Works Published in 2021
Displaying works 1 - 20 of 34 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 journal article
Potential Human Health Hazard of Post-Hurricane Harvey Sediments in Galveston Bay and Houston Ship Channel: A Case Study of Using In Vitro Bioactivity Data to Inform Risk Management Decisions
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(24).
author keywords: new approach methods (NAMs); environmental mixtures; disaster research
MeSH headings : Bays; Cyclonic Storms; Disasters; Environmental Monitoring; Geologic Sediments; Humans; Polycyclic Aromatic Hydrocarbons / analysis; Risk Management; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
TL;DR:
It is found that in vitro bioactivity can be used as a comprehensive indicator of potential hazards and is an example of a new approach method (NAM) to inform risk management decisions on site cleanup.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
13. Climate Action
(OpenAlex)
Source: Web Of Science
Added: January 24, 2022
2021 journal article
Regulatory status of pesticide residues in cannabis: Implications to medical use in neurological diseases
CURRENT RESEARCH IN TOXICOLOGY, 2, 140–148.
author keywords: Cannabis; Pesticide; Database; Regulation; Seizure; Contaminant
TL;DR:
Network analysis reveals potential interactions of insecticides, cannabinoids, and seizure at a functional level in cannabis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 3, 2022
2021 journal article
Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database
CURRENT RESEARCH IN TOXICOLOGY, 2, 272–281.
author keywords: E-cigarettes; Vaping; Juul; Respiratory disease; Database; Environmental exposure
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 3, 2022
2021 journal article
CTD anatomy: Analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications for environmental health studies
CURRENT RESEARCH IN TOXICOLOGY, 2, 128–139.
author keywords: Anatomy; Chemical; Phenotype; Disease; Environmental health; Database
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 3, 2022
2021 journal article
Intra- and Inter-Species Variability in Urinary N7-(1-Hydroxy-3-buten-2-yl)guanine Adducts Following Inhalation Exposure to 1,3-Butadiene
CHEMICAL RESEARCH IN TOXICOLOGY, 34(11), 2375–2383.
MeSH headings : Animals; Butadienes / administration & dosage; Butadienes / metabolism; Butadienes / urine; Chromatography, Liquid; DNA Adducts / administration & dosage; DNA Adducts / metabolism; DNA Adducts / urine; Female; Inhalation Exposure; Male; Mice; Mice, Inbred Strains; Nanotechnology; Spectrometry, Mass, Electrospray Ionization
TL;DR:
Urinary EB-GII levels, particularly from human studies, may be useful for quantitative characterization of human variability in cancer risks to butadiene, and are largely consistent with UFH estimates for other chemicals based on human data for non-cancer endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 29, 2021
2021 journal article
Prediction of synergistic drug combinations using PCA-initialized deep learning
BIODATA MINING, 14(1).
author keywords: Deep learning; Cancer treatment; Drug combination treatment; Feedforward neural network; Machine learning; XGBoost; Random Forests; Elastic net
TL;DR:
This work presents a new deep learning approach to predict synergistic drug combinations by integrating gene expression profiles from cell lines and chemical structure data using principal component analysis (PCA) to reduce the dimensionality of chemical descriptor data and gene expression data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 8, 2021
2021 article
ToxPi*GIS Toolkit: Creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS
Fleming, J., Marvel, S. W., Motsinger-Reif, A. A., & Reif, D. M. (2021, October 11). (Vol. 10). Vol. 10.
TL;DR:
An actively developed suite of software for creating, viewing, sharing, and analyzing interactive ToxPi figures in ArcGIS, and a collection of Python routines for useful data manipulation and preprocessing for both novice and advanced users looking for additional customizability are proposed.
