Works Published in 2017
Displaying works 1 - 20 of 50 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2017 journal article
Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
Molecular Psychiatry, 22(10), 1502–1508.
MeSH headings : Carrier Proteins / genetics; Case-Control Studies; Clozapine / adverse effects; Clozapine / therapeutic use; Exome; Female; Genome-Wide Association Study; HLA-DQ beta-Chains / genetics; Humans; Male; Neutropenia / chemically induced; Neutropenia / genetics; Neutropenia / metabolism; Odds Ratio; Schizophrenia / drug therapy; Schizophrenia / genetics; Solute Carrier Organic Anion Transporter Family Member 1B3 / genetics
TL;DR:
The results implicate biological pathways through which clozapine may act to cause this serious adverse effect of schizophrenia, and identify gene-wide associations of uncommon non-synonymous variants within UBAP2 and STARD9.
(via Semantic Scholar)
www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 28, 2021
2017 journal article
Reaction: Molecular Modeling for Novel Antibacterials
Chem, 3(1), 13–14.
TL;DR:
This research focuses on the development and applications of novel predictive cheminformatics methods and their applications in Chemistry and Bioinformatics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: December 21, 2020
2017 journal article
Cheminformatics Modeling of Amine Solutions for Assessing their CO2Absorption Properties
Molecular Informatics, 36(7), 1600143.
author keywords: amine scrubbing; molecular modeling; QSPR; CO2 recycling
MeSH headings : Algorithms; Amines / chemistry; Carbon Dioxide / analysis; Carbon Dioxide / chemistry; Cluster Analysis; Databases, Factual; Machine Learning; Models, Chemical; Models, Molecular; Quantitative Structure-Activity Relationship; Reproducibility of Results; Solutions
TL;DR:
The chemical analysis and series of QSPR models presented in this proof‐of‐concept study represent new knowledge and innovative tools that could be very useful for screening and prioritizing hypothetical amines to be synthesized and tested experimentally for their CO2 absorption properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: December 21, 2020
2017 journal article
Genetic effects on gene expression across human tissues
Nature, 550(7675), 204–213.
MeSH headings : Alleles; Chromosomes, Human / genetics; Disease / genetics; Female; Gene Expression Profiling; Gene Expression Regulation / genetics; Genetic Variation; Genome, Human / genetics; Genotype; Humans; Male; Organ Specificity / genetics; Quantitative Trait Loci / genetics
TL;DR:
It is found that local genetic variation affects gene expression levels for the majority of genes, and inter-chromosomal genetic effects for 93 genes and 112 loci are identified, enabling a mechanistic interpretation of gene regulation and the genetic basis of disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: December 19, 2020
2017 journal article
The impact of rare variation on gene expression across tissues
Nature, 550(7675), 239–243.
MeSH headings : Bayes Theorem; Female; Gene Expression Profiling; Genetic Variation / genetics; Genome, Human / genetics; Genomics; Genotype; Humans; Male; Models, Genetic; Organ Specificity / genetics; Sequence Analysis, RNA
TL;DR:
It is demonstrated that rare variants contribute to large gene expression changes across tissues and provide an integrative method for interpretation of rare variants in individual genomes.
(via Semantic Scholar)
Source: Crossref
Added: December 19, 2020
2017 journal article
Landscape of X chromosome inactivation across human tissues
Nature, 550(7675), 244–248.
MeSH headings : Chromosomes, Human, X / genetics; Female; Genes, X-Linked / genetics; Genome, Human / genetics; Genomics; Humans; Male; Organ Specificity / genetics; Phenotype; Sequence Analysis, RNA; Single-Cell Analysis; Transcriptome / genetics; X Chromosome Inactivation / genetics
TL;DR:
It is shown that incomplete XCI affects at least 23% of X-chromosomal genes, identified seven genes that escape XCI with support from multiple lines of evidence and demonstrated that escape from XCI results in sex biases in gene expression, establishing incomplete X CI as a mechanism that is likely to introduce phenotypic diversity.
(via Semantic Scholar)
Source: Crossref
Added: December 19, 2020
2017 journal article
Dynamic landscape and regulation of RNA editing in mammals
Nature, 550(7675), 249–254.
