Works Published in 2019
Displaying all 4 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
The regulatory TnaC nascent peptide preferentially inhibits release factor 2-mediated hydrolysis of peptidyl-tRNA
JOURNAL OF BIOLOGICAL CHEMISTRY, 294(50), 19224–19235.
author keywords: Regulatory nascent peptides; release factor; L-tryptophan; peptidyl transferase center; ribosomal arrest; gene regulation; translation termination; tnaC; GGQ tripeptide motif
MeSH headings : Escherichia coli K12; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Hydrolysis; Models, Molecular; Peptide Termination Factors / chemistry; Peptide Termination Factors / metabolism; RNA, Transfer, Amino Acyl / metabolism
TL;DR:
Results indicate that l-Trp preferentially blocks RF2 activity during translation termination of the tnaC gene, which depends on the identities of amino acid residues surrounding the RF2-GGQ functional motif.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 16, 2020
2019 article
Listeria monocytogenes at the human-wildlife interface: black bears (Ursus americanus) as potential vehicles for Listeria
(P. Brown, Ed.). MICROBIAL BIOTECHNOLOGY, Vol. 13, pp. 706–721.
Ed(s): P. Brown n
MeSH headings : Animals; Animals, Wild / microbiology; Listeria monocytogenes / isolation & purification; Listeria monocytogenes / physiology; Listeriosis / epidemiology; Listeriosis / microbiology; Listeriosis / transmission; Southeastern United States / epidemiology; Ursidae / microbiology
TL;DR:
The results suggest that the ursine host may preferentially select for L. monocytogenes of clinically relevant lineages over the diverse listerial populations in the environment, and highlight the public health significance of the human–wildlife interface.
(via Semantic Scholar)
sfamjournals.onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 25, 2019
2019 journal article
IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 7(1), 1–17.
author keywords: Intestinal Stem Cells; Interleukin-22; Inflammatory Bowel Disease
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage / drug effects; Cell Proliferation / drug effects; Cell Self Renewal / drug effects; Cellular Microenvironment / drug effects; Computer Simulation; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ileum / cytology; Inflammatory Bowel Diseases / pathology; Interleukins / pharmacology; Mice, Inbred C57BL; Models, Biological; Organoids / cytology; Organoids / drug effects; Organoids / metabolism; Receptors, Interleukin / metabolism; Serum / metabolism; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism
TL;DR:
Increased IL22 limits ISC expansion in favor of increased TA progenitor cell expansion, and chronically increased IL22 levels, similar to predicted microenvironment levels, showed increases in proliferative cells in the TA zone with no increase in ISCs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 14, 2019
2019 journal article
A Guide to Reproducibility in Preclinical Research
ACADEMIC MEDICINE, 94(1), 47–52.
MeSH headings : Biomedical Research / standards; Clinical Trials as Topic / standards; Guidelines as Topic; Humans; Reproducibility of Results; Research Design / standards; United States
TL;DR:
This Perspective, the authors address this “reproducibility crisis” by distilling discussions around reproducibility into a simple guide to facilitate understanding of the topic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 14, 2019
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