College of Veterinary Medicine - General

Works Published in 2017

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Displaying works 1 - 20 of 28 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2017 journal article

Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy

Journal of Cellular and Molecular Medicine, 21(8), 1503–1512.

By: M. Hensley n, J. Tang n, K. Woodruff n, T. Defrancesco n, S. Tou n, C. Williams n, M. Breen n, K. Meurs n ...

author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy; allogeneic
MeSH headings : Animals; Biomarkers / metabolism; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / immunology; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / therapy; Coronary Vessels / cytology; Coronary Vessels / immunology; Dogs; Echocardiography; Endoglin / genetics; Endoglin / immunology; Female; Gene Expression; Humans; Male; Myocardium / immunology; Myocardium / pathology; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / immunology; Spheroids, Cellular / cytology; Spheroids, Cellular / immunology; Spheroids, Cellular / transplantation; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / immunology; Thy-1 Antigens / genetics; Thy-1 Antigens / immunology; Transplantation, Homologous
TL;DR: The safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM and Histology on dog hearts revealed no sign of immune rejection from the transplanted cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 29, 2019

2017 journal article

Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure

Data in Brief, 15, 908–915.

By: M. Foster n, T. Bartnikas*, H. Maresca-Fichter n, C. Mercadante*, M. Dash*, C. Miller*, D. Dorman n

author keywords: Copper; Zinc; Iron; Manganese Toxicity; Mouse
TL;DR: Insight is provided into strain differences in the way Mn interacts with other trace metals in mice by evaluating responses in mice with a Parkin gene defect and a wildtype strain following neonatal Mn exposure. (via Semantic Scholar)
Source: Crossref
Added: July 21, 2019

2017 journal article

Teaching Tip: Improving Students' Email Communication through an Integrated Writing Assignment in a Third-Year Toxicology Course

Journal of Veterinary Medical Education, 44(2), 280–289.

By: A. Kedrowicz, S. Hammond & D. Dorman*

author keywords: communication; writing; electronic mail; client education
MeSH headings : Curriculum; Education, Veterinary; Electronic Mail; Female; Humans; Male; Students, Medical; Teaching; Toxicology / education; Writing
TL;DR: It is suggested that additional instruction and practice should emphasize the importance of incorporating examples, metaphors, analogies, and pictures to create texts that are comprehensible and memorable to clients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Source: Crossref
Added: July 21, 2019

2017 article

Manganese Neurodegeneration

ENVIRONMENTAL FACTORS IN NEURODEGENERATIVE DISEASES, pp. 157–183.

By: D. Dorman n

Source: Web Of Science
Added: August 6, 2018

2017 journal article

Survey of Diplomates of the American Board of Veterinary Toxicology Regarding Perceptions of the Value of This Certification

INTERNATIONAL JOURNAL OF TOXICOLOGY, 36(5), 380–385.

By: D. Dorman n & A. Kedrowicz n

author keywords: toxicology; specialty board; survey
MeSH headings : Adult; Aged; Aged, 80 and over; Certification; Female; Humans; Male; Middle Aged; Surveys and Questionnaires; Toxicology
TL;DR: There is concern about the number of DABVTs and the adequacy of training programs to meet this perceived need, and these findings improve the understanding of current attitudes of D ABVTs toward their specialty. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia

NEUROSCIENCE LETTERS, 661, 11–17.

By: R. Butler n, S. Ehling n, M. Barbar n, J. Thomas n, M. Hughes n, C. Smith n, V. Pogorelov*, D. Aryal*, W. Wetsel*, B. Lascelles n

author keywords: Nociception; Contextual fear; Fear-conditioned analgesia; Amygdala; cFos; Neural circuits
MeSH headings : Acute Pain / physiopathology; Amygdala / physiopathology; Analgesia / methods; Animals; Central Amygdaloid Nucleus / metabolism; Conditioning, Psychological / physiology; Fear / physiology; Male; Mice, Inbred C57BL; Neurons / metabolism; Pain Management; Periaqueductal Gray / metabolism; Periaqueductal Gray / physiopathology
TL;DR: The results show that amygdala processing of conditioned contextual aversive, nociceptive, and FCA behaviors involve different neuronal phenotypes and neural circuits between, within, and from various amygdala nuclei. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity

NEUROGASTROENTEROLOGY AND MOTILITY, 29(11).