(via Semantic Scholar)
Source: ORCID
Added: October 13, 2021
2021 journal article
Application of Edible Montmorillonite Clays for the Adsorption and Detoxification of Microcystin
ACS APPLIED BIO MATERIALS, 4(9), 7254–7265.
author keywords: adsorption isotherm; Hydra vulgaris; Lemna minor; Caenorhabditis elegans; molecular model; dietary sorbent
MeSH headings : Adsorption; Animals; Bentonite / chemistry; Caenorhabditis elegans; Charcoal / pharmacology; Clay / chemistry; Hydra; Microcystins / chemistry
TL;DR:
Edible montmorillonite clays were characterized for their ability to bind MC containing leucine and arginine under conditions simulating the gastrointestinal tract and compared with a medical-grade activated carbon and validated in a battery of living organisms, suggesting that edible montMorillonites are safe and efficacious binders for MC-LR.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: October 12, 2021
2021 journal article
A Neuroprotective Locus Modulates Ischemic Stroke Infarction Independent of Collateral Vessel Anatomy
FRONTIERS IN NEUROSCIENCE, 15.
author keywords: ischemic stroke; infarct volume; neuroprotection; wild-derived mouse strain; quantitative trait locus mapping
TL;DR:
This study used quantitative trait locus mapping to identify novel gene targets modulating infarct size and identified Macrophage Scavenger Receptor 1 (Msr1) as a strong candidate gene that harbors multiple coding SNPs predicted to be damaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 30, 2021
2021 article
Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances
Kirkwood, K. I., Fleming, J., Nguyen, H., Reif, D. M., Baker, E. S., & Belcher, S. M. (2021, August 26). (Vol. 8). Vol. 8.
TL;DR:
Over 70 PFAS were detected in the pine needles from this study, providing information from the last six decades related to PFAS exposure, contamination, and reduction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: August 27, 2021
2021 journal article
High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs
PLOS GENETICS, 17(8).
Ed(s): F. Vazquez
MeSH headings : Antineoplastic Agents / pharmacology; Biomarkers, Pharmacological / analysis; Cell Line, Tumor; Genome-Wide Association Study / methods; High-Throughput Screening Assays / methods; Humans; NAD(P)H Dehydrogenase (Quinone) / drug effects; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism
TL;DR:
The NAD(P)H quinone dehydrogenase 1 (NQO1) gene was found to be associated with the dose-response of arsenic trioxide, erlotinib, tramet inib, and a combination treatment of paclitaxel + epirubicin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: August 27, 2021
2021 article
Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies
McDonough, C. W., Warren, H. R., Jack, J. R., Motsinger-Reif, A. A., Armstrong, N. D., Bis, J. C., … Cooper-DeHoff, R. M. (2021, August 15). CLINICAL PHARMACOLOGY & THERAPEUTICS.
MeSH headings : Black or African American / genetics; Aged; Antihypertensive Agents / therapeutic use; Blood Pressure / drug effects; Blood Pressure / genetics; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / genetics; Cardiovascular System / drug effects; Drug-Related Side Effects and Adverse Reactions / etiology; Drug-Related Side Effects and Adverse Reactions / genetics; Female; Genome-Wide Association Study / methods; Humans; Hypertension / drug therapy; Hypertension / genetics; Male; Middle Aged; Pharmacogenomic Testing / methods; Polymorphism, Single Nucleotide / genetics
TL;DR:
The NTM region is associated with increased risk for adverse cardiovascular outcomes and less BP reduction in β-blocker treated patients and no SNPs attained genome-wide significance for any other drugs classes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 23, 2021
2021 article
A critical overview of computational approaches employed for COVID-19 drug discovery
Muratov, E. N., Amaro, R., Andrade, C. H., Brown, N., Ekins, S., Fourches, D., … Tropsha, A. (2021, July 2). CHEMICAL SOCIETY REVIEWS.
