Works Published in 2014
Displaying works 1 - 20 of 46 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles
Nature Communications, 5(1).
MeSH headings : Agranulocytosis / chemically induced; Agranulocytosis / genetics; Agranulocytosis / immunology; Alleles; Amino Acid Substitution; Antipsychotic Agents / adverse effects; Case-Control Studies; Clozapine / adverse effects; Exome; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; HLA-B Antigens / genetics; HLA-B Antigens / immunology; HLA-DQ beta-Chains / genetics; HLA-DQ beta-Chains / immunology; Heterozygote; Humans; Odds Ratio; Psychotic Disorders / drug therapy; Psychotic Disorders / genetics; Psychotic Disorders / immunology; Severity of Illness Index
TL;DR:
The largest and most comprehensive genetic study of CIAG to date is performed by interrogating 163 cases using genome-wide genotyping and whole-exome sequencing and finds that two loci in the major histocompatibility complex are independently associated with clozapine-induced agranulocytosis/granulocytopenia.
(via Semantic Scholar)
www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
QSAR Modeling: Where Have You Been? Where Are You Going To?
Journal of Medicinal Chemistry, 57(12), 4977–5010.
MeSH headings : Antimicrobial Cationic Peptides / chemistry; Artificial Intelligence; Complex Mixtures / chemistry; Databases, Factual; Drug Design; History, 20th Century; History, 21st Century; Models, Molecular; Nanostructures / chemistry; Pharmacokinetics; Quantitative Structure-Activity Relationship; Quantum Theory; Toxicology / methods
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems
Chemical Reviews, 114(15), 7740–7781.
MeSH headings : Biological Transport; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cytoskeleton / drug effects; Cytoskeleton / metabolism; DNA / chemistry; DNA / metabolism; Humans; Ion Channels / antagonists & inhibitors; Ion Channels / chemistry; Mitochondria / drug effects; Mitochondria / metabolism; Nanoparticles / chemistry; Nanoparticles / metabolism; Nanoparticles / toxicity; Oxidative Stress / drug effects; Phospholipids / chemistry; Phospholipids / metabolism; Proteins / chemistry; Proteins / metabolism; Surface Properties
TL;DR:
As the production and applications of ENMs rapidly expand, their environmental impacts and effects on human health are becoming increasingly significant, and a thorough understanding of how nanomaterials perturb cells and biological molecules is required.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
Data Set Modelability by QSAR
Journal of Chemical Information and Modeling, 54(1), 1–4.
MeSH headings : Computational Biology; Databases, Chemical / statistics & numerical data; Drug Design; Models, Chemical; Quantitative Structure-Activity Relationship
TL;DR:
A simple MODelability Index (MODI) is introduced that estimates the feasibility of obtaining predictive QSAR models (correct classification rate above 0.7) for a binary data set of bioactive compounds.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Expanding the scope of drug repurposing in pediatrics: The Children's Pharmacy Collaborative™
Drug Discovery Today, 19(11), 1696–1698.
MeSH headings : Child; Databases, Pharmaceutical; Drug Repositioning; Humans; Pediatrics
TL;DR:
The development of The Children's Pharmacy Collaborative is described, which should grow over time, serve as a resource for professionals and families, and stimulate drug-repurposing efforts for a range of pediatric disorders.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Heritability and genomics of gene expression in peripheral blood
Nature Genetics, 46(5), 430–437.
MeSH headings : Blood / metabolism; Gene Expression Profiling; Gene Expression Regulation / genetics; Genotype; Humans; Inheritance Patterns / genetics; Likelihood Functions; Netherlands; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics
TL;DR:
Gen expression profiles in 2,752 twins were assessed, using a classic twin design, to quantify expression heritability and quantitative trait loci (eQTLs) in peripheral blood, providing a new resource toward understanding the genetic control of transcription.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2014 journal article
Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol
The American Journal of Human Genetics, 94(2), 233–245.
MeSH headings : Adult; Aged; Apolipoproteins E / blood; Apolipoproteins E / genetics; Cholesterol, LDL / genetics; Cohort Studies; Dyslipidemias / blood; Dyslipidemias / genetics; Exome; Female; Follow-Up Studies; Gene Frequency; Genetic Code; Genome-Wide Association Study; Genotype; Humans; Lipase / genetics; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Proprotein Convertase 9; Proprotein Convertases / genetics; Receptors, LDL / genetics; Sequence Analysis, DNA; Serine Endopeptidases / genetics
TL;DR:
This large whole-exome-sequencing study for LDL-C identified a gene not known to be implicated in LDL- C and provides unique insight into the design and analysis of similar experiments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
ToxiFly: Can fruit flies be used to identify toxicity pathways for airborne chemicals?