By: C. Pohl*, J. Medland n, E. Mackey n, L. Edwards n, K. Bagley n, M. DeWilde*, K. Williams*, A. Moeser*

author keywords: developmental origins of health and disease; early life adversity; intestinal permeability; large animal model; mast cell; mast cell plexitis; translational research
MeSH headings : Animals; Cell Count; Colon / pathology; Diarrhea / etiology; Disease Models, Animal; Enteric Nervous System / pathology; Female; Ileum / metabolism; Ileum / pathology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Intestines / pathology; Intestines / physiopathology; Male; Mast Cells / metabolism; Mast Cells / physiology; Stress, Psychological / complications; Sus scrofa; Tryptases / metabolism; Weaning
TL;DR: Early life adversity is a risk factor for development of gastrointestinal disorders later in life and the underlying mechanisms through which ELA and sex interact to influence disease susceptibility remains poorly understood. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Canine scent detection of canine cancer: a feasibility study

Veterinary Medicine: Research and Reports, Volume 8, 69–76.

By: D. Dorman*, M. Foster n, K. Fernhoff & P. Hess n

author keywords: urinary tract cancer; cancer detection dogs; cancer odor; olfactory memory; multiple sample learning
TL;DR: The study illustrates the need to consider canine olfactory memory and the use of double-blind methods to avoid erroneous conclusions regarding the ability of dogs to alert on specimens from canine cancer patients and suggests that sample storage, confounding odors, and other factors need to be considered in the design of future studies that evaluate the detection of canine cancers by scent detection dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Metal imaging in the brain

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics, 349–362.

By: D. Dorman

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (126).

By: S. Nandi n & A. Brown n

author keywords: Bioengineering; Issue 126; cell migration; three dimensional; fibrin; wound healing; extracellular matrix; integrins; in vitro wound healing assay
MeSH headings : Bioengineering / methods; Cell Movement / physiology; Humans; Wound Healing / physiology
TL;DR: The method described herein allows for the study of cell migration in a three-dimensional model that better reflects physiological conditions than previously established two-dimensional scratch assays, thus increasing the relevance of in vitro cell studies prior to the use of in vivo animal models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Angiotensin-converting enzyme activity and inhibition in dogs with cardiac disease and an angiotensin-converting enzyme polymorphism

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 18(4).

By: K. Meurs n, J. Stern n, C. Atkins n, D. Adin n, B. Aona n, J. Condit n, T. DeFrancesco n, Y. Reina-Doreste n ...

author keywords: Polymorphism; canine; angiotensin-converting enzyme; enalapril
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Breeding; Dogs; Genotype; Heart Diseases / drug therapy; Heart Diseases / enzymology; Heart Diseases / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic
TL;DR: It is possible that the genetic status and ACE activity of dogs may impact the response of dogs with this variant to an ACE inhibitor, and an ACE polymorphism is associated with lower levels of ACE activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation

ONCOLOGY LETTERS, 14(3), 2723–2734.

author keywords: skin; epidermis; papillomas; cyclin D3; cyclin-dependent kinase 6; cell cycle
TL;DR: It is demonstrated that cyclin D3 ablation does not affect keratinocyte proliferation, but instead increases apoptosis levels in the bulge region of the hair follicle, which reduces skin papilloma development in a Ras-dependent carcinogenesis model and suggests alterations in cell survival are a crucial mechanism for crippling cellular defense against neoplasia. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

IMAGING DIAGNOSIS-USE OF RADIOGRAPHY, COMPUTED TOMOGRAPHY, AND ENDOSCOPY IN THE DIAGNOSIS OF ESOPHAGEAL PERFORATION BY AN EXTRA-LUMINAL TRACHEAL RING PROSTHESIS IN A GOLDEN RETRIEVER

VETERINARY RADIOLOGY & ULTRASOUND, 58(4), E37–E41.

