Works Published in 2014

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Displaying works 1 - 20 of 46 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2014 journal article

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

Nature Communications, 5(1).

By: J. Goldstein*, L. Fredrik Jarskog*, C. Hilliard*, A. Alfirevic*, L. Duncan*, D. Fourches*, H. Huang*, M. Lek* ...

co-author countries: Canada 🇨🇦 Germany 🇩🇪 Denmark 🇩🇰 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Israel 🇮🇱 Sweden 🇸🇪 United States of America 🇺🇸
MeSH headings : Agranulocytosis / chemically induced; Agranulocytosis / genetics; Agranulocytosis / immunology; Alleles; Amino Acid Substitution; Antipsychotic Agents / adverse effects; Case-Control Studies; Clozapine / adverse effects; Exome; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; HLA-B Antigens / genetics; HLA-B Antigens / immunology; HLA-DQ beta-Chains / genetics; HLA-DQ beta-Chains / immunology; Heterozygote; Humans; Odds Ratio; Psychotic Disorders / drug therapy; Psychotic Disorders / genetics; Psychotic Disorders / immunology; Severity of Illness Index
Source: Crossref
Added: August 28, 2020

2014 journal article

QSAR Modeling: Where Have You Been? Where Are You Going To?

Journal of Medicinal Chemistry, 57(12), 4977–5010.

By: A. Cherkasov*, E. Muratov*, D. Fourches*, A. Varnek*, I. Baskin*, M. Cronin*, J. Dearden*, P. Gramatica* ...

co-author countries: Canada 🇨🇦 Germany 🇩🇪 France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Italy 🇮🇹 Russian Federation 🇷🇺 Ukraine 🇺🇦 United States of America 🇺🇸
MeSH headings : Antimicrobial Cationic Peptides / chemistry; Artificial Intelligence; Complex Mixtures / chemistry; Databases, Factual; Drug Design; History, 20th Century; History, 21st Century; Models, Molecular; Nanostructures / chemistry; Pharmacokinetics; Quantitative Structure-Activity Relationship; Quantum Theory; Toxicology / methods
Source: Crossref
Added: August 28, 2020

2014 journal article

Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems

Chemical Reviews, 114(15), 7740–7781.

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Biological Transport; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cytoskeleton / drug effects; Cytoskeleton / metabolism; DNA / chemistry; DNA / metabolism; Humans; Ion Channels / antagonists & inhibitors; Ion Channels / chemistry; Mitochondria / drug effects; Mitochondria / metabolism; Nanoparticles / chemistry; Nanoparticles / metabolism; Nanoparticles / toxicity; Oxidative Stress / drug effects; Phospholipids / chemistry; Phospholipids / metabolism; Proteins / chemistry; Proteins / metabolism; Surface Properties
Source: Crossref
Added: August 28, 2020

2014 journal article

Data Set Modelability by QSAR

Journal of Chemical Information and Modeling, 54(1), 1–4.

By: A. Golbraikh, E. Muratov*, D. Fourches* & A. Tropsha*

co-author countries: Ukraine 🇺🇦 United States of America 🇺🇸
MeSH headings : Computational Biology; Databases, Chemical / statistics & numerical data; Drug Design; Models, Chemical; Quantitative Structure-Activity Relationship
Source: Crossref
Added: August 28, 2020

2014 journal article

Expanding the scope of drug repurposing in pediatrics: The Children's Pharmacy Collaborative™

Drug Discovery Today, 19(11), 1696–1698.

co-author countries: United States of America 🇺🇸
MeSH headings : Child; Databases, Pharmaceutical; Drug Repositioning; Humans; Pediatrics
Source: Crossref
Added: August 28, 2020

2014 journal article

Heritability and genomics of gene expression in peripheral blood

Nature Genetics, 46(5), 430–437.

By: F. Wright n, P. Sullivan*, A. Brooks*, F. Zou*, W. Sun*, K. Xia*, V. Madar*, R. Jansen* ...

co-author countries: Netherlands 🇳🇱 United States of America 🇺🇸
MeSH headings : Blood / metabolism; Gene Expression Profiling; Gene Expression Regulation / genetics; Genotype; Humans; Inheritance Patterns / genetics; Likelihood Functions; Netherlands; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics
Source: Crossref
Added: August 28, 2020

2014 journal article

Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

The American Journal of Human Genetics, 94(2), 233–245.

By: L. Lange, Y. Hu, H. Zhang, C. Xue, E. Schmidt, Z. Tang, C. Bizon, E. Lange ...