MeSH headings : Adenosine Deaminase / genetics; Adenosine Deaminase / metabolism; Animals; Female; Genotype; HEK293 Cells; Humans; Male; Mice; Muscles / metabolism; Nuclear Proteins / metabolism; Organ Specificity / genetics; Primates / genetics; Proteolysis; RNA Editing / genetics; RNA-Binding Proteins / genetics; RNA-Binding Proteins / metabolism; Spatio-Temporal Analysis; Species Specificity; Transcriptome / genetics
TL;DR:
This work curated an extensive set of ADAR1 and ADAR2 targets and showed that many editing sites display distinct tissue-specific regulation by the ADAR enzymes in vivo, suggesting stronger cis-directed regulation of RNA editing for most sites, although the small set of conserved coding sites is under stronger trans-regulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Crossref
Added: December 19, 2020
2017 journal article
Targeted metabolomics and medication classification data from participants in the ADNI1 cohort
Scientific Data, 4(1).
MeSH headings : Alzheimer Disease / drug therapy; Alzheimer Disease / genetics; Alzheimer Disease / metabolism; Cognitive Dysfunction; Cohort Studies; Humans; Metabolomics; Neuroimaging
TL;DR:
This report presents quantitative metabolomics data generated on serum from 199 control, 356 mild cognitive impairment and 175 AD subjects enrolled in ADNI1 using AbsoluteIDQ-p180 platform, along with the pipeline for data preprocessing and medication classification for confound correction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 21, 2020
2017 journal article
GUT DERIVED BILE ACID METABOLITES CORRELATE WITH STRUCTURAL AND FUNCTIONAL NEUROIMAGING MEASURES IN ALZHEIMER’S DISEASE
Alzheimer's & Dementia, 13(7), P543–P544.
TL;DR:
It is discovered that in the pooled-sex network, sphingomyelins and amines correlated with Sex and phosphatidylcholines connects to AD progression (Dx).
(via Semantic Scholar)
Source: Crossref
Added: February 21, 2020
2017 journal article
Metabolic network failures in Alzheimer's disease: A biochemical road map
Alzheimer's & Dementia, 13(9), 965–984.
author keywords: Metabolomics; Metabonomics; Pharmacometabolomics; Pharmacometabonomics; Biomarkers; Serum; Metabolism; Systems biology; Biochemical networks; Precision medicine; Alzheimer's disease; Dementia; Branched-chain amino acids; Sphingomyelins; Phospholipids; Acylcarnitines
MeSH headings : Aged; Aged, 80 and over; Aging / blood; Alzheimer Disease / blood; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / complications; Alzheimer Disease / diagnostic imaging; Amino Acids / blood; Amyloid beta-Peptides / metabolism; Aniline Compounds / metabolism; Cognitive Dysfunction / blood; Cognitive Dysfunction / diagnostic imaging; Cognitive Dysfunction / etiology; Cohort Studies; Cross-Sectional Studies; Fasting; Female; Humans; Male; Metabolic Diseases / blood; Metabolic Diseases / cerebrospinal fluid; Metabolic Diseases / diagnostic imaging; Metabolic Diseases / etiology; Metabolic Networks and Pathways / physiology; Metabolomics / methods; Peptide Fragments / metabolism; Phosphatidylcholines / blood; Phosphatidylcholines / metabolism; Sphingomyelins / blood; Thiazoles / metabolism; tau Proteins / cerebrospinal fluid
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 21, 2020
2017 journal article
Genetic Variants in HSD17B3 , SMAD3 , and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes
Clinical Pharmacology & Therapeutics, 103(4), 712–721.
MeSH headings : Aldehyde Reductase / genetics; Animals; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Dyslipidemias / blood; Dyslipidemias / complications; Dyslipidemias / drug therapy; Dyslipidemias / genetics; Female; Fenofibrate / administration & dosage; Fenofibrate / pharmacokinetics; Gene Expression Profiling / methods; Genome-Wide Association Study; Humans; Hypolipidemic Agents / administration & dosage; Hypolipidemic Agents / pharmacokinetics; Lipid Metabolism / drug effects; Lipid Metabolism / genetics; Male; Mice; Middle Aged; Pharmacogenomic Testing / methods; Signal Transduction / drug effects; Smad3 Protein / genetics; beta Karyopherins / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: February 21, 2020
2017 journal article
Genetics of Hereditary Ataxia in Scottish Terriers
Journal of Veterinary Internal Medicine, 31(4), 1132–1139.
author keywords: Canine; Cerebellar abiotrophy; Cerebellar ataxia; Neurodegeneration
MeSH headings : Animals; Brain / diagnostic imaging; Dog Diseases / diagnostic imaging; Dog Diseases / genetics; Dogs; Female; Genetic Linkage / genetics; Genome-Wide Association Study / veterinary; Homozygote; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Pedigree; Spinocerebellar Degenerations / diagnostic imaging; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / veterinary
TL;DR:
This finding suggests that further genetic investigation of the potential region of interest on CFA X should be considered in order to identify the causal mutation as well as develop a genetic test to eliminate the disease from this breed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 7, 2020
2017 article
Integrating Morphological and Behavioral Phenotypes in Developing Zebrafish
The Rights and Wrongs of Zebrafish: Behavioral Phenotyping of Zebrafish, pp. 259–272.