By: H. Paradise n, K. Mathews n & E. Cohen n

author keywords: CT; esophageal perforation; extraluminal ring prosthesis; golden retriever; tracheal collapse
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / etiology; Dogs; Esophageal Perforation / diagnostic imaging; Esophageal Perforation / etiology; Esophageal Perforation / veterinary; Esophagoscopy / veterinary; Male; Prosthesis Failure / adverse effects; Radiography / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR: A 6-year-old neutered male, Golden retriever presented with regurgitation and excitement-induced coughing, and computed tomography showed migration of a prosthetic tracheal ring, resulting in perforation of the esophagus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 article

Fifty years of contributions by the American Board of Veterinary Toxicology

Dorman, D. C., Beasley, V. R., & McClellan, R. O. (2017, August 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 251, pp. 268–270.

By: D. Dorman n, V. Beasley & R. McClellan

MeSH headings : Animals; Education, Veterinary; Toxicology; United States; Veterinary Medicine
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Effect of wearing a Telemetry jacket on behavioral and physiologic parameters of dogs in the open-field test

Journal of the American Association for Laboratory Animal Science, 56(4), 382–389.

Source: NC State University Libraries
Added: August 6, 2018

2017 personal communication

Janus kinase inhibitors display broad anti-itch properties: A possible link through the TRPV1 receptor

Fukuyama, T., Ganchingco, J. R., Mishra, S. K., Olivry, T., Rzagalinski, I., Volmer, D. A., & Baeumer, W. (2017, July).

By: T. Fukuyama n, J. Ganchingco n, S. Mishra n, T. Olivry n, I. Rzagalinski*, D. Volmer*, W. Baeumer

MeSH headings : Animals; Antipruritics / chemistry; Antipruritics / pharmacology; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Female; Humans; Janus Kinase Inhibitors / chemistry; Janus Kinase Inhibitors / pharmacology; Mice; Models, Molecular; Molecular Conformation; Molecular Imaging / methods; Protein Binding; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / metabolism; Structure-Activity Relationship; TRPV Cation Channels / antagonists & inhibitors; TRPV Cation Channels / chemistry; TRPV Cation Channels / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 article

Inhibition of spore germination, growth, and toxin activity of clinically relevant C-difficile strains by gut microbiota derived secondary bile acids

Thanissery, R., Winston, J. A., & Theriot, C. M. (2017, June). ANAEROBE, Vol. 45, pp. 86–100.

By: R. Thanissery n, J. Winston n & C. Theriot n

author keywords: C. difficile; Bile acids; Gut microbiota; Metabolome; Germination; Growth; Toxin
MeSH headings : Animals; Anti-Bacterial Agents / metabolism; Antibiosis; Bacterial Toxins / metabolism; Bile Acids and Salts / metabolism; Clostridioides difficile / drug effects; Clostridioides difficile / growth & development; Gastrointestinal Microbiome; Gastrointestinal Tract / microbiology; Humans; Mice; Spores, Bacterial / drug effects; Spores, Bacterial / growth & development
TL;DR: It is shown how clinically relevant C. difficile strains can have different responses when exposed to SBAs present in the gastrointestinal tract, and how these responses vary across all strains and ribotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog: An Update

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 47(5), 1103-+.

By: K. Meurs n

author keywords: Boxer; ARVC; Cardiomyopathy; Arrhythmia
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Dog Diseases / genetics; Dogs; Mutation; Pedigree; Prognosis
TL;DR: Arrhythmogenic right ventricular cardiomyopathy is an inheritable form of myocardial disease characterized most commonly by ventricular tachycardias, syncope, and sometimes systolic dysfunction and heart failure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing

Toxicology in Vitro, 41, 245–259.

By: J. Hamm*, K. Sullivan*, A. Clippinger, J. Strickland*, S. Bell*, B. Bhhatarai*, B. Blaauboer*, W. Casey* ...

author keywords: Acute systemic toxicity; Alternatives; LD50; Oral; Dermal Inhalation; 3Rs; In vitro; In silico
MeSH headings : Animal Testing Alternatives; Animals; Government Regulation; High-Throughput Screening Assays; Humans; Research; Toxicity Tests, Acute
TL;DR: A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state of the science of non-animal alternatives for this testing and explored ways to facilitate implementation of alternatives. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Presumed primary immune-mediated neutropenia in 35 dogs: A retrospective study

Journal of Small Animal Practice, 58(6), 307–313.

By: L. Devine, P. Armstrong, J. Whittemore, L. Sharkey, N. Bailiff, A. Huang, M. Rishniw

Source: NC State University Libraries
Added: August 6, 2018

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