Works Published in 2008
Displaying works 1 - 20 of 27 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 journal article
Plasma fatty acid concentrations in Boxers and Doberman Pinschers
American Journal of Veterinary Research, 69(2), 195–198.
MeSH headings : Animals; Arrhythmias, Cardiac / blood; Arrhythmias, Cardiac / veterinary; Dog Diseases / blood; Dogs / blood; Dogs / genetics; Fatty Acids / blood; Female; Male
TL;DR:
It is suggested that plasma fatty acid concentrations may differ between Boxers and Doberman Pinschers and that the relationship between fatty Acid concentrations and VPCs may be different between these 2 breeds.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 18, 2020
2008 journal article
Pharmacokinetic Modeling of Manganese in the Rat IV: Assessing Factors that Contribute to Brain Accumulation During Inhalation Exposure
Journal of Toxicology and Environmental Health, Part A, 71(7), 413–426.
MeSH headings : Administration, Oral; Air Pollutants / pharmacokinetics; Animals; Brain / drug effects; Brain Chemistry; Disease Models, Animal; Dust; Environmental Exposure / adverse effects; Inhalation Exposure / adverse effects; Liver / drug effects; Manganese / administration & dosage; Manganese / pharmacokinetics; Models, Biological; Rats; Risk Assessment
TL;DR:
Multi-dose-route PBPK models for Mn based on this alternative model structure can be readily scaled to evaluate tissue Mn kinetics in other species and for human populations, and will be useful in tissue-dose based risk assessment with manganese.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2008 journal article
Application of Physiological Computational Fluid Dynamics Models to Predict Interspecies Nasal Dosimetry of Inhaled Acrolein
Inhalation Toxicology, 20(3), 227–243.
MeSH headings : Acrolein / pharmacokinetics; Acrolein / toxicity; Air Pollutants / pharmacokinetics; Air Pollutants / toxicity; Animals; Computer Simulation; Dose-Response Relationship, Drug; Humans; Inhalation Exposure; Models, Biological; Nasal Cavity / drug effects; Nasal Cavity / metabolism; Nasal Cavity / pathology; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Nasal Mucosa / pathology; Rats
TL;DR:
In this study, anatomically accurate three-dimensional computational fluid dynamics (CFD) models were used to simulate steady-state inspiratory airflow and to quantitatively predict acrolein tissue dose in rat and human nasal passages to estimate a tissue dose-based no-observed-adverse-effect level (NOAEL) for inhaled ac rolein.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2008 journal article
Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity
NeuroToxicology, 29(3), 377–385.
author keywords: brain; monkey; air borne; manganese; glutathione; glutamate
MeSH headings : Amino Acid Transport System X-AG / metabolism; Animals; Biomarkers; Blotting, Northern; Blotting, Western; Brain / metabolism; Excitatory Amino Acid Transporter 2 / metabolism; Glutamate-Ammonia Ligase / metabolism; Glutathione / metabolism; Inhalation Exposure / adverse effects; Macaca mulatta; Male; Manganese / analysis; Manganese / pharmacokinetics; Manganese Poisoning / metabolism; Manganese Poisoning / pathology; Metallothionein / metabolism; Nerve Tissue Proteins / biosynthesis; Nerve Tissue Proteins / genetics; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
The nonhuman primate brain responds to airborne Mn in a heterogeneous manner and most alterations in these biomarkers of neurotoxicity are reversible upon cessation of Mn exposure.
(via Semantic Scholar)
libres.uncg.edu (repository)
Source: Crossref
Added: February 24, 2020
2008 journal article
Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency
Journal of Veterinary Cardiology, 10(1), 1–10.