MeSH headings : Adult; Aged; Apolipoproteins E / blood; Apolipoproteins E / genetics; Cholesterol, LDL / genetics; Cohort Studies; Dyslipidemias / blood; Dyslipidemias / genetics; Exome; Female; Follow-Up Studies; Gene Frequency; Genetic Code; Genome-Wide Association Study; Genotype; Humans; Lipase / genetics; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Proprotein Convertase 9; Proprotein Convertases / genetics; Receptors, LDL / genetics; Sequence Analysis, DNA; Serine Endopeptidases / genetics
Source: Crossref
Added: August 28, 2020

2014 journal article

ToxiFly: Can fruit flies be used to identify toxicity pathways for airborne chemicals?

Neurotoxicology and Teratology, 43, 89.

By: P. Bushnell*, R. Tatum-Gibbs*, J. McKee*, P. Evansky*, M. Higuchi*, M. MLin*, W. Oshiro*, R. Judson* ...

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 21, 2020

2014 journal article

Improved structural annotation of protein-coding genes in the Meloidogyne hapla genome using RNA-Seq

Worm, 3(1), e29158.

By: Y. Guo n, D. Bird n & D. Nielsen n

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
Sources: Crossref, ORCID
Added: January 7, 2020

2014 journal article

A Genome-Wide Association Study of the Maize Hypersensitive Defense Response Identifies Genes That Cluster in Related Pathways

PLoS Genetics, 10(8), e1004562.

By: B. Olukolu n, G. Wang n, V. Vontimitta*, B. Venkata*, S. Marla*, J. Ji*, E. Gachomo*, K. Chu* ...

co-author countries: United States of America 🇺🇸

Ed(s): J. McDowell

MeSH headings : Chromosome Mapping; Disease Resistance / genetics; Genome-Wide Association Study; Linkage Disequilibrium; Plant Diseases / genetics; Plant Proteins / genetics; Polymorphism, Single Nucleotide; Quantitative Trait Loci / genetics; Zea mays / genetics
Sources: Crossref, ORCID
Added: January 7, 2020

2014 journal article

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging

Acta Neuropathologica Communications, 2(1).

By: A. Motsinger-Reif n, H. Zhu*, M. Kling*, W. Matson*, S. Sharma*, O. Fiehn*, D. Reif n, D. Appleby* ...

co-author countries: United States of America 🇺🇸

Contributors: A. Motsinger-Reif n, H. Zhu*, M. Kling*, W. Matson*, S. Sharma*, O. Fiehn*, D. Reif n, D. Appleby* ...

author keywords: Alzheimer's disease; Dementias; Metabolomics; Cerebrospinal fluid biomarkers; Stepwise logistic regression
MeSH headings : Aged; Aging / cerebrospinal fluid; Aging / drug effects; Aging / pathology; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / diagnosis; Alzheimer Disease / drug therapy; Alzheimer Disease / pathology; Amyloid beta-Peptides / cerebrospinal fluid; Area Under Curve; Biomarkers / cerebrospinal fluid; Chromatography, Liquid; Cognition; Diagnosis, Differential; Female; Gas Chromatography-Mass Spectrometry; Humans; Logistic Models; Male; Metabolomics / methods; Neuropsychological Tests; tau Proteins / cerebrospinal fluid
Source: ORCID
Added: May 14, 2019

2014 journal article

Test driving ToxCast: Endocrine profiling for 1858 chemicals included in phase II

Current Opinion in Pharmacology, 19, 145–152.

By: D. Filer*, H. Patisaul n, T. Schug*, D. Reif n & K. Thayer*

co-author countries: United States of America 🇺🇸

Contributors: D. Filer*, H. Patisaul n, T. Schug*, D. Reif n & K. Thayer*

MeSH headings : Animals; Databases, Factual; Endocrine Disruptors / toxicity; High-Throughput Screening Assays; Humans; Models, Theoretical; Risk Assessment; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2014 journal article

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

Scientific Reports, 4.

By: R. Huang*, S. Sakamuru*, M. Martin*, D. Reif*, R. Judson*, K. Houck*, W. Casey*, J. Hsieh* ...

co-author countries: United States of America 🇺🇸

Contributors: R. Huang*, S. Sakamuru*, M. Martin*, D. Reif*, R. Judson*, K. Houck*, W. Casey*, J. Hsieh* ...

MeSH headings : Cell Line; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Genes, Reporter / drug effects; HEK293 Cells; High-Throughput Screening Assays / methods; Humans; Ligands; Protein Binding / drug effects; Signal Transduction / drug effects; Small Molecule Libraries / pharmacology; Structure-Activity Relationship
Source: ORCID
Added: May 14, 2019

2014 journal article

Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses

Environmental Science and Technology, 48(15), 8706–8716.

By: D. Rotroff*, M. Martin*, D. Dix*, D. Filer*, K. Houck*, T. Knudsen*, N. Sipes*, D. Reif* ...

co-author countries: United States of America 🇺🇸

Contributors: D. Rotroff*, M. Martin*, D. Dix*, D. Filer*, K. Houck*, T. Knudsen*, N. Sipes*, D. Reif* ...

