Works Published in 2012
Displaying all 19 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Neurological impacts from inhalation of pollutants and the nose–brain connection
NeuroToxicology, 33(4), 838–841.
author keywords: Air pollution; Neurotoxicity; Olfactory tract
MeSH headings : Air Pollutants / adverse effects; Animals; Body Burden; Environmental Monitoring; Humans; Inhalation Exposure / adverse effects; Nervous System / drug effects; Nervous System / physiopathology; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / physiopathology; Nose / drug effects; Nose / physiopathology; Olfactory Pathways / drug effects; Olfactory Pathways / physiopathology; Risk Assessment; Risk Factors
TL;DR:
The key available literature on nanoparticle uptake and transport through the olfactory pathway, the experimental data from animal and in vitro studies, and human epidemiological observations are reviewed to provide an increased understanding of the neurotoxicity associated with air pollution exposure.
(via Semantic Scholar)
digitalcommons.unl.edu (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Source: Crossref
Added: August 28, 2020
2012 journal article
The outdoor air pollution and brain health workshop
NeuroToxicology, 33(5), 972–984.
author keywords: Air pollution; Brain; Particulate matter; Ozone; Central nervous system; Susceptibility; Epidemiology; Neuroinflammation; Neurotoxicity; Behavior
MeSH headings : Air Pollutants / poisoning; Air Pollution / adverse effects; Brain / pathology; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / pathology; Disease Susceptibility; Encephalitis / etiology; Encephalitis / pathology; Humans; Lung Diseases / chemically induced; Lung Diseases / pathology; Neurotoxicity Syndromes / epidemiology; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / pathology
TL;DR:
Recent findings that have established the effects of inhaled air pollutants in the brain, explore the potential mechanisms driving these phenomena, and discuss the recommended research priorities/approaches that were identified by the panel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Crossref
Added: February 24, 2020
2012 journal article
Auscultatory, echocardiographic, biochemical, nutritional, and environmental characteristics of mitral valve disease in Norfolk terriers
Journal of Veterinary Cardiology, 14(1), 261–267.
author keywords: Heart murmur; Serotonin; NT-proBNP; Nutrition
MeSH headings : Animals; Biomarkers; Dog Diseases / pathology; Dogs; Echocardiography / veterinary; Female; Male; Mitral Valve / diagnostic imaging; Mitral Valve Insufficiency / veterinary; Risk Factors
TL;DR:
DMVD is relatively common in Norfolk terrier and echocardiographic changes consistent with mild DMVD can be seen in dogs without a heart murmur, as well as select environmental variables from a cohort of apparently healthy Norfolk terriers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
2012 journal article
Identification of beta-1 adrenergic receptor polymorphisms in cats
Research in Veterinary Science, 93(1), 210–212.
author keywords: Pharmacogenomics; Beta-blocker; Feline; Beta-1 adrenergic receptor
MeSH headings : Adrenergic beta-1 Receptor Antagonists / pharmacology; Amino Acid Substitution / genetics; Animals; Cats / genetics; Heart Diseases / drug therapy; Heart Diseases / veterinary; Polymorphism, Genetic / genetics; Receptors, Adrenergic, beta-1 / genetics; Sequence Analysis, DNA / veterinary
TL;DR:
Three polymorphisms within the feline ADRB1 gene were identified, including an AA/CC substitution at the 830-831 base pair sites and an alteration changed the amino acid produced from proline to glutamine at position 277 and computer modeling predicts an altered protein structure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
2012 journal article
Familial subvalvular aortic stenosis in golden retrievers: inheritance and echocardiographic findings
Journal of Small Animal Practice, 53(4), 213–216.
MeSH headings : Animals; Aortic Stenosis, Subvalvular / diagnostic imaging; Aortic Stenosis, Subvalvular / genetics; Aortic Stenosis, Subvalvular / veterinary; Aortic Valve Insufficiency / diagnostic imaging; Aortic Valve Insufficiency / genetics; Aortic Valve Insufficiency / veterinary; Blood Flow Velocity / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / genetics; Dogs; Echocardiography / veterinary; Female; Genetic Predisposition to Disease; Hypertrophy, Left Ventricular / diagnostic imaging; Hypertrophy, Left Ventricular / genetics; Hypertrophy, Left Ventricular / veterinary; Male; Severity of Illness Index
TL;DR:
Severity of stenosis correlates well with cumulative presence of echocardiographic characteristics (left ventricular hypertrophy, subvalvular ridge and aortic insufficiency), and appears familial.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
2012 journal article
Body size and metabolic differences in Maine Coon cats with and without hypertrophic cardiomyopathy
Journal of Feline Medicine and Surgery, 15(2), 74–80.
