Works Published in 2016
Displaying works 1 - 20 of 59 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
Erratum: Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases
Scientific Reports, 6(1), 19384.
TL;DR:
This work catalogueed age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project, finding the aging gene expression signatures are very tissue specific and enrichment for some well-known aging components such as mitochondrial biology is observed in many tissues.
(via Semantic Scholar)
www.nature.com (publisher PDF)
Source: Crossref
Added: January 4, 2021
2016 journal article
GENETIC INFLUENCE ON LEVELS OF TARGETED METABOLITES ASSOCIATED WITH ALZHEIMER’S DISEASE
Alzheimer's & Dementia, 12(7), P164–P165.
Source: Crossref
Added: August 28, 2020
2016 journal article
THE ALZHEIMER’S METABOLOME: RELATIONSHIP TO PATHOLOGICAL MARKERS AND COGNITIVE DECLINE IN THE ALZHEIMER’S DISEASE NEUROIMAGING INITIATIVE (ADNI)
Alzheimer's & Dementia, 12(7), P164.
TL;DR:
The results suggest that both coding and non-coding rare variants influence LOAD susceptibility, and show the continued utility of family-based approaches.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2016 journal article
Activity prediction and identification of mis-annotated chemical compounds using extreme descriptors
Journal of Chemometrics, 30(3), 99–108.
author keywords: extreme descriptors; low-variance descriptors; mislabeling; QSAR; Prediction
TL;DR:
It is demonstrated using two case studies (M2 muscarinic receptors and skin sensitization) that extreme descriptors can be used for the identification of possibly mislabeled compounds and should be considered in quantitative structure–activity relationship modeling studies.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2016 journal article
Integrative approaches for large-scale transcriptome-wide association studies
Nature Genetics, 48(3), 245–252.
MeSH headings : Animals; Gene Expression Regulation / genetics; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Mice; Obesity / genetics; Obesity / pathology; Phenotype; Quantitative Trait Loci / genetics; Transcriptome / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2016 journal article
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
Nature Genetics, 48(9), 1055–1059.
MeSH headings : Blood Glucose / analysis; Body Mass Index; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Genome-Wide Association Study; Glucose Transporter Type 2 / genetics; Glycated Hemoglobin / analysis; Humans; Hypoglycemic Agents / therapeutic use; Metformin / therapeutic use; Polymorphism, Single Nucleotide / genetics; Quantitative Trait, Heritable; White People
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: February 24, 2020
2016 journal article
INDICES OF PLASMALOGEN BIOSYNTHESIS IN ADNI-1 BASELINE SERUM SAMPLES: ASSOCIATION WITH PROGRESSION TO DEMENTIA IN SUBJECTS WITH MILD COGNITIVE IMPAIRMENT
Alzheimer's & Dementia, 12(7), P879–P880.
TL;DR:
The results demonstrate that in patients with AD, T4 levels are about 10 times higher than normal, suggesting that along the development occurs a reduction in expression of isoform of the enzyme D2 or oxidative neurodegeneration cholinergic accompanying this disease, contributes to a reduction of the enzymatic activity D2.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2016 journal article
Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka, Oryzias latipes
Toxicological Sciences, 11, kfw229.
author keywords: receptor, aryl hydrocarbon; gene expression/regulation, bone; transgenic models; methods, developmental/teratology; reproductive and developmental toxicology
MeSH headings : Animals; Calcification, Physiologic / drug effects; Down-Regulation / drug effects; Microscopy, Confocal; Musculoskeletal Diseases / metabolism; Oryzias / embryology; Osteogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Real-Time Polymerase Chain Reaction; Skeleton / drug effects; Skeleton / metabolism; Trans-Activators / drug effects
TL;DR:
It is suggested that TCDD exposure inhibits axial bone formation through dysregulation of osteoblast differentiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2016 journal article
Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.
Toxicological Sciences : an Official Journal of the Society of Toxicology, 8(2), 323–339.