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / etiology; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / metabolism; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Base Sequence; Blotting, Western / veterinary; Breeding; Calcium / metabolism; Case-Control Studies; Dog Diseases / etiology; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Female; Male; Microarray Analysis / veterinary; Polymerase Chain Reaction / veterinary; RNA, Messenger / metabolism; Ryanodine Receptor Calcium Release Channel / genetics; Ryanodine Receptor Calcium Release Channel / metabolism; Tacrolimus Binding Proteins / deficiency; Tacrolimus Binding Proteins / genetics
TL;DR:
Calstabin2 deficiency is a potential mechanism of Ca(2+) leak-induced ventricular arrhythmias and heart disease in Boxer dogs with ARVC and was associated with a significantly increased open probability of single RyR2 channels indicating intracellular Ca( 2+) leak.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019
2008 journal article
Evaluation of the flanking nucleotide sequences of sarcomeric hypertrophic cardiomyopathy substitution mutations
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 642(1-2), 86–89.
author keywords: hypertrophic cardiomyopathy; mutation; methylation; deamination
MeSH headings : Amino Acid Substitution; Base Sequence; Cardiomyopathy, Hypertrophic / genetics; DNA Methylation; Humans; Mutation; Sarcomeres / genetics
TL;DR:
The large number of G to A and C to T mutations as well as the relative mutability of CG may suggest that deamination of methylated CpG is an important mechanism for mutation development in at least some of these cardiac genes.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019
2008 journal article
Prevalence of the Myosin-Binding Protein C Mutation in Maine Coon Cats
Journal of Veterinary Internal Medicine, 22(4), 893–896.
author keywords: hypertrophic cardiomyopathy; genetics; MYBC3
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / epidemiology; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Carrier Proteins / genetics; Cat Diseases / epidemiology; Cat Diseases / genetics; Cats; Female; Genetic Predisposition to Disease; Male; Prevalence
TL;DR:
Because of the high prevalence of this mutation, a breeding recommendation to eliminate all cats with the mutation could have a substantial impact on the gene pool, and additional studies are indicated to explore the relationship between genotype and clinical outcome in affected cats.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: December 16, 2019
2008 journal article
Breed distribution of the ABCB1-1Δ (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping
Journal of the American Veterinary Medical Association, 233(6), 921–924.
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics; Alleles; Animals; Breeding; Cross-Sectional Studies; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dog Diseases / genetics; Dogs / genetics; Drug Resistance, Multiple / genetics; Female; Gene Deletion; Gene Frequency; Genes, MDR / genetics; Genotype; Male; Polymorphism, Genetic; Veterinary Drugs / adverse effects
TL;DR:
The ABCB1-1Delta polymorphism is associated with increased susceptibility to many adverse drug reactions and with suppression of the hypothalamic-pituitary-adrenal axis and is present in many herding breeds of dog.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: December 16, 2019
2008 journal article
Molecular evaluation of five cardiac genes in Doberman Pinschers with dilated cardiomyopathy
American Journal of Veterinary Research, 69(8), 1050–1053.
MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dogs; Exons; Heart / physiopathology; Lamin Type A / genetics; Lamins / genetics; Myosin Heavy Chains / genetics; Troponin C / genetics; Troponin T / genetics
Sources: Crossref, ORCID
Added: December 16, 2019
2008 journal article
An index of myocardial performance applied to the right ventricle of Boxers with arrhythmogenic right ventricular cardiomyopathy
American Journal of Veterinary Research, 69(8), 1029–1033.
MeSH headings : Animals; Arrhythmias, Cardiac / physiopathology; Arrhythmias, Cardiac / veterinary; Cardiomyopathies / physiopathology; Cardiomyopathies / veterinary; Dog Diseases / physiopathology; Dogs; Heart Function Tests / veterinary; Ventricular Dysfunction, Right / physiopathology; Ventricular Dysfunction, Right / veterinary; Ventricular Function, Right / physiology
TL;DR:
Right ventricular dysfunction does not develop in Boxers with ARVC, suggesting that a more severe phenotype of the disease may be necessary for detection of dysfunction or that additional studies that use more sensitive techniques to evaluate myocardial function may be warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: December 11, 2019
2008 journal article
Gene Expression Changes Following Acute Hydrogen Sulfide (H2S)-induced Nasal Respiratory Epithelial Injury
TOXICOLOGIC PATHOLOGY, 36(4), 560–567.
author keywords: gene expression; nasal respiratory epithelium; LCM; rat; H2S; inhalation; DNA microarray
MeSH headings : Air Pollutants / toxicity; Animals; Cluster Analysis; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Gene Expression / drug effects; Gene Expression Profiling; Hydrogen Sulfide / toxicity; Inhalation Exposure / adverse effects; Male; Microdissection; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Nasal Mucosa / pathology; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
Gene ontology enrichment analysis showed that H2S exposure altered gene expression associated with a variety of biological processes, including cell cycle regulation, protein kinase regulation, and cytoskeletal organization and biogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 review
"Current Pathology Techniques" Symposium Review: Advances and Issues in Neuropathology
[Review of ]. TOXICOLOGIC PATHOLOGY, 36(6), 871–889.