Contributors: G. Zhang n, L. Truong *, R. Tanguay * & D. Reif n
TL;DR:
It is concluded that appropriate design and analysis of integrated morphological and behavioral studies using zebrafish can elucidate new chemical bioactivity pathways, identify compounds eliciting a broad range of effects, and paint a more comprehensive picture of development than either class of phenotype alone.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2017 journal article
Embryonic exposure to TCDD impacts osteogenesis of the axial skeleton in Japanese medaka, Oryzias latipes
Toxicological Sciences, 155(2), 485–496.
Contributors: A. Watson, A. Planchart n, C. Mattingly n, C. Winkler *, D. Reif n & S. Kullman n
author keywords: receptor, aryl hydrocarbon; gene expression/regulation, bone; transgenic models; methods, developmental/teratology; reproductive and developmental toxicology
MeSH headings : Animals; Calcification, Physiologic / drug effects; Down-Regulation / drug effects; Microscopy, Confocal; Musculoskeletal Diseases / metabolism; Oryzias / embryology; Osteogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Real-Time Polymerase Chain Reaction; Skeleton / drug effects; Skeleton / metabolism; Trans-Activators / drug effects
TL;DR:
It is suggested that TCDD exposure inhibits axial bone formation through dysregulation of osteoblast differentiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2017 journal article
An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines
Frontiers in Pharmacology, 8(APR).
Contributors: K. Roell n, D. Reif n & A. Motsinger-Reif n
author keywords: synergy; mixtures; non-additive; interactions; drug combinations
TL;DR:
The various terminology surrounding the idea of synergy is discussed, providing a comprehensive list of terms defined across numerous disciplines, including the two most prominent reference models for describing additive interactions: Loewe Additivity and Bliss Independence.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2017 journal article
A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades
Toxicology and Applied Pharmacology, 314, 109–117.
Contributors: G. Zhang n, K. Roell n, L. Truong *, R. Tanguay * & D. Reif n
author keywords: Zebrafish; High-dimensional; Bayesian; Developmental cascade; ToxRefDB; Risk assessment; Multiple endpoints; Multivariate; Scoring
MeSH headings : Animals; Models, Theoretical; Multivariate Analysis; Phenotype; Zebrafish / embryology
TL;DR:
The results suggest that developmental cascade effects triggered by chemical exposure can be recapitulated by analyzing the relationships among endpoints, and wAggE offers a powerful approach for analysis of multivariate phenotypes that can reveal underlying etiological processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2017 journal article
A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish
PLOS ONE, 12(1).
Contributors: G. Zhang n, L. Truong *, R. Tanguay * & D. Reif n
Ed(s): S. Neuhauss
MeSH headings : Animals; Biometry / methods; High-Throughput Screening Assays / methods; Models, Statistical; Zebrafish
TL;DR:
A novel, robust statistical approach to characterize chemical-elicited effects in behavioral data from high-throughput screening of all 1,060 Toxicity Forecaster chemicals across 5 concentrations at 120 hours post-fertilization (hpf) achieves a significant reduction in coefficient of variation compared to many traditional statistical modeling methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2017 journal article
RealityConvert: a tool for preparing 3D models of biochemical structures for augmented and virtual reality
BIOINFORMATICS, 33(23), 3816–3818.
MeSH headings : Computational Biology / methods; Models, Molecular; Molecular Conformation; Software; Virtual Reality
TL;DR:
The RealityConvert software tool and associated website are presented, which allow users to easily convert molecular objects to high quality 3D models directly compatible for AR and VR applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
The Effect of Heart Disease on Anesthetic Complications During Routine Dental Procedures in Dogs
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 53(4), 206–213.
MeSH headings : Anesthesia / adverse effects; Anesthesia / veterinary; Animals; Case-Control Studies; Dental Prophylaxis / veterinary; Dog Diseases / etiology; Dogs; Heart Diseases / complications; Heart Diseases / veterinary; Intraoperative Complications / etiology; Intraoperative Complications / veterinary; Retrospective Studies; Risk Factors
TL;DR:
This study suggests dogs with heart disease, when anesthetized by trained personnel and carefully monitored during routine dental procedures, are not at significantly increased risk for anesthetic complications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Data descriptor: Targeted metabolomics and medication classification data from participants in the ADNI1 cohort
Scientific Data, 4.
Source: NC State University Libraries
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