MeSH headings : Algorithms; Animals; Biological Assay; Endocrine Disruptors / analysis; Estrogen Antagonists / analysis; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Estrogen Receptor beta / agonists; Estrogen Receptor beta / antagonists & inhibitors; Estrogens / analysis; High-Throughput Screening Assays; Humans; MCF-7 Cells; Models, Chemical; Pesticides; Signal Transduction
Source: ORCID
Added: May 14, 2019

2014 journal article

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Nature Biotechnology, 32(6), 583–591.

By: N. Kleinstreuer*, J. Yang*, E. Berg*, T. Knudsen*, A. Richard*, M. Martin*, D. Reif*, R. Judson* ...

co-author countries: United States of America 🇺🇸

Contributors: N. Kleinstreuer*, J. Yang*, E. Berg*, T. Knudsen*, A. Richard*, M. Martin*, D. Reif*, R. Judson* ...

MeSH headings : Animal Testing Alternatives / methods; Animals; Computer Simulation; High-Throughput Screening Assays / methods; Humans; Mice; Models, Biological; Phenotype; Rats; Small Molecule Libraries; Toxicity Tests / methods; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2014 journal article

Multidimensional in vivo hazard assessment using zebrafish.

Toxicological Sciences, 137(1), 212–233.

By: L. Truong*, D. Reif n, M. St*, M. Geier*, H. Truong* & R. Tanguay*

co-author countries: United States of America 🇺🇸

Contributors: L. Truong*, D. Reif n, L. Mary*, M. Geier*, H. Truong* & R. Tanguay*

MeSH headings : Animals; Cluster Analysis; Computational Biology; Dose-Response Relationship, Drug; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Embryo, Nonmammalian / pathology; Embryonic Development / drug effects; Environmental Pollutants / toxicity; High-Throughput Screening Assays; Humans; Motor Activity / drug effects; Notochord / drug effects; Notochord / pathology; Reproducibility of Results; Risk Assessment; Toxicity Tests / methods; Zebrafish / embryology
Source: ORCID
Added: May 14, 2019

2014 journal article

Hierarchical dose-response modeling for high-throughput toxicity screening of environmental chemicals

Biom, 70(1), 237–246.

co-author countries: United States of America 🇺🇸

Contributors: A. Wilson n, D. Reif n & B. Reich n

author keywords: Bayesian; Computational toxicology; Dose-response; MCMC; Monotonicity; Semiparametric; ToxCast
MeSH headings : Algorithms; Bayes Theorem; Computer Simulation; Dose-Response Relationship, Drug; Environmental Pollutants / toxicity; Estrogen Receptor alpha / metabolism; Humans; Markov Chains; Models, Statistical; Monte Carlo Method; PPAR gamma / metabolism; Toxicity Tests / methods; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2014 journal article

Erratum to Incorporating human dosimetry and exposure into High-throughput in Vitro Toxicity Screening [Toxicological sciences 137, 2, (2014), 499]

Toxicological Sciences, 137(2).

By: D. Rotroff, B. Wetmore, D. Dix, S. Ferguson, H. Clewell, K. Houck, E. LeCluyse, M. Andersen ...

Contributors: D. Rotroff, B. Wetmore, D. Dix, S. Ferguson, H. Clewell, K. Houck, E. LeCluyse, M. Andersen ...

Source: ORCID
Added: May 14, 2019

2014 journal article

PGxClean: a quality control GUI for the Affymetrix DMET chip and other candidate gene studies with non-biallelic alleles

Biodata Mining, 7.

By: D. Rotroff, J. Jack, N. Campbell, S. Clark & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Integrative Genetic Analysis of Allergic Inflammation in the Murine Lung

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 51(3), 436–445.

By: S. Kelada*, D. Carpenter*, D. Aylor n, P. Chines*, H. Rutledge, E. Chesler*, G. Churchill*, F. Villena*, D. Schwartz*, F. Collins*

co-author countries: United States of America 🇺🇸
author keywords: allergic airway disease; systems genetics; gene expression quantitative trait loci
MeSH headings : Animals; Antigens, Dermatophagoides / immunology; Bronchial Hyperreactivity / immunology; Dermatophagoides pteronyssinus / metabolism; Disease Models, Animal; Gene Expression Regulation; Genetics; Hypersensitivity / immunology; Hypersensitivity / metabolism; Immunoglobulin E / blood; Inflammation; Lung / immunology; Lung / metabolism; Male; Mice; Phenotype; Quantitative Trait Loci; Respiratory Hypersensitivity / immunology
Source: Web Of Science
Added: August 6, 2018

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