Works Published in 2011
Displaying works 1 - 20 of 46 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Gene Expression profile and response to maize kernels by Aspergillus flavus
Phytopathology, 101(7), 797–804.
MeSH headings : 6-Phytase / genetics; 6-Phytase / metabolism; Aflatoxins / biosynthesis; Aspergillus flavus / enzymology; Aspergillus flavus / genetics; Aspergillus flavus / growth & development; Aspergillus flavus / pathogenicity; Down-Regulation; Gene Expression Profiling / methods; Gene Expression Regulation, Fungal / genetics; Oligonucleotide Array Sequence Analysis / methods; Reverse Transcriptase Polymerase Chain Reaction; Seeds / microbiology; Sequence Deletion; Transformation, Genetic; Up-Regulation; Virulence; Zea mays / growth & development; Zea mays / microbiology
TL;DR:
The study revealed the genome-wide effects of immature maize kernels on A. flavus and suggest that phytase has a role in pathogenesis, and the fungal response to the kernel environment during colonization.
(via Semantic Scholar)
apsjournals.apsnet.org (publisher PDF)
Sources: Web Of Science, ORCID
Added: March 19, 2021
2011 journal article
Nuclear Factor κ-Light Chain-Enhancer of Activated B Cells is Activated by Radiotherapy and is Prognostic for Overall Survival in Patients With Rectal Cancer Treated With Preoperative Fluorouracil-Based Chemoradiotheraphy
International Journal of Radiation Oncology*Biology*Physics, 80(3), 705–711.
author keywords: Chemoradiotherapy; NF-kappa B; rectal cancer; prognostic markers; inducible resistance genes; TRAF1; Bcl-2; cIAP-2; interleukin 8
MeSH headings : Adult; Aged; Aged, 80 and over; Combined Modality Therapy / methods; Female; Genes, bcl-2 / genetics; Humans; Inhibitor of Apoptosis Proteins / genetics; Interleukin-8 / genetics; Male; Middle Aged; NF-kappa B / metabolism; Neoplasm Proteins / metabolism; Prognosis; Prospective Studies; Radiation Tolerance / genetics; Rectal Neoplasms / drug therapy; Rectal Neoplasms / genetics; Rectal Neoplasms / metabolism; Rectal Neoplasms / mortality; Rectal Neoplasms / radiotherapy; Retrospective Studies; TNF Receptor-Associated Factor 1 / genetics; Treatment Outcome
TL;DR:
NF-κB might play an important role in tumor metastasis but not to the resistance to chemoradiotherapy, and nuclear expression at baseline in rectal cancer was prognostic for overall survival but not predictive of the response to RT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 4, 2021
2011 journal article
Genome-wide linkage study of atopic dermatitis in West Highland White Terriers
BMC Genetics, 12(1), 37.
MeSH headings : Animals; Chromosome Mapping; Dermatitis, Atopic / genetics; Dermatitis, Atopic / veterinary; Dog Diseases / genetics; Dogs; Genetic Linkage; Genotype
TL;DR:
The study was unable to detect any chromosomal regions significantly linked to canine AD, and a genome-wide SNP association study in a larger cohort of WHWTs may prove more successful by providing higher density coverage and higher statistical power.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: September 5, 2020
2011 journal article
Predicting Drug-Induced Hepatotoxicity Using QSAR and Toxicogenomics Approaches
Chemical Research in Toxicology, 24(8), 1251–1262.
MeSH headings : Animals; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Databases, Factual; Hepatocyte Nuclear Factor 4 / metabolism; Male; Models, Statistical; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Small Molecule Libraries / chemistry; Small Molecule Libraries / toxicity; Toxicogenetics
TL;DR:
Results suggest that concurrent exploration of the chemical features and acute treatment-induced changes in transcript levels will both enrich the mechanistic understanding of subchronic liver injury and afford models capable of accurate prediction of hepatotoxicity from chemical structure and short-term assay results.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2
Nature Genetics, 43(6), 539–546.
