College of Veterinary Medicine - General

Works Published in 2011

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Displaying all 14 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2011 journal article

Comparison of Polymerase Chain Reaction with Bacterial 16s Primers to Blood Culture to Identify Bacteremia in Dogs with Suspected Bacterial Endocarditis

Journal of Veterinary Internal Medicine, 25(4), 959–962.

By: K. Meurs* , A. Heaney*, C. Atkins, T. DeFrancesco, P. Fox*, B. Keene, H. Kellihan *, M. Miller * ...

author keywords: Bartonella; Canine; Infectious; Molecular; Valvular
MeSH headings : Animals; Bacteremia / blood; Bacteremia / microbiology; Bacteremia / veterinary; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Dog Diseases / blood; Dog Diseases / microbiology; Dogs; Endocarditis, Bacterial / blood; Endocarditis, Bacterial / microbiology; Endocarditis, Bacterial / veterinary; Female; Male; Polymerase Chain Reaction / veterinary; Prospective Studies; RNA, Ribosomal, 16S / chemistry; RNA, Ribosomal, 16S / genetics
TL;DR: The results of this study suggest that although single sample PCR with 16s primers was not more sensitive than blood culture for detection of bacteremia in dogs with suspect endocarditis, performing both techniques simultaneously did increase the likelihood of identification of bacteria in blood. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID
Added: November 16, 2019

2011 journal article

The sensory field and repeatability of the cutaneous trunci muscle reflex of the dog

Veterinary Surgery, 40(7), 781–785.

By: A. Muguet-Chanoit, N. Olby , K. Babb, J. Lim, R. Gallagher, Z. Niman, S. Dillard, J. Campbell

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Skp2 Is Necessary for Myc-Induced Keratinocyte Proliferation but Dispensable for Myc Oncogenic Activity in the Oral Epithelium

AMERICAN JOURNAL OF PATHOLOGY, 178(6), 2470–2477.

By: C. Sistrunk, E. Macias  n, K. Nakayama *, Y. Kim* & M. Rodriguez-Puebla n

MeSH headings : Animals; Cell Cycle Proteins / metabolism; Cell Proliferation; Epidermis / metabolism; Epidermis / pathology; Epithelium / metabolism; Epithelium / pathology; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Transgenic; Mouth / pathology; Mouth Neoplasms / metabolism; Mouth Neoplasms / pathology; Phenotype; Precancerous Conditions / pathology; Proto-Oncogene Proteins c-myc / metabolism; S-Phase Kinase-Associated Proteins / metabolism
TL;DR: It is suggested that Skp2 and p27(Kip1) are critical for Myc-driven keratinocyte proliferation; however, MyC-mediated tumorigenesis in the oral epithelium is independent of the Skp 2-p27( Kip 1) axis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 article

Leflunomide pharmacokinetics after single oral administration to dogs

Singer, L. M., Cohn, L. A., Reinero, C. R., & Papich, M. G. (2011, December). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 34, pp. 609–611.

By: L. Singer*, L. Cohn*, C. Reinero * & M. Papich n 

MeSH headings : Administration, Oral; Animals; Chromatography, High Pressure Liquid / veterinary; Crotonates / blood; Crotonates / pharmacokinetics; Dogs / blood; Drug Administration Schedule / veterinary; Female; Half-Life; Hydroxybutyrates; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / blood; Immunosuppressive Agents / pharmacokinetics; Isoxazoles / administration & dosage; Isoxazoles / blood; Isoxazoles / pharmacokinetics; Leflunomide; Linear Models; Nitriles; Toluidines / blood; Toluidines / pharmacokinetics
TL;DR: Leflunomide has been used as an adjunctive therapy for dogs refractory to traditional immunosuppressive drugs and to prevent anti-allograft immune responses and all procedures were approved by the NIH Guide for the Care and Use of Laboratory Animals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Analysis of Manganese Tracer Kinetics and Target Tissue Dosimetry in Monkeys and Humans with Multi-Route Physiologically Based Pharmacokinetic Models

TOXICOLOGICAL SCIENCES, 120(2), 481–498.