author keywords: neuropathology; neurotoxicity; review
TL;DR:
This mini-review has been designed to communicate the principal technical advances and current issues of importance in neuropathology research today in the context of traditional neuropathological practices.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Age and Sex Differences in Brain Gene Expression in Neonatal Rats
NEUROPEDIATRICS, 39(4), 219–225.
author keywords: brain development; gene expression; gene profiling; microarrays; neonatal rats
MeSH headings : Aging / physiology; Animals; Animals, Newborn; Brain / anatomy & histology; Brain / growth & development; Brain / metabolism; Female; Gene Expression / physiology; Male; Microarray Analysis / methods; Pregnancy; Rats; Rats, Sprague-Dawley; Sex Characteristics
TL;DR:
This work tested the hypothesis that certain developmental biomarkers could be detected in the whole brain or in cortical, subcortical or cerebellar structures and found 53 signi up-regulated and 8 down-regulated genes at 10 days.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
MORTALITIES ASSOCIATED WITH SEPSIS, PARASITISM, AND DISSEMINATED ROUND CELL NEOPLASIA IN YELLOW-LIPPED SEA KRAITS (LATICAUDA COLUBRINA)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 39(4), 626–630.
author keywords: Laticauda colubrina; neoplasia; parasite; sepsis; yellow-tipped sea krait
MeSH headings : Animals; Animals, Zoo; Cause of Death; Elapidae; Neoplasms / mortality; Neoplasms / pathology; Neoplasms / veterinary; Parasitic Diseases, Animal / mortality; Parasitic Diseases, Animal / pathology; Sepsis / mortality; Sepsis / pathology; Sepsis / veterinary; Stress, Psychological; Transportation
TL;DR:
It is presumed that an immunosuppressive event, such as transport, captivity stress, or possible concurrent viral infection, resulted in a septic event and death in yellow-lipped sea kraits at an exhibit aquarium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 article
Echocardiographic quantification of Dirofilaria immitis in experimentally infected cats
Atkins, C. E., Arther, R. G., Ciszewski, D. K., Davis, W. L., Ensley, S. M., Guity, P. S., … Settje, T. L. (2008, December 10). VETERINARY PARASITOLOGY, Vol. 158, pp. 164–170.
author keywords: Heartworm diagnosis; Safety; Imidacloprid; Moxidectin; Echocardiography
MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cat Diseases / parasitology; Cat Diseases / prevention & control; Cats; Dirofilaria immitis / isolation & purification; Dirofilariasis / diagnostic imaging; Dirofilariasis / parasitology; Dirofilariasis / prevention & control; Echocardiography / standards; Echocardiography / veterinary; Female; Filaricides / adverse effects; Filaricides / pharmacology; Male; Radiography, Thoracic / veterinary; Random Allocation; Safety; Sensitivity and Specificity
TL;DR:
Echocardiography is useful for detecting mature experimental heartworm infections, identifying cats that have rejected mature infection, and detecting very heavy heartworm burdens, but it is only moderately accurate in classifying lesser burdens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Metabolomic analyses of body fluids after subchronic manganese inhalation in rhesus monkeys
TOXICOLOGICAL SCIENCES, 106(1), 46–54.
author keywords: metabolomics; metal; neurotoxicity
MeSH headings : Air Pollutants / blood; Air Pollutants / toxicity; Air Pollutants / urine; Animals; Biomarkers / blood; Biomarkers / urine; Chromatography, Liquid; Cluster Analysis; Environmental Monitoring; Globus Pallidus / drug effects; Globus Pallidus / metabolism; Inhalation Exposure; Macaca mulatta; Male; Manganese Compounds / blood; Manganese Compounds / urine; Metabolomics / methods; Principal Component Analysis; Sulfates / blood; Sulfates / toxicity; Sulfates / urine; Tandem Mass Spectrometry
TL;DR:
Biochemical changes identified in manganese-exposed monkeys included endpoints relate to oxidative stress and neurotransmission (aminobutyrate, glutamine, phenylalanine), and 27 metabolites with statistically significant expression differences were structurally confirmed by MS-MS methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Tick-Borne Diseases in North Carolina: Is "Rickettsia amblyommii" a Possible Cause of Rickettsiosis Reported as Rocky Mountain Spotted Fever?