MeSH headings : Adolescent; Adult; Child; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 20; Cystic Fibrosis / genetics; Female; Genetic Linkage; Genome-Wide Association Study; Humans; Lung Diseases / genetics; Male; Phenotype; Quantitative Trait Loci
TL;DR:
The authors' findings provide insight into the causes of variation in lung disease severity in cystic fibrosis and suggest new therapeutic targets for this life-limiting disorder.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
MicroRNA expression in the livers of inbred mice
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 714(1-2), 126–133.
author keywords: MicroRNA; Liver; Mouse; Gene expression
MeSH headings : Animals; Gene Expression; Liver / metabolism; Mice; Mice, Inbred Strains / genetics; MicroRNAs / metabolism; Polymorphism, Single Nucleotide
TL;DR:
The stability of mouse liver miRNA expression in a genetically diverse population suggests that treatment-induced disruptions in liver mi RNA expression may indicate an important mechanism for the disturbance of normal liver function, and may prove to be a useful genetic background-independent biomarker of toxicant effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis Genetic modifier studies
Pediatric Pulmonology, 46(9), 857–869.
author keywords: forced expiratory volume; age effects; severity of illness index
MeSH headings : Adolescent; Child; Chronic Disease; Clinical Trials as Topic; Cystic Fibrosis / genetics; Cystic Fibrosis / mortality; Female; Humans; Male; Multicenter Studies as Topic; Phenotype; Respiratory Function Tests; Severity of Illness Index; Survival Analysis
TL;DR:
Genetic studies of lung disease in cystic fibrosis are hampered by the lack of a severity measure that accounts for chronic disease progression and mortality attrition and combining analyses across studies requires common phenotypes that are robust to study design and patient ascertainment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer
British Journal of Cancer, 105(11), 1654–1662.
author keywords: MTHFR polymorphisms; 5-FU; mucositis; diarrhoea; rectal cancer; neoadjuvant chemoradiation
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / adverse effects; Antimetabolites, Antineoplastic / therapeutic use; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Camptothecin / administration & dosage; Camptothecin / adverse effects; Camptothecin / analogs & derivatives; Chemoradiotherapy, Adjuvant / adverse effects; Disease-Free Survival; Fluorouracil / administration & dosage; Fluorouracil / adverse effects; Genotype; Humans; Irinotecan; Methylenetetrahydrofolate Reductase (NADPH2) / genetics; Methylenetetrahydrofolate Reductase (NADPH2) / metabolism; Middle Aged; Pharmacogenetics / methods; Polymorphism, Genetic; Prospective Studies; Radiation-Sensitizing Agents / administration & dosage; Radiation-Sensitizing Agents / adverse effects; Rectal Neoplasms / enzymology; Rectal Neoplasms / genetics; Rectal Neoplasms / therapy; Treatment Outcome; Young Adult
TL;DR:
MTHFR polymorphisms can potentially predict toxicity in patients treated with 5-FU as a single chemotherapeutic drug.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: February 24, 2020
2011 journal article
Abstracts of NEMASYM: The Third Nematode-Bacteria Symbioses Research Coordination Network Meeting
Symbiosis, 55(3), 97–109.
TL;DR:
This project has focused on one of the most common eukaryote-prokaryote interactions: that between nematodes and bacteria, and the ubiquity and diversity of nematode-bacterium symbioses make them an excellent model to understand the key questions in symbiosis.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 12, 2020
2011 journal article
Using Nuclear Receptor Activity to Stratify Hepatocarcinogens
PLoS ONE, 6(2).
Contributors: I. Shah *, K. Houck *, R. Judson *, R. Kavlock*, M. Martin*, D. Reif* , J. Wambaugh *, D. Dix*
Ed(s): S. Wölfl
MeSH headings : Animals; Carcinogens / classification; Carcinogens / toxicity; Carcinoma, Hepatocellular / chemically induced; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / metabolism; Cells, Cultured; Constitutive Androstane Receptor; Disease Progression; Drug Evaluation, Preclinical / methods; Gene Expression / drug effects; Gene Expression Profiling; Gene Regulatory Networks / drug effects; High-Throughput Screening Assays / methods; Humans; Liver / drug effects; Liver / metabolism; Liver / pathology; Liver Neoplasms / chemically induced; Liver Neoplasms / genetics; Liver Neoplasms / metabolism; Mice; Microarray Analysis; Rats; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Cytoplasmic and Nuclear / physiology
TL;DR:
These results do not prove the role of NR activation in human liver cancer, but they do have implications for nuclear receptor chemical biology and provide insights into putative toxicity pathways and suggest the utility of in vitro assays for stratifying environmental contaminants based on a combination of human bioactivity and rodent toxicity.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data.