Neurotoxicology and Teratology, 43, 89.
Sources: Crossref, NC State University Libraries
Added: February 21, 2020
2014 journal article
Improved structural annotation of protein-coding genes in the Meloidogyne hapla genome using RNA-Seq
Worm, 3(1), e29158.
TL;DR:
The current genome annotation for the Meloidogyne hapla genome utilizing RNA-Seq data is refined, and in silico predictions of trans-splicing were validated by comparison with earlier results derived from an independent cDNA library constructed to capture trans- spliced transcripts.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 7, 2020
2014 journal article
A Genome-Wide Association Study of the Maize Hypersensitive Defense Response Identifies Genes That Cluster in Related Pathways
PLoS Genetics, 10(8), e1004562.
Ed(s): J. McDowell
MeSH headings : Chromosome Mapping; Disease Resistance / genetics; Genome-Wide Association Study; Linkage Disequilibrium; Plant Diseases / genetics; Plant Proteins / genetics; Polymorphism, Single Nucleotide; Quantitative Trait Loci / genetics; Zea mays / genetics
TL;DR:
This study provides the first system-wide analysis of natural variation that modulates the HR response in plants with low but significant correlations between HR-related traits and several previously-measured disease resistance traits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 7, 2020
2014 journal article
Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging
Acta Neuropathologica Communications, 2(1).
Contributors: A. Motsinger-Reif n, H. Zhu *, M. Kling*, W. Matson*, S. Sharma *, O. Fiehn *, D. Reif n , D. Appleby *
author keywords: Alzheimer's disease; Dementias; Metabolomics; Cerebrospinal fluid biomarkers; Stepwise logistic regression
MeSH headings : Aged; Aging / cerebrospinal fluid; Aging / drug effects; Aging / pathology; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / diagnosis; Alzheimer Disease / drug therapy; Alzheimer Disease / pathology; Amyloid beta-Peptides / cerebrospinal fluid; Area Under Curve; Biomarkers / cerebrospinal fluid; Chromatography, Liquid; Cognition; Diagnosis, Differential; Female; Gas Chromatography-Mass Spectrometry; Humans; Logistic Models; Male; Metabolomics / methods; Neuropsychological Tests; tau Proteins / cerebrospinal fluid
TL;DR:
Several CSF small-molecule metabolites that discriminated especially well between clinically diagnosed AD and control groups appear to be suitable for further confirmatory and validation studies, and show the potential to provide predictive performance for AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2014 journal article
Test driving ToxCast: Endocrine profiling for 1858 chemicals included in phase II
Current Opinion in Pharmacology, 19, 145–152.
Contributors: D. Filer*, H. Patisaul n, T. Schug*, D. Reif n & K. Thayer *
MeSH headings : Animals; Databases, Factual; Endocrine Disruptors / toxicity; High-Throughput Screening Assays; Humans; Models, Theoretical; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR:
Results from this exercise suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated, and that some aspects of endocrine disruption are not fully covered in ToxCast.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: May 14, 2019
2014 journal article
Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
Scientific Reports, 4.
Contributors: R. Huang *, S. Sakamuru *, M. Martin*, D. Reif* , R. Judson *, K. Houck *, W. Casey *, J. Hsieh *
MeSH headings : Cell Line; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Genes, Reporter / drug effects; HEK293 Cells; High-Throughput Screening Assays / methods; Humans; Ligands; Protein Binding / drug effects; Signal Transduction / drug effects; Small Molecule Libraries / pharmacology; Structure-Activity Relationship
TL;DR:
The results demonstrate the feasibility of qHTS to identify environmental chemicals with the potential to interact with the ERα signaling pathway and the two different assay formats improve the confidence in correctly identifying these chemicals.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses
Environmental Science and Technology, 48(15), 8706–8716.