VECTOR-BORNE AND ZOONOTIC DISEASES, 8(5), 597–606.
author keywords: Rocky Mountain spotted fever; Amblyomma americanum; lone star tick; spotted fever group rickettsiae; "Rickettsia amblyommii"; Rickettsia rickettsii; Ehrlichia chaffeensis
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antigens, Bacterial / blood; Arachnid Vectors; Child; Child, Preschool; Deer / immunology; Female; Humans; Male; Middle Aged; North Carolina / epidemiology; Rickettsia / classification; Rocky Mountain Spotted Fever / epidemiology; Rocky Mountain Spotted Fever / microbiology; Serologic Tests; Ticks / microbiology
TL;DR:
It is proposed that some cases of rickettsiosis reported as RMSF may have been caused by "R. amblyommii" transmitted through the bite of A. americanum, a preferred hosts of lone star ticks.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice
Chemico-Biological Interactions, 173(3), 166–178.
MeSH headings : Animals; Atmosphere Exposure Chambers; Benzene / toxicity; Benzene Derivatives / urine; Body Weight / drug effects; Bone Marrow Cells / drug effects; DNA / chemistry; DNA / drug effects; Drug Administration Schedule; Glutathione / blood; Glutathione / metabolism; Inhalation Exposure; Liver / drug effects; Liver / metabolism; Male; Mice; Micronuclei, Chromosome-Defective / chemically induced; Molecular Structure; Mutagenicity Tests; Time Factors; Toluene / toxicity
TL;DR:
The higher frequency of micronucleated PCE following benzene and toLUene co-exposure when compared with mice exposed to benzene or toluene alone suggests that, at the doses used in this study, toluenes can enhance benzene-induced clastogenic or aneugenic bone marrow injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2008 article
Evaluation of wraps covering the distal aspect of pelvic limbs for prevention of bacterial strike-through in an ex vivo canine model
Vince, K. J., Lascelles, B. D. X., Mathews, K. G., Altier, C., & Roe, S. C. (2008, June). VETERINARY SURGERY, Vol. 37, pp. 406–411.
MeSH headings : Administration, Cutaneous; Animals; Anti-Infective Agents, Local / pharmacology; Bacteria / drug effects; Bacteria / growth & development; Cadaver; Dogs / surgery; Hindlimb; Random Allocation; Surgical Wound Infection / prevention & control; Surgical Wound Infection / veterinary
TL;DR:
A distal leg wrap of Vetrap+sterile Coban is not effective in preventing bacterial strike-through in canine cadaveric pelvic limbs, and a sterile impermeable barrier must be incorporated into the distal legs wrap to prevent bacterialstrike-through.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Comparative analysis of transcript abundance in Pinus sylvestris after challenge with a saprotrophic, pathogenic or mutualistic fungus
TREE PHYSIOLOGY, 28(6), 885–897.
author keywords: defence; ectomycorrhiza; Heterobasidion annostan; Laccaria bicolor; microarray; recognition; Trichoderma aureoviride
MeSH headings : Basidiomycota / pathogenicity; Cell Communication; Microscopy, Electron, Scanning; Pinus sylvestris / genetics; Pinus sylvestris / microbiology; Pinus sylvestris / physiology; Plant Diseases / microbiology; Plant Proteins / metabolism; Plant Roots / microbiology; Plant Roots / ultrastructure; Ribosomal Proteins / biosynthesis; Ribosomal Proteins / metabolism; Seedlings / microbiology; Transcription, Genetic; Trichoderma / pathogenicity; Trichoderma / ultrastructure
TL;DR:
There were specific transcriptional responses depending on whether the conifer roots were challenged with mutualistic, saprotrophic or pathogenic fungi, suggesting that pine trees are able to recognize diverse fungal species and specifically distinguish whether they are pathogenic, neutral or beneficial microbial agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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