Works Published in 2001
Displaying all 8 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2001 journal article
Evolution of the Simulated Data Problem
Genetic Epidemiology, 21(S1), S325–S331.
author keywords: complex diseases; linkage disequilibrium; pedigree data; population genetics; simulation
MeSH headings : Chromosome Mapping; Computer Simulation; Genetics, Population; Genotype; Humans; Phenotype
TL;DR:
The simulated data problem was designed via an interactive process by the Simulation Problem Organizing Committee and the selected data simulators and a population genetics model was used to generate the simulated genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2021
2001 journal article
Dwarf8 polymorphisms associate with variation in flowering time
Nature Genetics, 28(3), 286–289.
MeSH headings : Genes, Plant; Linkage Disequilibrium; Phenotype; Plant Proteins / genetics; Plant Shoots / genetics; Plant Shoots / growth & development; Polymorphism, Genetic; Quantitative Trait, Heritable; Reproduction / genetics; Zea mays / genetics; Zea mays / growth & development
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2021
2001 journal article
Association mapping: where we’ve been, where we’re going
Expert Review of Molecular Diagnostics, 1(3), 334–342.
MeSH headings : Analysis of Variance; Case-Control Studies; Chromosome Mapping; Family Health; Genetic Markers; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Molecular Diagnostic Techniques; Phenotype; Quantitative Trait, Heritable
TL;DR:
The basis of association mapping is described, and a number of the commonly used techniques used for localizing – or mapping – genes affecting a trait of interest are discussed.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID
Added: January 25, 2021
2001 journal article
Applying Data Mining Techniques to the Mapping of Complex Disease Genes
Genetic Epidemiology, 21(S1), S435–S440.
MeSH headings : Chromosome Mapping / statistics & numerical data; Data Collection / statistics & numerical data; Decision Trees; Gene Frequency; Genetic Markers / genetics; Genetic Predisposition to Disease / genetics; Genotype; Humans; Models, Genetic; Polymorphism, Single Nucleotide / genetics; Regression Analysis
TL;DR:
The result of incorporating data mining techniques with more classical methods is an improvement in the analysis, both by correctly classifying the affection status of more individuals and by locating more single nucleotide polymorphisms related to the disease, relative to analyses that use classical methods alone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2021
2001 journal article
GAW12: Simulated Genome Scan, Sequence, and Family Data for a Common Disease
Genetic Epidemiology, 21(S1), S332–S338.
author keywords: population isolate; quantitative trait; simulation
MeSH headings : Adolescent; Adult; Aged; Child; Chromosome Mapping / statistics & numerical data; Female; Genetic Markers / genetics; Genetic Variation / genetics; Genetics, Population; Genome, Human; Humans; Lod Score; Male; Microsatellite Repeats; Middle Aged; Models, Genetic; Phenotype; Polymorphism, Genetic; Quantitative Trait, Heritable; Recombination, Genetic
TL;DR:
The Genetic Analysis Workshop (GAW) 12 simulated data involves a common disease defined by imposing a threshold on a quantitative liability distribution Associated with the disease are five quantitative risk factors, a quantitative environmental exposure, and a dichotomous environmental variable.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 5, 2020
2001 journal article
Association Studies under General Disease Models
Theoretical Population Biology, 60(3), 253–263.
MeSH headings : Alleles; Apolipoproteins E / genetics; Chromosome Mapping / methods; Cytochrome P-450 CYP2D6 / genetics; Genetic Markers; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Models, Genetic; Phenotype
TL;DR:
A general framework to examine association mapping methods is adopted which helps to clarify the nature of case-control and transmission/disequilibrium-type tests and reveals the relationship between measures of association and coefficients of linkage disequilibrium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 5, 2020
2001 journal article
Cytochrome c is not essential for viability of the fungus Aspergillus nidulans
Molecular Genetics and Genomics, 266(1), 48–55.
Contributors: R. Bradshaw *, D. Bird* , S. Brown *, R. Gardiner* & P. Hirst*
author keywords: cytochrome c; Aspergillus; gene replacement; alternative respiration
MeSH headings : Aspergillus nidulans / enzymology; Aspergillus nidulans / genetics; Aspergillus nidulans / growth & development; Aspergillus nidulans / metabolism; Cytochrome c Group / metabolism; Diploidy; Ethanol / metabolism; Fermentation; Genes, Fungal; Mutation; Oxygen / metabolism; Spores, Fungal
TL;DR:
This is the first report of a filamentous fungus that remains viable after complete elimination of a functional cytochrome c gene, and it is proposed that the mutants are viable due to their ability to ferment and to use alternative respiratory pathways.
(via Semantic Scholar)
Source: ORCID
Added: January 30, 2020
2001 journal article
Overlapping plant signal transduction pathways induced by a parasitic nematode and a rhizobial endosymbiont
MOLECULAR PLANT-MICROBE INTERACTIONS, 14(10), 1168–1177.
Contributors: H. Koltai*, M. Dhandaydham, C. Opperman*, J. Thomas* & D. Bird*
author keywords: cytokinin; Meloidogyne incognita; Nod factor; PHANTASTICA; polar auxin flow; rough sheath2
MeSH headings : Amino Acid Sequence; Animals; Cell Cycle Proteins / genetics; Cell Cycle Proteins / physiology; Cell Size; DNA-Binding Proteins / genetics; DNA-Binding Proteins / physiology; Gene Expression Regulation, Plant; Growth Substances / genetics; Growth Substances / physiology; Homeodomain Proteins / genetics; Homeodomain Proteins / physiology; Host-Parasite Interactions; Humans; Medicago / genetics; Medicago / microbiology; Medicago / parasitology; Mitosis; Molecular Sequence Data; Nematoda / genetics; Nematoda / physiology; Nuclear Proteins / genetics; Nuclear Proteins / physiology; Plant Diseases / microbiology; Plant Diseases / parasitology; Plant Proteins / genetics; Plant Proteins / physiology; Plant Roots / genetics; Plant Roots / microbiology; Plant Roots / parasitology; Proto-Oncogene Proteins c-myb; Sequence Homology, Amino Acid; Signal Transduction / physiology; Sinorhizobium meliloti / genetics; Sinorhizobium meliloti / physiology; Symbiosis
TL;DR:
Common elements of host responses to mutualistic and parasitic plant endosymbionts are revealed and imply that overlapping regulatory pathways lead to giant cells and nodules.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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