MeSH headings : Animals; Body Size; Cardiomyopathy, Hypertrophic / metabolism; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / metabolism; Cats; Energy Metabolism
TL;DR:
The hypothesis that early growth and nutrition, larger body size and obesity may be environmental modifiers of genetic predisposition to HCM is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
2012 journal article
Neurological impacts from inhalation of pollutants and the nose-brain connection
NeuroToxicology, 33(4), 838–841.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Application of a Multi-Route Physiologically Based Pharmacokinetic Model for Manganese to Evaluate Dose-Dependent Neurological Effects in Monkeys
TOXICOLOGICAL SCIENCES, 129(2), 432–446.
author keywords: manganese; neurotoxicity; dose response; physiologically based pharmacokinetic modeling
MeSH headings : Animals; Cebus; Dose-Response Relationship, Drug; Manganese / pharmacokinetics; Models, Biological; Risk Assessment
TL;DR:
A physiologically based pharmacokinetic model that accurately accounts for the dose dependencies of Mn distribution was used to estimate increases in brain Mn concentrations in monkeys following Mn exposure and provides strong evidence of a dose-dependent transition in the mode of action for the neurological effects of Mn that needs to be considered in risk assessments for this essential metal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher
HUMAN GENETICS, 131(8), 1319–1325.
MeSH headings : Animals; Blotting, Western; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Chromosome Mapping / veterinary; Dog Diseases / genetics; Dogs; Genome-Wide Association Study; Microscopy, Electron; Mutation; Myocardium / ultrastructure; Protein Kinases / genetics; RNA Splicing; Real-Time Polymerase Chain Reaction
TL;DR:
The identification of a splice site deletion in the PDK4 gene that is associated with the development of familial dilated cardiomyopathy in the Doberman pinscher dog is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
WNT7B in fibroblastic foci of idiopathic pulmonary fibrosis
RESPIRATORY RESEARCH, 13.
author keywords: Myofibroblasts; Alveolar epithelium; Interstitial lung disease
MeSH headings : Aged; Aged, 80 and over; Basement Membrane / pathology; Female; Fibroblasts / pathology; Humans; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Macrophages / pathology; Male; Middle Aged; Muscle, Smooth / pathology; Respiratory Mucosa / pathology; Respiratory System / blood supply; Respiratory System / pathology; Severity of Illness Index; Wnt Proteins / analysis; Wnt Proteins / metabolism
TL;DR:
Tissue samples from the Lung Tissue Research Consortium of 39 patients diagnosed with mild to severe IPF/usual interstitial pneumonia and 19 normal patients were examined for the immunolocalization of Wnt7B, demonstrating Wnt 7B to be expressed at high concentrations in regions of active hyperplasia, metaplasia and fibrotic change in IPF patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 review
The outdoor air pollution and brain health workshop
[Review of]. NeuroToxicology, 33(5), 972–984.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Over-expression of human endosulfatase-1 exacerbates cadmium-induced injury to transformed human lung cells in vitro
TOXICOLOGY AND APPLIED PHARMACOLOGY, 265(1), 27–42.
author keywords: Cadmium; HSulf-1; Lung epithelial injury; 6-O-sulfate
MeSH headings : Adenoviridae / genetics; Apoptosis / drug effects; Blotting, Western; Cadmium / toxicity; Cell Count; Cell Line, Tumor; Cell Survival / drug effects; Cell Transformation, Neoplastic / drug effects; Coloring Agents; Down-Regulation / drug effects; Heparan Sulfate Proteoglycans / pharmacology; Humans; In Situ Nick-End Labeling; Lac Operon / genetics; Lung / pathology; Polymerase Chain Reaction; Respiratory Mucosa / pathology; Sulfotransferases / biosynthesis; Sulfotransferases / physiology; Tetrazolium Salts; Thiazoles; Transduction, Genetic; Up-Regulation / drug effects
TL;DR:
The finding that HSulf-1 sensitizes these cancer cells and intensifies the injury induced by cadmium suggests that 6-O-sulfate groups on HSPGs may play important roles in protection against certain environmental toxicants, such as heavy metals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
B-mode and Doppler ultrasonography in pony mares with experimentally induced ascending placentitis
EQUINE VETERINARY JOURNAL, 44, 88–94.