Contributors: D. Rotroff *, M. Martin*, D. Dix*, D. Filer*, K. Houck *, T. Knudsen *, N. Sipes *, D. Reif*
MeSH headings : Algorithms; Animals; Biological Assay; Endocrine Disruptors / analysis; Estrogen Antagonists / analysis; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Estrogen Receptor beta / agonists; Estrogen Receptor beta / antagonists & inhibitors; Estrogens / analysis; High-Throughput Screening Assays; Humans; MCF-7 Cells; Models, Chemical; Pesticides; Signal Transduction
TL;DR:
A novel method for combining in vitro concentration response data from multiple assays and, when applied to a large set of ER data, accurately predicted estrogenic responses and demonstrated its utility for chemical prioritization is provided.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
Nature Biotechnology, 32(6), 583–591.
Contributors: N. Kleinstreuer *, J. Yang *, E. Berg*, T. Knudsen *, A. Richard *, M. Martin*, D. Reif* , R. Judson *
MeSH headings : Animal Testing Alternatives / methods; Animals; Computer Simulation; High-Throughput Screening Assays / methods; Humans; Mice; Models, Biological; Phenotype; Rats; Small Molecule Libraries; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
The results demonstrate that assaying complex biological pathways in primary human cells can identify potential chemical targets, toxicological liabilities and mechanisms useful for elucidating adverse outcome pathways.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Multidimensional in vivo hazard assessment using zebrafish.
Toxicological Sciences, 137(1), 212–233.
Contributors: L. Truong *, D. Reif n , L. Mary *, M. Geier*, H. Truong* & R. Tanguay *
MeSH headings : Animals; Cluster Analysis; Computational Biology; Dose-Response Relationship, Drug; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Embryo, Nonmammalian / pathology; Embryonic Development / drug effects; Environmental Pollutants / toxicity; High-Throughput Screening Assays; Humans; Motor Activity / drug effects; Notochord / drug effects; Notochord / pathology; Reproducibility of Results; Risk Assessment; Toxicity Tests / methods; Zebrafish / embryology
TL;DR:
An experimental design for high-throughput characterization of multidimensional in vivo effects with the power to evaluate trends relating to commonly cited chemical predictors is described and it is demonstrated that the developmental zebrafish detects adverse responses that would be missed by less comprehensive testing strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2014 journal article
Hierarchical dose-response modeling for high-throughput toxicity screening of environmental chemicals
Biom, 70(1), 237â246.
Contributors: A. Wilson n, D. Reif n & B. Reich n
author keywords: Bayesian; Computational toxicology; Dose-response; MCMC; Monotonicity; Semiparametric; ToxCast
MeSH headings : Algorithms; Bayes Theorem; Computer Simulation; Dose-Response Relationship, Drug; Environmental Pollutants / toxicity; Estrogen Receptor alpha / metabolism; Humans; Markov Chains; Models, Statistical; Monte Carlo Method; PPAR gamma / metabolism; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
This work proposes a semiparametric Bayesian model that borrows strength across chemicals and assays and demonstrates that the hierarchical method provides more accurate estimates of the probability of response, efficacy, and potency than separate curve estimation in a simulation study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: May 14, 2019
2014 journal article
Erratum to Incorporating human dosimetry and exposure into High-throughput in Vitro Toxicity Screening [Toxicological sciences 137, 2, (2014), 499]
Toxicological Sciences, 137(2).
Contributors: D. Rotroff, B. Wetmore, D. Dix, S. Ferguson, H. Clewell, K. Houck, E. LeCluyse, M. Andersen
Source: ORCID
Added: May 14, 2019
2014 journal article
PGxClean: a quality control GUI for the Affymetrix DMET chip and other candidate gene studies with non-biallelic alleles
Biodata Mining, 7.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Integrative Genetic Analysis of Allergic Inflammation in the Murine Lung
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 51(3), 436–445.
author keywords: allergic airway disease; systems genetics; gene expression quantitative trait loci
MeSH headings : Animals; Antigens, Dermatophagoides / immunology; Bronchial Hyperreactivity / immunology; Dermatophagoides pteronyssinus / metabolism; Disease Models, Animal; Gene Expression Regulation; Genetics; Hypersensitivity / immunology; Hypersensitivity / metabolism; Immunoglobulin E / blood; Inflammation; Lung / immunology; Lung / metabolism; Male; Mice; Phenotype; Quantitative Trait Loci; Respiratory Hypersensitivity / immunology
TL;DR:
The results demonstrate that hallmark allergic airway disease phenotypes are associated with distinct genetic loci on Chrs 4 and 11, and that gene expression in the allergically inflamed lung is controlled by both cis and trans regulatory factors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