Contributors: R. Judson *, K. Houck *, M. Martin*, A. Richard *, T. Knudsen *, I. Shah *, S. Little *, J. Wambaugh *
author keywords: In vitro; high-throughput screening; oxidative stress; cytotoxicity; cell stress
MeSH headings : Biological Assay / methods; Humans; In Vitro Techniques; Stress, Physiological; Toxicity Tests / methods
TL;DR:
Responses of 1060 chemicals including pharmaceuticals, natural products, pesticidals, consumer, and industrial chemicals across a battery of in vitro assay endpoints from 7 high-throughput assay technology platforms were analyzed to suggest that activity can be broadly divided into specific biomolecular interactions against one or more targets at concentrations below which overt cytotoxicity-associated activity is observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: May 14, 2019
2016 journal article
Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.
Toxicological Sciences : an Official Journal of the Society of Toxicology, 10(2), 409–409.
Contributors: R. Judson *, K. Houck *, M. Martin*, A. Richard *, T. Knudsen *, I. Shah *, S. Little *, J. Wambaugh *
TL;DR:
Responses of 1060 chemicals including pharmaceuticals, natural products, pesticidals, consumer, and industrial chemicals across a battery of 815 in vitro assay endpoints from 7 high-throughput assay technology platforms were analyzed to suggest that activity can be broadly divided into specific biomolecular interactions at concentrations below which overt cytotoxicity-associated activity is observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2016 journal article
Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database.
Environmental Health Perspectives, 10. http://europepmc.org/abstract/med/27170236
Source: ORCID
Added: May 14, 2019
2016 journal article
Incorporating concomitant medications into genome-wide analyses for the study of complex disease and drug response
Frontiers in Genetics, 7.
Source: NC State University Libraries
Added: August 6, 2018
2016 conference paper
Poster: risk-based attack surface approximation
Symposium and Bootcamp on the Science of Security, 121–123.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Homologous recombination and translesion DNA synthesis play critical roles on tolerating DNA damage caused by trace levels of hexavalent chromium
PLoS One, 11(12).
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Genomic Characterization of Metformin Hepatic Response
PLOS GENETICS, 12(11).
MeSH headings : AMP-Activated Protein Kinases / biosynthesis; AMP-Activated Protein Kinases / genetics; Activating Transcription Factor 3 / genetics; Adaptor Proteins, Signal Transducing / genetics; Ataxia Telangiectasia Mutated Proteins / biosynthesis; Ataxia Telangiectasia Mutated Proteins / genetics; DEAD-box RNA Helicases / genetics; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / pathology; Enhancer Elements, Genetic; Gene Knockdown Techniques; Gluconeogenesis / genetics; Haplotypes; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Linkage Disequilibrium; Liver / drug effects; Liver / metabolism; Metformin / adverse effects; Metformin / therapeutic use; Polymorphism, Single Nucleotide
TL;DR:
It is shown that activating transcription factor 3 (ATF3), the top metformin upregulated AMPK-dependent gene, could have an important role in gluconeogenesis repression and the findings provide a genome-wide representation of met formin hepatic response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership
PLOS ONE, 11(12).
Contributors: E. Kollitz n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n
Ed(s): C. Zhang n
MeSH headings : Animals; Biological Evolution; Hep G2 Cells; Humans; Lithocholic Acid / metabolism; Receptors, Calcitriol / metabolism; Vertebrates
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Decoupling of a neutron interferometer from temperature gradients
REVIEW OF SCIENTIFIC INSTRUMENTS, 87(12).
TL;DR:
The vacuum chamber is found to have no depreciable effect on the performance of the interferometer (contrast) while improving system stability, thereby showing that it is feasible to replace large temperature isolation and control systems with a compact vacuum enclosure for perfect crystal neutron interferometry.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
QSAR models of human data can enrich or replace LLNA testing for human skin sensitization
GREEN CHEMISTRY, 18(24), 6501–6515.
TL;DR:
Predictive QSAR models developed here provide more accurate alternative to LLNA testing for human skin sensitization assessment across diverse chemical data and can also be used to guide the structural optimization of toxic compounds to reduce their skin sensitized potential.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero
BMC Genomics, 17.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
A European spectrum of pharmacogenomic biomarkers: Implications for clinical pharmacogenomics
PLoS One, 11(9).
Source: NC State University Libraries
Added: August 6, 2018
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