Toxicological Sciences, 124(1), 109–127.
Contributors: N. Sipes *, M. Martin*, D. Reif* , N. Kleinstreuer *, R. Judson *, A. Singh*, K. Chandler*, D. Dix*, R. Kavlock*, T. Knudsen *
author keywords: developmental toxicity; ToxCast; ToxRefDB; high-throughput screening; predictive models; computational models predictive toxicology
MeSH headings : Animals; Congenital Abnormalities / etiology; Databases, Factual; Embryonic Development / drug effects; Endpoint Determination; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Fetal Development / drug effects; High-Throughput Screening Assays; Models, Biological; Rabbits; Rats; Species Specificity; Teratogens / classification; Teratogens / toxicity; United States; United States Environmental Protection Agency
TL;DR:
This work indicates the utility of HTS assays for developing pathway-level models predictive of developmental toxicity, and builds statistical associations based on HTS and in vivo developmental toxicity data from ToxRefDB.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Predictive model of rat reproductive toxicity from ToxCast high throughput screening.
Biology of Reproduction, 85(2), 327–339.
Contributors: M. Martin*, T. Knudsen *, D. Reif* , K. Houck *, R. Judson *, R. Kavlock*, D. Dix*
author keywords: female reproductive tract; fertility; male reproductive tract; predictive toxicology; reproductive toxicity; toxicology
MeSH headings : Animals; Environmental Pollutants / toxicity; Gene Expression Regulation / drug effects; Male; Predictive Value of Tests; Rats; Reproduction / drug effects; Risk Assessment; Small Molecule Libraries; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
A robust and stable predictive model was produced capable of identifying rodent reproductive toxicants with 77% ± 2% and 74% ± 5% training and test cross-validation balanced accuracies, further indicating the model's potential for prioritizing the many thousands of environmental chemicals with little to no hazard information.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 conference paper
Optimization of grammatical evolution decision trees
Proceedings of the 13th annual conference companion on Genetic and evolutionary computation - GECCO '11, 35–36.
Contributors: K. Hoover n, R. Marceau n, T. Harris n, N. Hardison n, D. Reif n & A. Motsinger-Reif n
TL;DR:
The results of a parameter sweep evaluating the power of GEDT are presented and it is shown that improved parameter choices improves the performance of the method.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2011 journal article
Mechanistic indicators of childhood asthma (MICA) study: piloting an integrative design for evaluating environmental health.
BMC Public Health, 11, 344.
Contributors: J. Gallagher*, E. Hudgens*, A. Williams *, J. Inmon*, S. Rhoney*, G. Andrews*, D. Reif* , B. Heidenfelder*
MeSH headings : Adolescent; Asthma / diagnosis; Asthma / etiology; Biomarkers / blood; Child; Disease Susceptibility; Environmental Health; Environmental Monitoring / methods; Female; Genetic Predisposition to Disease / genetics; Humans; Male; Michigan; Risk Factors
TL;DR:
The MICA study provides an opportunity to evaluate complex relationships between environmental factors, physiological biomarkers, genetic susceptibility and health outcomes and incorporates exposure metrics, internal dose measures, and clinical indicators to decipher the biological complexity inherent in diseases such as asthma and cardiovascular disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2011 journal article
Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
BMC Medical Genetics, 12, 25.
