), 374–383.
author keywords: Carbon nanotubes; cheminformatics; nanotoxicity; QSAR; virtual screening
MeSH headings : Cell Survival / drug effects; Chemical Safety; Computer Simulation; Computer-Aided Design; Databases, Factual; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Protein Binding; Quantitative Structure-Activity Relationship
TL;DR:
This proof-of-concept study shows that computational models can be employed to guide the design of surface-modified nanomaterials with the desired biological and safety profiles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Integrative approaches for large-scale transcriptome-wide association studies
Nature Genetics, 48(3), 245–252.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Gene expression in major depressive disorder
Molecular Psychiatry, 21(3), 339–347.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Comprehensive characterization of the Published Kinase Inhibitor Set
Nature Biotechnology, 34(1), 95–103.
Source: NC State University Libraries
Added: August 6, 2018
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