By: J. Schroeter*, A. Nong*, M. Yoon *, M. Taylor *, D. Dorman n, M. Andersen *, H. Clewell*

author keywords: manganese; PBPK; inhalation exposure; risk assessment; neurotoxicity; pharmacokinetics
MeSH headings : Administration, Oral; Adult; Animals; Humans; Inhalation Exposure; Injections; Macaca mulatta; Manganese Compounds / pharmacokinetics; Metabolic Clearance Rate; Models, Biological; Organ Specificity; Physiology; Radioisotopes; Species Specificity; Time Factors; Tissue Distribution
TL;DR: The use of this human Mn PBPK model can become a key component of future human health risk assessment, allowing the consideration of various exposure routes, natural tissue background levels, and homeostatic controls to explore exposure conditions that lead to increased target tissue levels resulting from Mn overexposure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Suppression of COX-2, IL-1 beta and TNF-alpha expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L.

FITOTERAPIA, 82(3), 414–421.

By: E. Mengoni*, G. Vichera*, L. Rigano*, M. Rodriguez-Puebla n, S. Galliano*, E. Cafferata *, O. Pivetta*, S. Moreno*, A. Vojnov*

author keywords: Skin inflammation; Carnosic acid; Carnosol; Cyclooxygenase; Interleukin; Tumor necrosis factor
MeSH headings : Abietanes / pharmacology; Abietanes / therapeutic use; Animals; Cyclooxygenase 2 Inhibitors / pharmacology; Cyclooxygenase 2 Inhibitors / therapeutic use; Dose-Response Relationship, Drug; Fibronectins / genetics; Fibronectins / metabolism; Gene Expression; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / metabolism; Intercellular Adhesion Molecule-1 / genetics; Intercellular Adhesion Molecule-1 / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; Macrophages / drug effects; Macrophages / metabolism; Male; Mice; Mice, Inbred BALB C; Neutrophil Infiltration / drug effects; Nitric Oxide / biosynthesis; Phytotherapy; Plant Extracts / pharmacology; Plant Extracts / therapeutic use; Reverse Transcriptase Polymerase Chain Reaction; Rosmarinus / chemistry; Skin / drug effects; Skin / metabolism; Skin / pathology; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR: It is shown for the first time in vivo that CA and CS differentially regulate the expression of inflammation-associated genes, thus demonstrating the pharmacological basis for the anti-inflammatory properties reported for CA andCS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

C/EBP alpha Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBP alpha Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(6), 1339–1346.

By: E. Thompson n, S. Zhu n, J. Hall n, J. House n , R. Ranjan n, J. Burr n, Y. He *, D. Owens *, R. Smart n 

MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / analysis; CCAAT-Enhancer-Binding Protein-alpha / physiology; Carcinoma, Squamous Cell / chemistry; Carcinoma, Squamous Cell / etiology; Cell Cycle; Cells, Cultured; Genes, p53; Humans; Keratosis, Actinic / metabolism; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mutation; Neoplasms, Radiation-Induced / etiology; Precancerous Conditions / chemistry; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / chemistry; Skin Neoplasms / etiology; Ultraviolet Rays / adverse effects
TL;DR: It is observed that C/EBPα is induced in normal human epidermal keratinocytes and in the epidermis of human subjects exposed to UVB radiation, and loss of C/ EBPα confers susceptibility toUVB-induced skin SCCs involving defective cell cycle arrest in response to UVBs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Physiologically Based Pharmacokinetic Modeling of Fetal and Neonatal Manganese Exposure in Humans: Describing Manganese Homeostasis during Development

TOXICOLOGICAL SCIENCES, 122(2), 297–316.