Contributors: B. Joubert *, D. Reif* , S. Edwards*, K. Leiner*, E. Hudgens*, P. Egeghy *, J. Gallagher*, E. Hubal
MeSH headings : Adolescent; Black or African American / genetics; Asthma / genetics; Child; Chromosomes, Human, Pair 11 / genetics; Cross-Sectional Studies; Female; Food Hypersensitivity / genetics; Genetic Predisposition to Disease; Glutathione S-Transferase pi / genetics; Glutathione Transferase / genetics; Haplotypes; Humans; Hypersensitivity / genetics; Hypersensitivity, Immediate / genetics; Linkage Disequilibrium; Male; Michigan; Odds Ratio; Polymorphism, Single Nucleotide; Receptors, IgE / genetics; Risk Factors; Sequence Deletion; Urban Population
TL;DR:
Variation in genes associated with asthma in predominantly non-African ethnic groups contributed to increased odds of asthma in this African American study population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2011 journal article
Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay
PLoS ONE, 6(6), e18540.
Contributors: K. Chandler*, M. Barrier*, S. Jeffay*, H. Nichols*, N. Kleinstreuer *, A. Singh*, D. Reif* , N. Sipes *
Ed(s): A. Cooney
MeSH headings : Animals; Biological Assay; Cell Adhesion / drug effects; Cell Death / drug effects; Cell Differentiation / drug effects; Cell Line; Embryonic Stem Cells / cytology; Embryonic Stem Cells / drug effects; Endpoint Determination; Environmental Pollutants / toxicity; Male; Mice; Models, Biological; Multivariate Analysis; Toxicity Tests / methods
TL;DR:
An initial characterization of metabolic and regulatory pathways by which some environmental chemicals may act to disrupt ES cell growth and differentiation is provided.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Environmental Impact on Vascular Development Predicted by High-Throughput Screening
Environ Health Perspect, 119(11), 1596â1603.
Contributors: N. Kleinstreuer *, R. Judson *, D. Reif* , N. Sipes *, A. Singh*, K. Chandler*, R. DeWoskin*, D. Dix*, R. Kavlock*, T. Knudsen *
author keywords: angiogenesis; developmental toxicity; high-throughput screening (HTS); thalidomide; vascular development
MeSH headings : Animals; Cardiovascular System / drug effects; Cardiovascular System / embryology; Computational Biology; Databases, Factual; Environmental Pollutants / analysis; Environmental Pollutants / classification; Environmental Pollutants / immunology; Environmental Pollutants / toxicity; Female; High-Throughput Screening Assays; Humans; Male; Maternal Exposure; Mice; Models, Animal; Multivariate Analysis; Pregnancy; Rabbits; Rats; Risk Assessment; Small Molecule Libraries / analysis; Small Molecule Libraries / classification; Small Molecule Libraries / toxicity; Species Specificity; Toxicology / methods; United States; United States Environmental Protection Agency
TL;DR:
It is predicted that blood vessel development is a target for environmental chemicals acting as putative vascular disruptor compounds (pVDCs) and identified potential species differences in sensitive vascular developmental pathways.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets
Toxicology, 282(1-2), 1â15.
Contributors: T. Knudsen *, K. Houck *, N. Sipes *, A. Singh*, R. Judson *, M. Martin*, A. Weissman, N. Kleinstreuer *
author keywords: High-throughput screening; Computational toxicology; ToxCast; Environmental chemicals
MeSH headings : Animal Use Alternatives; Animals; Automation, Laboratory; Cell-Free System; Data Interpretation, Statistical; Databases, Factual; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Enzyme Inhibitors / toxicity; High-Throughput Screening Assays; Humans; Ligands; Models, Biological; Osmolar Concentration; Pesticide Residues / toxicity; Rats; Reproducibility of Results; Toxicity Tests; United States; United States Environmental Protection Agency
TL;DR:
Mapping relationships across 93,440 chemical-assay pairs based on half-maximal activity concentration (AC50) revealed both known and novel targets in signaling and metabolic pathways.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
The NIDDK central repository at 8 years-ambition, revision, use and impact
Database-The Journal of Biological Databases and Curation.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Optimization of nonlinear dose- and concentration-response models utilizing evolutionary computation
Dose-Response, 9(3), 387–409.
Source: NC State University Libraries
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