MeSH headings : Antiviral Agents / therapeutic use; COVID-19 / virology; Clinical Trials as Topic; Computer Simulation; Drug Design; Drug Discovery / methods; Drug Repositioning; Humans; Pandemics; SARS-CoV-2 / drug effects; COVID-19 Drug Treatment
TL;DR:
It is proposed that truly impactful computational tools must deliver actionable, experimentally testable hypotheses enabling the discovery of novel drugs and drug combinations, and that open science and rapid sharing of research results are critical to accelerate the development of novel, much needed therapeutics for COVID-19.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 26, 2021
2021 journal article
Data Processing Workflow to Identify Structurally Related Compounds in Petroleum Substances Using Ion Mobility Spectrometry-Mass Spectrometry
ENERGY & FUELS, 35(13), 10529–10539.
TL;DR:
This work demonstrates how rapid untargeted IMS-MS analysis and the proposed data processing workflow can be used to provide confident compositional characterization of hydrocarbon-containing substances.
(via Semantic Scholar)
Source: Web Of Science
Added: July 26, 2021
2021 journal article
Multiomic Big Data Analysis Challenges: Increasing Confidence in the Interpretation of Artificial Intelligence Assessments
ANALYTICAL CHEMISTRY, 93(22), 7763–7773.
MeSH headings : Artificial Intelligence; Big Data; Data Analysis
TL;DR:
The present and future capabilities of AI techniques in multiomic studies are discussed while introducing analytical checks and balances to validate the computational conclusions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 19, 2021
2021 journal article
Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology
PLOS COMPUTATIONAL BIOLOGY, 17(7).
Ed(s): V. Hatzimanikatis
MeSH headings : Animals; Computational Biology; Embryo, Nonmammalian / drug effects; High-Throughput Screening Assays; Models, Chemical; Neural Networks, Computer; Toxicity Tests; Toxicology; Zebrafish
TL;DR:
E embryonic zebrafish were used to examine a suite of morphological and mortality endpoints at six concentrations from over 1,000 unique chemicals found in the ToxCast library, and Go-ZT significantly outperformed the cGAN, support vector machine, random forest and multilayer perceptron models in cross-validation, and when tested against an external test dataset.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 5, 2021
2021 journal article
CATMoS: Collaborative Acute Toxicity Modeling Suite
ENVIRONMENTAL HEALTH PERSPECTIVES, 129(4).
MeSH headings : Animals; Computer Simulation; Government Agencies; Rats; Toxicity Tests, Acute; United States; United States Environmental Protection Agency
TL;DR:
In silico models built using existing data facilitate rapid acute toxicity predictions without using animals, and CATMoS is being evaluated by regulatory agencies for its utility and applicability as a potential replacement for in vivo rat acute oral toxicity studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 28, 2021
2021 journal article
Concurrent Evaluation of Mortality and Behavioral Responses: A Fast and Efficient Testing Approach for High-Throughput Chemical Hazard Identification
Frontiers in Toxicology, 3.
TL;DR:
It is found that combining information from behavioral and mortality assessments captures early signals of potential chemical hazards, obviating the need to evaluate a comprehensive suite of morphological endpoints in initial screens for toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2021
2021 journal article
Knockoff boosted tree for model-free variable selection
BIOINFORMATICS, 37(7), 976–983.
MeSH headings : Algorithms; Computer Simulation; Genome; Machine Learning
TL;DR:
This work proposes a novel strategy for conducting variable selection without prior model topology knowledge using the knockoff method with boosted tree models and applies this method for tumor purity estimation and tumor classification using Cancer Genome Atlas data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 21, 2021
2021 journal article
Toward genetic modification of plant-parasitic nematodes: delivery of macromolecules to adults and expression of exogenous mRNA in second stage juveniles
G3-GENES GENOMES GENETICS, 11(2).
author keywords: plant-parasitic nematodes; transient expression; genetic modification; lipofection; transformation; germline
MeSH headings : Animals; Arabidopsis / genetics; Male; Plant Diseases; RNA Interference; RNA, Messenger; Tylenchoidea / genetics
TL;DR:
Some of the foundational biology required to deliver a functional genetic tool kit in plant-parasitic nematodes are developed, and the gonads of male Heterodera schachtii and Meloidogyne hapla are characterised in the context of spermatogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
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