By: M. Yoon *, J. Schroeter*, A. Nong*, M. Taylor*, D. Dorman n, M. Andersen *, H. Clewell*

author keywords: manganese; potentially susceptible subpopulation; environmental exposure to Mn; formula; fetus; neonate
MeSH headings : Adult; Animals; Child, Preschool; Female; Fetus / drug effects; Fetus / metabolism; Homeostasis; Humans; Infant; Inhalation Exposure; Lactation; Male; Manganese / blood; Manganese / pharmacokinetics; Manganese / toxicity; Maternal Exposure; Milk, Human / chemistry; Models, Biological; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Tissue Distribution
TL;DR: A physiologically based pharmacokinetic model for Mn during human gestation and lactation was developed to predict Mn in fetal and neonatal brain using a parallelogram approach based upon extrapolation across life stages in rats and cross-species extrapolation to humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Evaluation of Postceliotomy Peritoneal Drain Fluid Volume, Cytology, and Blood-to-Peritoneal Fluid Lactate and Glucose Differences in Normal Dogs

VETERINARY SURGERY, 40(4), 444–449.

By: S. Szabo n, K. Jermyn n, J. Neel n  & K. Mathews n

MeSH headings : Animals; Ascitic Fluid / chemistry; Ascitic Fluid / cytology; Blood Glucose; Dogs / physiology; Female; Glucose / analysis; Lactic Acid / analysis; Lactic Acid / blood; Male
TL;DR: After day 4, blood-to-peritoneal glucose concentration differences were consistent with septic effusion based on previously reported values used to diagnose septic peritonitis in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

How quantum bound states bounce and the structure it reveals

European Physical Journal. A, Hadrons and Nuclei, 47(3).

By: D. Lee & M. Pine

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

The pharmacokinetics of levetiracetam in healthy dogs concurrently receiving phenobarbital

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 34(1), 31–34.

By: S. Moore  n, K. Munana n , M. Papich n  & J. Nettifee-Osborne n

MeSH headings : Absorption; Animals; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Area Under Curve; Dogs / blood; Drug Interactions; Half-Life; Levetiracetam; Phenobarbital / pharmacokinetics; Piracetam / analogs & derivatives; Piracetam / blood; Piracetam / pharmacokinetics
TL;DR: Conurrent PB administration significantly alters the pharmacokinetics of LEV in the dog, indicating that dosage adjustments might be necessary when the drug is administered with PB. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Diazepam pharmacokinetics after nasal drop and atomized nasal administration in dogs

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 34(1), 17–24.

By: S. Musulin n , C. Mariani n  & M. Papich n 

MeSH headings : Administration, Intranasal; Animals; Anticonvulsants / administration & dosage; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Diazepam / administration & dosage; Diazepam / blood; Diazepam / pharmacokinetics; Dogs; Dosage Forms; Drug Administration Routes; Female; Half-Life; Male; Nordazepam / blood; Nordazepam / metabolism; Oxazepam / blood; Oxazepam / metabolism
TL;DR: This study confirms that i.n. administration of diazepam yields rapid anticonvulsant concentrations of d Xanax in the dog before a hepatic first-pass effect, and exceeds previously published bioavailability data for rectal administration ofdiazepam in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Unexpected Reduction of Skin Tumorigenesis on Expression of Cyclin-Dependent Kinase 6 in Mouse Epidermis

AMERICAN JOURNAL OF PATHOLOGY, 178(1), 345–354.

By: X. Wang  n, C. Sistrunk  n & M. Rodriguez-Puebla n

MeSH headings : Animals; Cell Proliferation; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 4 / biosynthesis; Cyclin-Dependent Kinase 4 / genetics; Cyclin-Dependent Kinase 6 / biosynthesis; Cyclin-Dependent Kinase 6 / genetics; Epidermis / enzymology; Epidermis / pathology; Hyperplasia / enzymology; Keratin-5 / genetics; Keratinocytes / enzymology; Keratinocytes / pathology; Mice; Mice, Transgenic; Promoter Regions, Genetic; Skin Neoplasms / enzymology; Skin Neoplasms / genetics; Skin Neoplasms / metabolism
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos

CHEMISTRY & BIOLOGY, 18(2), 252–263.

By: M. Dush n, A. McIver n, M. Parr n, D. Young n, J. Fisher n, D. Newman n, P. Sannes n, M. Hauck n, A. Deiters n, N. Nascone-Yoder n

MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
TL;DR: A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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