author keywords: horse; placentitis; Doppler; ultrasound; diagnosis; CTUP
MeSH headings : Animals; Animals, Newborn; Female; Horse Diseases / diagnostic imaging; Horse Diseases / microbiology; Horse Diseases / pathology; Horses; Placenta Diseases / microbiology; Placenta Diseases / pathology; Placenta Diseases / veterinary; Pregnancy; Pregnancy Complications, Infectious / microbiology; Pregnancy Complications, Infectious / pathology; Pregnancy Complications, Infectious / veterinary; Stillbirth; Streptococcal Infections / microbiology; Streptococcal Infections / pathology; Streptococcal Infections / veterinary; Streptococcus equi; Ultrasonography, Doppler / instrumentation; Ultrasonography, Doppler / methods; Ultrasonography, Doppler / veterinary
TL;DR:
Doppler and B-mode ultrasonography for the detection of experimentally-induced ascending placentitis in mares was compared and the CTUP, but not uterine blood flow, was different between groups (P = 0.00001).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited
TISSUE ANTIGENS, 80(2), 175–183.
author keywords: breeds; canine; class I genes; major histocompatibility complex; polymorphisms
MeSH headings : Alleles; Amino Acid Sequence; Animals; Breeding; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Dogs / genetics; Dogs / immunology; Gene Frequency; Genetic Loci; Haplotypes; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Homozygote; Models, Molecular; Molecular Sequence Data; Phylogeny; Polymorphism, Genetic; Sequence Alignment
TL;DR:
The finding of highly prevalent alleles fulfills an important prerequisite for studying canine CD8+ T-cell responses and represents a significant advance over previous analyses of major histocompatibility complex class I genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Effect of estrous cycle phase on clinical pathology values in beagle dogs
Veterinary Clinical Pathology, 41(1), 71–76.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Surgical treatment of a pulmonary artery vascular hamartoma in a dog
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 240(7), 858–862.
MeSH headings : Animals; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Hamartoma / surgery; Hamartoma / veterinary; Male; Pulmonary Artery / pathology; Pulmonary Artery / surgery; Vascular Neoplasms / pathology; Vascular Neoplasms / surgery; Vascular Neoplasms / veterinary
TL;DR:
Computed tomography was helpful in predicting the resectability of the intracardiac mass in this dog, and treatment with arteriotomy under inflow occlusion and mild hypothermia resulted in a favorable outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Hypertrophic cardiomyopathy in the Sphynx cat: A retrospective evaluation of clinical presentation and heritable etiology
JOURNAL OF FELINE MEDICINE AND SURGERY, 14(4), 246–249.
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / genetics; Cats; Female; Male; Phenotype; Retrospective Studies; Species Specificity
TL;DR:
The observation that Sphynx and Ragdoll breeds may have different clinical presentations, as well as different genetic mutations, suggests that hypertrophic cardiomyopathy is a diverse disease in the cat.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development
CELL CYCLE, 11(2), 335–342.
author keywords: cell cycle; D-type cyclins; skin; carcinogenesis; epidermis
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1 / genetics; Cyclin D1 / metabolism; Cyclin D2 / metabolism; Cyclin D3 / genetics; Cyclin D3 / metabolism; Gene Expression Regulation; Mice; Mice, Transgenic; Oncogene Protein p21(ras) / genetics; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tumor Burden
TL;DR:
Modulation of the levels of particular members of the D-type cyclin family could be useful to inhibit tumor development and, in particular, ras-mediated tumorigenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Biological responses in rats exposed to cigarette smoke and Middle East sand (dust)
INHALATION TOXICOLOGY, 24(2), 109–124.
author keywords: Particle toxicity; nanoparticles; rat; in vivo; in vitro; pulmonary toxicity; cytotoxicity; dust inhalation
MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Behavior, Animal / drug effects; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Dust / analysis; Gene Expression / drug effects; Hand Strength; Iraq; Larynx / drug effects; Larynx / pathology; Lung / drug effects; Lung / pathology; Lung / physiology; Male; Metals / analysis; Metals / toxicity; Motor Activity / drug effects; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Respiratory Mucosa / drug effects; Respiratory Mucosa / pathology; Silicon Dioxide / analysis; Silicon Dioxide / toxicity; Tobacco Smoke Pollution / adverse effects; Trachea / drug effects; Trachea / pathology
TL;DR:
The studies show that the respiratory toxicity of IS is qualitatively similar to or less than that seen following short-term silica exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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